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	题名	作者	年代	出处	被引量
1	TSC1-mTOR-PLK轴以阶段特异性方式调节从施旺细胞增殖到髓鞘形成的内稳态开关显示文摘恰如其分的外周髓鞘形成取决于雪旺细胞增殖与分化进程间的平衡。丝氨酸/苏氨酸激酶(mTOR)整合多种环境因素,是细胞生长、代谢、发挥作用的中枢调节者。本文报道了一种mTOR的负性调节剂——结节性硬化复合体(TSC1),通过控制细胞增殖和髓鞘稳态,建立了雪旺细胞谱系进展和髓鞘形成的阶段依赖性程序。小鼠雪旺细胞祖细胞中TSC1的解离导致mTOR信号通路激活,继而导致雪旺细胞过量增殖,分化受阻,髓鞘形成减少。转录组分析显示,TSC1突变体中的mTOR活化使得polo样激酶(PLK)依赖性通路和细胞周期调节剂上调。弱化mTOR或者对PLK进行药理抑制部分挽救了因TSC1缺失导致的外周神经发育过程中的髓鞘形成减少。相较之下,成年小鼠成熟雪旺细胞中TSC1缺失可导致髓鞘的过度增殖和过度生长。本文的发现提示了TSC1-mTOR-PLK信号轴在控制雪旺细胞的发育过程中,从增殖到分化和髓鞘内稳态中起到的阶段特异性功能。	Jiang M Rao R Wang J Wang J1 Xu L Wu LM Chan JR Wang H Lu QR 聂昊(编译)	2018	神经损伤与功能重建2018，13，5：	2
2	Positive lymph node ratio is an in- dependent prognostic factor in gastric cancer after d2 resection regard- less of the examined number of lymph nodes 显示文摘	Xu DZ Geng QR Long ZJ	2009	Ann Surg Oncol2009，16，9：	1
3	Enhanced oral bioavailability of novel mucoadhesive pellets containing valsartan prepared by a dry powder-coating technique显示文摘	Cao QR Liu Y Xu WJ	2012	Int J Pharm2012，434，12：	1
4	Development of a mode of application of bioorganic fertilizer for improving the biocontrol efficacy to Fusarium wilt 显示文摘	Ling N Xue C Huang QW Yang XM Xu YC Shen QR	2010	Biol Control2010，55，：	1
5	Activated mammalian target of rapamycin is a potential therapeutic target in gastric cancer显示文摘	Xu DZ Geng QR Tian Y	2010	BMC Cancer2010，10，：	1
6	Positive lymph node ratio is an independent prognostic factor in gastric cancer after d2 resection regardless of the examined number of lymph nodes显示文摘	Xu DZ Geng QR Long ZJ	2009	Ann Surg Oncol2009，16，2：	1
7	The N-classification for esophageal cancer staging:should it be based on number,distance,or extent of the lymph node metastasis显示文摘	Xu QR Zhuge XP Zhang HL	2011	World J Surg2011，35，6：	1
8	Activated mammalian larger of rapamycin is a potential therapeutic target in gastric cancer显示文摘	Xu DZ Geng QR Tian Y	2010	BMC Cancer2010，10，：	1
9	Linear stapled esophagogas- trostomy is more effective than hand-sewn or circular stapler in pre- vention of anastomotic stricture: a comparative clinical study 显示文摘	Xu QR Wang KN Wang WP	2011	J Gastrointest Surg2011，15，6：	1
10	The lymph node metastasis in e- sophageal carcinoma:extent is more important than number in reflecting prognosis显示文摘	Chen LQ Xu QR Hu C	2009	World J Surg2009，，：	1
11	Positive lymph node ratio is an independent prognostic factor in gastric cancer after d2 resection regardless of the examined number of lymph nodes显示文摘	Xu DZ Geng QR Long ZJ		0，，：	1
12	Diversity of soil actinomycetes in Yunnan, China显示文摘	Xu LH Li QR Jiang CL	1996	Applied and Environment Microbiology1996，62，1：	1
13	Positive lymph node ratio is an independent prognostic factor in gastric cancer after D2 resection regardless of the examinednumber of lymph nodes显示文摘	Xu DZ Geng QR Long ZJ	2009	Ann Surg Oncol2009，16，2：	1
14	Linear stapled esophagogastrostomy is more effective than hand-sewn or circular stapler in prevention of anastomotic stricture: a comparative clinical study 显示文摘	Xu QR Wang KN Wang WP	2011	J Gastrointest Surg2011，15，6：	1
15	Application of bio-organic fertilizer significantly affected fungal diversity of soils显示文摘	Luo J Ran W Hu J Yang XM Xu YC Shen QR	2010	Soil Science Society ofAmerica Journal2010，74，6：	1
16	Linear stapled esoph- agogastrostomy is more effective than hand-sewn or circular stapler in prevention of anastomotic strieture:a comparative clinical study显示文摘	Xu QR Wang KN Wang WP	2011	J Gastrointest Surg2011，15，6：	1
17	Activated mammalian tar- get of rapamycin is a potential therapeutic target in gastric cancer 显示文摘	XU DZ GENG QR TIAN Y	2010	BMCCancer2010，10，：	1
18	Beclin-1 expression is a significant predictor of survival in patients with lymph node-positive gastric cancer显示文摘	Geng QR Xu DZ He LJ	2012	PLoS One2012，7，45：	1
19	Risk of sexual HIV transmission among wives left behind and wives of nonmigrant men in rural areas of China 显示文摘	Qin QR Ji GP Xu J	2009	J Assoc Nurses AIDS Care2009，20，4：	1
20	Refining the N classification for esophageal cancer staging: Should it based on number, dis- tance, or extent of the lymph node metastasis? 显示文摘	Xu QR Zhuge XP Zhang HL	2011	World J Surg2011，35，6：	1

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