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| 1 | Low-threshold topological nanolasers based on the second-order corner state显示文摘Topological lasers are immune to imperfections and disorder.They have been recently demonstrated based on many kinds of robust edge states,which are mostly at the microscale.The realization of 2D on-chip topological nanolasers with a small footprint,a low threshold and high energy efficiency has yet to be explored.Here,we report the first experimental demonstration of a topological nanolaser with high performance in a 2D photonic crystal slab.A topological nanocavity is formed utilizing the Wannier-type 0D corner state.Lasing behaviour with a low threshold of approximately 1μW and a high spontaneous emission coupling factor of 0.25 is observed with quantum dots as the active material.Such performance is much better than that of topological edge lasers and comparable to that of conventional photonic crystal nanolasers.Our experimental demonstration of a low-threshold topological nanolaser will be of great significance to the development of topological nanophotonic circuitry for the manipulation of photons in classical and quantum regimes. | Weixuan Zhang Xin Xie Huiming Hao Jianchen Dang Shan Xiao Shushu Shi Haiqiao Ni Zhichuan Niu Can Wang Kuijuan Jin Xiangdong Zhang Xiulai Xu | 2020 | Light(Science & Applications)2020，9，1： | 10 |
| 2 | High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells显示文摘Clear cell renal cell carcinoma(ccRCC)is a frequently occurring renal cancer.The Von Hippel-Lindau disease tumor suppressor VHL,a known tumor suppressor gene,is frequently mutated in about 50%of patients with ccRCC.However,it is unclear whether VHL influences the progression of ccRCC tumors expressing wild-type VHL.In the present study,we found that higher expression of VHL was correlated with the better disease-free survival(DFS)in ccRCC patients using The Cancer Genome Atlas(TCGA)datasets.We revealed that VHL overexpression in ccRCC cells inhibited epithelial-mesenchymal transition(EMT),sterol regulatory elementbinding protein 1(SREBP1)-regulated triglyceride synthesis,and cell proliferation.Proteomic analysis provided us a global view that VHL regulated four biological processes,including metabolism,immune regulation,apoptosis,and cell movement.Importantly,we found that VHL overexpression led to up-regulated expression of proteins associated with antigen processing and interferonresponsive proteins,thus rendering ccRCC cells more sensitive to interferon treatment.We defined an interferon-responsive signature(IRS)composed of ten interferon-responsive proteins,whose m RNA expression levels were positively correlated with DFS in ccRCC patients.Taken together,our results propose that the subset of ccRCC patients with high VHL expression benefit from immunotherapy. | Songbiao Zhu Wenxi Ding Yuling Chen Weixuan Wang Renhua Xu Chongdong Liu Xiaohui Liu Haiteng Deng | 2022 | Genomics, Proteomics & Bioinformatics2022，20，4： | 1 |
| 3 | Applications and Development of Industrial Engineering in China 显示文摘 | XU Weixuan WANG Ruigang | 1995 | Computers and Industrial En- gineering1995，31，3： | 1 |
| 4 | A weighted Lq adaptive least squares support vector machine classi- fiers-Robust and sparse approximation 显示文摘 | Liu Jingli Li Jianping Xu Weixuan | 2011 | Expert Sys- tems with Applications2011，38，3： | 1 |
| 5 | Artificial Neural Network Based Predictive Method for Flood Disaster 显示文摘 | Wei Yiming Xu Weixuan Fang Yin | 2002 | Computer &Industrial Engineering2002，42，24： | 1 |
| 6 | A weighted Lq adaptive least squares support vector machine Classifiers Robust and sparse approximation显示文摘 | IAU Jingli LI Jingping XU Weixuan | 2011 | Expert Systems with Applications2011，38，3： | 1 |
| 7 | Virtual Enterprise and Its Intelligence Management显示文摘 | XU Weixuan WEI Yiming FAN Ying | 2002 | Computers & Industrial Engineering2002，42，： | 1 |
| 8 | Virtual enterprise and its intelligence management 显示文摘 | Xu Weixuan Wei Yiming Fan Ying | 2002 | Computers and Industrial Engineering2002，42，11： | 1 |
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