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| 1 | Millennial temperature reconstruction based on tree-ring widths of Qilian juniper from Wulan,Qinghai Province,China显示文摘The climate of the past 1000 years is an important context for evaluating the recent climate warming.However,there are few 1000-year-long climate reconstructions with annual resolution in the Qing-hai-Tibet Plateau.In this paper,a dendroclimatic analysis was conducted for the radial growth of Qilian juniper from the upper forest limit in Wulan,Qinghai Province.The results of correlation analysis between the tree-ring widths and the climate variables indicate that the growth of junipers at the upper forest limit is mainly limited by low temperatures of September,November and February of the pregrowth season,and July of the current growth season.There is no significant correlation between the tree-ring widths and precipitation.A mean temperature from the previous year's September to the current year's April was reconstructed for the Wulan area since A.D.1000.The reconstruction can explain 40.8% of the instrumental variance in the calibration period(1856―2002).The reconstruction shows that the 20th century is the warmest 100 years,and the 1990s is the warmest decade during the past 1000 years,while the coldest 100 years and decade occur at 1600―1699 and 1642―1651,respectively.The variations are verified well by the temperature reconstruction of the middle Qilian Mountain(QL) and the total organic carbon(TOC) in the Qinghai Lake sediments.The comparison of our reconstruction with the annual temperature reconstruction of extra-tropical Northern Hemisphere suggests that the climate of Wulan during the Medieval Warm Period is of obvious regional specialty,but there was a good response to the climate of hemispheric scales during the recent 400 years. | ZHU HaiFeng ZHENG YongHong SHAO XueMei LIU XiaoHong XU Yan LIANG ErYuan | 2008 | Chinese Science Bulletin2008，53，24： | 40 |
| 2 | Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails显示文摘 | Yanbin Fu Chenwen Huang Xinxiu Xu Haifeng Gu Youqiong Ye Cizhong Jiang Zilong Qiu Xin Xie | 2015 | Cell Research2015，25，9： | 24 |
| 3 | Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells显示文摘体的房间能由定义因素是进导致的 pluripotent 干细胞(iPSCs ) 的 reprogrammed。reprogramming 的低效率和 oncogenes 和病毒的向量的 genomic 集成限制了 iPSCs 的潜在的申请。这里,我们报导那锂(李) ,药过去常对待心情混乱,极大地从老鼠提高 iPSC 产生胚胎的成纤维细胞和人的脐的静脉 endothelial 房间。李与(Oct4 ) 或二个因素(OS 或好) 便于 iPSC 产生。支持 reprogramming 上的李的效果仅仅部分取决于它的主要目标 GSK3β。不同于另外的 GSK3β禁止者,李不仅增加 Nanog 的表示,而且提高 Nanog 的 transcriptional 活动。我们也发现李由经由 LSD1 的 downregulation 支持 epigenetic 修正施加它的效果, H3K4 特定的 histone demethylase。将 LSD1 击倒部分在提高 reprogramming 模仿李的效果。我们的结果不仅提供一个直接方法改进 iPSC 产生效率,而且为体的房间 reprogramming 作为一个批评调节的人识别了 histone demethylase。 | Quan Wang Xinxiu Xu Jun Li Jing Liu Haifeng Gu Ru Zhang Jiekai Chen Yin Kuang Jian Fei Cong Jiang Ping Wang Duanqing Pei Sheng Ding Xin Xie | 2011 | Cell Research2011，21，10： | 23 |
| 4 | Formation and destruction processes of upper Sinian oil-gas pools in the Dingshan-Lintanchang structural belt, southeast Sichuan Basin, China显示文摘The lower Cambrian Niutitang Formation hydrocarbon source rocks at the Dingshan-Lintanchang structure in the southeast Sichuan Basin were of medium-good quality with two excellent hydrocarbon-generating centers developed in the periphery areas, with a possibility of forming a medium to large-sized oil-gas field. Good reservoir rocks were the upper Sinian (Dengying Formation) dolomites. The mudstone in the lower Cambrian Niutitang Formation with a good sealing capacity was the cap rock. The widely occurring bitumen in the Dengying Formation indicates that a paleo oil pool was once formed in the study area. The first stage of paleo oil pool formation was maturation of the lower Cambrian source rocks during the late Ordovician. Hydrocarbon generation from the lower Cambrian source rocks stopped due to the Devonian-Carboniferous uplifting. The lower Cambrian source rocks then restarted generation of large quantities of hydrocarbons after deposition of the middle Permian sediments. This was the second stage of the paleo oil pool formation. The oil in the paleo oil pool began to crack during the late Triassic and a paleo gas pool was formed. This paleo gas pool was destroyed during the Yanshan-Himalayan folding, uplifting and denudation. Bitumen can be widely seen in the Dengying Formation in wells and outcrops in the Sichuan Basin and its periphery areas. This provides strong evidence that the Dengying Formation in the Sichuan Basin and its periphery areas was once an ultra-large structural-lithologic oil-gas field, which was damaged during the Yanshan-Himalayan period. | Liu Shugen Zhang Zhijing Huang Wenming Wang Guozhi Sun Wei Xu Guosheng Yuan Haifeng Zhang Changjun Deng Bin | 2010 | Petroleum Science2010，7，3： | 20 |
| 5 | A comparative study between Embosphere~ and conventional transcatheter arterial chemoembolization for treatment of unresectable liver metastasis from GIST显示文摘Objective:Transcatheter arterial chemoembolization(TACE) is a standard treatment for hepatocellular carcinoma(HCC) and/or some unresectable liver metastasis tumors.Hypervascular liver metastatic lesions such as metastasis from gastrointestinal stromal tumor(GIST) are an indication for transcatheter arterial embolization(TAE).The purpose of this study was to evaluate the efficacy and safety of Embosphere~-TAE(Embo-TAE) in comparison with conventional TACE(cTACE) for the treatment of liver metastasis from GIST.Methods:A total of 45 patients who underwent TACE between Aug 2008 and Feb 2013 were enrolled.Patients with GIST who underwent TAE with Embosphere~(n=19) were compared with controls who received cTACE(n=26).The primary end points were treatment response and treatment-related adverse events.The secondary end points were progression-free survival(PFS) and overall survival(OS).Results:The treatment response of Embo-TAE group was significantly higher than that of the cTACE group(P<0.001).The PFS was significantly better in the Embosphere~-group than in the cTACE group(56.6 and 42.1 weeks,respectively;P=0.003).However,there was no statistically significant difference in liver toxicity between the two groups(P>0.05).The median OS in the Embo-TAE group was longer than that in the cTACE group(74.0 weeks,95% CI:68.2-79.8 vs.61.7 weeks,95% CI:56.2-67.2 weeks)(unadjusted P=0.045).The use of Embo-TAE significantly reduced the risk of death in patients with GIST with liver metastases according to the Cox proportional hazards regression model [hazard ratio(HR):0.149;95% CI:0.064-0.475].Conclusions:TAE with Embosphere~ showed better treatment response and delayed tumor progression compared with cTACE.There was no significant difference in treatment-related hepatic toxicities.EmboTAE thus appears to be a feasible and promising approach in the treatment of liver metastasis from GIST. | Guang Cao Xu Zhu Jian Li Lin Shen Renjie Yang Hui Chen Xiaodong Wang Song Gao Haifeng Xu Linzhong Zhu Peng Liu Jianhai Guo | 2014 | Chinese Journal of Cancer Research2014，26，1： | 18 |
| 6 | Downstaging and resection of hepatocellular carcinoma in patients with extrahepatic metastases after stereotactic therapy显示文摘Background:A combination of tyrosine kinase inhibitors(TKIs)and anti-PD-1 antibodies with local regional therapy has elicited yield substantial clinical benefits in patients who have hepatocellular carcinoma(HCC)with extrahepatic metastases.Using this treatment strategy to convert HCC patients with extrahepatic metastases from unresectable to resectable has not yet been reported.Methods:Consecutive hepatocellular carcinoma patients with extrahepatic metastases who received first-line therapy with a combination of TKIs and anti-PD-1 antibodies and at least one local regional therapy were analysed.Results:Nine patients with localized disease who received first-line systemic therapy were enrolled.At baseline,all of them had oligometastatic disease,namely,Barcelona Clinic Liver Cancer stage C(or Chinese Liver Cancer stage IIIB).The most common treatment administered was lenvatinib plus anti-PD-1 antibody and transarterial chemoembolization,and the median time span from systemic therapy to surgery was 3.2(IQR,2.8-6.2)months.Three patients achieved a pathological complete response.Six patients underwent laparoscopic surgery,and the other 3 patients underwent open surgery.After a median follow-up of 10.2(IQR,8.6-20.0)months,7 patients survived without disease recurrence,and 2 experienced tumour recurrence.All patients had any-grade AEs,and 55.6%of the patients experienced grade 3 AEs.Fatigue was the most common AE,followed by elevated aminotransferase levels and hypertension.Conclusions:Stereotactic therapy is a feasible conversion therapy for HCC patients with extrahepatic metastases to become resectable.This is the first study to analyse therapeutic outcomes of patients receiving these therapies for HCC with extrahepatic metastases. | Xiaobo Yang Haifeng Xu Bangyou Zuo Xu Yang Jin Bian Junyu Long Dongxu Wang Junwei Zhang Cong Ning Yanyu Wang Ziyu Xun Yunchao Wang Xin Lu Yilei Mao Xinting Sang Haitao Zhao | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 17 |
| 7 | Effect of alkalinity on nitrite accumulation in treatment of coal chemical industry wastewater using moving bed biofilm reactor显示文摘Nitrogen removal via nitrite(the nitrite pathway) is more suitable for carbon-limited industrial wastewater. Partial nitrification to nitrite is the primary step to achieve nitrogen removal via nitrite. The effect of alkalinity on nitrite accumulation in a continuous process was investigated by progressively increasing the alkalinity dosage ratio(amount of alkalinity to ammonia ratio, mol/mol). There is a close relationship among alkalinity, pH and the state of matter present in aqueous solution. When alkalinity was insufficient(compared to the theoretical alkalinity amount), ammonia removal efficiency increased first and then decreased at each alkalinity dosage ratio, with an abrupt removal efficiency peak. Generally, ammonia removal efficiency rose with increasing alkalinity dosage ratio. Ammonia removal efficiency reached to 88% from 23% when alkalinity addition was sufficient. Nitrite accumulation could be achieved by inhibiting nitrite oxidizing bacteria(NOB) by free ammonia(FA) in the early period and free nitrous acid in the later period of nitrification when alkalinity was not adequate. Only FA worked to inhibit the activity of NOB when alkalinity addition was sufficient. | Baolin Hou Hongjun Han Shengyong Jia Haifeng Zhuang Qian Zhao Peng Xu | 2014 | Journal of Environmental Sciences2014，26，5： | 16 |
| 8 | MdGSTF6,activated by MdMYB1,plays an essential role in anthocyanin accumulation in apple显示文摘Anthocyanins are biosynthesized on the cytosolic surface of the endoplasmic reticulum and then transported into the vacuole for storage.Glutathione S-transferases(GSTs)are considered to be responsible for the transport of anthocyanins into the vacuole.However,the regulatory mechanisms of GSTs in plants are still unclear.Here,we performed a genome-wide analysis and identified 69 GST genes in apple.The expression of MdGSTF6 was positively correlated with the anthocyanin content(r=0.949)during‘Yanfu 8’fruit development.The overexpression of MdGSTF6 in the Arabidopsis thaliana tt19 mutant resulted in seedlings of 35S::MdGSTF6-GFP/tt19 that could accumulate anthocyanin and rescue its phenotype,suggesting that MdGSTF6 was an anthocyanin transporter.The silencing of MdGSTF6 affected anthocyanin accumulation in apple fruit.Moreover,the knockdown of MdGSTF6 by RNA interference in cultured‘Gala’seedlings inhibited anthocyanin accumulation.The interaction experiments showed that MdMYB1 could bind directly to the MdGSTF6 promoter to transcriptionally activate its expression.Collectively,our results demonstrate that MdGSTF6 encodes an important GST transporter of anthocyanins in apple fruit and provide evidence for the associated regulatory mechanisms.Therefore,MdMYB1 can not only regulate anthocyanin synthesis,but also control the transport of anthocyanin in apples.This information may be useful for further clarifying the regulation of anthocyanin transport in apple. | Shenghui Jiang Min Chen Naibo He Xiaoliu Chen Nan Wang Qingguo Sun Tianliang Zhang Haifeng Xu Hongcheng Fang Yicheng Wang Zongying Zhang Shujing Wu Xuesen Chen | 2019 | Horticulture Research2019，6，1： | 16 |
| 9 | Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft显示文摘Polyphyllin 我(PPI ) ,从巴黎 polyphyllin 的根茎提取的小分子的单体,在以前的学习显示出强壮的 anticancer 效果。人的肺腺癌 A549 房间,人的肺有鳞的房间癌 SK-MES-1 房间,和人的肺大房间癌 H460 房间与 PPI 有教养然后对待。房间增长和 apoptosis 被 3- 测量[4,5-dimethylthiazol-2-yl ]-2,5-diphenyltetrazolium 溴化物试金,流动 cytometry,西方的污点分析,和 DNA 梯子。Athymic 裸体老鼠适用肿瘤与 PPI 被注射,并且肿瘤生长被记录。我们的结果证明 PPI 显著地禁止了房间衬里的三非小的房间肺癌症(NSCLC ) 的增长,与为 A549, H460,和 SK-MES-1 的 1.24, 2.40,和 2.33 g/ml 的禁止的集中(IC50 ) 房间分别地。在为 24 h 与 PPI 的 2.5 g/ml 被对待以后, A549 房间的 apoptotic 率是 39.68% ,它比控制的显著地高。肿瘤生长显著地与在裸体老鼠与 cisplatin (DDP ) 或 PBS 对待的组相比在对待 PPI 的组被禁止。在在 vitro 并且在 vivo 的 NSCLC 房间的 PPI 展览 antitumor 能力,它可能与 apoptosis 有关由 PPI 导致了。 | Minjian Kong Junqiang Fan Aiqiang Dong Haifeng Cheng Rongzhen Xu | 2010 | Acta Biochimica et Biophysica Sinica2010，42，11： | 15 |
| 10 | Simulation of hydraulic fracture utilizing numerical manifold method显示文摘A 2nd order numerical manifold method(NMM) based method is developed to simulate the hydraulic fractures propagating process in rock or concrete. The proposed method uses a weak coupling technique to analyze the fluid phase and solid phase. To study the seepage behavior of the fluid phase, all the fractures in solid are identified by a block cutting algorithm and form a flow network. Then the hydraulic heads at crack ends are solved. To study the deformation and destruction of solid phase, the 2-order NMM and sub-region boundary element method are combined to solve the stress-strain field. Crack growth is controlled by the well-accepted criterion, including the tension criterion or Mohr-Coulomb criterion for the initialization of cracks and the maximum circumferential stress theory for crack propagation. Once the crack growth occurs, the seepage and deformation analysis will be resolved in the next simulation step. Such weak coupling analysis will continue until the structure becomes stable or is destructed. Five examples are used to verify the new method. The results demonstrate that the method can solve the SIFs at crack tip and fluid flow in crack network precisely, and the method is effective in simulating the hydraulic facture problem. Besides, the NMM shows great convenience and is of high accuracy in simulating the crack growth problem. | ZHANG GuoXin LI Xu LI HaiFeng | 2015 | Science China(Technological Sciences)2015，58，9： | 15 |
| 11 | Malus sieversii: the origin, flavonoid synthesis mechanism, and breeding of red-skinned and red-fleshed apples显示文摘Flavonoids play essential roles in human health.Apple(Malus domestica Borkh.),one of the most widely produced and economically important fruit crops in temperate regions,is a significant source of flavonoids in the human diet and is among the top nutritionally rated and most widely consumed fruits worldwide.Epidemiological studies have shown that the consumption of apples,which are rich in a variety of free and easily absorbable flavonoids,is associated with a decreased risk of various diseases.However,apple production is challenged by serious inbreeding problems.The narrowing of the hereditary base has resulted in apples with poor nutritional quality and low flavonoid contents.Recently,there have been advances in our understanding of the roles that Malus sieversii(Ledeb.)M.Roem has played in the process of apple domestication and breeding.In this study,we review the origin of cultivated apples and red-fleshed apples,and discuss the genetic diversity and construction of the core collections of M.sieversii.We also discuss current research progress and breeding programs on red-skinned and red-fleshed apples and summarize the exploitation and utilization of M.sieversii in the breeding of high-flavonoid,and red-fleshed apples.This study highlights a valuable pattern of horticultural crop breeding using wild germplasm resources.The future challenges and directions of research on the molecular mechanisms of flavonoid accumulation and high-flavonoid apple breeding are discussed. | Nan Wang Shenghui Jiang Zongying Zhang Hongcheng Fang Haifeng Xu Yicheng Wang Xuesen Chen | 2018 | Horticulture Research2018，5，1： | 15 |
| 12 | Comprehensive eco-environmental effects of the shelter-forest ecological engineering along the Tarim Desert Highway显示文摘In this work, we report a comprehensive study about the eco-environmental effects of the shelter forest along the Tarim Desert Highway, including the effects on aeolian environment, soil, micro-climate, biodiversity, and groundwater. The results show that: (1) The movement of windblown sand near the ground surface was affected by the shelter forest. The wind speed and sediment transport rate in the shelter forest decreased by 64%―80% and 87.45%―99.02%, respectively. In addition, there were also significant changes in the sand flux structure, the sand grain size, and the deflation and deposition on the ground surface. (2) Compared to the natural mobile sand, the soil bulk density in the forest area decreased while the total salt content, the total porosity, and the water content increased. In addition, the soil fertility was significantly improved in the forest area, and showed the 'first rapid, then slow' variation pattern. (3) The shelter forest showed positive effects on the micro-climate. Within the 6 m height above the ground, the air temperature in the shelter forest at different heights was lower than that in the mobile sand, while the air humidity was higher, while, the soil temperature was also lower in the shelter forest than mobile sand. (4) The number of soil microbial species increased significantly with the improvement of habitat in the shelterbelt. However, the population of different species was not distributed evenly across the surveyed area. (5) Currently, no significant effects of groundwater-pumping and forest-irrigation water have been found on the groundwater level and its salinity. The variation amplitude of both groundwater level and salinity was at the level of centimeters and 1g/L, respectively. No obvious variation trend has been observed. | LEI JiaQiang LI ShengYu JIN ZhengZhong FAN JingLong WANG HaiFeng FAN DongDong ZHOU HongWei GU Feng QIU YongZhi XU Bo | 2008 | Chinese Science Bulletin2008，53，S2： | 14 |
| 13 | Characteristics of Cd isotopic compositions and their genetic significance in the lead-zinc deposits of SW China显示文摘Up to now,the evaporation and condensation,as well as the biological absorption and inorganic absorptions,have been proved to be major factors in Cd isotope fractionation.And Cd isotopes have been widely applied in studies on the universal evolution and marine environment and so on.However,only a few researches have been conducted in applying Cd isotopes to trace the source of metallogenic material and the evolution of the ore-forming fluid in a complex mineralization environment,especially in a hydrothermal ore-formation system.We measured the Cd isotopic compositions of sphalerite,galena,and ores from five lead-zinc deposits in SW China,and found that the 114/110Cd values varied from 1.53‰to 0.34‰,with a total range of1.87‰,which is greater than most of measured geological samples.Meanwhile,through contrasting the Cd content with Cd isotopic compositions of different deposits,it may be concluded that different genetic lead-zinc deposits have different Cd content and isotopic compositions,which could be a tool for the studies on the origin of ore deposits.Also,the biomineralization and crystal fractionation may also result in Cd isotope fractionation.In a word,although the research of Cd isotopes is presently at the preliminary stage(especially in hydrothermal ore-formation system),this study demonstrated that Cd isotopes can give a clue in tracing the evolution of ore-forming fluid and metallogenic environment. | ZHU ChuanWei WEN HanJie ZHANG YuXu FAN HaiFeng FU ShaoHong XU Juan QIN TingRong | 2013 | Science China Earth Sciences2013，56，12： | 14 |
| 14 | SWMM-based methodology for block-scale LID-BMPs planning based on site-scale multi-objective optimization: a case study in Tianjin显示文摘最好的管理惯例(LID-BMPs ) 的低影响发展类型试图减轻城市的 stormwater 流量并且以一个节俭、 eco 友好的方法减少污染物质负担并且在现代城市的 stormwater 管理成为了一颗全球担心。新方法论基于为块规模 LID-BMPs 计划的 stormwater 管理模型(SWMM ) 被开发。在地点规模的综合 LID-BMP 链布局优化在全部块规模与情形分析打包的这个方法城市的区域。非统治的排序的基因算法(NSGA-II ) 成功地通过大蟒被联合到 SWMM 完成地点规模优化过程。研究区域的不同的盖情形根据优化 LID-BMP 链布局被设计。认为流量是数量索引,污染物质负担,和构造费用的多索引评估同时帮助了作为计划计划的期末考试选择划算的情形。在天津的案例研究,中国,被进行表明建议方法论。结果显示出全部的流量体积, 22%-46% 山峰流动减小效率,和超过 32% 污染物质移动率的那超过 75% 控制率被完成。坚韧性分析显示选择最后的计划计划与改变的重量价值是更加柔韧的。 | Te Xu Haifeng Jia Zheng Wang Xuhui Mao Changqing Xu | 2017 | Frontiers of Environmental Science & Engineering2017，11，4： | 13 |
| 15 | Small molecule compound induces chromatin de-condensation and facilitates induced pluripotent stern cell generation显示文摘 | Xiaoyuan Wei Yueting Chen Yongyu Xu YangZhan Ru Zhang Min Wang Qiuhong Hua Haifeng Gu Fajun Nan Xin Xie | 2014 | Journal of Molecular Cell Biology2014，8，5： | 13 |
| 16 | Stress-mediated p38 activation promotes somatic cell reprogramming显示文摘环境调停压力的改编在生活的进化起必要作用。细胞的改编机制通常包含染色质结构,抄写, mRNA 稳定性和翻译的规定,它最后在基因表示导致有效变化。全球 epigenetic 变化也涉及体的细胞的 reprogramming 进导致的 pluripotent 由定义因素的茎(iPS ) 细胞。这里,我们报导象 hyperosmosis 那样的那个环境压力不仅便于四调停因素的 reprogramming,而且提高二或一导致因素的 iPS 房间代。导致 Hyperosmosis 的 p38 激活在这个过程起一个关键作用。组成的活跃 p38 模仿 hyperosmosis 的积极效果,当主导的否定 p38 和 p38 禁止者堵住 hyperosmosis 的效果时。进一步的学习显示调停压力的 p38 激活可以由减少全球 DNA methylation 水平并且提高 pluripotency 基因的表示支持 reprogramming。我们的结果表明象 hyperosmosis 一样的简单环境应力怎么帮助经由细胞内部的发信号和 epigenetic 调整改变房间的命运。 | Xinxiu Xu Quan Wang Yuan Long Ru Zhang Xiaoyuan Wei Mingzhe Xing Haifeng Gu Xin Xie | 2013 | Cell Research2013，23，1： | 12 |
| 17 | Side Effects during Treatment of Advanced Gastric Carcinoma by Chemotherapy Combined with CIK-cell Transfusion in Elderly People显示文摘OBJECTIVE To study the side effects and therapeutic results of autologous cytokine-induced killer(CIK)cell treatment in elderly patients with advanced gastric cancer. METHODS CIK cells were induced and cultured using biotechnics in vitro,and then the cells were infused back into the patients.Sixty elderly gastric cancer patients treated by chemotherapy(FOLFOX4 protocol)were followed-up.Among them,29 patients were treated with CIK cells during application of chemotherapy.Short-term curative effects and adverse events from the CIK transfusion and chemotherapy were observed. RESULTS Eight cases developed partial remission(PR),9 cases moderate remission(MR),7 cases stable disease(SD)and 5 cases progressive disease(PD).Out of a total of 29 patients who received chemotherapy combined with autologous CIK therapy, the total remission rate(PR+MR)was 58.6%.The total remission rate following chemotherapy alone was 45.2%,including 5 PR cases,9 MR cases,7 SD cases,and 10 PD cases.There was a relatively lower rate of severe chemotherapic toxicities in the CIK- cell transfusion group.Side e?ects of autologous CIK transfusion included chills(13 cases),fever(9 cases),nausea and vomiting (1 case)and general malaise(3 cases).Side effects were treated with conventional therapy resulting in their amelioration.No patients developed shock,blood capillary leakage syndrome,or abnormalities in routine blood,urine,liver and renal function tests. CONCLUSION Adoptive immunotherapy with autologous CIK cells may decrease the clinical signs and symptoms of elderly patients who suffer from advanced gastric cancer.Adverse reactions of patients can be alleviated by conventional therapy. Autologous CIK-cell transfusion may improve endurance to chemotherapy. | Jingting Jiang Changping Wu Liangrong Shi Ning Xu Haifeng Deng Mingyang Lu Mei Ji Hbei Zhu Xueguang Zhang | 2008 | Chinese Journal of Clinical Oncology2008，5，2： | 10 |
| 18 | Features of the fault system and its relationship with migration and accumulation of hydrocarbon in Liaodong Bay显示文摘The fault system of Liaodong Bay developed extensively under the control of the Tanlu Fault.The fault system can be grouped into strike-slip faults of grade I,trunk faults of grade II and branch faults (induced faults) of grade III respectively based on its developmental scale.The faults of grade I and II were deep,early and large while the faults of grade III were shallow,late and small.The formation,evolution and distribution features played a significant role in controlling the migration of oil and gas in both horizontal and vertical directions.The fluid transfer in the fault system occurred in the process of faulting.The strike-slip and trunk faults moved actively forming predominant pathways for oil and gas migration.The branch faults,with weak activity,generally controlled the development of traps and were beneficial for the accumulation and preservation of oil and gas.The faults of grade I and II formed the major migration pathways for oil and gas,but their fault activity rates appeared to vary along their strikes.The zones with a relatively low fault activity rate might be favorable for oil and gas accumulation.When the activities of strike-slip,trunk,and branch faults came to a halt,the fault seal behavior had a vitally important effect on the accumulation of oil and gas.The controlling role of the fault over fluid distribution was further analyzed by calculating the fault activity quantitatively. | Xu Guosheng Ma Ruolong Gong Deyu Zhou Donghong Li Jianping Guo Yonghua Yuan Haifeng Wu Changrong | 2011 | Petroleum Science2011，8，3： | 8 |
| 19 | Blocking autocrine VEGF signaling by sunitinib, an anti-cancer drug, promotes embryonic stem cell selfrenewal and somatic cell reprogramming显示文摘 | Guofang Chen Xinxiu Xu Lihong Zhang Yanbin Fu Min Wang Haifeng Gu Xin Xie | 2014 | Cell Research2014，24，9： | 8 |
| 20 | Experimental Investigation on Noise of Cavitation Nozzle and Its Chaotic Behaviour显示文摘The researches of cavitation noise mainly focus on the incipiency and developing of cavitation to prevent the cavititation erosion in the hydraulic machinery, while there is few report about the collapse strength of cavitation bubbles produced by water jet through the cavitation nozzle to utilize efficiently the collapse energy of cavitation bubbles. The cavitation noise signals are collected with hydrophones for the cavitation nozzle and general nozzle at the target position and the nozzle exit separately in the conditions of different standoff distance. The features of signal's frequency spectrum and power spectrum are analyzed for various nozzles by way of classical methods. Meanwhile, based on chaotic theory, phase space reconstruction is processed and the maximum Lyapunov index is calculated separately for each cavitation signal's time series. The results of chaotic analysis are compared with the one of conventional analysis. The analyzed data show that there are the marked differences at the spectrum between the cavitation nozzle and general nozzle at the target position while the standoff distance is 35 mm, which mainly displays at the high frequency segment (60-120 kHz). The maximum Lyapunov index calculated appear at standoff distance 35 mm, which is an optimum standoff distance for the most bubbles to collapse at the target. At the nozzle exit, the noise signal of cavitation nozzle is different from the general nozzle, which also displays at the high frequency segment. The results demonstrate that the water jet modulated by the cavitation nozzle can produce effectually cavitation, and at the target position the amplitude and energy of noise spectrum in high frequency segment for cavitation nozzle are higher than conventional nozzle and the Lyapunov index of cavitation nozzle is larger than conventional nozzle as the standoff distance is less than 55 mm. The proposed research reveals that the cavitation noise produced by collapse of cavitation bubbles attributes mainly to the high frequency segment of the spectrum, which provides references for the research on cavitation noise. | ZHANG Fenghua LIU Haifeng XU Junchao TANG Chuanlin | 2013 | Chinese Journal of Mechanical Engineering2013，26，4： | 8 |
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