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| 1 | Rapeseed research and production in China显示文摘Rapeseed(Brassica napus L.) is the largest oilseed crop in China and accounts for about 20% of world production.For the last 10 years,the production,planting area,and yield of rapeseed have been stable,with improvement of seed quality and especially seed oil content.China is among the leading countries in rapeseed genomic research internationally,having jointly with other countries accomplished the whole genome sequencing of rapeseed and its two parental species,Brassica oleracea and Brassica rapa.Progress on functional genomics including the identification of QTL governing important agronomic traits such as yield,seed oil content,fertility regulation,disease and insect resistance,abiotic stress,nutrition use efficiency,and pod shattering resistance has been achieved.As a consequence,molecular markers have been developed and used in breeding programs.During 2005–2014,215 rapeseed varieties were registered nationally,including 210 winter-and 5 spring-type varieties.Mechanization across the whole process of rapeseed production was investigated and operating instructions for all relevant techniques were published.Modern techniques for rapeseed field management such as high-density planting,controlled-release fertilizer,and biocontrol of disease and pests combined with precision tools such as drones have been developed and are being adopted in China.With the application of advanced breeding and production technologies,in the near future,the oil yield and quality of rapeseed varieties will be greatly increased,and more varieties with desirable traits,especially early maturation,high yield,high resistance to biotic and abiotic stress,and suitability for mechanized harvesting will be developed.Application of modern technologies on the mechanized management of rapeseed will greatly increase grower profit. | Qiong Hu Wei Hua Yan Yin Xuekun Zhang Lijiang Liu Jiaqin Shi Yongguo Zhao Lu Qin Chang Chen Hanzhong Wang | 2017 | The Crop Journal2017，5，2： | 25 |
| 2 | m^6A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2显示文摘N6-methyladenosine (m6A),catalyzed by the methyltransferase complex consisting of Mettl3 and Mettl14,is the most abundant RNA modification in mRNAs and participates in diverse biological processes. However,the roles and precise mechanisms of m6A modification in regulating neuronal development and adult neurogenesis remain unclear. Here,we examined the function of Mettl3,the key component of the complex,in neuronal development and adult neurogenesis of mice. We found that the depletion of Mettl3 significantly reduced m6A levels in adult neural stem cells (aNSCs) and inhibited the proliferation of aNSCs. Mettl3 depletion not only inhibited neu-ronal development and skewed the differentiation of aNSCs more toward glial lineage,but also affected the morphological maturation of newborn neurons in the adult brain. m6A immunoprecip-itation combined with deep sequencing (MeRIP-seq) revealed that m6A was predominantly enriched in transcripts related to neurogenesis and neuronal development. Mechanistically,m6A was present on the transcripts of histone methyltransferase Ezh2,and its reduction upon Mettl3 knockdown decreased both Ezh2 protein expression and consequent H3K27me3 levels. The defects of neurogenesis and neuronal development induced by Mettl3 depletion could be rescued by Ezh2 overexpression. Collectively,our results uncover a crosstalk between RNA and histone modifica-tions and indicate that Mettl3-mediated m6A modification plays an important role in regulating neurogenesis and neuronal development through modulating Ezh2. | Junchen Chen Yi-Chang Zhang Chunmin Huang Hui Shen Baofa Sun Xuejun Cheng Yu-Jie Zhang Yun-Gui Yang Qiang Shu Ying Yang Xuekun Li | 2019 | Genomics, Proteomics & Bioinformatics2019，17，2： | 12 |
| 3 | New Method for Monitoring Tire Pressure of Cars Based on the Tire Radial Deformation显示文摘Monitoring tire pressure of cars and signaling abnormal conditions is an important means to prevent deadly accidents.Large achievements have been gained,especially in direct tire pressure monitoring system(TPMS).But there has been rarely research on indirect TPMS in the world.In China,the research on indirect TPMS is almost lacking.The international research on the indirect monitoring tire pressure method is mainly based on measuring and comparing the rotating speed of wheels.But it is very difficult to measure wheel rotating speed accurately because of the influence of many random factors.In this paper,the authors propose a new method in which the tire pressure can be monitored indirectly.This method can be used for tire calibration,wheel speed frequency standardization,wheel speed frequency comparison,and abnormal tire pressure determination.The pulse frequencies from wheel speed sensors of ABS are used to indicate tire deformation.Because the frequency has a relationship with tire deformation,the tire deformation reflects the tire pressure.Small sample statistics is used in the new method to increase the accuracy,and the experimental samples using the principle of the new method have been made and tested.The result of vehicle tests on road demonstrates that the method is efficient and accurate to monitor tire pressure.The research has positive potential for developing products. | HAN Zongqi WANG Liqiang LIU Quanyou JU Xuekun | 2010 | Chinese Journal of Mechanical Engineering2010，23，2： | 7 |
| 4 | Jointly Optimized Request Dispatching and Service Placement for MEC in LEO Network显示文摘Integrating Multi-access Edge Computing(MEC) in Low Earth Orbit(LEO) network is an important way to provide globally seamless low-delay service. In this paper, we consider the scenario that MEC platforms with computation and storage resource are deployed on LEO satellites, which is called 'LEO-MEC'. Service request dispatching decision is very important for resource utilization of the whole LEO-MEC system and Qo E of MEC users. Another important problem is service placement that is closely coupled with request dispatching. This paper models the joint service request dispatching and service placement problem as an optimization problem, which is a Mixed Integer Linear Programming(MILP). Our proposed mechanism solves this problem and uses the solved decision variables to dispatch requests and place services. Simulation results show that our proposed mechanism can achieve better performance in terms of ratio of served users and average hop count compared with baseline mechanism. | Chengcheng Li Yasheng Zhang Xuekun Hao Tao Huang | 2020 | China Communications2020，17，8： | 5 |
| 5 | Compositional dependence of microstructure and tribological properties of plasma sprayed Fe-based metallic glass coatings显示文摘Gas-atomized powders of three Fe-based glass-forming alloys were sprayed on mild steel substrates by atmospheric plasma spaying using the same spaying parameters. Microstructures, thermal stabilities and tribological properties of the sprayed coatings were analyzed. The coating performances showed a strong dependence on the intrinsic characters of the compositions, i.e., glass-forming ability (GFA) and supercooled liquid region (?Tx). The coatings tended to exhibit higher amorphous phase fraction for the composition with higher GFA and lower porosity for that with larger ?Tx. All the coatings exhibited superior wear resistance compared with the substrate. Higher wear resistance could be obtained in coatings with higher amorphous phase fraction, i.e. higher GFA of the composition. This study has important implications for composition selecting and optimizing in the fabrication of metallic glass coatings. | YANG Qin LI Ran LIU ZengQian SHI MinJie LUO XueKun ZHANG Tao | 2012 | Science China(Technological Sciences)2012，55，5： | 4 |
| 6 | Efficacy and safety of anlotinib plus S-1as thirdly-line or later-line treatmentin advanced non-small cell lung cancer显示文摘Objective Anlotinib,an oral vascular endothelial growth factor receptor 2(VEGFR2)inhibitor,has confirmed antitumor activity in lung cancer in both in vitro and in vivo assays,and has been recommended as third-line treatment agent in non-oncogene driven non-small cell lung cancer(NSCLC).This prospective study aimed to investigate the efficacy and safety of anlotinib plus S-1 for third-or later-line treatment in patients with advanced NSCLC.Methods Patients with histologically or cytologically confirmed NSCLC,and documented disease progression following second-line chemotherapy,and/or epidermal growth factor receptor-tyrosine kinase inhibitor(EGFR-TKI)treatment were enrolled in this study.The patients were treated anlotinib(8 mg daily d 1–14)and S-1(60 mg/m^2 d 1–14)and the treatment was repeated every 3 weeks.Treatment was continued until disease progression or unacceptable toxicity occurred.The objective response rate(ORR),disease control rate(DCR),progression-free survival(PFS),and adverse events(AEs)were reviewed and evaluated.Results Forty-one patients were enrolled in the study between June 2018 and December 2018.The total ORR and DCR were 26.8%and 80.5%,respectively.The median PFS was 5.2 months[95%confidence interval(CI),3.9 to 6.6 months].In the univariate analysis,there was a significant difference in the median PFS between patients with brain metastases and those without brain metastases(4.8 months vs 5.9 months,respectively;P=0.039).The Eastern Cooperative Oncology Group(ECOG)performance status(P=0.002),lines of therapy(P=0.015),and therapeutic evaluation(P=0.014)were independent factors that influenced PFS.The most common AEs were hypertension,proteinuria,myelosuppression,gastrointestinal reactions,fatigue,and mucositis.Conclusion Anlotinib plus S-1 is an effective and safe regimen for advanced NSCLC as third-or later-line therapy. | Heng Cao Kai Liang Peng Liu Jing Wang Yuanyuan Ji Lujuan Xu Weilong Wu Shengnan Guo Xuekun Song Yonggui Hong | 2020 | Oncology and Translational Medicine2020，6，1： | 4 |
| 7 | Highly efficient S_(2-)-adsorbed MoSx-modified TiO_(2) photocatalysts:A general grafting strategy and boosted interfacial charge transfer显示文摘Exploiting efficient and low-cost cocatalyst with a facile grafting strategy is of critical importance for significantly boosting the photocatalytic H2-evolution activity.In this study,S2^--adsorbed MoSx nanoparticle as a superior H2-evolutoin cocatalyst was successfully grafted on the TiO2 surface to greatly boost its photocatalytic activity via one-step lactic acid-induced synthesis strategy.Herein,the lactic acid can induce the homogeneous production of amorphous MoSx(a-MoSx)nanoparticles from MoS42-precursor,while the symbiotic S2^-ions can be easily and availably self-adsorbed on the a-Mo Sxsurface,resulting in the formation of S2^--adsorbed a-Mo Sxnanoparticles with a small size of 0.5-3 nm.Photocatalytic results manifested that the S2^--adsorbed Mo Sxnanoparticles could dramatically facilitate the H2-generation rate of TiO2 photocatalysts(3452μmol h^-1 g^-1,AQE=16.5%).In situ irradiated XPS in conjunction with transient-state PL and photoelectrochemical tests reveal that the improved H_(2)-generation activity can be ascribed to the synergistic effect of boosted interfacial charge transfer from TiO_(2) to S^(2-)adsorbed Mo Sx and the superior H_(2)-evolution reaction on self-adsorbed S_(2-)ions.In addition,the S^(2-)-adsorbed Mo Sx nanoparticles can also act as the general H_(2)-generation cocatalyst to obviously promote the activity of other typical host photocatalysts such as g-C_(3) N_(4) and Cd S.This work provides an innovative approach to develop high-efficiency Mo Sx-based cocatalyst with boosted interfacial charge transfer toward highly efficient photocatalytic materials. | Duoduo Gao Ranran Yuan Jiajie Fan Xuekun Hong Huogen Yu | 2020 | Journal of Materials Science & Technology2020，56，21： | 3 |
| 8 | Determination of dioxin-like polychlorinated biphenyls in soil and moss from Fildes Peninsula,Antarctica显示文摘Dioxin-like polychlorinated biphenyls(PCBs) are a class of toxic and persistent chemicals that are often found in the environment.The determination of dioxin-like PCBs in Fildes Peninsula,Antarctica,is reported in this paper.Dioxin-like PCBs were widely distributed in Antarctic soil and moss with concentration of 2.23-27.2 pg/g in soil and 10.4-812 pg/g in moss.The highest concentrations were found in the Ardley Island area and the lowest concentrations on the west coast.The contribution of PCB-118 to the ∑12PCBs ranged from 36.0% to 69.6% in soil,and 17.2% to 43.4% in moss.The congener specific patterns in soil and moss were similar.Long-range atmospheric transport is thought to be the main source of PCBs detected on King George Island.The ∑12PCBs toxic equivalent(TEQ) in soil was 0.400×10?3 to 516×10?3 pg(TEQ)/g with a mean value of 147×10?3 pg(TEQ)/g.PCB-126 had the largest contribution(81.1%) to the ∑12PCBs TEQ in soil.The ∑12PCBs TEQ in moss ranged from 2.90×10?3 to 1.19 pg/g with a mean value of 0.482 pg/g.PCB-126 was also the largest contributor(91.4%) to the ∑12PCBs TEQ in moss.The mean TEQ in moss was about 40 times that in soil. | WANG Qiang SHI YeHong HU JianXin YAO ZiWei FANG XueKun DONG YiAn | 2012 | Chinese Science Bulletin2012，57，9： | 3 |
| 9 | Identification of QTLs for Branch Number in Oilseed Rape(Brassica napus L.)显示文摘Oilseed rape(Brassica napus L.)is one of the most important oil crops worldwide and provides about 50 percent of the vegetable oil supply in China(Yin et al.,2009).The development of rapeseed varieties with higher yield is an effective measure to optimize balance between the supply and | Jinsong Xu Xi Song Yong Cheng Xiling Zou Liu Zeng Xing Qiao Guangyuan Lu Guiping Fu Zhen Qu Xuekun Zhang | 2014 | Journal of Genetics and Genomics2014，41，10： | 2 |
| 10 | Mechanism analysis and performance improvement of mechanized ridge forming of whole plastic film mulched double ridges显示文摘In order to achieve high-performance and mechanization construction standard of whole plastic mulched double ridge seedbed,and to meet its forming process and corresponding agronomic requirements of the mechanized double ridge seedbed,the key working parameters such as the speed of rotary blade group,the thickness of upturned sod and the power consumption of rotary blade group under different parameters were analyzed based on related working performance in ridge forming.Also,the test factors and their range of values were finally determined in this study.Discrete element method(DEM)simulation was applied in the numerical simulation of the mechanized ridge forming process of whole plastic mulched double ridges,and the ridge forming effect and digging resistance variation characteristics of different types of shovels were compared.Taking the forward speed of the combined machine,the penetration angle of the arc-shaped shovel and the depth of rotary tillage as independent variables,and the qualified rate of seedbed tillage as the response value,the mathematical model between the test factors and the qualified rate of the seedbed tillage was established,to explore the influence sequence of the factors on the qualified rate of seedbed tillage,and obtained the following optimal working parameters of the ridge forming device:the advancing velocity of the combined machine of 0.50 m/s,penetration angle of the arc-shaped shovel of 31°,rotary tillage depth of 140 mm,and average qualified rate 95.20%of seedbed tillage in corresponding simulation verification test.Field test showed that the average qualified rate of seedbed tillage in ridge forming device was 93.60%,which was close to that of the simulation results.The actual working condition of the sample machine was basically in line with the simulation process and could relatively precisely reflect the mechanized ridge forming mechanism of whole plastic double ridges.The results showed that the established DEM model and its parameter setting were relatively accurate and reasonable. | Fei Dai Xuefeng Song Wuyun Zhao Ruijie Shi Fengwei Zhang Xuekun Zhang | 2020 | International Journal of Agricultural and Biological Engineering2020，13，5： | 2 |
| 11 | LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice显示文摘The LIM domain-containing proteins Pinch1/2 regulate integrin activation and cell–extracellular matrix interaction and adhesion.Here,we report that deleting Pinch1 in limb mesenchymal stem cells(MSCs)and Pinch2 globally(double knockout;dKO)in mice causes severe chondrodysplasia,while single mutant mice do not display marked defects.Pinch deletion decreases chondrocyte proliferation,accelerates cell differentiation and disrupts column formation.Pinch loss drastically reduces Smad2/3 protein expression in proliferative zone(PZ)chondrocytes and increases Runx2 and Col10a1 expression in both PZ and hypertrophic zone(HZ)chondrocytes.Pinch loss increases sclerostin and Rankl expression in HZ chondrocytes,reduces bone formation,and increases bone resorption,leading to low bone mass.In vitro studies revealed that Pinch1 and Smad2/3 colocalize in the nuclei of chondrocytes.Through its C-terminal region,Pinch1 interacts with Smad2/3 proteins.Pinch loss increases Smad2/3 ubiquitination and degradation in primary bone marrow stromal cells(BMSCs).Pinch loss reduces TGF-β-induced Smad2/3 phosphorylation and nuclear localization in primary BMSCs.Interestingly,compared to those from single mutant mice,BMSCs from dKO mice express dramatically lower protein levels ofβ-catenin and Yap1/Taz and display reduced osteogenic but increased adipogenic differentiation capacity.Finally,ablating Pinch1 in chondrocytes and Pinch2 globally causes severe osteopenia with subtle limb shortening.Collectively,our findings demonstrate critical roles for Pinch1/2 and a functional redundancy of both factors in the control of chondrogenesis and bone mass through distinct mechanisms. | Yiming Lei Xuekun Fu Pengyu Li Sixiong Lin Qinnan Yan Yumei Lai Xin Liu Yishu Wang Xiaochun Bai Chuanju Liu Di Chen Xuenong Zou Xu Cao Huiling Cao Guozhi Xiao | 2020 | Bone Research2020，8，4： | 2 |
| 12 | Reduction of phonon thermal conduction in isotopic graphene nanoribbon superlattices显示文摘Graphene nanoribbons(GNR_s)recently have drawn much interest because of their novel electronic properties such as well-controlled electronic structures[1],high Seebeck coefficient[2],and intriguing electronic transport[3].For the thermoelectric energy conversion,GNR_s are thought to be rather poor candidates because of too high phonon | ZhongXiang Xie XueKun Chen Xia Yu Yong Zhang HaiBin Wang LiFu Zhang | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，10： | 2 |
| 13 | Predicting densities and elastic moduli of SiO_(2)-based glasses by machine learning显示文摘Chemical design of SiO_(2)-based glasses with high elastic moduli and low weight is of great interest.However,it is difficult to find a universal expression to predict the elastic moduli according to the glass composition before synthesis since the elastic moduli are a complex function of interatomic bonds and their ordering at different length scales.Here we show that the densities and elastic moduli of SiO_(2)-based glasses can be efficiently predicted by machine learning(ML)techniques across a complex compositional space with multiple(>10)types of additive oxides besides SiO_(2).Our machine learning approach relies on a training set generated by high-throughput molecular dynamic(MD)simulations,a set of elaborately constructed descriptors that bridges the empirical statistical modeling with the fundamental physics of interatomic bonding,and a statistical learning/predicting model developed by implementing least absolute shrinkage and selection operator with a gradient boost machine(GBM-LASSO). | Yong-Jie Hu Ge Zhao Mingfei Zhang Bin Bin Tyler Del Rose Qian Zhao Qun Zu Yang Chen Xuekun Sun Maarten de Jong Liang Qi | 2020 | npj Computational Materials2020，，1： | 2 |
| 14 | Vertical Distribution of Soil Nematode Communities under Different Tillage Systems in Lower Reaches of Liaohe River显示文摘Vertical distribution of soil nematode communities under conventional tillage (CT),no-tillage (NT) and fallow field (FF) treatments in the Lower Reaches of the Liaohe River was investigated at six soil depths (0-5 cm,5-15 cm,15-30 cm,30-50 cm,50-75 cm and 75-100 cm). The results show that total nematode abundance gradually decreases with depth,and the highest number of total nematodes is observed at 0-5 cm depth under NT and FF treatments. The number of fungivores and plant parasites is significantly higher under FF and NT treatments than under CT treatment at the 0-5 cm depth. There is significant soil depth effect on the abundances of bacterivores and omnivores-predators,which exhibits a similar trend to that of total nematodes; whereas,no significant tillage effect is found. Tillage effect on soil nematode communities can be reflected by values of relative tillage response of index V. Results of index V indicate that total nematodes,bacterivores,fungivores and plant parasites are mildly inhibited,and omnivores-predators is moderately inhibited under CT treatment; while,under FF treatment total nematodes is mildly,and fungivores and plant parasites are moderately stimulated,respectively. | HOU Xuekun HU Ning ZHANG Xiaoke LIANG Lei ZHAI Ruichang | 2010 | Chinese Geographical Science2010，20，2： | 2 |
| 15 | Synthetic polycistronic sequences in eukaryotes显示文摘The need for co-ordinate,high-level,and stable expression of multiple genes is essential for the engineering of biosynthetic circuits and metabolic pathways.This work outlines the functionality and design of IRES-and 2 A-peptide-based constructs by comparing different strategies for co-expression in polycistronic vectors.In particular,2 A sequences are small peptides,mostly derived from viral polyproteins,that mediate a ribosome-skipping event such that several,different,separate proteins can be generated from a single open reading frame.When applied to metabolic engineering and synthetic gene circuits,2 A peptides permit to achieve co-regulated and reliable expression of various genes in eukaryotic cells. | Xuekun Wang Mario Andrea Marchisio | 2021 | Synthetic and Systems Biotechnology2021，6，4： | 1 |
| 16 | Cloning and molecular characterization of a functional flavonoid 3 '-hydroxylase gene from Bras- sica napus显示文摘 | XU Benbo LI Jiana ZHANG Xuekun | 2007 | Journal of Plant Physiology2007，164，3： | 1 |
| 17 | Mechanical properties of three dimensional braided composites显示文摘 | Sun Xuekun Sun Changjie | 2004 | Composites Structure2004，65，： | 1 |
| 18 | Correlation of gammadelta-T-cells,Th17 cells and IL-17 in Peripheral blood of patients with allergic rhinitis显示文摘 | Xuekun H Qintai Y Yulian C | 2014 | Asian Pac J Allergy Immunol2014，32，3： | 1 |
| 19 | Digital-element simulation of textile processes显示文摘 | Wang Youqi Sun Xuekun | 2001 | Composites Science and Tech- nology2001，61，2： | 1 |
| 20 | Multichain digital element analysis in textile mechanics 显示文摘 | Zhou Guangming Sun Xuekun Youqi Wang | 2004 | Composites Science and Technology2004，64，2： | 1 |
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