|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Enhanced glioma-targeting and stability of ~LGICP peptide coupled with stabilized peptide ~DA7R显示文摘Malignant glioma is usually accompanied by vigorous angiogenesis to provide essential nutrients. An effective glioma targeting moiety should include excellent tumor-cell homing ability as well as good neovasculature-targeting efficiency, and should be highly resistant to enzyme degradation in the bloodstream. The phage display-selected heptapeptide, the glioma-initiating cell peptide(GICP), was previously reported as a ligand for the VAV3 protein(a Rho-GTPase guanine nucleotide exchange factor),which is mainly expressed on glioma cells; the stabilized heptapeptide ~DA7R has been shown to be the ligand of both vascular endothelial growth factor receptor 2(VEGFR2) and neuropilin-1(NRP-1), and has demonstrated good neovasculature-targeting ability. By linking ~DA7R and GICP, a multi-receptor targeting molecule was obtained. The stability of these three peptides was evaluated and their targeting efficiency on tumor-related cells and models was compared. The ability of these peptides to cross the blood–tumor barrier(BTB) was also determined. The results indicate that the coupled Y-shaped peptide ~DA7R–GICP exhibited improved tumor and neovasculature targeting ability and had higher efficiency in crossing the BTB than either individual peptide. | Mingfei Zhang Weiyue Lu | 2018 | Acta Pharmaceutica Sinica B2018，8，1： | 5 |
| 2 | Aerosol-assisted submicronγ-Fe2O3/C spheres as a promising heterogeneous Fenton-like catalyst for soil and groundwater remediation:Transport,adsorption and catalytic ability显示文摘This research reports a novel heterogeneous Fenton-like catalyst which could freely move through the model sediments and easily seize the pollutants in addition to efficiently catalyze H2O2,well suitable for soil and groundwater remediation.Herein,submicron y-Fe2O3/C spheres were synthesized through a facile one-step aerosol-based process.In a series of column tests,these spheres exhibit better transport ability due to their optimal size,conforming to the prediction by the Tufenkji-Elimelech filtration theo ry.Meanwhile,y-Fe2O3/C spheres could act as a strong adsorbent for organic pollutants owing to the presence of carbon,thereby providing a driving force to gather contaminants into their vicinity and facilitating the reaction.In addition,immobilization of y-Fe2O3 nanoparticles into carbon spheres protects iron oxides from aggregation,and thus retains the number of active sites for catalytic decomposition of H2O2.Hence,the system containing the as-prepared y-Fe2O3/C spheres and H2O2 shows the high removal efficiency and degradation efficiency in the remediation of recalcitrant organic contaminants such as methylene blue and sulfamethoxazole. | Jingjing Zhan Mingfei Li Xiujuan Zhang Yu An Weiqi Sun Aixia Peng Hao Zhou | 2020 | Chinese Chemical Letters2020，31，3： | 3 |
| 3 | 2020 Roadmap on two-dimensional nanomaterials for environmental catalysis显示文摘Environmental catalysis has drawn a great deal ofattention due to its clean ways to produce useful chemicals or carry out some chemical processes.Photocatalysis and electrocatalysis play important roles in these fields.They can decompose and remove organic pollutants from the aqueous environment,and prepare some fine chemicals.Moreover,they also can carry out some important reactions,such as 02 reduction reaction(ORR),O2 evolution reaction(OER),H2 evolution reaction(HER),CO2 reduction reaction(C02 RR),and N2 fixation(NRR).For catalytic reactions,it is the key to develop high-performance catalysts to meet the demand fortargeted reactions.In recentyears,two-dimensional(2 D) materials have attracted great interest in environmental catalysis due to their unique layered structures,which offer us to make use of their electronic and structural characteristics.Great progress has been made so far,including graphene,black phosphorus,oxides,layered double hydroxides(LDHs),chalcogenides,bismuth-based layered compounds,MXenes,metal organic frameworks(MOFs),covalent organic frameworks(COFs),and others.This content drives us to invite many famous groups in these fields to write the roadmap on two-dimensional nanomaterials for environmental catalysis.We hope that this roadmap can give the useful guidance to researchers in future researches,and provide the research directions. | Yulu Yang Mingguang Wu Xingwang Zhu Hui Xu Si Ma Yongfeng Zhi Hong Xia Xiaoming Liu Jun Pan Jie-Yinn Tang Siang-Piao Chai Leonardo Palmisano Francesco Parrino Junli Liu Jianzhong Ma Ze-Lin Wang Ling Tan Yu-Fei Zhao Yu-Fei Song Pardeep Singh Pankaj Raizada Deli Jiang Di Li R.A.Geioushy Jizhen Ma Jintao Zhang Song Hu Rongjuan Feng Gang Liu Minghua Liu Zhenhua Li Mingfei Shao Neng Li Jiahe Peng Wee-Jun Ong Nikolay Kornienko Zhenyu Xing Xiujun Fan Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 2 |
| 4 | I-V and C-V properties of TiO_2 thin film by pulsed-laser reactive deposition显示文摘TiO-2 thin films have bee deposited on p-Si(111) substrates by pulsed-laser ablation of metallic Ti target in the O-3 ambient. The current-voltage and capacitance-voltage of the Al/TiO-2/Si capacitors are measured. The results show that the dielectric constant of thin film after being annealed at 700℃ is found to be 46, and the border trap density and the interface state density at the TiO-2/p-Si interface are 1.8×10 12 cm -2 and 2×10 12 eV -1·cm -2, respectively. The conduction mechanisms of as-deposited films are also discussed. | FU Zhengwen 1, ZHOU Mingfei 1, ZHANG Shengkun 2,CHEN Lianyao 2 and QIN Qizong 1 1. Laser Chemistry Institute, Fudan University, Shanghai 200433, China 2. Department of Physics, Fudan University, Shanghai 200433, China | 1998 | Chinese Science Bulletin1998，43，16： | 2 |
| 5 | Predicting densities and elastic moduli of SiO_(2)-based glasses by machine learning显示文摘Chemical design of SiO_(2)-based glasses with high elastic moduli and low weight is of great interest.However,it is difficult to find a universal expression to predict the elastic moduli according to the glass composition before synthesis since the elastic moduli are a complex function of interatomic bonds and their ordering at different length scales.Here we show that the densities and elastic moduli of SiO_(2)-based glasses can be efficiently predicted by machine learning(ML)techniques across a complex compositional space with multiple(>10)types of additive oxides besides SiO_(2).Our machine learning approach relies on a training set generated by high-throughput molecular dynamic(MD)simulations,a set of elaborately constructed descriptors that bridges the empirical statistical modeling with the fundamental physics of interatomic bonding,and a statistical learning/predicting model developed by implementing least absolute shrinkage and selection operator with a gradient boost machine(GBM-LASSO). | Yong-Jie Hu Ge Zhao Mingfei Zhang Bin Bin Tyler Del Rose Qian Zhao Qun Zu Yang Chen Xuekun Sun Maarten de Jong Liang Qi | 2020 | npj Computational Materials2020，，1： | 2 |
| 6 | Active facet determination of layered double hydroxide for oxygen evolution reaction显示文摘Oxygen evolution reaction(OER) plays an indispensable role in developing renewable clean energy resources. One of the critical bottlenecks for the reaction is the development of highly efficient electrocatalyst to decrease the high overpotentials of four-electron transfer process of OER. Recently, layered double hydroxides(LDHs) have been widely investigated among the most promising electrocatalysts for OER due to their high intrinsic activity, excellent stability as well as low-cost. However, it remains unclear how the exposed facet of the LDHs affects their electrocatalytic activity. Here we elucidate the active edge facet of LDHs towards OER by combining the finely control of edge facet ratio coupled with molecular probe method and computational calculation. The LDHs with higher edge facet area ratio show superior activity with low onset potential as well as decreased Tafel slope. The active edge site is further proved by blocking the unsaturated edge sites with cyanate probe anion, of which the adsorption largely inhibits OER activity. Furthermore, based on density functional theory(DFT) calculation, twodimensional map of theoretical overpotentials as a function of Gibbs free energy reveals that the edge(100) facet exhibits a much higher OER activity than basal plane(001) facet. | Yunqi Zhang Wenfu Xie Jialing Ma Lifang Chen Chunyuan Chen Xin Zhang Mingfei Shao | 2021 | Journal of Energy Chemistry2021，30，9： | 2 |
| 7 | Autotrophic denitrification and its effect on metal speeiation during marine sediment remediation 显示文摘 | Shao Mingfei Zhang Tong Herbert H | 2009 | Water Research2009，43，12： | 1 |
| 8 | Degradation of brominated epoxy resin and metal recovery from waste printed circuit boards through batch sub/supercritical water treatments显示文摘 | Mingfei Xing Fu-Shen Zhang | 2013 | Chemical Engineering Journal2013，，： | 1 |
| 9 | The Role of Dihydroresveratrol in Enhancing the Synergistic Effect of Ligilactobacillus salivarius Liol and Resveratrol in Ameliorating Colitis in Mice显示文摘Currently approved therapeutical strategies for inflammatory bowel diseases(IBD)suffer from variable efficacy and association with risk of serious side effects.Therefore,efforts have been made in searching for alternative therapeutics strategies utilizing gut microbiota manipulation.In this study,we show that the probiotic strain Ligilactobacillus salivarius Li01(Li01)and the phytochemical prebiotic resveratrol(RSV)have synergistic effect in ameliorating colitis in mice.Oral coadministration of Li01(109 CFU/d)and RSV(1.5 g/kg/d)promoted restoration of various inflammatory injuries and gut microbiota composition,exhibiting a favorable anti-inflammatory effect in DSS-induced colitis mice.The combination treatment was associated with reductions in the levels of proinflammatory cytokines IL-1βand IL-6 and increases in the levels of the anti-inflammatory cytokine IL-17A in mouse serum.Moreover,the combination treatment was found to alter the composition and metabolism of the gut microbiota,especially influencing the production of short chain fatty acids and anti-inflammatory related molecules.The mechanism underlying the improved anti-inflammatory effect from the RSV and Li01 combination treatment was found to be associated with the environmental sensor mammalian aryl hydrocarbon receptor(AHR)and tryptophan metabolism pathway.Administration of RSV in combination with Li01 in different mouse model led to enhanced conversion of RSV into metabolites,including dihydroresveratrol(DHR),resveratrol-sulfate,and resveratrol-glucuronide.DHR was found to be the dominant metabolite of RSV in conventional and colitis mice.An increased DHR/RSV ratio was confirmed to activate AHR and contribute to an enhanced anti-inflammatory effect.DHR is considered as a potential AHR ligand.The DHR/RSV ratio also affected the serotonin pathway by controlling the expression of Tph1,SERT,and 5-HT7R leading to amelioration of colitis in mice.Our data suggest that treatment with a combination of Li01 and RSV has potential as a therapeutic strategy for IBD;further investigation of this combination in clinical settings is warranted. | Yiqiu Fei Shuobo Zhang Shengyi Han Bo Qiu Yanmeng Lu Weixing Huang Fang Li Deying Chen Bjorn Berglund Hang Xiao Lanjuan Li Mingfei Yao | 2022 | Research2022，，4： | 1 |
| 10 | Targeting RAS phosphorylation in cancer therapy:Mechanisms and modulators显示文摘RAS,a member of the small GTPase family,functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded state.RAS gain-of-function mutations are one of the leading causes in human oncogenesis,accounting for w19%of the global cancer burden.As a well-recognized target in malignancy,RAS has been intensively studied in the past decades.Despite the sustained efforts,many failures occurred in the earlier exploration and resulted in an‘undruggable’feature of RAS proteins.Phosphorylation at several residues has been recently determined as regulators for wild-type and mutated RAS proteins.Therefore,the development of RAS inhibitors directly targeting the RAS mutants or towards upstream regulatory kinases supplies a novel direction for tackling the anti-RAS difficulties.A better understanding of RAS phosphorylation can contribute to future therapeutic strategies.In this review,we comprehensively summarized the current advances in RAS phosphorylation and provided mechanistic insights into the signaling transduction of associated pathways.Importantly,the preclinical and clinical success in developing anti-RAS drugs targeting the upstream kinases and potential directions of harnessing allostery to target RAS phosphorylation sites were also discussed. | Yuran Qiu Yuanhao Wang Zongtao Chai Duan Ni Xinyi Li Jun Pu Jie Chen Jian Zhang Shaoyong Lu Chuan Lv Mingfei Ji | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 1 |
| 11 | 454 Pyrose-quencing reveals bacterial diversity of activated sludge from 14 sewage treatment plants显示文摘 | ZHANG Tong SHAO Mingfei YE Lin | 2012 | ISME J2012，6，6： | 1 |
| 12 | Nano-lead particlesynthesis from waste cathode ray-tube funnel glass显示文摘 | XING Mingfei ZHANG Fushen | 2011 | Journal of Hazardous Materials2011，194，5： | 1 |
| 13 | Autotrophic denitrification and its effect on metal speciation during marine sediment remediation显示文摘 | Mingfei Shao Tong Zhang Herbert H.P. Fang | 2009 | Water Research2009，，12： | 1 |
| 14 | 454 Pyrosequeneing reveals bacterial diversity of aetivated sludge from 14 sewage treatment plants 显示文摘 | Zhang Tong Shao Mingfei Ye Lin | 2012 | Isme Journal2012，6，6： | 1 |
| 15 | C,N,and P Ecological Stoichiometric Characteristics of Two Dominant Mosses in Baotianman Nature Reserve显示文摘In order to investigate ecological adaptation mechanism of bryophyte,two dominant mosses Thuidium cymbifolium and Mnium immarginatum in Baotianman Nature Reserve were measured the content of C,N,P and their ratio in bryophyte and soil,and analyzed the relationships of plant and soil ecological stoichiometric characteristics along altitudinal gradients.Results indicate that the content of C,N and P in green tissues of T.cymbifolium and M.immarginatum in Baotianman Nature Reserve was 46.81%-49.09%,0.21%-0.25%,and0.02%-0.08%.Among the different altitudinal gradients,C,N and P displayed significant differences: the significantly different content of C and N were showed in T.cymbifolium,and the content of N and P differed significantly in M.immarginatum.However,only N declined obviously as increasing altitude.In soil,the C,N,N/P and C/P showed an increasing trend with increasing elevation,while the P and C/N along altitudinal gradients exhibited no unified trend.With the increasing in the content C,N of soil,the content C and N of T.cymbifolium raised,while the content C and N of M.immarginatum declined.With the rise in P element of soil,N/P showed different trends between two bryophyte species,the N/P in T.cymbifolium significantly decreased,while N/P in M.immarginatum significantly increased.In addition,mean value of leaf N/P was 8.51,ranking 14-16.These results suggested that the growth of the bryophyte plants in Baotianman Nature Reserve were restricted by N element,and different utilization strategies in soil P element in different bryophyte plants led to differences in ecological stoichiometric characteristics. | Mingfei JI Shoufang WU Xiaowei ZHANG | 2017 | Asian Agricultural Research2017，9，8： | 1 |
| 16 | Engineering of Push‐Pull Thiophene Dyes to Enhance Light Absorption and Modulate Charge Recombination in Mesoscopic Solar Cells显示文摘 | Ning Cai Yinglin Wang Mingfei Xu Ye Fan Renzhi Li Min Zhang Peng Wang | 2012 | Adv Funct Mater2012，，14： | 1 |
| 17 | Simultaneous Optimization of Efficiency,Stretchability,and Stability in All-Polymer Solar Cells via Aggregation Control显示文摘With the emergence of Y-series small molecule acceptors,polymerizing the small molecule acceptors with aromatic linker units has attracted significant research attention,which has greatly advanced the photovoltaic performance of all-polymer solar cells.Despite the rapid increase in efficiency,the unique characteristics(e.g.,mechanical stretchability and flexibility)of all-polymer systems were still not thoroughly explored.In this work,we demonstrate an effective approach to simultaneously improve device performance,stability,and mechanical robustness of all-polymer solar cells by properly suppressing the aggregation and crystallization behaviors of polymerized Y-series acceptors.Strikingly,when introducing 50 wt%PYF-IT(a fluorinated version of PY-IT)into the well-known PM6:PY-IT system,the all-polymer devices delivered an impressive photovoltaic efficiency of 16.6%,significantly higher than that of the control binary cell(15.0%).Compared with the two binary systems,the optimal ternary blend exhibits more efficient charge separation and balanced charge transport accompanying with less recombination.Moreover,a high-performance 1.0 cm^(2)large-area device of 15%efficiency was demonstrated for the optimized ternary all-polymer blend,which offered a desirable PCE of 14.5%on flexible substrates and improved mechanical flexibility after bending 1000 cycles.Notably,these are among the best results for 1.0 cm^(2)all-polymer OPVs thus far.This work also heralds a bright future of all-polymer systems for flexible wearable energy-harvesting applications. | Kaihu Xian Kangkang Zhou Mingfei Li Junwei Liu Yaowen Zhang Tao Zhang Yong Cui Wenchao Zhao Chunming Yang Jianhui Hou Yanhou Geng Long Ye | 2023 | Chinese Journal of Chemistry2023，41，2： | 1 |
| 18 | La 0.6 Sr 0.4 Co 0.2 Fe 0.8 O 3? δ cathodes infiltrated with samarium-doped cerium oxide for solid oxide fuel cells显示文摘 | Lifang Nie Mingfei Liu Yujun Zhang Meilin Liu | 2010 | Journal of Power Sources2010，，15： | 1 |
| 19 | QTL analysis reveals reduction of fruit water loss by NAC042 through regulation of cuticular wax synthesis in citrus fruit显示文摘Postharvest water loss is a critical factor that determines the quality and shelf life of fresh fruit.Cuticular wax constitutes a key barrier to reduce fruit water loss.Our previous study has shown that HJ(Citrus reticulata)has a significantly higher postharvest water loss rate than ZK(Poncirus trifoliata).Here,we investigated the fruit water loss rate of the HJ×ZK F1pseudo-testcross population in 2016 and 2019.QTL mapping for fruit water loss rate was performed by high-density genetic map and bulk segregant analysis,and QTL9 was identified to be associated with fruit water loss.The expression of NAC042 from QTL9 in ZK was 170-fold that in HJ.Heterologous expression in Arabidopsis showed that NAC042could reduce the water loss of leaves by increasing the cuticular wax content(especially alkanes).Further expression analysis revealed that NAC042 could enhance the expression of many wax-related genes in Arabidopsis leaves,including AtKCS1,AtKCS2,AtKCS9,AtKCS20,At CER1 and At CER3.Therefore,NAC042 might be involved in fruit cuticular wax synthesis to reduce fruit water loss.The findings provide new insights into the regulation of cuticular wax and fruit water loss as well as valuable information for breeding of citrus with better storability. | Hongbin Yang Zhifeng Zhu Mingfei Zhang Xin Li Rangwei Xu Feng Zhu Juan Xu Xiuxin Deng Yunjiang Cheng | 2022 | Horticultural Plant Journal2022，8，6： | 1 |
| 20 | Humanoid robot heads for human-robot interaction:A review显示文摘The humanoid robot head plays an important role in the emotional expression of human-robot interaction(HRI).They are emerging in industrial manufacturing,business reception,entertainment,teaching assistance,and tour guides.In recent years,significant progress has been made in the field of humanoid robots.Nevertheless,there is still a lack of humanoid robots that can interact with humans naturally and comfortably.This review comprises a comprehensive survey of state-of-the-art technologies for humanoid robot heads over the last three decades,which covers the aspects of mechanical structures,actuators and sensors,anthropomorphic behavior control,emotional expression,and human-robot interaction.Finally,the current challenges and possible future directions are discussed. | LI Yi ZHU LiXiang ZHANG ZiQian GUO MingFei LI ZhiXin LI YanBiao HASHIMOTO Minoru | 2024 | Science China(Technological Sciences)2024，67，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员