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| 1 | Hepatitis B virus evades immune recognition via RNA adenosine deaminase ADAR1-mediated viral RNA editing in hepatocytes显示文摘HBV is considered as a“stealth”virus that does not invoke interferon(IFN)responses;however,the mechanisms by which HBV bypasses innate immune recognition are poorly understood.In this study,we identified adenosine deaminases acting on RNA 1(ADAR1),which is a key factor in HBV evasion from IFN responses in hepatocytes.Mechanically,ADAR1 interacted with HBV RNAs and deaminated adenosine(A)to generate inosine(I),which disrupted host immune recognition and thus promoted HBV replication.Loss of ADAR1 or its deficient deaminase activity promoted IFN responses and inhibited HBV replication in hepatocytes,and blocking the IFN signaling pathways released the inhibition of HBV replication caused by ADAR1 deficiency.Notably,the HBV X protein(HBx)transcriptionally promoted ADAR1 expression to increase the threshold required to trigger intrinsic immune activation,which in turn enhanced HBV escape from immune recognition,leading to persistent infection.Supplementation with 8-azaadenosine,an ADAR1 inhibitor,efficiently enhanced liver immune activation to promote HBV clearance in vivo and in vitro.Taken together,our results delineate a molecular mechanism by which HBx promotes ADAR1-derived HBV immune escape and suggest a targeted therapeutic intervention for HBV infection. | Liyuan Wang Yang Sun Xiaojia Song Zehua Wang Yankun Zhang Ying Zhao Xueqi Peng Xiaodong Zhang Chunyang Li Chengjiang Gao Nailin Li Lifen Gao Xiaohong Liang Zhuanchang Wu Chunhong Ma | 2021 | Cellular & Molecular Immunology2021，18，8： | 2 |
| 2 | Primary tumor location in lung cancer:the evaluation and administration显示文摘Lung cancer continues to be the leading cause of cancer-related death in the world,which is classically subgrouped into two major histological types:Non-small cell lung cancer(NSCLC)(85%of patients)and small-cell lung cancer(SCLC)(15%).Tumor location has been reported to be associated with the prognosis of various solid tumors.Several types of cancer often occur in a specific region and are more prone to spread to predilection locations,including colorectal cancer,prostate cancer,gastric cancer,ovarian cancer,cervical cancer,bladder cancer,lung tumor,and so on.Besides,tumor location is also considered as a risk factor for lung neoplasm with chronic obstructive pulmonary disease/emphysema.Additionally,the primary lung cancer location is associated with specific lymph node metastasis.And the recent analysis has shown that the primary location may affect metastasis pattern in metastatic NSCLC based on a large population.Numerous studies have enrolled the“location”factor in the risk model.Anatomy location and lobe-specific location are both important in prognosis.Therefore,it is important for us to clarify the characteristics about tumor location according to various definitions.However,the inconsistent definitions about tumor location among different articles are controversial.It is also a significant guidance in multimode therapy in the present time.In this review,we mainly aim to provide a new insight about tumor location,including anatomy,clinicopathology,and prognosis in patients with lung neoplasm. | Xueqi Xie Xiaolin Li Wenjie Tang Peng Xie Xuefen Tan | 2022 | Chinese Medical Journal2022，，2： | 2 |
| 3 | Alpha-lipoic acid enhances DMSO-induced cardiomyogenic differentiation of P19 cells显示文摘Alpha-lipoic 酸(-LA) 是在 mitochondrial 脱氢酶反应充当一个必要余因子的一种有势力抗氧化剂。-LA 被显示了拥有反煽动性并且 cytoprotective 性质,并且被用来改进糖尿病的神经病的症状。然而,在干细胞区别和未知的内在的分子的机制遗体的 -LA 的角色。在现在的学习,我们证明 -LA 显著地支持了导致的 dimethyl sulfoxide (DMSO ) 老鼠的 cardiomyogenic 区别胚胎的癌 P19 房间。-LA 剂量依赖地增加了区分 DMSO 的 P19 房间的跳动的胚胎的身体(EB ) 百分比。心脏的特定的基因 TNNT2, Nkx2.5, GATA4, MEF2C,和 MLC2V 和 troponin T (cTnT ) 的心脏的 isoform 的表情断然染色了房间人口由 -LA 的增加是显著地起来调整的。我们也证明在 EB 形成以后的区别时间是批评的让 -LA 生效。没有 DMSO 处理,有趣地, -LA 没刺激 P19 房间的 cardiomyogenic 区别。进一步的调查显示了那骨胶原而不是抗氧化的性质,提高合成的活动在 cardiomyogenic 起一个重要作用 -LA 的支持区别的功能。这些调查结果热点为在心疾病的再生治疗的 -LA 的潜在的使用。 | Xinghua Shen Qinghui Yang Peng Jin Xueqi Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，9： | 1 |
| 4 | Biological nitrogen removal in SBR bypassing nitrate generation accomplished by chlorination and aeration time control 显示文摘 | PENG Yongzhen SONG Xueqi PENG Chenyao | 2004 | Water Science and Technology2004，49，56： | 1 |
| 5 | Characteristics of SARS-CoV-2-specific cytotoxic T cells revealed by single-cell immune profiling of longitudinal COVID-19 blood samples显示文摘Dear Editor,The SARS-CoV-2 virus outbreak that started in December 2019 is now a global pandemic with over 42.7 million confirmed cases and 1.15 million deaths as of October 25,2020.It has been predicted that resurgence in contagion may be possible as late as 2024.1 A persistent anti-SARS-CoV-2 adaptive immune surveillance post infection is critical to lower the risk of resurgence and transmission.T cells are the primary effectors of cellular adaptive immunity that not only clear virus-infected cells during infection but also provide long-term protection post infection as memory cells in some pathogen infections.However,little is known regarding the longitudinal T cell response during and after SARSCoV-2 infection.Single-cell T cell receptor(TCR)sequencing allows rapid identification of expanded T cell clones that are potentially the antigen-specific clonotypes.2 To further characterize the anti-SARS-CoV-2 T cells,we sequenced the circulating T cells of five moderate or severe COVID-19 patients at different stages of infection(two patients at 1,7 and 16 weeks and three patients at 1 and 17 weeks post symptom onset)and of two healthy donors(Supplementary Tables S1,S2 and S7). | Qing Xiong Cheng Peng Xiaomin Yan Xueqi Yan Lin Chen Beicheng Sun Shiping Jiao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 6 | Characteristics of SARS-CoV-2-specific cytotoxic T cells revealed by single-cell immune profiling of longitudinal COVID-19 blood samples显示文摘Dear Editor,The SARS-CoV-2 virus outbreak that started in December 2019 is now a global pandemic with over 42.7 million confirmed cases and 1.15 million deaths as of October 25,2020.It has been predicted that resurgence in contagion may be possible as late as 2024.1 A persistent anti-SARS-CoV-2 adaptive immune surveillance post infection is critical to lower the risk of resurgence and transmission.T cells are the primary effectors of cellular adaptive immunity that not only clear virus-infected cells during infection but also provide long-term protection post infection as memory cells in some pathogen infections.However,little is known regarding the longitudinal T cell response during and after SARSCoV-2 infection.Single-cell T cell receptor(TCR)sequencing allows rapid identification of expanded T cell clones that are potentially the antigen-specific clonotypes. | Qing Xiong Cheng Peng Xiaomin Yan Xueqi Yan Lin Chen Beicheng Sun Shiping Jiao | 2021 | Signal Transduction and Targeted Therapy2021，6，1： | 0 |
| 7 | Information retrieval:a view from the Chinese IR community显示文摘During a two day strategic workshop in February 2018,22 information retrieval researchers met to discuss the future challenges and opportunities within the field.The outcome is a list of potential research directions,project ideas,and challenges.This report describes the major conclusions we have obtained during the workshop.A key result is that we need to open our mind to embrace a broader IR field by rethink the definition of information,retrieval,user,system,and evaluation of IR.By providing detailed discussions on these topics,this report is expected to inspire our IR researchers in both academia and industry,and help the future growth of the IR research community. | Zhumin CHEN Xueqi CHENG Shoubin DONG Zhicheng DOU Jiafeng GUO Xuanjing HUANG Yanyan LAN Chenliang LI Ru LI Tie-Yan LIU Yiqun LIU Jun MA Bing QIN Mingwen WANG Jirong WEN Jun XU Min ZHANG Peng ZHANG Qi ZHANG | 2021 | Frontiers of Computer Science2021，15，1： | 0 |
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