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| 1 | Gene expression profiles in an hepatitis B virus transfected hepatoblastoma cell line and differentially regulated gene expression by interferon-α显示文摘AIM: To study interactions between hepatitis B virus (HBV) and interferon-a in liver- derived cells. METHODS. mRNAs were separately isolated from an HBV-transfected cell line (HepG2 2.2.15) and its parental cell line (HePG2) pre- and post-interferon-a (IFN-a) treatment at 6, 24 and 48 h, followed by hybridization with a cDNA microarray filter dotted with 14 000 human genes. After hybridization and scanning of the arrays, the data were analyzed using ArrayGauge software. The microarray data were further verified by Northern blot analysis. RESULTS: Compared to HepG2 cells, 14 genes with known functions were down-regulated 3 to 12- magnitudes, while 7 genes were up-regulated 3-13 magnitudes in HepG2 2.2.15 cells prior to IFN-a treatment. After interferon-a treatment, the expression of four genes (vascular endothelial growth factor, tyrosine phosphate 1E, serine protein with IGF-binding motif and one gene of clathrin light chain) in HepG2 2.2.15 were up-regulated, while one gene encoding a GTP-binding protein, two genes of interferon-induced kinases and two proto-oncogenes were further down- regulated. Interestingly, under IFN-a treatment, a number of differentially regulated genes were new ESTs or genes with unknown functions. CONCLUSION: The up-regulated genes in HepG2 2.2.15 cell line suggested that under IFN-a treatment, these repressed cellular genes in HBV infected hepatooltes could be partially restored, while the down- regulated genes were most likely the cellular genes which could not be restored under interferon treatment. These down-regulated genes identified by microarray analysis could serve as new targets for anti-HBV drug development or for novel therapies. | Xunwang Zheng-HongYuan Ling-JieZheng FengYu WeiXiong Jiang-XiaLiu Gen-XiHu YaoLi | 2004 | World Journal of Gastroenterology2004，10，12： | 6 |
| 2 | Fast coating analysis and modeling for RCS reduction of aircraft显示文摘In order to fast analyze the aircraft Radar Cross Section(RCS) and accurately reduce it with Radar Absorbing Materials(RAM), a comprehensive analysis method based on Higher-Order Method of Moments(HOMOM), termed Locally Coating Method(LCM), is proposed in this paper. There are two steps to fast analyze coatings for RCS reduction in this method: analyze the RCS of various parts before coating the aircraft;model a coating over the aircraft and analyze the wave absorbing effect of it. The aircraft RCS is calculated as a whole but analyzed in various parts by LCM, and thus the RCS contribution of different parts can be compared without disturbing the current continuity. A model expansion algorithm is also presented in LCM to model absorption coatings on specified aircraft parts for later stage RCS calculation of the coated aircraft. | Haotian ZENG Xunwang ZHAO Qin SU Yu ZHANG Hao LI | 2019 | Chinese Journal of Aeronautics2019，32，6： | 2 |
| 3 | Performance of a Massively Parallel Higher-Order Method of Moments Code Using Thousands of CPUs and Its Applications 显示文摘 | ~u Zhang Zhongchao Lin Xunwang Zhao | 2014 | IEEE Transactions on Antennas and Propagation2014，62，12： | 1 |
| 4 | Time-domain method of moments accelerated by adaptivecross approximation algorithm显示文摘 | YAN Ying ZHANG Yu ZHAO Xunwang | 2012 | APSURSI2012，8，14： | 1 |
| 5 | Statins Decrease Adverse Outcomes in Coronary Artery Bypass for Extensive Coronary Artery Disease as well as Left Main Coronary Stenosis显示文摘 | Hui‐LiGan Jian‐QunZhang PingBo Sheng‐XunWang Chun‐ShangLu | 2010 | Cardiovascular Therapeutics2010，，2： | 1 |
| 6 | Time domain method of moments accelerated by adaptive cross approximation algorithm显示文摘 | YAN Ying ZHANG Yu ZHAO Xunwang | | 0，，14： | 1 |
| 7 | Fluorescence Resonant Energy Transfer Biosensor Based on Upconversion‐Luminescent Nanoparticles显示文摘 | LeyuWang RuoxueYan ZiyangHuo LunWang JinghuiZeng JieBao XunWang QingPeng YadongLi | 2005 | Angewandte Chemie International Edition2005，，37： | 1 |
| 8 | Fluorescence Resonant Energy Transfer Biosensor Based on Upconversion‐Luminescent Nanoparticles显示文摘 | LeyuWang RuoxueYan ZiyangHuo LunWang JinghuiZeng JieBao XunWang QingPeng YadongLi | 2005 | Angewandte Chemie International Edition2005，，37： | 1 |
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