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| 1 | The complete mitochondrial genome of the Chinese oak silkmoth, Antheraea pernyi (Lepidoptera: Saturniidae)显示文摘我们从中国橡树丝绸蛾决定了 mitogenome 的完全的核苷酸顺序, Antheraea pernyi (鳞翅目:Saturniidae ) 。15,566 bp 通报染色体为鳞翅类的 mitogenomes 包含不正常的基因组织和顺序。mitogenome 在已知的鳞翅类的 mitogenome 序列之中包含最低 A+T 内容(80.16%) 。一个不平常的特征比作为是更多的 T 的出现,与一在偏斜度(−0.021 ) 稍微否定,在主要染色体海滨的作文。所有编码蛋白质的基因被 ATN 鳕鱼 ons 开始,除了细胞色素 oxidase 子单元我,它被在另外的 lepidopterans 观察了的 TTAG 顺序建议。所有转移 RNA (tRNAs ) 有 mitochondrial tRNA 的典型四叶苜蓿形的立体道路交叉点结构,除了 tRNA 重量的单位 (AGN), 哪个不能形成稳定的茎环结构的 DHU 手臂。二与一段超过 50 bp 排列了顺序块, 90% 顺序身份在 Saturniidae 和 Bombycoidae 种类的 A+T 富有的区域被识别。 | Yanqun Liu Yuping Li Minhui Pan Fangyin Dai Xuwei Zhu Cheng Lu Zhonghuai Xiang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，8： | 21 |
| 2 | Bio-clickable mussel-inspired peptides improve titanium-based material osseointegration synergistically with immunopolarization-regulation显示文摘Upon the osteoporotic condition,sluggish osteogenesis,excessive bone resorption,and chronic inflammation make the osseointegration of bioinert titanium(Ti)implants with surrounding bone tissues difficult,often lead to prosthesis loosening,bone collapse,and implant failure.In this study,we firstly designed clickable mussel-inspired peptides(DOPA-N3)and grafted them onto the surfaces of Ti materials through robust catechol-TiO2 coordinative interactions.Then,two dibenzylcyclooctyne(DBCO)-capped bioactive peptides RGD and BMP-2 bioactive domain(BMP-2)were clicked onto the DOPA-N3-coated Ti material surfaces via bio-orthogonal reaction.We characterized the surface morphology and biocompatibility of the Ti substrates and optimized the osteogenic capacity of Ti surfaces through adjusting the ideal ratios of BMP-2/RGD at 3:1.In vitro,the dual-functionalized Ti substrates exhibited excellent promotion on adhesion and osteogenesis of mesenchymal stem cells(MSCs),and conspicuous immunopolarization-regulation to shift macrophages to alternative(M2)phenotypes and inhibit inflammation,as well as enhancement of osseointegration and mechanical stability in osteoporotic rats.In summary,our biomimetic surface modification strategy by bio-orthogonal reaction provided a convenient and feasible method to resolve the bioinertia and clinical complications of Ti-based implants,which was conducive to the long-term success of Ti implants,especially in the osteoporotic or inflammatory conditions. | Jie Sun Yingkang Huang Huan Zhao Junjie Niu Xuwei Ling Can Zhu Lin Wang Huilin Yang Zhilu Yang Guoqing Pan Qin Shi | 2022 | Bioactive Materials2022，7，3： | 0 |
| 3 | Self-oriented central-tumor delivery of legumain-cleavable vehicles governed by circulating monocyte/macrophage for precise tumor enrichment and immune activation显示文摘Compressed blood and intratumoral lymphatic vessels induced by proliferated tumor cells and elevated interstitial fluid pressure produce regional hypoxic and necrotic region within tumors,which severely reduced the accessibility of immunogenic cell death(ICD)related drugs and immune-related cells.Herein,the strategy of self-oriented deep tumor delivery by circulating monocyte/macrophage was proposed.Briefly,CS-AI including an indoleamine 2,3-dioxygenase(IDO)inhibitor indoximod(IND)and hydrophilic chitosan(CSO)linked with alanine-alanine-asparagine(AAN)was prepared,which could be selectively cleaved by legumain overexpressed in macrophages and promote the collapse in structure.Then,CS-AI was modified with mannose on the surface and further encapsulated the ICD inducer doxorubicin(DOX)to obtain M-CS-AI/DOX.Upon intravenous injection,MCS-AI/DOX was specially recognized and internalized by circulating monocyte in vivo.The formed drugs/monocyte tend to distribute in hypoxia/necrosis region guided by the homing signals released by tumor.Accumulated monocytes then further differentiated into macrophages,up-regulating the expression of legumain and promoting the sensitive-release of chemo-drug DOX,IND,and the mannose-modified CSO(M-CSO).The released IND would specifically regulate immunosuppressive tumor microenvironment,and synergistically inhibit tumor growth with immune activation elements,ICD-induced DOX,and the favorable adjuvant M-CSO.In summary,the self-oriented deep tumor delivery of legumain-cleavable nanovesicles through circulating monocyte makes it possible for reaching tumor regions inaccessible for nanoparticles and provides a novel insight for precise tumor enrichment and immune activation. | Fangying Yu Xuwei Shang Yun Zhu Lijun Peng Simin Chen Tingting Meng Hong Yuan Fuqiang Hu | 2023 | Nano Research2023，16，4： | 0 |
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