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| 1 | Enhancement of activity of sol-gel immobilized lipase in organic media by pretreatment with substrate analogues 显示文摘 | Furukawa S Y Ono T Ijima H | 2001 | Mol Catal B: Enzym2001，15，： | 1 |
| 2 | Blood-brain barrier opening following transient reflex sympathetic hypertension显示文摘 | Ijima T Kubota Y Kuroiwa T | 1994 | Acta Neurochir Suppl (Wien)1994，60，： | 1 |
| 3 | Enzymatic synthesis of (R)-flurbiprofen显示文摘 | Terao Y Ijima Y Kakidani H | 2003 | Bull Chem Soc Jpn2003，76，12： | 1 |
| 4 | Pyroelectric properties and application to infrared sensors of PbTiO2, PbLaTiO3 and PbZrTiO3 ferroelectric thin films 显示文摘 | TAKAYAMA R TOMITA Y IJIMA K | 1991 | Ferroelectrics1991，118，： | 1 |
| 5 | Composition of culture medium is more important than co-culture with he- patic non-parenchymal cells in albumin production activity of primary rat hepatocytes, and the effect was enhanced by hepa- tocytes spheroid culture in collagen gel 显示文摘 | Ijima H Kakeya Y Yokonuma T Hou YT Takei T | 2009 | Biochem Eng J2009，45，3： | 1 |
| 6 | Study Towards a 21^st Century Intelligent Ship显示文摘 | Ijima Y Hayashi S | 1992 | Journal of Institute of Navigation1992，，44： | 1 |
| 7 | Role of interleukin-1 induction of matrix metalloproteinases synthesized by rat temporomandibular joint chandrocytes and disc cells 显示文摘 | IJIMA Y KOBAYASHI M KUBOTA E | 2001 | Eur J Oral Sci2001，109，1： | 1 |
| 8 | Purification of a β -primeverosidase concerned with alcoholic aroma formation in tea leaves显示文摘 | K Ogawa Y Ijima W Guo | 1997 | Journal of Agriculture and Food Chemistry1997，45，： | 1 |
| 9 | Cis and trans-linalool 3,7 oxides and methyl salicylate glycosides and (Z)-3-hexenyl fl-D-glucopyranoside as aroma precursors from tea leaves for oolong tea显示文摘 | MOON J K WATANABE N IJIMA Y | 1996 | Bioscienee Biotechnology and Bi ochemistry1996，60，18： | 1 |
| 10 | Character ization of primeverosidase, being concerned with alcoholic aroma formation in tea leaves to be processed into black tea, and preliminary observations on its substrate specificity显示文摘 | IJIMA Y OGAWA K WATANABE N | 1998 | Journal of Agricultural and Food Chemistry1998，46，： | 1 |
| 11 | Thin-film metal-coated recording tape “ ANGROM”显示文摘 | | 1979 | National Tech Rep1979，25，5： | 1 |
| 12 | Inversion of enantioselectivity of arylmalonate decarboxylase via site-directed mutation based on the proposed reaction mechanism 显示文摘 | Terao Y Ijima Y Miyamoto K | 2007 | Journal of Molecular Catalysis B : Enzymatic2007，45，： | 1 |
| 13 | Inversion of enantioselectivity of asymmetric biocatalytic decarboxylation by site-directed mu- tagenesis based on the reaction mechanism显示文摘 | Ijima Y Matoishi K Terao Y | 2005 | Chemical Com- munications2005，7，： | 1 |
| 14 | Linaly β- D-glucopyranoside and its 6-O-malonate as aroma precursors from Jasminum sambac Ait 显示文摘 | Moon J H Watanabe N Ijima Y | 1994 | Phytochemistry1994，36，6： | 1 |
| 15 | Cis- and trans- linalool 3, 7-oxides and methyl salicylate glycosides and(z)- 3-hexenyl β-D-glucopyranoside as aroma precursors from tea leaves for oolang tea 显示文摘 | Moon J H Watanabe N Ijima Y | 1996 | Bioscience Biotechnology and Biochemistry1996，60，11： | 1 |
| 16 | Cis- and trans-Linalool 3, 7-oxides and methyl salicylate glycosides and (Z)-3-hexenyl β-D-glucopyranoside as aroma precursors from tea leaves for oolong tea 显示文摘 | Moon JK Watanabe N Ijima Y Yagi A Sakata K | 1996 | Biosci Biotechnol Biochem1996，60，： | 1 |
| 17 | 显示文摘 | Takayama R Tomita Y Ijima K | 1991 | Ferroelectrics1991，118，： | 1 |
| 18 | Characterization of β- primeverosidase, being concerned with alcoholic aroma formation in tea leaves to be processed into black tea,and preliminary observations on its substrate specificity显示文摘 | Ijima Y Ogawa K Watanabe N | 1998 | Journal of Agricultural and Food Chemistry1998，46，5： | 1 |
| 19 | Human IgG1 antibodies suppress angiogenesis in a target-independent manner显示文摘Aberrant angiogenesis is implicated in diseases affecting nearly 10%of the world’s population.The most widely used antiangiogenic drug is bevacizumab,a humanized IgG1 monoclonal antibody that targets human VEGFA.Although bevacizumab does not recognize mouse Vegfa,it inhibits angiogenesis in mice.Here we show bevacizumab suppressed angiogenesis in three mouse models not via Vegfa blockade but rather Fc-mediated signaling through FcγRI(CD64)and c-Cbl,impairing macrophage migration.Other approved humanized or human IgG1 antibodies without mouse targets(adalimumab,alemtuzumab,ofatumumab,omalizumab,palivizumab and tocilizumab),mouse IgG2a,and overexpression of human IgG1-Fc or mouse IgG2a-Fc,also inhibited angiogenesis in wild-type and FcγR humanized mice.This anti-angiogenic effect was abolished by Fcgr1 ablation or knockdown,Fc cleavage,IgG-Fc inhibition,disruption of Fc-FcγR interaction,or elimination of FcRγ-initated signaling.Furthermore,bevacizumab’s Fc region potentiated its anti-angiogenic activity in humanized VEGFA mice.Finally,mice deficient in FcγRI exhibited increased developmental and pathological angiogenesis.These findings reveal an unexpected anti-angiogenic function for FcγRI and a potentially concerning off-target effect of hIgG1 therapies. | Sasha Bogdanovich Younghee Kim Takeshi Mizutani Reo Yasuma Laura Tudisco Valeria Cicatiello Ana Bastos-Carvalho Nagaraj Kerur Yoshio Hirano Judit Z Baffi Valeria Tarallo Shengjian Li Tetsuhiro Yasuma Parthasarathy Arpitha Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Menotti Ruvo Annamaria Sandomenico Miho Nozaki Ryo Ijima Hiroki Kaneko Yuichiro Ogura Hiroko Terasaki Balamurali K Ambati Jeanette HW Leusen Wallace Y Langdon Michael R Clark Kathryn L Armour Pierre Bruhns J Sjef Verbeek Bradley D Gelfand Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 0 |
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