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| 1 | Would integrated Western and traditional Chinese medicine have more benefits for stroke rehabilitation? A systematic review and meta-analysis显示文摘Background Stroke is a major cause of death or long-term disability worldwide.Many patients with stroke receive integrative therapy consisting of Western medicine(WM)and routine rehabilitation in conjunction with Chinese medicine(CM),such as acupuncture and Chinese herbal medicine.However,there is no available evidence on the effectiveness of the combined use of WM and CM interventions in stroke rehabilitation.Aims The purpose of this meta-analysis is to evaluate the results of all individual studies to assess the combined use of CM and WM in stroke rehabilitation compared with WM only.Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were followed.MEDLINE,EMBASE,Cochrane and China National Knowledge Infrastructure(CNKI)were searched.The included outcomes were dependency,motor function,depression and swallowing function.Subgroup analysis was performed,and publication bias was assessed using funnel plots.Summary of review 58 studies and 6339 patients were included in the meta-analysis.Subgroup analysis revealed that combined therapy comprising both acupuncture and WM had a superior effect on improving dependency and swallowing function compared with standard WM therapy alone.Potential superiority of combined therapy comprising CM and WM in improving depression compared with standard WM therapy was also found.Conclusions Our results indicate that the combined use of CM and WM could be more efficacious in stroke rehabilitation compared with the use of WM therapy alone.However,most studies were short in duration(2 to 4 weeks)and prone to different types of biases,which prevents making any conclusion regarding the long-term effects and raises concerns regarding true efficacy in context of high likelihood of Hawthorn bias.So,more randomised controlled trials with more rigorous design and longer duration of treatment and follow-up need to be conducted to compare WM alone versus WM and CM combined. | Linda LD Zhong Ya Zheng Alexander Y Lau Norman Wong Liang Yao Xingyao Wu Tengteng Shao Zhenxing Lu Huijuan Li Chun Sum Yuen Jianwen Guo Suzanne Lo Janita Chau Kam Wa Chan Bacon Fung Leung Ng Zhaoxiang Bian Edwin Chau-leung Yu | 2022 | Stroke & Vascular Neurology2022，7，1： | 7 |
| 2 | 二十碳五烯酸对三种肝癌细胞系作用的实验研究显示文摘目的 探讨二十碳五烯酸 (eicosapentaenoicacid ,EPA)对 3种肝癌细胞系作用。方法EPA作用于HepG2 (携带有野生型p5 3基因 )、Huh7(携带有突变型p5 3基因 )和Hep3B(p5 3基因缺失 )这 3种肝癌细胞系 ,通过细胞计数、DNA电泳、流式细胞技术和末端转移酶标记技术等来检测EPA对这 3种细胞系的作用和可能的机制。结果 EPA主要是通过诱导HepG2肝癌细胞系的细胞凋亡来抑制其生长 ,而且这种抑制作用呈现出时间和剂量依赖的关系 ,而且同时发现EPA对于Huh7和Hep3B这两种肝癌细胞系无明显抑制作用。结论 细胞凋亡的诱导可能是EPA抑制HepG2肝癌细胞系生长的主要机制 ,而且p5 3基因可能参与EPA诱导HepG2细胞系细胞凋亡的过程。 | 王蓬 陈孝平 PBS Lai CK leow Joseph W Y Lau | 2001 | 中华普通外科杂志2001，16，1： | 4 |
| 3 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 4 |
| 4 | Evolving treatment landscape for early and advanced pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma is an infrequent cancer with a high disease related mortality rate, even in the context of early stage disease. Until recently, the rate of death from pancreatic cancer has remained largely similar whereby gemcitabine monotherapy was the mainstay of systemic treatment for most stages of disease. With the discovery of active multiagent chemotherapy regimens, namely FOLFIRINOX and gemcitabine plus nab-paclitaxel, the treatment landscape of pancreatic cancer is slowly evolving. FOLFIRINOX and gemcitabine plus nab-paclitaxel are now considered standard first line treatment options in metastatic pancreatic cancer. Studies are ongoing to investigate the utility of these same regimens in the adjuvant setting. The potential of these treatments to downstage disease is also being actively examined in the locally advanced context since neoadjuvant approaches may improve resection rates and surgical outcomes. As more emerging data become available, the management of pancreatic cancer is anticipated to change significantly in the coming years. | Sally C Lau Winson Y Cheung | 2017 | World Journal of Gastrointestinal Oncology2017，9，7： | 3 |
| 5 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 6 | Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study显示文摘 | Hongjie Yu Joseph T Wu Benjamin J Cowling Qiaohong Liao Vicky J Fang Sheng Zhou Peng Wu Hang Zhou Eric H Y Lau Danhuai Guo Michael Y Ni Zhibin Peng Luzhao Feng Hui Jiang Huiming Luo Qun Li Zijian Feng Yu Wang Weizhong Yang Gabriel M Leung | 2013 | The Lancet2013，，： | 2 |
| 7 | Microproteinuria for detecting calcineurin inhibitor-related nephrotoxicity after liver transplantation显示文摘AIM: To investigate whether microproteinuria could be used as an early and sensitive indicator to detect calcineurin inhibitor (CNI)-related nephrotoxicity after liver transplantation. METHODS: All liver transplant recipients with normal serum creatinine (SCr) and detectable microproteinuria at baseline were included in this study. The renal function was monitored by the blood clearance of 99mTc-diethylenetriaminepentaacetic acid every 6 mo. Microproteinuria, SCr and blood urea nitrogen (BUN) were measured at entry and at subsequent follow-up visits. The patients were divided into different groups according to the mean values of glomerular filtration rate (GFR) at the follow-up time points: Group 1, GFR decreased from baseline by 0%-10%; Group 2, GFR decreased from baseline by 11%-20%; Group 3, GFR decreased from baseline by 21%-40%; Group 4, GFR decreased from baseline by > 40% and/or SCr was increasing. RESULTS: A total of 143 patients were enrolled into this study (23 females and 120 males). The mean follow-up was 32 mo (range 16-36 mo). Downward trends in renal function over time were observed in the study groups. SCr and BUN increased significantly only in Group 4 patients (P < 0.001). β2-microglobulin (β2m) and α1-microglobulin (α1m) significantly increased with the subtle change of renal function in recipients who were exposed to CNI-based immunosuppression regimens. The reductions in GFR were closely correlated with elevated α1m (r2 = -0.728, P < 0.001) and β2m (r2 = -0.787, P < 0.001). CONCLUSION: β2m and α1m could be useful as early and sensitive indicators of CNI-induced nephrotoxicity. | Jing Li Bin Liu Lu-Nan Yan Lan-Lan Wang Wan Y Lau Bo Li Wen-Tao Wang Ming-Qing Xu Jia-Yin Yang Fu-Gui Li | 2009 | World Journal of Gastroenterology2009，15，23： | 2 |
| 8 | Development of fuzzy algorithm for servo system显示文摘 | Li Y F Lau C C | 1989 | IEEE Control System Magazine1989，9，3： | 2 |
| 9 | Global Nanoteehnology Research Literature Overview显示文摘 | Kostoff R N Koytcheff R G Lau C G Y | 2007 | Current Science2007，，11： | 1 |
| 10 | Daytime urban heat island effect in high-rise and high-density residential developments in Hong Kong显示文摘 | Giridharan R Ganesan S Lau S S Y | 2004 | Energy and Building2004，36，6： | 1 |
| 11 | Using tone information in cantonese continuous speech recognition显示文摘 | Lee T Lau W Wong Y W | 2002 | ACM Transactions on Asian Language Information Processing2002，1，1： | 1 |
| 12 | High level expression of hepatitis B viral antigens in fibrosing cholestatic hepatitis 显示文摘 | Lau J Y N Davis GL Bain V G | 1992 | Gastroenterology1992，102，： | 1 |
| 13 | An effective quasi-human based heuristic for solving the rectangle packing problem显示文摘 | Wu Y L Huang W Q Lau S | 2002 | Europearl Journal of Operational Research2002，141，： | 1 |
| 14 | Effect of Milk Fat on the Stability of Vitamin A in Ultra-High Temperature Milk 显示文摘 | LAU B L T KAKUDA Y ARNOTT D R | 1986 | J Dairy Sci1986，69，： | 1 |
| 15 | Suppression subtractive hy+bridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries显示文摘 | Lau Y F Campbell A P | 1996 | Proc Natl Acad Sci U S A1996，93，12： | 1 |
| 16 | Catheter-related microbacterium bacteremia identified by 16 S rRNA gene sequencing显示文摘 | Lau K P Woo C Y Moo M Y et a1 | 2002 | Clin Microbiol2002，40，7： | 1 |
| 17 | Carbon Nanotube Films Prepared by Thermal Chemical Vapor Deposition at Low Temperature for Field Emission Applications显示文摘 | Li Y J Sun Z Lau S P | 2001 | Appl Phys Lett2001，79，11： | 1 |
| 18 | Suppression subtractive hybridization:a method for generating differentially regulated or tissue specific cDNA probes and libraries显示文摘 | Diatchenko L Lau Y F Campbell A P | 1996 | Proc Natl Acad Sci U S A1996，93，12： | 1 |
| 19 | Enhancement of nearband-edge photoluminescence from ZnO films by face-to-face annealing显示文摘 | Wang Y G Lau S P Zhang X H | 2003 | J Crystal Gruth2003，259，： | 1 |
| 20 | Robust Input Shaper Control Design for Parameter Variations in Flexible Structures显示文摘 | Pao L Y Lau M A | 2000 | Journal of Dynamic Systems Measurement and Control2000，122，1： | 1 |
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