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您的检索式：作者名="Y.Alex Zhang"
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| 1 | Accelerated generation of oligodendrocyte progenitor cells from human induced pluripotent stem cells by forced expression of Sox10 and Olig2显示文摘Oligodendrocyte progenitor cells(OPCs) hold great promise for treatment of dysmyelinating disorders, such as multiple sclerosis and cerebral palsy. Recent studies on generation of human OPCs mainly use human embryonic stem cells(hESCs) or neural stem cells(NSCs) as starter cell sources for the differentiation process. However, NSCs are restricted in availability and the present method for generation of oligodendrocytes(OLs) from ESCs often requires a lengthy period of time. Here, we demonstrated a protocol to efficiently derive OPCs from human induced pluripotent stem cells(hiPSCs) by forced expression of two transcription factors(2TFs), Sox10 and Olig2. With this method, PDGFRα+ OPCs can be obtained in 14 days and O4^+ OPCs in 56 days.Furthermore, OPCs may be able to differentiate to mature OLs that could ensheath axons when co-cultured with rat cortical neurons. The results have implications in the development of autologous cell therapies. | Pengyan Li Mo Li Xihe Tang Shuyan Wang Y.Alex Zhang Zhiguo Chen | 2016 | Science China(Life Sciences)2016，59，11： | 4 |
| 2 | Cell therapy for macular degeneration—first phase Ⅰ/Ⅱ pluripotent stem cell-based clinical trial shows promise显示文摘Embryonic stem(ES)cells,a type of pluripotent stem cells(PSCs)that are derived from the inner cell mass of blastocysts,have been discovered for more than three decades[1].Given the almost infinite self-renewal capacity and the potential to differentiate into any specific cell type in an individual,ES cells and PSCs have brought hope for the treatment of many unmet diseases.However,the advantages of PSCs—the highly proliferative and plastic capacities,also give rise to concerns regarding the development of | CHEN ZhiGuo ZHANG Y.Alex | 2015 | Science China(Life Sciences)2015，58，1： | 4 |
| 3 | Comparative characterization of mesenchymal stem cells from different age groups of cynomolgus monkeys显示文摘Bone marrow mesenchymal stem cells(BM-MSCs) are a potential tool for cell therapy and tissue engineering.In this study,we carried on a comparative study of the characteristics of MSCs from different age cynomolgus monkeys.A variety of factors,including donor age,must be considered before further applications,and various tests should be used to properly assess MSCs before the clinical application,especially when a prolonged culture and ex vivo expansion is necessary. | ZHANG Y.Alex | 2010 | Science China(Life Sciences)2010，53，5： | 3 |
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