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| 1 | 蛋白酶激活受体2在载脂蛋白E缺陷小鼠的血管炎症和动脉粥样硬化中发挥关键作用显示文摘凝血系统与血管炎症密切相关,尽管其潜在机制仍不清楚。最近的研究结果表明,蛋白酶激活受体(protease-activated receptor,PAR)2——活化因子X(activated factor X,FXa)的主要受体之一——在血管细胞和白细胞中均有表达,这提示PAR-2可能参与炎症性疾病的发病机制。 | Hara T Phuong PT Fukuda D Yamaguchi K Murata C Nishimoto S Yagi S Kusunose K Yamada H Soeki T Wakatsuki T Imoto I Shimabukuro M Sata M 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，6： | 11 |
| 2 | 根据血压等级确定脑卒中和冠状动脉粥样硬化性心脏病死亡的终生风险:日本EPOCH(观察队列的心血管预防证据)研究显示文摘在亚洲人群中.很少研究关注根据血压分类确定脑卒中和冠状动脉粥样硬化性心脏病(coronary heartdisease,CHD)的终生风险。该研究旨在用一个包含个体参与者数据的荟萃分析大数据库来评估它。该荟萃分析纳入来源于13个队列的107 737名日本人(男性占42.4%,平均年龄55.1岁)。在平均(15.2±5.3)年(1 559 136人年)的随访期.1922人死于脑卒中,913人死于CHDO研究者在调整其他死亡危险因素后估计风险。 | 陈嘉睿(译) 练桂丽(审校) Satoh M Ohkubo T Asayama K Murakami Y Sugiyama D Yamada M Saitoh S Sakata K Irie F Sairenchi T Ishikawa S Kiyama M Ohnishi H Miura K Imai Y Ueshima H Okamura T EPOCH-JAPAN research group | 2019 | 中华高血压杂志2019，27，4： | 9 |
| 3 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 4 | 步行6min负荷超声心动图预测结缔组织病患者远期显性肺高血压显示文摘肺高血压是结缔组织病(connective tissue disease,CTD)的主要死因。运动负荷试验已用于筛查早期肺高血压[1],但由于缺乏相关证据,最新的指南已停止其作为发现肺高血压的方法。近期研究发现平均肺动脉压(mean pulmonary arterial pressure,mPAP)升高导致心输出量异常可用于评估肺高血压进展及肺功能分级[2]。该研究将步行6min后的超声心动图参数作为非侵入性负荷试验。 | Kusunose K Yamada H Hotchi J Bando M Nishio S Hirata Y Ise T Yamaguchi K Yagi S Soeki T Wakatsuki T Kishi J Sata M 曲浥晨 | 2015 | 中华高血压杂志2015，23，10： | 3 |
| 5 | Transfer of the von Hippel-Lindau gene to neuronal progenitor cells in treatment for Parkinson's disease显示文摘 | Yamada H Dezawa M Shimazu S | 2003 | Ann Neurol2003，54，3： | 1 |
| 6 | Feasibility of magnetic liposomes as a targeting device for drug 显示文摘 | Kiwada H Sato J Yamada S | 1986 | Chem Pharm Bull1986，34，： | 1 |
| 7 | The effectiveness of perioperative intravenous flurbiprofen in minor ear,neck and nose surgery显示文摘 | Aoki H Satomoto M Yamada S | 2002 | Masui2002，51，8： | 1 |
| 8 | Improvement of tensile properties of wrought magnesium alloys by grain refining显示文摘 | Kamado S Ashie T Yamada H | 2000 | Mater Sci Forum2000，35，： | 1 |
| 9 | Effectiveness of lanthanum carbonate treatment used in combination with other phosphate binders in peritoneal dialysis patients 显示文摘 | Yamada S Yoshida H Taniguchi M | 2012 | Intern Med2012，51，16： | 1 |
| 10 | Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathological features 显示文摘 | Yamada T Nakamori S Ohzato H | 1998 | Clin Cancer Res1998，4，6： | 1 |
| 11 | Predation by fishes on hatchery-reated Japanese flounder (Paralichthys olivaceus), juveniles released in the coastal area of Tottori Prefecture显示文摘 | Furuta S Watnabe T Yamada H | 1998 | Nippon Suisan Gakkaishi1998，64，1： | 1 |
| 12 | 查看详情显示文摘 | Minamikawa H Hayakawa S Yamada T Iwasawa N Narasaka K | | 0，，： | 1 |
| 13 | The cell binding fragment of fibronectin is chemotactic for fibroblasts显示文摘 | Seppa H E Yamada K M Seppa S T | 1981 | Cell Biol Int Rep1981，5，8： | 1 |
| 14 | Detection ofK-ras gene mutations in plas- ma DNA of patients with pancreatic aden-ocarcinoma: correlation with clinicopat- hologieal features显示文摘 | Yamada T Nakamori S Ohzato H | 1998 | Clin Cancer Res1998，4，6： | 1 |
| 15 | Upper gastrointestinal bleeding in patients receiving dual antiplatelet therapy after coronary stenting显示文摘 | Yasuda H Yamada M Sawada S | 2009 | Intern Med2009，48，19： | 1 |
| 16 | R spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutant显示文摘 | Kamata T Katsube K Michikawa M Yamada M Takada S Mizusawa H | 2004 | Biochim Biophys Acta2004，1676，： | 1 |
| 17 | Simulation of space weathering of planet-forming materials : Nanosecond pulse laser irradiation and proton implantation on olivine and pyrnxene samples 显示文摘 | Yamada M Sasaki S Nagahara H | 1999 | Earth Planets Space1999，，： | 1 |
| 18 | Application of a cubic-like mesoporous silica film to a surface photovoltage gas sensing system 显示文摘 | Yamada T Zhou H S Uchida H | 2002 | Microporous and Mesoporous Materials2002，，54： | 1 |
| 19 | Expression of MMP-9 in mesangial cells and its changes in anti-GBM glomerulonephritis in WKY rats显示文摘 | Kuroda T Yoshida Y Kamiie J Kovalenko P Nameta M Fujinaka H Yaoita E Endo T Ishizuka S Nakabayashi K Yamada A Nagasawa T Yamamoto T | 2004 | Clin Exp Nephrol2004，8，： | 1 |
| 20 | Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, { betat-defensins and LL37, produced by human epi- thelial cells显示文摘 | Ouhara K Komatsuzawa H Yamada S | 2005 | J Antimicrob Chemother2005，55，6： | 1 |
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