3篇
您的检索式：作者名="YAN Tingjun"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The structure of erastin-bound xCT-4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis显示文摘Dear Editor,Ferroptosis is an iron-dependent,non-apoptotic form of regulated cell death characterized by an accumulation of lipid.derived reactive oxygen species(ROS).The small-molecule compo und erastin in duces ferroptosis via in hibiti ng the cystineglutamate antiporter system x_(c).which consists of two subunits,namely the light chain xCT and the heavy chain 4F2hc(encoded by the SLC7A11 and SLC3A2 genes,respectively).^(1-4) | Renhong Yan Enjun Xie Yaning Li Jin Li Yuanyuan Zhang Ximin Chi Xueping Hu Lei xu Tingjun Hou Brent R.Stockwell Junxia Min Qiang Zhou Fudi Wang | 2022 | Cell Research2022，32，7： | 4 |
| 2 | Structural insights into ligand recognition and activation of the melanocortin-4 receptor显示文摘Melanocortin-4 receptor(MC4R)plays a central role in the regulation of energy homeostasis.Its high sequence similarity to other MC receptor family members,low agonist selectivity and the lack of structural information concerning MC4R-specific activation have hampered the development of MC4R-seletive therapeutics to treat obesity.Here,we report four high-resolution structures of full-length MC4R in complex with the heterotrimeric Gs protein stimulated by the endogenous peptide ligand a-MSH,FDA-approved drugs afamelanotide(Scenesse™)and bremelanotide(Vyleesi™),and a selective small-molecule ligand THIQ,respectively.Together with pharmacological studies,our results reveal the conserved binding mode of peptidic agonists,the distinctive molecular details of small-molecule agonist recognition underlying receptor subtype selectivity,and a distinct activation mechanism for MC4R,thereby offering new insights into G protein coupling.Our work may facilitate the discovery of selective therapeutic agents targeting MC4R. | Huibing Zhang Li-Nan Chen Dehua Yang Chunyou Mao Qingya Shen Wenbo Feng Dan-Dan Shen Antao Dai Shanshan Xie Yan Zhou Jiao Qin Jin-Peng Sun Daniel H.Scharf Tingjun Hou Tianhua Zhou Ming-Wei Wang Yan Zhang | 2021 | Cell Research2021，31，11： | 0 |
| 3 | An optimization method of fidelity parameters of formation fluid sampling cylinder while drilling显示文摘A design idea of fidelity sampling cylinder while drilling based on surface nitrogen precharging and supplemented by downhole pressurization was proposed, and the working mode and optimization method of sampling parameters were discussed. The nitrogen chamber in the sampling cylinder functions as an energy storage air cushion, which can supplement the pressure loss caused by temperature change in the sampling process to some extent. The downhole pressurization is to press the sample into the sample chamber as soon as possible, and further increase the pressure of sample to make up for the pressure that the nitrogen chamber cannot provide. Through the analysis of working mode of the sampling fidelity cylinder, the non-ideal gas state equation was used to deduce and calculate the optimal values of fidelity parameters such as pre-charged nitrogen pressure, downhole pressurization amount and sampling volume according to whether the bubble point pressure of the sampling fluid was known and on-site emergency sampling situation. Besides, the influences of ground temperature on fidelity parameters were analyzed, and corresponding correction methods were put forward. The research shows that the fidelity sampling cylinder while drilling can effectively improve the fidelity of the sample. When the formation fluid sample reaches the surface, it can basically ensure that the sample does not change in physical phase state and keeps the same chemical components in the underground formation. | JIANG Chuanlong YAN Tingjun ZHANG Yang SUN Tengfei CHEN Zhongshuai SUN Haoyu | 2022 | Petroleum Exploration and Development2022，49，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员