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	题名	作者	年代	出处	被引量
1	S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial显示文摘	Wasaburo Koizumi Hiroyuki Narahara Takuo Hara Akinori Takagane Toshikazu Akiya Masakazu Takagi Kosei Miyashita Takashi Nishizaki Osamu Kobayashi Wataru Takiyama Yasushi Toh Takashi Nagaie Seiichi Takagi Yoshitaka Yamamura Kimihiko Yanaoka Hiroyuki Orita M	2008	Lancet Oncology2008，，3：	12
2	Novel risk markers for gastric cancer screening: Present status and future prospects显示文摘Initial identification of populations at high risk of gastric cancer (GC) is important for endoscopic screening of GC. As serum pepsinogen (PG) test-positive subjects with progression of chronic atrophic gastritis (CAG) show a high likelihood of future cancer development, this population warrants careful follow-up observation as a high-risk GC group. By combining the PG test with Helicobacter pylori (HP) antibody titers, the HP-related chronic gastritis stage can be classified, thus identifying not only a GC high-risk group but also a low-risk group. Among PG test-negative patients without CAG, those with high serum PG Ⅱ levels and HP antibody titers are thought to have severe gastric mucosal inflammation and the risk of diffuse-type GC is also high. Meanwhile, in gastric mucosae obtained by endoscopic biopsy, HP infection induces aberrant DNA methylation in CpG islands in multiple gene regions and the extent of methylation clearly correlates with GC risk. By quantifying aberrant DNA methylation in suitable gene markers, we can determine the extent of the epigenetic field for cancerization. These novel concepts and risk markers will have many clinical applications in gastrointestinal endoscopy, including more efficient endoscopic GC screening and a strategic approach to metachronous multiple GCs after endoscopic treatment.	Shotaro Enomoto Takao Maekita Hiroshi Ohata Kimihiko Yanaoka Masashi Oka Masao Ichinose	2010	World Journal of Gastrointestinal Endoscopy2010，2，12：	10
3	S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial显示文摘	Wasaburo Koizumi Hiroyuki Narahara Takuo Hara Akinori Takagane Toshikazu Akiya Masakazu Takagi Kosei Miyashita Takashi Nishizaki Osamu Kobayashi Wataru Takiyama Yasushi Toh Takashi Nagaie Seiichi Takagi Yoshitaka Yamamura Kimihiko Yanaoka Hiroyuki Orita M	2008	Lancet Oncology2008，，3：	2
4	Cancer highrisk subjects identified by serum pepsinogen tests:outcomes after 10-year follow-up in asymptomatic middleaged males显示文摘	Yanaoka K Oka M Mukoubayashi C	2008	Cancer Epidemiol Biomarkers Prev2008，17，4：	1
5	Gastric cancer screening of a highrisk population in Japan using pepsinogen and barium digital radiography显示文摘	Ohata H Oka M Yanaoka K	2005	Cancer Sci2005，96，：	1
6	S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial显示文摘	Wasaburo Koizumi Hiroyuki Narahara Takuo Hara Akinori Takagane Toshikazu Akiya Masakazu Takagi Kosei Miyashita Takashi Nishizaki Osamu Kobayashi Wataru Takiyama Yasushi Toh Takashi Nagaie Seiichi Takagi Yoshitaka Yamamura Kimihiko Yanaoka Hiroyuki Orita M	2008	Lancet Oncology2008，，3：	1
7	Gastric cancer screening of high-risk population in Japan using serum pepsinogen and barium digital radiography 显示文摘	Ohata H Oka M Yanaoka K	2005	Cancer Sei2005，96，10：	1
8	Serum pepsinogen and gastric cancer screening显示文摘	MUKOUBAYASHI C YANAOKA K OHATA H		0，，：	1
9	Gastric cancer screening of a high-risk population in Japan using serum pepsinogen and barium digital radiography显示文摘	Ohata H Oka M Yanaoka K	2005	Cancer Sci2005，96，10：	1
10	Serum pepsinogen and gastric cancer screening显示文摘	Mukoubayashi C Yanaoka K Ohata H	2007	Intern Med2007，46，6：	1
11	Serum pep-sino- gen and gastric cancer screening显示文摘	Mukoubayashi C Yanaoka K Ohata H	2007	Intern Med2007，46，6：	1
12	Serum pepsinogen and gastric cancer screening 显示文摘	Mukoubayashi C Yanaoka K Ohata H	2007	Intern Med2007，46，6：	1
13	Serum pepsinogen and gastric cancer screening显示文摘	Mukoubayashi C Yanaoka K Ohata H	2007	Intern M ed2007，46，6：	1
14	Serum pepsinogen and gastric cancer screening显示文摘	Mukoubayashi C Yanaoka K Ohata H	2007	Intern Med2007，46，6：	1
15	Serum pepsinogen and gastric cancer screening显示文摘	Mukoubayashi C Yanaoka K Ohma H	2007	Intern Med2007，46，6：	1
16	Gastric cancer screening of a high-risk population in Japan using serum pepsinogen and barium digital radiography 显示文摘	Ohata H Oka M Yanaoka K	2005	Cancer Sci2005，96，10：	1
17	Serumpepsinogen and gastrie cancer screening显示文摘	Mukoubayashi C Yanaoka K Ohata Helal	2007	Intern Meal2007，46，：	1
18	Gastric cancer screening of a high-risk population in Japan using serum pepsinogen and barium digital radiography显示文摘	Ohata H Oka M Yanaoka K	2005	Cancer Sci2005，96，10：	1
19	Serum pepsinogen and gastric cancer screening 显示文摘	Mukoubayashi C Yanaoka K Ohata H	2007	Intern Med2007，46，6：	1
20	Serum pepsino gen and gastric cancer screening 显示文摘	Mukoubayashi C Yanaoka K Ohata H	2007	Intern Med2007，46，6：	1

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