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1A unique deubiquitinase that deconjugates phosphoribosyl-linked protein ubiquitination显示文摘Ubiquitination 调整主人免疫的许多方面并且因此是为传染代理人的一个普通目标。最近的研究表明了细菌的病原体 Legionella pneumophila 的方面受动器家庭的成员攻击不要求主人 ubiquitination 机械的 E1 和 E2 酶的新奇 ubiquitination 机制与 endoplasmic 蜂窝胃联系的几小 GTPases。在这种情况中, ubiquitin 被一项 mono-ADP-ribosyltransferase 活动被 ADP-ribosylation 首先在 Arg 42 激活;中介然后被也住在 SdeA 以内的一项 phosphodiesterase 活动劈开,有到经由一个 phosphoribosyl 连接器的底层蛋白质的丝氨酸残余的 ubiquitin 的附件的伴随物。这里,我们证明方面的效果被 SidJ 反对,一个受动器由位于为方面家庭(SdeC, SdeB 和 SdeA ) 的三个成员编码的地点的基因编码了。SidJ 由劈开连接 phosphoribosylated ubiquitin 到蛋白质底层的 phosphodiester 契约颠倒修改方面的底层的 ubiquitination。SidJ 也显示古典 deubiquitinase 活动但是不要求催化半胱氨酸残余。进一步, SidJ 的这些 deubiquitinase 活动为它在 L 的角色是必要的。pneumophila 感染。最后, SidJ 的活动为高效地在细菌的举起以后在一些小时以内在感染的房间减少许多 ubiquitinated Rab33b 被要求。我们的结果作为工作在方面受动器的活动强加时间的规定的 ubiquitin-deconjugating 酶建立 SidJ。SidJ 可能在表明串联的未来研究是重要的由这唯一的 ubiquitination 调停了,潜在地也在真核细胞的房间调整细胞的过程的。Jiazhang Qiu Kaiwen Yu Xiaowen Fei Yao Liu Emesto S Nakayasu Paul D Piehowski Jared B Shaw Kedar Puva Chittaranjan Das Xiaoyun Liu Zhao-Qing Luo 2017Cell Research2017,27,7:2
2Effect of interleukin-10 on gene expression of osteoclastogenic regulatory molecules in the rat dental follicle 显示文摘Liu D Yao S Wise GE 2006Eur J Oral Sci2006,114,1:1
3Regulation of aecretion of osteoptegerin in rat dental follicle cells 显示文摘WISE GE DING D YAO S 2004Eur J Oral Sci2004,112,5:1
4Nr(f)2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction显示文摘Adenuga D Caito S Yao H 0,,:1
5Rohust optimization for emergency logistic planning:Risk mitigation in humanitarian relief supply chains显示文摘Ben-Tal A Chung B D Mandala S R Yao T 2011Transportation Research Part B2011,45,8:1
6Hydroxyphenylbenzothiazole based full color organic emitting materials generated by facile molecular modification显示文摘YAO D ZHAO S GUO J 2011J Mater Chem2011,21,11:1
7Transcription and temporal cascade in Chilo iridescent virus infected cells 显示文摘D'Costa S M Yao H Bilimoria S L 2001Arch Viro2001,146,11:1
8Recent Advances in Graphene Based Polymer Composites 显示文摘Kuilla T Bhadra S Yao D 2010Progress in Polymer Science2010,35,11:1
9Comparison of proliferative and muhilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow 显示文摘Baksh D Yao R Tuan R S 2007Stem Cells2007,25,6:1
10Production, purification, and characterization of an intracellar aflatoxin2detoxifizyme from Armil ( E - 20 ) 显示文摘LIU D L YAO D S LIANG Y Q 2001Food and Chemical Toxicology2001,39,:1
11Transcription and temporal cascade in Chilo iridescent virus infected ceils 显示文摘D'COSTA S M YAO H BILIMORIA S L 2001Archives of Virology2001,146,11:1
12Microstructure of Nbbearing pipeline steel with improved property applying ultrafast cooling process显示文摘Yao S J Du L X Wang G D 2014Steel Research International2014,85,1:1
13Plant hormone jasmonate prioritizes defense over growth by interfering with gibberellin signaling cascade显示文摘YANG D L YAO J MEI C S 2012Proc Natl Acad Sci USA2012,109,19:1
14Recent advances in graphene based polymer composites显示文摘Kuilla T Bhadra S Yao D 2010Progress in Polymer Science2010,35,11:1
15Sequence variations in the bovine growth hormone gene characterized by single-strand conformation polymorphism (SSCP) analysis and their association with milk production traits in Holsteins显示文摘 Aggrey S E Zadworny D 1996Genetics1996,144,4:1
16Effect of interleukin-10 on gene expression of osteoclastogenic regulatory molecules in the rat dental follicle 显示文摘LIU D YAO S WISE G E 2006Eur J Oral Sci2006,114,1:1
17Characterization of the bovine prolactin gene显示文摘CAMPER S LUCK D N YAO Y 1984DNA1984,3,:1
18Adsorption of turin with a novel β-cyclodextrin polymer adsorbent-thermodynamic and ki- netic study 显示文摘Zhao J Lin D Q Yao S J 2012Carbohydr Polym2012,90,:1
19B23 acts as a nucleolar stress sensor and promotes cell survival through its dynamic interaction with hnRNPU and hnRNPA1显示文摘Yao Z Duan S Hou D 0,,12:1
20Transient stability limit conditions analysis using a corrected transient energy function approach显示文摘Fang D Z Chung T S Zhang Yao 2000IEEE Trans on Power Systems2000,15,2:1
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