|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cathepsin L upregulation-induced EMT phenotype is associated with the acquisition of cisplatin or paclitaxel resistance in A549 cells显示文摘组织蛋白酶 L (CTSL ) , lysosomal 酸半胱氨酸朊酶,被知道在肿瘤起重要作用转移和化疗抵抗。在这研究,我们调查了在人的肺癌症 cells.Methods 由 CTSL 位于 chemoresistance 的规定下面的分子的机制:人的肺癌症 A549 房间, A549/PTX (paclitaxel 抵抗) 房间和 A549/DDP (cisplatin 抵抗) 房间被测试。到 cisplatin 或 paclitaxel 的抵抗用 MTT 和殖民地形成试金被检测。肌动朊改变与 FITC-Phalloidin 被观察荧光灯的染色或 immunofluorescence。愈合创伤的试金或 Transwell 试金被用来估计迁居或侵略能力。CTSL 和上皮、间充质的标记的表示与西方的弄污和 immunofluorescence 被分析。联系 EMT 的抄写因素的表示与西方的弄污或 q-PCR 被测量。BALB/c 裸体老鼠与 A549 房间 overexpressing CTSL 皮下地被植入,并且老鼠是管理 paclitaxel (10, 15 mg/kg, ip ) 为 5 times.Results 的每 3 d:Cisplatin 或 paclitaxel 治疗(10-80 ng/mL ) 在 A549 房间导致了 CTSL 表示。CTSL 层次比在 A549 房间在 A549/PTX 和 A549/DDP 房间是高得多的。CTSL 的 Silencing 在 A549/DDP 和 A549/TAX 房间颠倒了 chemoresistance,而 CTSL 的 overexpression 稀释了 A549 房间的敏感到 cisplatin 或 paclitaxel。而且, A549/DDP 和 A549/TAX 房间经历了词法并且有增加的房间侵略和迁居能力的细胞骨架变化,由上皮的标记( E-cadherin 和 cytokeratin-18 )的减少的表示伴随了并且增加间充质的标记( N-cadherin 和 vimentin )的表示,以及 联系EMT 的抄写因素的 upregulation 蜗牛,蛞蝓, ZEB1 和 ZEB2 。CTSL 的 Silencing 在 A549/DDP 和 A549/TAX 房间颠倒了 EMT;相反, CTSL 的 overexpression 在 A549 房间导致了 EMT。在异种皮移植裸体人鼠标模型,与 A549 房间 overexpressing CTSL 植入的鼠标展出了显著地减少的敏感到 paclitaxel 处理,并且在肿瘤 tissues.Conclusion 增加了联系 EMT 的蛋白质和抄写因素的表示:Cisplatin 和 paclitaxel 抵抗在 A549 房间与 CTSL 导致 upregulation 的 EMT 被联系。因此,调停 CTSL 的 EMT 可以作为一个目标被利用对肺癌症和恶意的另外的类型提高 cisplatin 或 paclitaxel 的功效。 | Mei-ling HAN Yi-fa n ZHAO Cai-hong TAN Ya-jie XIONG Wen-juan WANG Feng WU Yao FEI Long WANG Zhong-qin LIANG | 2016 | Acta Pharmacologica Sinica2016，37，12： | 15 |
| 2 | Geochemistry of the subduction-related magmatic rocks in the Dahong Mountains, northern Hubei Province--Constraint on the existence and subduction of the eastern Mianlüe oceanic basin显示文摘The existence and subduction of the eastern Mianl黣 oceanic basin in the south Qinling belt are keys to understand the Qinling orogen. Based on geological mapping, several volcanic slices have been identified in Tumen, Zhoujiawan, Xiaofu and Yuantan areas, which distribute in the northern margin of the Dahong Mountains (DHM), and thrust into the Sanli-gang-Sanyang fault. These slices consist mainly of diabases, basaltic-andesitic lavas, pyroclastic rocks and a minor tuff. The geochemistry of the basalts, andesites,and diabases is characterized by depleting in Nb and Ta, enriching in Th and LILE (e.g.K, Rb, Ba), and undifferentiating in HFSE. These geochemical characteristics suggest that the original magma of these rocks was derived from a mantle wedge above a subduction zone, and formed in an island-arc setting in Carboniferous-early Triassic. Comparing with the ophiolites and island-arc volcanic rocks in Mianxian-Leyang area to the west, it is reasonable to consider that there had been an oceanic basin connecting with the Mianle ancient ocean to the westward, distributing along the south edge of the Tongbai-Dabie block. In view of the ophiolite in Huashan area and these island-arc volcanic rocks along the north of the Dahong Mountains, it is suggested that there had been a plate tectonic evolutionary history with oceanic basin rifting and subduction in this region. | DONG Yunpeng, ZHANG Guowei, ZHAO Xia, YAO Anping & LIU Xiaoming The Key Laboratory of Continental Dynamics, Ministry of Education, Department of Geology, Northwest University, Xi抋n 710069,China | 2004 | Science China Earth Sciences2004，47，4： | 12 |
| 3 | Male infertility: lifestyle factors and holistic, complementary, and alternative therapies显示文摘当我们可能与男不孕的一条对症疗法的途径是舒适的时,我们为生活方式修正和被许多我们的病人使用的整体、互补、其他的治疗的知识也负责。这份报纸提供为几这些治疗把事实与小说分开的基于证据的评论。有足够的文学由饮食和锻练支持重量减小,吸停止,和白酒中等。在小使随机化的控制试用(RCT ) 上在男富饶上表明了积极效果的补充包括 aescin,辅酶 Q 10, 谷胱甘肽,朝鲜红人参, L 肉毒碱, nigella sativa, omega-3,硒,锌的联合并且叶酸,并且 Menevit 抗氧化剂。对维生素 C,维生素 E,或藏花的使用没有支持。为中国草药的药的数据,针灸,头脑身体实践,阴囊的冷却,并且基于信心的愈合稀少或不确定。 | David F Yao Jesse N Mills | 2016 | Asian Journal of Andrology2016，18，3： | 11 |
| 4 | A new cumulative fatigue damage model for fiber-reinforced plastics 显示文摘 | Yao Weixing Himmel N | 2000 | Composites Science and Technololgy2000，60，1： | 2 |
| 5 | Photochromism induced in an eleetrolytically pretreated MoO3 thin film by visible light 显示文摘 | Yao J N Hashmto H Fujishhima A | 1992 | Nature1992，355，： | 1 |
| 6 | Rigid polyurethane foams from combined liquefaction mixtures of wood and starch 显示文摘 | Yao Y G Yoshioka M Shiraishi N | 1995 | Mokuzai Gakkaishi1995，41，7： | 1 |
| 7 | Effects of supplementing with single or multiple trace minerals on growth performance,fecal mineral excretion and nutrient utilization in pullets from 1 to 18 weeks of age显示文摘 | Zhong L L Yao J H Cheng N | 2007 | Asian-Australasian Journal of Animal Science2007，20，： | 1 |
| 8 | Sexual behavior and risks for HIV infection and transmission among male injecting drug uses in Yunnan, China显示文摘 | Yao Y Wang N Chu J | 2009 | International Journal of Infection Diseases2009，13，2： | 1 |
| 9 | Prevalence of Chronic Ob- structive Pulmonary Disease in China A Large, Population-based Survey显示文摘 | Zhong N S Wang C Yao W Z | 2007 | Am J Respir Crit Care Med2007，176，： | 1 |
| 10 | Study on electrocatalytic oxidation of L-cysteine at glassy carbon electrode by (FcM) TMA and its electrochemical kinetics显示文摘 | GAO Z N YAO H Q LIU W Y | 2005 | Electroanal2005，17，： | 1 |
| 11 | Microbial production of 1 ,3-propanediol from glycerol by encapsulated Klebsiella pneumoniae显示文摘 | ZHAO Y N C HEN G YAO S J | 2006 | Biochemi- cal Engineering Journal2006，32，2： | 1 |
| 12 | Prevalence of chronic obstructive pulmonary disease in China: A large population - based survey显示文摘 | Zhong N Wang C Yao W | 2007 | Am J Respir Crit Care Mcd2007，176，8： | 1 |
| 13 | Hydrothermal synthesis, crystal structure, and magnetic properties of FeVO4- Ⅱ 显示文摘 | Oka Y Yao T Yamamoto N | 1996 | J Solid State Chem1996，123，： | 1 |
| 14 | Molecular mechanics of binding in carbon nanotube-polymer composites显示文摘 | LORDI V YAO N | 2000 | J Mat Res2000，15，12： | 1 |
| 15 | Determinants influencing seasonal variations of methane emissions from alpine wetlands in Zoige Plateau and their implications显示文摘 | Chen H Yao S P Wu N etal | 2008 | Journal of Geophysical Research2008，113，12： | 1 |
| 16 | Prevalence of chronic obstructive pulmonary disease in China:a large,population-based survey显示文摘 | Zhong N Wang C Yao W | | 0，，8： | 1 |
| 17 | 查看详情显示文摘 | Chen X Xu S Yao N | | 0，，： | 1 |
| 18 | Numerical simu- lation of cavity flow induced noise by LES and FW-H acoustic analogy 显示文摘 | ZHANG N SHEN H C YAO H Z | 2010 | Journal of Hydrodynamics2010，22，5： | 1 |
| 19 | Prevalence of chron- ic obstructive pulmonary disease in China -A large, pop- ulation-based survey显示文摘 | Zhong N S Wang C Yao W Z | 2007 | Am J Respir Crit Care Med2007，176，8： | 1 |
| 20 | Soluble Properties of Liquefied Biomass Prepared in Organic Solvents the Soluble Behavior of Liquefied Biomass in Various Diluents显示文摘 | YAO Y YOSHIOKA M SHIRAISHI N | 1994 | Moku- zai Gakkaishi1994，40，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员