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| 1 | Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases显示文摘Matrix metalloproteinases(MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to degrade and remodel of extracellular matrix. However, recent studies have shown that MMPs are implicated in initiation and progression of kidney fibrosis through tubular cell epithelial–mesenchymal transition(EMT) as well as activation of resident fibroblasts, endothelial-mesenchymal transition(Endo MT) and pericyte-myofibroblast transdifferentiation. Interstitial macrophage infiltration has also been shown to correlate with the severity of kidney fibrosis in various chronic kidney diseases. MMPs secreted by macrophages, especially MMP-9, hasbeen shown by us to be profibrotic by induction of tubular cells EMT. EMT is mainly induced by transforming growth factor-β(TGF-β). However, MMP-9 was found by us and others to be up-regulated by TGF-β1 in kidney tubular epithelial cells and secreted by activated macrophages, resulting in EMT and ultimately kidney fibrosis. Therefore, MMP-9 may serve as a potential therapeutic target to prevent kidney fibrosis in chronic kidney disease. This review, by a particular focus on EMT, seeks to provide a comprehensive understanding of MMPs, especially MMP-9, in kidney fibrosis. | Hong Zhao Yanting Dong Xinrui Tian Thian Kui Tan Zhuola Liu Ye Zhao Yun Zhang David CH Harris Guoping Zheng | 2013 | World Journal of Nephrology2013，2，3： | 21 |
| 2 | Micronuclei in Nasal Mucosa, Oral Mucosa and Lymphocytes in Students Exposed to Formaldehyde Vapor in Anatomy Class显示文摘The frequency of micronuclei (MN) in cells of the nasal mucosa, oral mucosa and in lym-phocytes was evaluated for 25 students in anatomy classes exposed to formaldehyde (FA) overan 8-week period. Each student served as his or her own control. The time-weighted averageconcentration (TWA) of fOrmaldehyde in anatomical laboratories and in students’ dormitorieswas 0. 508 ± 0. 299 mg/m3 and 0. 012 ± 0. 0025mg/m3, respectively. A higher frequency ofmicronuclei was observed in nasal and oral exfoliative cells after formaldehyde exposure (3. 85± 1. 48 vs 1 .20± 0. 676 and 0. 857 ± 0. 558 vs 0. 568 ± 0. 317, paired-t test: P< 0. 001and P < 0. 01, respectively). No significant increase in the frequency of lymphocyte micronu-clei was found after formaldehyde exposure (P >0. 05 ). The present study shows that nasalmucosa cel1s exposed through respiration are the chief target of FA-induced genotoxic | YING CHEN -JlANG YAN WEN-SHENG ZHAO MEI-YING YE XIAO-LEI XIE HONG YIN SHU-YI ZHU XIAN-SHU(Department of Environmental Health, n Dgurtment of Anatomy,Tongji the ical University, Wuhan, China)(Department of Public Health, Wengzhou theical Chllege, Ch | 1997 | Biomedical and Environmental Sciences1997，10，4： | 7 |
| 3 | 声音通过皮质丘脑环路缓解疼痛显示文摘声音(包括音乐和噪音)可以减轻人类的疼痛,但潜在的神经机制仍然未知。该研究发现高于环境噪音5-dB的声音可以缓解疼痛。病毒追踪、显微内镜钙成像和在体多通道记录表明,低信噪比(SNR)声音抑制了从听觉皮质(ACx)到丘脑后核(PO)和丘脑腹后核(VP)的谷氨酸能输入。光遗传学或化学遗传学抑制ACx^(Glu)→PO和ACx^(Glu)→VP环路分别模拟了低SNR声音对炎症痛模型小鼠后爪和前爪的镇痛作用,而激活这些环路可反转声音诱导的镇痛作用。该研究通过解读听觉系统在疼痛处理中的作用,揭示声音促进镇痛作用背后的皮质丘脑环路机制。 | Zhou WJ Ye CH Wang HT 胡丹丹(译) 张玲(校) | 2022 | 中国疼痛医学杂志2022，28，12： | 4 |
| 4 | NMR imaging studies of coal swollen with pyridine显示文摘NMR imaging is a new NMR technique which appeared in these twenty years. The most important difference from the traditional NMR technique is that it can distinguish what signals will be provided by which part of the sample. Since Lauterbur reported the first NMR imaging in 1973, this technique has been widely used in biological, medical, geological, and material studies. NMR imaging technique has also been used in the study of coal structure in | Ma, ZR Zhang, PZ Ding, GL Li, LY Ye, CH | 1997 | Chinese Science Bulletin1997，42，16： | 2 |
| 5 | A prospective, randomized trial comparing mechanical methods of hemostasis plus epinephrine inject-tion to epinephrine injection alone for bleeding peptic ulcer显示文摘 | PARK CH JOO YE KIM HS | 2004 | Gastroi-ntest Endosc2004，60，： | 1 |
| 6 | Combined effects of apoE-C-C cluster and LDL-R gene polymorphisms on chro mosome 19 and coronary artery disease risk显示文摘 | WANG CH ZHOU X YE SQ | 2006 | Int J Hyg En biron Health2006，20，9： | 1 |
| 7 | The impact of altered annexin Ⅰ protein levels on apoptosis and signal transduction pathways in prostate cancer cells显示文摘 | Tunoda T Whang YE | 2006 | Prostate2006，66，13： | 1 |
| 8 | Cap-assisted ERCP in patients with a B illroth II gastrectomy显示文摘 | Park CH Lee WS Joo YE | 2007 | Gastrointest Endosc2007，66，3： | 1 |
| 9 | Gas chromatography-mass spectrometry following microwave distillation and headspace solid-phase microextraction for fast analysisof essential oil in dry traditional Chinese medicine显示文摘 | LI N DENG CH H LI Y YE H ZHANG X M | 2006 | Journal of Chromatography A2006，1133，： | 1 |
| 10 | Combined effects of apoE- CⅠ -CⅡ cluster and LDL-R gene polymor phisms on chromosome 19 and coronary artery disease risk 显示文摘 | Wang CH Zhou X Ye SQ | 2006 | Int J Hyg Enbiron Health2006，209，： | 1 |
| 11 | Teleportation of a two-particle entangled state显示文摘 | Ye L Yao Ch M Guo G C | 2001 | Chin Phys2001，10，11： | 1 |
| 12 | Cap-assisted ERCP in patients with a Billroth Ⅱ gastrectomy显示文摘 | Park CH Lee WS Joo YE | | 0，，03： | 1 |
| 13 | Radiation dose modu- lation techniques in the multidetector CT era: from bas- ics to practice显示文摘 | Lee CH Goo JM Ye HJ | 2008 | Radio Graphics2008，28，： | 1 |
| 14 | Determination of molecular self diffusion coefficient using multiple spin - echo NMR spectroscopy with removal of convection and background gradient artifacts 显示文摘 | Zhang X Li CG Ye CH | 2001 | Anal Chem2001，73，7： | 1 |
| 15 | The association of quantitative ultrasound parameters of the calcaneus with vitamin D receptor gene and estrogen receptor gene polymorphism in Korean postmenopausal women 显示文摘 | Kim SW Kim CH Chung YE | 1999 | J Bone Miner Res1999，14，1： | 1 |
| 16 | Draft genome of the kiwifruit Actinidia chinensis 显示文摘 | Huang SX Ding J Deng DJ Tang W Sun HH Liu DY Zhang L Niu XL Zhang X Meng M Yu JD Liu J Han Y Shi W Zhang DF Cao SQ Wei ZJ Cui YL Xia YH Zeng HP Bao K Lin L Min Y Zhang H Miao M Tang XF Zhu YZ Sui Y Li GW Sun HJ Yue JY Sun JQ Liu FF Zhou LQ Lei L Zheng XQ Liu M Huang L Song J Xu CH Li JW Ye KY Zhong SL Lu BR He GH Xiao FM Wang HL Zheng HK Fei ZJ Liu YS | 2013 | Nat Commun2013，4，： | 1 |
| 17 | Neural networks for improved text-independent speaker identification 显示文摘 | Yue X C Ye D T Zheng Ch X | 2002 | IEEE Engineering in Medicine and Biology Magazine2002，21，2： | 1 |
| 18 | Response of lymphocyte sub- sets and cytokines to Shenyang prescription in Sprague-Dawley rats with tongue squamous cell carcinomas induced by 4NQO 显示文摘 | Jiang CH Ye DX Qiu WL | 2007 | BMC Cancer2007，7，： | 1 |
| 19 | Two new secoiridoid glycosides from Tripterospermum chinense 显示文摘 | Zhu KC Ma CH Ye G | 2007 | Helv Chim Acta2007，90，2： | 1 |
| 20 | Interaction of the anticancer drug 8-azaguanine with DNA显示文摘 | Ye BX Wang CH Jing AH | 2003 | Journal of the Chinese Chemical Society2003，50，3： | 1 |
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