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| 1 | A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion显示文摘heterodimeric 的激活(α /β) 由 cytosolic 蛋白质 talin 的 integrin transmembrane 受体为调整多样的 cell-adhesion-dependent 过程是关键的包括血凝结,改变的组织,和癌症转移。这进程被 talin (talin-FERM ) 的 N 终端 FERM (four-point-one-protein/ezrin/radixin/moesin ) 领域的重合的绑定触发到内部膜表面和 integrin β细胞质的尾巴,但是这些有约束力的事件怎么空间与时间地被调整,仍然保持阴暗。这里,我们报导休眠 talin 的水晶结构,揭示怎么一个 C 终端 talin 杆片断(talin-RS ) 自我面具经由一个大接口的 talin-FERM 上的一个关键 integrin 有约束力的地点。出人意料地,结构也在静电地妨碍 talin-FERM 绑定到膜的 talin-RS 上揭示不同否定地控告的表面。为 talin 的如此的双禁止的拓扑学与生物化学、功能的数据一致,但是与一个以前的模型显著地不同。我们与 phosphotidylinositol-4,5-bisphosphate (PIP2 ) 在丰富之上显示出那 - 已知的 talin 使活跃之物,膜强烈在 talin-FERM 上吸引断然控告的表面并且同时在 talin-RS 上排斥否定地控告的表面。如此的静电的 “ pull-push”过程支持 talin-FERM 的双抑制的消除,它不同于经典 “位的 clash”为常规导致 PIP2 的 FERM 领域激活当模特儿。这些数据因此解开膜依赖者 FERM 领域规定的一种新类型并且说明它怎么调停 talin 开/关换到调整 integrin transmembrane 发信号和房间粘附。 | Xianqiang Song Jun Yang Jamila Hirbawi Sheng Ye H Dhanuja Perera Esen Goksoy Pallavi Dwivedi Edward F Plow Rongguang Zhang Jun Qin | 2012 | Cell Research2012，22，11： | 5 |
| 2 | Analysis on the weld defects of AZ91D magnesium alloy joints显示文摘 | YE H YAN Z L SHEN B XUE Z F | 2009 | Materials Science Forum2009，610，： | 1 |
| 3 | Raman scattering spectra of coupled LO-phonon-plasmon modes in N-In codoped p-type ZnO thin films显示文摘 | KONG J F CHEN H YE H B | 2007 | Appl Phys Lett2007，90，04： | 1 |
| 4 | An energy efficient clustering scheme in wireless sensor networks显示文摘 | M Ye C F Li G H Chen J Wu | 2007 | International Journal of Ad Hoc & Sensor Wireless Networks2007，3，2： | 1 |
| 5 | Analysis of marker or complex chromosomal rearrangements present in pre-and post-natal karyotypes utilizing a combination of G-banding,spectral karyotyping and fluorescence in situ hybridization 显示文摘 | Heng H H Ye C J Yang F | 2003 | Clin Genet2003，63，5： | 1 |
| 6 | An energy efficient clustering scheme in wireless sensor networks 显示文摘 | Ye M Li C F Chen G H | 2006 | Ad Hoc & Sensor Wireless Networks2006，3，： | 1 |
| 7 | Plasmonic nanoclus- ters : near field properties of the Fano resonance interroga-ted with sers显示文摘 | YE J WEN F SOBHANI H | 2012 | Nano Letters2012，12，： | 1 |
| 8 | Security in mobile Ad hoc networks: challenges and solutions显示文摘 | YANG H LUO H Y YE F | 2004 | IEEE Wireless Communications2004，11，1： | 1 |
| 9 | Symmetric division and expression of its regulatory gene Numb in human cervical squamous carcinoma cells 显示文摘 | Chen H Chen X Ye F | 2009 | Pathobiology2009，76，3： | 1 |
| 10 | Preparation and Characterization of Well-aligned Carbon Nanotubes-Ruthenium Oxide Nanocomposites for Supercapacitors 显示文摘 | Ye J Cui H F Liu X | 2005 | Small2005，1，5： | 1 |
| 11 | Using prod uct family evaluation graphs in product family design显示文摘 | YE Xiaoli THEVENOT H ALIZON F | 2009 | In ternational Journal of Production Research2009，47，13： | 1 |
| 12 | Syntheses and characterization of two monomeric zinc complexes containing aqua ligands显示文摘 | Ye B H Xue F | 1999 | Polyhedron1999，18，： | 1 |
| 13 | Relationship between haemolytic and adjuvant activity and structure of protopanaxadiol- type saponins from the roots of Panax notoginseng 显示文摘 | Sun H X Qin F Ye Y P | 2005 | Vaccine2005，，23： | 1 |
| 14 | Reconstruction of integrin activation显示文摘 | YE F KIM C GINSBERG M H | 2012 | Blood2012，119，1： | 1 |
| 15 | A facile solution route for the synthesis of PbSe-Au nanocomposites with different mor- phologies显示文摘 | Hu W Liu H Ye F | 2012 | CrystEngComm2012，14，20： | 1 |
| 16 | High- solids mar resistant clearcoats prepared from an isophthalatebased oligoester and a melamine resin 显示文摘 | C D Diakoumakos F N Jones H Ye | 2002 | Journal of Applied Polymer Science2002，83，6： | 1 |
| 17 | Effects of butachlor on microbial populations and enzyme activities in paddy soil显示文摘 | Min H Ye Y F Chen Z Y | 2001 | J Environ Sci Health(B)2001，36，5： | 1 |
| 18 | Molecular mechanism of anti-prostate cancer activity of Scutellaria baicalensis extract 显示文摘 | Ye F Jiang S Volshonok H | 2007 | Nutr Cancer2007，57，1： | 1 |
| 19 | An uneven cluster-based routingprotocol for wireless sensor networks显示文摘 | Li C F Chen G H Ye M | 2007 | Chinese Journal of Com-puter2007，30，1： | 1 |
| 20 | The immediate economic impact of maternal deaths on rural Chinese households显示文摘 | Ye F Wang H Huntington D | 2012 | PLoS One2012，7，38： | 1 |
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