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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | The effects of Pva/chitosan/fibroin (PCF)-blended spongy sheets on wound healing in rats 显示文摘 | YEO J H LEE K G KIM H C | 2000 | Biol Pharm Bull2000，23，10： | 1 |
| 3 | Laboratory evaluation of temperature effects on the germination and growth of entomopathogenic fungi and on their pathogenicity to two aphid species显示文摘 | Yeo H Pell J K Alderson P G Clark S J Pye B J | 2003 | Pest Manage Sci2003，59，： | 1 |
| 4 | Apoptosis in rheumatoid arthritis synovium 显示文摘 | Firestein G S Yeo M Zvaifler N J | 1995 | J Clin Invest1995，96，3： | 1 |
| 5 | Neoadjuvant paclitaxel and cisplatin in uterine cervical cancer: long-term results显示文摘 | Park D C Sub M J Yeo S G | 2009 | Int J Gynecol Cancer2009，19，5： | 1 |
| 6 | Three-dimensional hierarchical composite scaffolds consisting of polycaprolactone, 13-tricalcium phosphate, and collagen nanofibers : fabrication, physical properties, and in vitro cell activity for bone tissue regeneration 显示文摘 | Yeo M Lee H Kim G | 2011 | Biomacromolecules2011，12，2： | 1 |
| 7 | Formation of microparticulate protein powders using a supercritical fluid antisolvent 显示文摘 | YEO S D LIM G B DEBENEDETTI P G | 1993 | Bioteehnology and Bioengineering1993，41，3： | 1 |
| 8 | Design of microstructure of ZrO2/SUS316 functionally graded materials by tape casting显示文摘 | YEO J G JUNG Y G CHOI S C | 1998 | Mater Lett1998，37，： | 1 |
| 9 | Quantitative profiling of plasma peptides in asthmatic mice using liquid chromatography and mass spectrometry 显示文摘 | YEO S ROH G S KIM D H | 2004 | Proteomics2004，4，11： | 1 |
| 10 | ERK-MAPK signaling opposes Rho-kinase to promote endothelial cell survival and sprouting during angiogenesis 显示文摘 | MAVRIA G VERCOULEN Y YEO M | 2006 | Cancer Cell2006，9，1： | 1 |
| 11 | Dosimetric comparison of intensity- modulated, conformal, and four-field pelvic radiotherapy boost plans for gynecologic cancer: a retrospective planning study 显示文摘 | Chan P Yeo I Perkins G | 2006 | Radiat Oncol2006，1，： | 1 |
| 12 | The greedy algorithm for the symmetric TSP显示文摘 | Gutin G Yeo A | 2007 | Algorithmic Operations Research2007，1，： | 1 |
| 13 | Environmental efficiency analysis of port cities: Slacks-based measure data envelopment analysis ap- proach显示文摘 | Lee T Yeo G Thai V V | 2014 | Transport Policy2014，33，： | 1 |
| 14 | Evaluation of the marine traffic congestion of north harbor in Busan port显示文摘 | YEO G T MICHAEL R SOAK S M | 2007 | J Waterway Port Coastal & Ocean Eng2007，133，2： | 1 |
| 15 | Complex shaped on-wafer interconnects modeling for CMOS RFICs显示文摘 | SHI X K YEO S MA J G | 2008 | IEEE Trans VLSI Syst2008，16，7： | 1 |
| 16 | A multilevel analysis of effort, practice, and performance: Effects of ability, conscien- tiousness, and goal orientation显示文摘 | Yeo G B Neal A | 2004 | Journal of Applied Psychology2004，89，2： | 1 |
| 17 | RNA se- quence analysis defines Dicer's role in mouse embryonic stem cells显示文摘 | Calabrese J M Seila A C Yeo G W | 2007 | Proc Natl Acad Sci USA2007，104，18： | 1 |
| 18 | Polynomial approximation algorithms for the TSP and the QAP with a factorial domination number显示文摘 | Gutin G Yeo A | 2002 | Discrete Applied Mathematics2002，119，12： | 1 |
| 19 | Cloning and sequence analysis of the nucleocapsid gene of porcine epidemicdiarrhea virus Chinju99显示文摘 | Lee H K Yeo S G | 2003 | Virus Genes2003，26，2： | 1 |
| 20 | Ghost fluid method for strong shock impacting on material interface显示文摘 | Liu T G Khoo B C Yeo K S | 2003 | JCP2003，190，： | 1 |
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