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| 1 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 2 | Quality control measures for lowering the seroconversion rate of hemodialysis patients with hepatitis B or C virus显示文摘BACKGROUND: Hemodialysis (HD) patients are at high risk of infection by hepatitis B virus (HBV) or hepatitis C virus (HCV). The present study was designed to determine the impact of quality control measures on the prevention of transmission of blood-borne viruses. METHODS: A total of 6182 adult maintenance HD patients from all HD units in Zhejiang Province were recruited on January 1, 2007. The baseline demographic and clinical characteristics were recorded and all patients were followed up until death or survival at 4 years later. The Quality Control Standards of Hemodialysis were gradually implemented in HD units. The HBV or HCV seroconversion rates of the recruited patients were calculated and compared every year during the observation period. RESULTS: The prevalence of HBV was 8.3% at the beginning of the study, and 6.6% for HCV. With the implementation of the HD quality control measures, the HBV seroconversion rate tended to decrease year by year (χ 2 =6.620, P=0.085), and the HCV seroconversion rate decreased significantly (χ 2 =10.41, P=0.015). Compared with the data in 2007, the HBV seroconversion rate (χ 2 =4.204, P=0.040, relative risk ratio 0.393, 95% CI 0.156-0.991) and the HCV seroconversion rate (χ 2 =7.373, P=0.007, relative risk ratio 0.386, 95% CI 0.189-0.787) decreased significantly in 2010. CONCLUSION: Quality control measures for HD decreased the seroconversion rates of HBV or HCV in HD patients, showing that updated quality control measures reduce the risk for transmission of blood-borne viruses in the HD population. | Jing Yuan,Yi Yang, Fei Han, Ping Zhang, Xiao-Ying Du, Hua Jiang and Jiang-Hua Chen The Kidney Disease Center, First Affiliated Hospital, Zhejiang University School of Medicine (Yuan J, Yang Y, Han F, Zhang P, Du XY, Jiang H and Chen JH) and Hemodialysis Quality Control Center of Zhejiang Province (Yuan J, Zhang P, Du XY and Chen JH), Hangzhou 310003, China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 2 |
| 3 | In situ drift study of low-temperature methanol synthesis mechanism on Cu/ZnO catalysts from CO2-containing syngas using ethanol promoter 显示文摘 | Ruiqin Y Yilu F Yi Z | 2004 | J Catal2004，228，1： | 1 |
| 4 | Study on the non isothermal crystallization kinetics of novel polyamide 6/silica nanocomposites containing epoxy resins 显示文摘 | ZhaoCX Zhang P Yi L H Xu F Wang X Y Yong J | 2008 | Polymer Testing2008，27，4： | 1 |
| 5 | Overexpression of malate dehydrogenase in transgenic tobacco leaves: Enhanced malate synthesis and augmented Al-resistance 显示文摘 | Wang Q F Zhao Y Yi Q | 2010 | Acta Physiol Plant2010，32，6： | 1 |
| 6 | 查看详情显示文摘 | Liu L Li F Tan L Ming L Yi Y | | 0，，： | 1 |
| 7 | Energy efficiency based on joint mobile node grouping and data packet fragmentation in short- range communication system显示文摘 | Zhang Z F Yi Y X Yang J | 2014 | International Journal of Corn munication Systems2014，27，4： | 1 |
| 8 | Room-temperature electronic phase transitions in the continuous phase diagrams of perovskite manganites 显示文摘 | YOO Y K DUEWER F YANG H YI D LI J W XIANG X D | 2000 | Nature2000，406，： | 1 |
| 9 | Proteome analysis of human liver carcinoma Huh7 cells harboring hepatitis C virus subgenomie replieon 显示文摘 | FANG C Y YI Z LIU F | 2006 | Proteomics2006，6，2： | 1 |
| 10 | 查看详情显示文摘 | Liu L Li F Tan L Ming L Yi Y | | 0，，： | 1 |
| 11 | Research of the entry of rare earth elements Eu3+and La3+into plant cell显示文摘 | Gao Y S Zeng F L Yi A | 2003 | Biological Trace Element Research2003，91，3： | 1 |
| 12 | Synthesis and ion conductivity of poly(oxyethylene) methacrylates containing a quaternary ammonium group显示文摘 | Yi F Yang X P Li Y J | 1999 | Polym Adv Technol1999，10，： | 1 |
| 13 | Swelling kinetics and stimuli-responsiveness of poly (DMAEMA) hydrogels prepared by UV-irradiation 显示文摘 | Chen Y F Yi M | 2001 | Radiation Physics and Chemistry2001，61，： | 1 |
| 14 | A novel effective way of comprising a 13-nucleating agent in isotactic polypropylene (i-PP):Polymerized dispersion and polymer characterization 显示文摘 | Yi Q F Wen X J Dong J Y | 2008 | Polymer2008，49，： | 1 |
| 15 | Characterization of photosynthetic path way of plant species growing in the eastern Tibetan plateau using stable carbon isotope composition 显示文摘 | Li M C Liu H Y Yi X F | 2006 | Photosynthetica2006，44，1： | 1 |
| 16 | Density functional theory study of calixarene-N-azacrown-5, calixC4'larene-N-phenyb azacrown-5, and their complexes with alkali-metal eationss Na+, K+ , and Rb+ 显示文摘 | ZHENG X Y WANG X Y YI S F | 2010 | J Comput Chem2010，，31： | 1 |
| 17 | The draft genome of watermelon (Citrullus lanatus ) and reseqnencing of 20 diverse accessions显示文摘 | Guo S G Zhang J G Sun H H Salse J Lucas W J Zhang H Y Zheng Y Mao L Y Ren Y WangZ W Min J M Guo X S Murat F Ham B K Zhang Z L Gao S Huang M Xu Y M Zhong S L Bombarely A Mueller L Zhao H He H Q Zhang Y Zhang Z H Huang S W Tan T Pang E Lin K Hu Q Kuang H H Ni P X Wang B Liu J G Kou Q H Hou W J Zou X H Jiang J Gong G Y Klee K Schoof H Huang Y Hu X S Dong S S Liang D Q Wang J Wu K Xia Y Zhao X Zheng Z Q Xing M Liang X M Huang B Q Lv T Wang J Y Yin Y Yi H P Li R Q Wu M Z Levi A Zhang X P Giovannoni J Wang J Li YF Fei Z J Xu Y | 2013 | Nature genetics2013，45，1： | 1 |
| 18 | Response of photosynthesis and chlorophy Ⅱ fluorescence quenching to leaf dichotocarpism in Ligustrum vicaryi,an ornamental herb显示文摘 | Yang Y Q Yi X F Prasad P | 2009 | Photosynthetica?2009，47，1： | 1 |
| 19 | FTIR spectroscopiccharacterization of soy proteins obtained through AOTreverse micelles显示文摘 | CHEN X Y YI R CHEN F L | 2013 | Food Hydrocolloids2013，31，2： | 1 |
| 20 | Impact of feeding 2-hydroxy-4-(methylthio)butanoic acid and DL-methionine supplemented maize-soybean-rapeseed meal diets on growth performance and carcase quality of broilers显示文摘 | Liua Y L Yi G F | | 0，，02： | 1 |
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