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| 1 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 2 | How to perform gastrointestinal ultrasound: anatomy and normal findings显示文摘Gastrointestinal ultrasound is a practical, safe, cheap and reproducible diagnostic tool in inflammatorybowel disease gaining global prominence amongst clinicians. Understanding the embryological processes of the intestinal tract assists in the interpretation of abnormal sonographic findings. In general terms, the examination principally comprises interrogation of the colon, mesentery and small intestine using both lowfrequency and high-frequency probes. Interpretation of findings on GIUS includes assessment of bowel wall thickness, symmetry of this thickness, evidence of transmural changes, assessment of vascularity using Doppler imaging and assessment of other specific features including lymph nodes, mesentery and luminal motility. In addition to B-mode imaging, transperineal ultrasonography, elastography and contrast-enhanced ultrasonography are useful adjuncts. This supplement expands upon these features in more depth. | Nathan S S Atkinson Robert V Bryant Yi Dong Christian Maaser Torsten Kucharzik Giovanni Maconi Anil K Asthana Michael Blaivas Adrian Goudie Odd Helge Gilja Dieter Nuernberg Dagmar Schreiber-Dietrich Christoph F Dietrich | 2017 | World Journal of Gastroenterology2017，23，38： | 5 |
| 3 | Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-specific Entry into Hepatocytes显示文摘 | Yi Ni Florian A. Lempp Stefan Mehrle Shirin Nkongolo Christina Kaufman Maria F?lth Jan Stindt Christian K?niger Michael Nassal Ralf Kubitz Holger Sültmann Stephan Urban | 2013 | Gastroenterology2013，，： | 5 |
| 4 | Proteome analysis of human liver carcinoma Huh7 cells harboring hepatitis C virus subgenomic replicon显示文摘 | Fang C Yi Z Liu F Lan S Wang J Lu H Yang P Yuan Z | 2006 | Proteomics2006，6，2： | 1 |
| 5 | A Numerical Study of Nonlinear Propagation of a Gravity-Wave Packet in Compressible Atmosphere显示文摘 | Zhang S D Yi F | 1999 | J Geophys Res1999，104，14： | 1 |
| 6 | Synthesis and Characterization of Novel Fluorescent BOPIM Dyes with Large Stokes Shift 显示文摘 | MAO M F XIAO S Z YI T | 2011 | J Fluorine Chem2011，132，9： | 1 |
| 7 | Experimental veri- fication of multiinput seismic control strategies for smart dampers 显示文摘 | YI F DYKE S J CARLSON J D | 1998 | Journal of Engeineering Mechanics1998，127，11： | 1 |
| 8 | Adsorption of VOC on modified activated carbon fiber显示文摘 | Yi F Lin X Chen S | 2009 | Journal of Porous Materials2009，16，5： | 1 |
| 9 | Dynamic responses of plates with viscoelastic free layer damping treatment显示文摘 | YI S AHMAD M F HILTON H H | 1996 | Journal of Vibration and Acoustics1996，188，3： | 1 |
| 10 | Developing a spatially-explicit, sustainable and risk-based insurance scheme to mitigatehuman- wildlife conflict显示文摘 | Chen S Yi Z F Ahimasa C A | 2013 | Biological Conservation2013，168，： | 1 |
| 11 | Effect of activated carbon fiber anode structure and electrolysis conditions on electrochemical degradation of dye wastewater显示文摘 | Yi F Chen S Yuan C | | 0，，01： | 1 |
| 12 | Research of the entry of rare earth elements Eu3+and La3+into plant cell显示文摘 | Gao Y S Zeng F L Yi A | 2003 | Biological Trace Element Research2003，91，3： | 1 |
| 13 | Synthesis and characterization of novel room temperature vulcanized(RTV) silicone rubbers using octa -POSS as cross-linker显示文摘 | CHEN D Z YI S P FANG P F | 2011 | React Funct Polym2011，71，4： | 1 |
| 14 | Epidemiology and prevention of human papillomavirus and cervical cancer in China and Mongo- lia显示文摘 | Shi J F Qiao YI Smith J S | 2008 | Vaecine2008，26，12： | 1 |
| 15 | Physicochemical properties and ability to generate free radicals of ambient coarse,fine,and ultrafine particles in the atmosphere of Xuanwei,China,an area of high lung cancer incidence显示文摘 | Lu S Yi F Hao X J | 2014 | Atmospheric Environment2014，97，： | 1 |
| 16 | Exploration of regeneration and reusability of human serum albumin as a stereoselective ligand for chiral separation in affinity ultrafiltration显示文摘 | Edwie F Li Yi Chung T S | 2010 | Journal of Membrane Science2010，362，10： | 1 |
| 17 | Experimental verification af multiinput seismic control strategies for smart dampers 显示文摘 | YI F DYKE S J CAICEDO J M | 2001 | Journal of Engineering Mechanics2001，127，11： | 1 |
| 18 | Density functional theory study of calixarene-N-azacrown-5, calixC4'larene-N-phenyb azacrown-5, and their complexes with alkali-metal eationss Na+, K+ , and Rb+ 显示文摘 | ZHENG X Y WANG X Y YI S F | 2010 | J Comput Chem2010，，31： | 1 |
| 19 | The draft genome of watermelon (Citrullus lanatus ) and reseqnencing of 20 diverse accessions显示文摘 | Guo S G Zhang J G Sun H H Salse J Lucas W J Zhang H Y Zheng Y Mao L Y Ren Y WangZ W Min J M Guo X S Murat F Ham B K Zhang Z L Gao S Huang M Xu Y M Zhong S L Bombarely A Mueller L Zhao H He H Q Zhang Y Zhang Z H Huang S W Tan T Pang E Lin K Hu Q Kuang H H Ni P X Wang B Liu J G Kou Q H Hou W J Zou X H Jiang J Gong G Y Klee K Schoof H Huang Y Hu X S Dong S S Liang D Q Wang J Wu K Xia Y Zhao X Zheng Z Q Xing M Liang X M Huang B Q Lv T Wang J Y Yin Y Yi H P Li R Q Wu M Z Levi A Zhang X P Giovannoni J Wang J Li YF Fei Z J Xu Y | 2013 | Nature genetics2013，45，1： | 1 |
| 20 | Effect of activated carbon fiber anode structure and electrolysis conditions on electrochemical degradation of dye wastewater显示文摘 | Yi F Chen S Yuan C | | 0，，01： | 1 |
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