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| 1 | 健康成人动脉粥样硬化斑块易感性和血栓形成的生物标志物变化与极端空气污染水平相关:北京AIRCHD研究显示文摘空气污染与心血管事件恶化的病理生理机制尚不完全清楚。该文探讨环境空气污染是否可以触发易损斑块.通过全身炎症途径促进血栓形成。方法:在北京AIRCHD研究中.2014-2016年间对73名健康成年人[年龄(23.3±5.4)岁]进行了随访。研究者使用线性混合效应模型评估了空气污染物与动脉粥样硬化斑块易损性、血栓形成和炎症相关生物标志物之间的关系,并使用中介效应分析(mediation analyses)探讨涉及的生物学途径。通过受试者工作特征(receiver operating characteristic,ROC)曲线分析评估每种生物标记物预测环境空气污染暴露的能力。 | 刘青 叶鹏 Xu H Wang T Liu S Brook RD Feng B Zhao Q Song X Yi T Chen J Zhang Y Wang Y Zheng L Rajagopalan S Li J Huang W | 2019 | 中华高血压杂志2019，27，4： | 13 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | Influence of environmental factors on reductive bioprecipitation of uranium by sulfate reducing bacteria 显示文摘 | Yi Z J Tan K X Tan A L | 2007 | International Biodeterioration and Biodegradation2007，60，4： | 1 |
| 4 | Antidepressant-like behavioral and neurochemical effects of the citrusassociated chemical apigenin 显示文摘 | Yi L T Li J M Li Y C | 2008 | Life Sci2008，82，1314： | 1 |
| 5 | Study on the non isothermal crystallization kinetics of novel polyamide 6/silica nanocomposites containing epoxy resins 显示文摘 | ZhaoCX Zhang P Yi L H Xu F Wang X Y Yong J | 2008 | Polymer Testing2008，27，4： | 1 |
| 6 | Design and optical performance research of multi-phase diffractive microlens arrays显示文摘 | KONG L B YI X J LIAN K | 2004 | J Micromech Microeng2004，14，8： | 1 |
| 7 | Si rings, Si clusters, and Si nanocrystals-different states of ultrathin SiO layers显示文摘 | Yi L X Heitmann J Scholz R | 2002 | Appl Phys Lett2002，81，22： | 1 |
| 8 | Neurological Soft Signs and Their Relationship with Measures of Executive Function in Chinese Adolescents显示文摘 | Cai L Zhu X Yi J | 2013 | J Dev Behav Pediatr2013，34，3： | 1 |
| 9 | Adaptive emergency braking control with underestimation of friction co- efficient显示文摘 | Yi J Alvarez L Horowitz R | 2002 | IEEE Transactions on Control Systems Technology2002，10，3： | 1 |
| 10 | Palladium-catalyzed reductive homocoupling of aromatic halides and oxidation of alcohols显示文摘 | Zeng M F Yi J D Shao L J | 2010 | Journal of Organic Chemistry2010，75，8： | 1 |
| 11 | An efficient protocol for genomic DNA extraction from Citrus species显示文摘 | Cheng Y J Guo W W Yi H L Pang X M Deng X X | 2003 | Plant Molecular Biology Report2003，21，： | 1 |
| 12 | Mapping QTLs for tissue culture response of mature wheat embryos显示文摘 | Jia H Y Yi D L Yu J X | 2007 | Molecules and Cells2007，23，3： | 1 |
| 13 | Nasopharyngeal carcinoma treated by radical radiotherapy alone: ten year experience of a single institution显示文摘 | Yi J L Gao L Huang X D | 2006 | Int J Radiat Oncol Biol Phys2006，65，1： | 1 |
| 14 | Meta-analysis:tota! parenteral nutrition versus total enteral nutrition in predicted severe acute pancreatitis 显示文摘 | Yi F Ge L Zhao J | 2012 | Intern Med2012，51，6： | 1 |
| 15 | 查看详情显示文摘 | Dong Z H Lai X Y Halpert J E Yang N L Yi L X Zhai J Wang D Tang Z Y Jiang L | | 0，，08： | 1 |
| 16 | Removal of methylene blue dye from aqueous solution by adsorption onto sodium hu- mate/polyacrylamide/clay hybrid hydrogels 显示文摘 | Yi J Z Zhang L M | 2008 | Biore- source Technology2008，99，： | 1 |
| 17 | Combined effects of freezing rate, storage tem- perature and time on bread dough and baking properties显示文摘 | YI J Kerr W L | 2009 | Food Science and Technology2009，42，9： | 1 |
| 18 | Over-expression of OsA- GAP,an ARF-GAP,interferes with auxin influx,vesicle traf- ficking and root development显示文摘 | Zhuang X L Jiang J F Li J Yi etal | 2006 | The Plant Journal2006，48，7： | 1 |
| 19 | Intensity modulated radiotherapy with simultaneous integrated boost for locoregionally advanced nasopharyngeal carcinoma显示文摘 | Yi J Huang X Gao L | 2014 | Radiat Oncol2014，9，： | 1 |
| 20 | Proxy multi-signature scheme:A new type of proxy signature scheme显示文摘 | YI L J BAI G Q XIAO G Z | 2000 | Electron Lett2000，36，6： | 1 |
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