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| 1 | 健康成人动脉粥样硬化斑块易感性和血栓形成的生物标志物变化与极端空气污染水平相关:北京AIRCHD研究显示文摘空气污染与心血管事件恶化的病理生理机制尚不完全清楚。该文探讨环境空气污染是否可以触发易损斑块.通过全身炎症途径促进血栓形成。方法:在北京AIRCHD研究中.2014-2016年间对73名健康成年人[年龄(23.3±5.4)岁]进行了随访。研究者使用线性混合效应模型评估了空气污染物与动脉粥样硬化斑块易损性、血栓形成和炎症相关生物标志物之间的关系,并使用中介效应分析(mediation analyses)探讨涉及的生物学途径。通过受试者工作特征(receiver operating characteristic,ROC)曲线分析评估每种生物标记物预测环境空气污染暴露的能力。 | 刘青 叶鹏 Xu H Wang T Liu S Brook RD Feng B Zhao Q Song X Yi T Chen J Zhang Y Wang Y Zheng L Rajagopalan S Li J Huang W | 2019 | 中华高血压杂志2019，27，4： | 13 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 4 | Anti-N-methyl-D-aspartate receptor encephalitis that aggravates after acinetobacter baumannii pneumonia:A case report显示文摘We report an atypical case of anti-N-methyl-D-aspartate receptor encephalitis(ANMDARE). A 27-year-old man diagnosed with ANMDARE received immunotherapy and had a good recovery. However, within one month, he developed severe status epilepticus and decreased level of conscience with new hyperpyrexia and dyspnea, and was admitted to the emergency intensive care unit. Acinetobacter baumanii were found in the sputum culture; and anti-NMDAR antibodies were positive(titer: 1/80) in the cerebrospinal fluid. Repeated immunotherapy was administered with antibacterial agents, and the patient recovered except for mild psychiatric sequelae. This is the first report of ANMDARE that aggravates after acinetobacter baumannii pneumonia. Awareness and knowledge of this disorder should be extended, especially in the emergency medicine community. | Cheng C Wang Da J Li Yi Q Xia Kai Liu | 2017 | World Journal of Clinical Cases2017，5，9： | 3 |
| 5 | A fundamental understanding to the failure of cement concrete pavement based on the concept of fracture mechanics显示文摘 | YI Z J YANG Q G TANG B M | 2002 | International Journal of Road Material and Pavement Design2002，3，3： | 1 |
| 6 | Prognostic relevance of immunophenotyping in 379 patients with acute myeloid leukemia 显示文摘 | Chang H Salma F Yi Q L | 2004 | Leuk Res2004，28，1： | 1 |
| 7 | A novel titanium-supported Ag/Ti electrode for the electro-oxidation of hydrazine 显示文摘 | Yi Q F Li L Yu W Q | 2008 | Journal of Molecular Catalysis A: Chemical2008，295，： | 1 |
| 8 | Albuminuria and risk ofcardiovascular events,death,and heart failure in diabetic andnondiabetic individuals显示文摘 | Gerstein HC Mann JF Yi Q | 2001 | JAMA2001，286，4： | 1 |
| 9 | Development of novel self-humidifying composite membranes for fuel cells显示文摘 | Liu F Q Yi Xing D M | 2003 | Power Source2003，124，： | 1 |
| 10 | 显示文摘 | CHEN X YI C Q LI M J | 2002 | Anal Chim Acta2002，466，： | 1 |
| 11 | Overexpression of malate dehydrogenase in transgenic tobacco leaves: Enhanced malate synthesis and augmented Al-resistance 显示文摘 | Wang Q F Zhao Y Yi Q | 2010 | Acta Physiol Plant2010，32，6： | 1 |
| 12 | Microfluidics technology for manipulation and analysis of biological cells 显示文摘 | YI C Q LI C W JI S L | 2006 | Analytica Chimica Acta2006，560，12： | 1 |
| 13 | Experimental study on progressive col- lapse-resistant behavior of reinforced concrete frame structures 显示文摘 | Yi W He Q Xiao Y | 2008 | ACI Structural Journal2008，105，43： | 1 |
| 14 | Dynamic characteristics and wind- induced response of a super-tall building during typhoons 显示文摘 | Yi J Zhang J W Li Q S | 2013 | Journal of Wind Engineering and Industrial Aerodynamics2013，，7： | 1 |
| 15 | Systematic review: D-dimer to predict recurrent disease after stopping anticoagulant therapy for un- provoked venous thromboembolism 显示文摘 | Verhovsek M Douketis JD Yi Q | 2008 | Ann Intern Med2008，149，49： | 1 |
| 16 | Insight into the electrode mechanism in lithium-sulfur batteries with ordered microporous carbon confined sulfur as the cathode显示文摘 | LI Z YUAN L X YI Z Q | 2014 | Advanced Energy Materials2014，4，13： | 1 |
| 17 | Estimation of stage -specific fibrosis progression rate in chronic hepatitis C virus infection, a meta -analy- sis and meta -regression显示文摘 | THIEN HH YI Q DORE G J | 2008 | Hepatotogy2008，48，2： | 1 |
| 18 | Current and future therapies for myasthenia gravis显示文摘 | Lefvert AK | 1997 | Drugs Aging1997，11，2： | 1 |
| 19 | β2-microglobulin as a potential initiator of inflamma- tory responses 显示文摘 | Xie J Yi Q | 2003 | Trends Immunol2003，24，5： | 1 |
| 20 | The study on transient charac- teristic of proton exchange membrane fuel cell stack during dynamic loading显示文摘 | YAN X Q HOU M YI B L | 2007 | J Power Sources2007，163，2： | 1 |
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