|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comprehensive test stand for high-intensity cyclotron development显示文摘A comprehensive test stand for high-intensity cyclotron development,a 10 MeV 430 μA cyclotron,has been successfully constructed at China Institute of Atomic Energy (CIAE) for the experimental verification of the viability of a 100 MeV high-intensity cyclotron (CYCIAE-100) being constructed at CIAE.The verification includes the overall design technology,detail design and engineering technology for the crucial parts of the machine,e.g.main magnet and beam diagnostics.It will also pave the way for future enhancement of the beam intensity.The test stand consists of a H-ion source,axial injection system,central region,main magnet and coil,RF resonator,stripping extraction,and auxiliary systems,which include the RF power amplifier,high voltage and DC power supplies,electric apparatus,beam diagnostics,control,vacuum,water cooling,pneumatic system,and safety interlock.This paper presents the work regarding the design and sub-system development of the test sand,and the results of the beam commissioning of the machine. | ZHANG TianJue LI ZhenGuo CHU ChengJie XING JianSheng GUAN FengPing ZHONG JunQing JI Bin GE Tao YIN ZhiGuo HOU ShiGang PAN GaoFeng YAO HongJuan LU YinLong WANG ZhenHui WU LongCheng LIN Jun JIA XianLu WEI SuMin WEN LiPeng WANG Feng XIA Le CAI HongRu XIE HuaiDong CHEN RongFan ZHANG Yan ZHANG SuPing LIU GengShou ZOU Jian AN ShiZhong YANG JianJun BI YuanJie YANG Fang | 2011 | Chinese Science Bulletin2011，56，3： | 3 |
| 2 | Epigenetic regulations in immune evasion of the deadliest malaria parasite Plasmodium falciparum显示文摘Both eukaryotic and prokaryotic pathogens infect the host stably via an immune evasion mechanism termed mutually exclusive expression.Nowadays,little is known about this epigenetic mechanism,largely limiting the understanding of pathogenesis of many bacterial,fungal and protozoan pathogens and therefore the development of novel drugs and vaccines.In the most severe malaria parasite,Plasmodium falciparum,there is a major virulence gene family termed var,by which the variant antigen PfEMP1 is encoded and expressed on the surface of parasite-infected erythrocytes.Each parasite carries about 60 antigenically various var genes,however,only one of which is expressed at a given time during infection.P.falciparum expresses PfEMP1 s in this clonally variant manner to bind to different human endothelial receptors,allowing the infected erythrocytes to sequester in tissues to escape the host's immune response including spleen killing and humoral immunity.At present,the mechanism of mutually exclusive expression of the var gene family remains largely unknown,even though there is increasing evidence suggesting important roles of the epigenetic regulation involved in var gene expression.In addition,epigenetic factors were also found in association with transcriptional regulation of other antigenic variant gene families in P.falciparum.In this paper,we review the current understanding of epigenetic regulations of P.falciparum virulence genes with particular views toward the design of novel vaccines,drugs,and diagnosis to malaria. | YIN ShiGang CHENG Xiu ZHANG Xu JIANG LuBin | 2014 | Science Foundation in China2014，22，1： | 0 |
| 3 | Epigenetic regulation of SARS-Cov-2 spike protein modulates cellular viability and nascent RNA transcription in neuronal cells显示文摘SARS-CoV-2 has been demonstrated to be highly susceptible to neuron-and glial-like cells,1 but there is no consensus regarding how the virus affects neurons following neuroinvasion.It is therefore unknown if and how SARS-CoV-2 maintains the homeostasis of neuronal cells.Herein,we revealed that the receptor-binding domain(RBD)of the SARS-CoV-2 spike protein acted as an extracellular remodeling component to undermine epigenetic regulation,perturbnascentRNA(nsRNA)transcription,promote mitochondrial biogenesis,and increase cellular viability in SH-SY5Y cells. | Xi Kong Peng Lu Jinyue Zhang Zheng Bao Chenghao Kuang Bingqing Xie Jianhua Peng Ning Ma Yong Jiang Shigang Yin | 2024 | Genes & Diseases2024，11，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员