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| 1 | Human mesenchymal stem cells overexpressing pigment epitheliumderived factor inhibit hepatocellular carcinoma in nude mice(摘要)显示文摘 | Gao, Y Yao, A Zhang, W Lu, S Yu, Y Deng, L Yin, A Xia, Y Sun, B Wang, X | 2010 | 南京医科大学学报(自然科学版)2010，30，8： | 25 |
| 2 | Mechanisms of hepatocellular carcinoma progression显示文摘Hepatocellular carcinoma(HCC) is the most common primary malignancy of the liver. It is the second leading cause of cancer-related deaths worldwide, with a very poor prognosis. In the United States, there has been only minimal improvement in the prognosis for HCC patients over the past 15 years. Details of the molecular mechanisms and other mechanisms of HCC progression remain unclear. Consequently, there is an urgent need for better understanding of these mechanisms. HCC is often diagnosed at advanced stages, and most patients will therefore need systemic therapy, with sorafenib being the most common at the present time. However, sorafenib therapy only minimally enhances patient survival. This review provides a summary of some of the known mechanisms that either cause HCC or contribute to its progression. Included in this review are the roles of viral hepatitis, non-viral hepatitis, chronic alcohol intake, genetic predisposition and congenital abnormalities, toxic exposures, and autoimmune diseases of the liver. Well-established molecular mechanisms of HCC progression such as epithelial-mesenchymal transition, tumor-stromal interactions and the tumor microenvironment, cancer stem cells, and senescence bypass are also discussed. Additionally, we discuss the roles of circulating tumor cells,immunomodulation, and neural regulation as potential new mechanisms of HCC progression. A better understanding of these mechanisms could have implications for the development of novel and more effective therapeutic and prognostic strategies, which are critically needed. | Olorunseun O Ogunwobi Trisheena Harricharran Jeannette Huaman Anna Galuza Oluwatoyin Odumuwagun Yin Tan Grace X Ma Minhhuyen T Nguyen | 2019 | World Journal of Gastroenterology2019，25，19： | 21 |
| 3 | The structural basis of the dominant negative phenotype of the Gαi1β1Y2 G203A/A326S heterotrimer显示文摘 | Ping LIU Ming-zhu JIA X Edward ZHOU Parker W DE WAAL Bradley M DICKSON Bo LlU Li HOU Yan-ting YIN Ya n-yong KANG Yi SHI Karsten MELCHER H Eric XU Yi JIANG | 2016 | Acta Pharmacologica Sinica2016，37，9： | 3 |
| 4 | Stereoselective pharmacokinetics of tetrahydropalmatine after oral administration of (-)-enantiomer and the racemate显示文摘 | Hong Z Fan G Chai Y Yin X Wu Y | 2005 | 第二军医大学学报2005，26，10： | 3 |
| 5 | Thermal analysis of ethylenepropylene copolymer-grafted-glycidyl methacrylate显示文摘 | X Zhang L Li Z Yin | 1996 | J Appl Polym Sci1996，62，： | 2 |
| 6 | Design,synthesis,and anti-inflammatory evaluation of a series of novel amino acid-binding 1,5-diarylpyrazole derivatives显示文摘Aim: To design and synthesize a series of novel amino acid-binding 1,5-diarylpyrazole derivatives, which are intended to act as prodrugs with better aqueous solubility than celecoxib, and which will exert potent anti-inflammatory activi-ties after being converted to their parent compounds in vivo. Methods: To introduce an amino acid, celecoxib analogs containing amino or methylamino group were synthesized first through multi-step chemical reactions. All the synthesized compounds were screened in an intact cell-based assay in vitro and in carrageenan-induced mouse paw edema in vivo. Some active compounds were selected for further evaluation in a carrageenan-induced rat paw edema model. The preliminary pharmacokinetics experiments were conducted using high performance liquid chromatography/mass spectrometry (HPLC/MS). Results: Celecoxib, 6 of the 1,5-diarylpyrazole class of celecoxib analogs, and their amino acid derivatives (hydrochloride salts) were synthesized. In vitro screening, the hydrochloride salts showed decreased inhibitory effects on cyclooxygenase (COX)- 1 and COX-2 compared with their parent compounds, but some exhibited potent anti-inflammatory activity in vivo. Compound 4a was selected for further evaluation, and its anti-inflammatory effect was equivalent to that of celecoxib after oral administration in the carrageenan-induced rat paw edema model. At three doses (25 mg/kg, 50 mg/kg, and 100 mg/kg) the percentage inhibition on edema was 20.7%, 52.6%, and 62.6% (for compound 4a) and 27.8%, 38.4%, and 40.1% (for celecoxib), respectively. Preliminary pharmacokinetic evaluations support the hypothesis that compound 4a was actually converted to its parent compound, compound 4. Conclusion: The compound bound with amino acid acts like prodrug, which can exert anti-inflammatory effect similar to celecoxib after being converted to its parent compound. This finding will be of great benefit in carrying out structural modifications of prodrug-like selective COX-2 inhibitors. | Li MH Yin LL Cai MJ Zhang WY Huang Y Wang X Zhu XZ Shen JK | 2005 | Acta Pharmacologica Sinica2005，26，7： | 2 |
| 7 | Adjuvant intraportal venous chemotherapy for patients with hepatocellular carcinoma and portal vein tumor thrombi following hepatectomy plus portal thrombectolny 显示文摘 | Liang L J Hu W J Yin X Y | 2008 | World J Surg2008，32，4： | 1 |
| 8 | Myc target in myeloid cells-l,a novel c-Myc target,recapitulates multiple c-Myc phenotypes显示文摘 | Yin X Grove L Rogulski K | 2002 | J Biol Chem2002，277，19： | 1 |
| 9 | A Characterization On Potentially K6-E(K3)-graphic sequences显示文摘 | Yin M X and Y J H | | Accepted by Ars Combinatoria0，，： | 1 |
| 10 | Single amino acid alteration between Valine and Isoleucine determines the distinct pyrabactin selectivity by PYLI and PYL2 显示文摘 | Yuan X Yin P Hao Q | 2010 | J Biol Chem2010，285，28： | 1 |
| 11 | 显示文摘 | YIN X B WANG E K | 2005 | Analytica Chimica Acta2005，533，： | 1 |
| 12 | A Geochemical Method for Reconstruction of the Occupation History of Penguin Colony in the Maritime Antarctic显示文摘 | SUN L G ZHU R B YIN X B | 2004 | Polar Biology2004，27，： | 1 |
| 13 | Anomaly intrusion detection method based on HMM显示文摘 | Y Qiao X W Yin Y Bin | 2002 | Electronics Letters2002，38，13： | 1 |
| 14 | Kinetics of liquid-phase synthesis of ethyl ter-butyl ether from ter-butyl alcohol and ethanol catalyzed by ion exchange resin and heteropoly acid显示文摘 | Yin X Yang B Goto S | 1995 | Int J Chem Kinet1995，27，： | 1 |
| 15 | Markowitz's Mean-variance Portfolio Selection with Regime Switching:A Continuous-time model 显示文摘 | ZHOU X Y YIN G | 2003 | SIAM J Control Optim2003，42，： | 1 |
| 16 | Removal of phosphateby mesoporous ZrO2显示文摘 | Liu H L Sun X F Yin C Q | 2008 | J Hazard Mater2008，151，23： | 1 |
| 17 | Non-extinction and critical exponent for a polytropic filtration equation 显示文摘 | Yin J X Li J Jin C H | 2009 | Nonl Anal2009，71，12： | 1 |
| 18 | Phage displayed peptides recognizing porcine aminopeptidase N inhibit transmissible gastroenteritis coronavirus infection in vitro显示文摘 | Ren X Liu B Yin J | 2011 | Virology2011，410，2： | 1 |
| 19 | Fabrication and mierostructure of in situ toughened Al2O3/Fe3 Al显示文摘 | Gong H Y Yin Y S Wang X | 2004 | Materials Research Bulletin2004，39，45： | 1 |
| 20 | Large - scale fabrication of tower - like,flower- like, and tube- like ZnO arrays by a simple chemical solution route 显示文摘 | WANG Z QIAN X F YIN J | 2004 | Langmuir2004，20，8： | 1 |
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