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| 1 | Structural basis of AMPK regulation by adenine nucleotides and glycogen显示文摘激活安培的蛋白质 kinase (AMPK ) 为糖尿病,肥胖,和癌症的治疗是一个中央细胞的精力传感器和精力动态平衡,和一个有希望的药目标的管理者。这里我们人的 α 的现在的低分辨率的水晶结构; 1 β 2 γ 1 holo-AMPK 建筑群跳了到它的 allosteric 调节的人安培和肝糖模仿 cyclodextrin,两个在 phosphorylated (4.05 Å) 并且 non-phosphorylated (4.60 Å) 状态。另外,我们解决了 2.95 Å人的 kinase 领域(KD ) 的结构跳了到邻近的 autoinhibitory 领域(帮助) 并且表现了广泛生物化学并且 mutational 研究。一起,这些研究由安培和肝糖说明 allosteric AMPK 调整的内在的机制,其绑定改变在交替的帮助(安培) 和糖类绑定模块(肝糖) 之间的 equilibria 相互作用。 | Xiaodan Li Lili Wang X Edward Zhou Jiyuan Ke Parker W de Waal Xin Gu M H Eileen Tan Dongye Wang Donghai Wu H Eric Xu Karsten Melcher | 2015 | Cell Research2015，25，1： | 8 |
| 2 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 3 | Structure and activation of rhodopsin显示文摘视紫红质是第一 G-protein-coupled 受体(GPCR ) ,它的三维的结构由 X 光检查晶体学解决了。视紫红质的水晶结构在视觉系统揭示了 photoreception 和信号 transduction 的分子的机制。尽管几另外的 GPCR 水晶结构在过去几年被报导了,视紫红质结构为理解另外的 GPCR 的结构、功能的特征仍然是一个重要模型。这评论总结结构的特征, photoactivation,和视紫红质的 G 蛋白质信号 transduction。 | X Edward ZHOU Karsten MELCHER H Eric XU | 2012 | Acta Pharmacologica Sinica2012，33，3： | 4 |
| 4 | The structural basis of the dominant negative phenotype of the Gαi1β1Y2 G203A/A326S heterotrimer显示文摘 | Ping LIU Ming-zhu JIA X Edward ZHOU Parker W DE WAAL Bradley M DICKSON Bo LlU Li HOU Yan-ting YIN Ya n-yong KANG Yi SHI Karsten MELCHER H Eric XU Yi JIANG | 2016 | Acta Pharmacologica Sinica2016，37，9： | 3 |
| 5 | Missing-value Estimation Using Linear and Non-linear Regression with Bayesian Gene Selection显示文摘 | Zhou X B Wang X D Edward R D | 2003 | Bioinformatics2003，19，17： | 1 |
| 6 | A test of climate, sun, and culture relationships from an 1810-year Chinese cave record显示文摘 | Zhang P Z Cheng H Edwards R L Chen F H Wang Y J Yang X L Liu J Tan M Wang X F Liu J H An C L Dai Z B Zhou J Zhang D Z Jia J H Jin L Y Johnson K R | 2008 | Science2008，322，5903： | 1 |
| 7 | The gennme of the mesopolyploid crop species Brassica rapa 显示文摘 | Wang X Wang H Wang J Sun R Wu J Liu S Bai Y Mun JH Bancroft I Cheng F Huang S Li X Hua W Wang J Wang X Freeling M Pires JC Paterson AH Chalhoub B Wang B Hayward A Sharpe AG Park BS Weisshaar B Liu B Li B Liu B Tong C Song C Duran C Peng C Geng C Koh C Lin C Edwards D Mu D Shen D Soumpourou E Li F Fraser F Conant G Lassalle G King G J Bonnema G Tang H Wang H Belcram H Zhou H Hirakawa H Abe I-I Guo H Wang H Jin H Parkin IA Batley J Kim JS Just J l i J Xu J Deng J Kim JA Li J Yu J Meng J Wang J Min J Poulain J Wang J Hatakeyama K Wu K Wang L Fang L Trick M Links MG Zhao M Jin M Ramchiary N Drou N Berkman PJ Cai Q Huang Q Li R Tabata S Cheng S Zhang S Zhang S Huang S Sato S Sun S Kwon SJ Choi SR Lee TH Fan W Zhao X Tan X Xu X Wang Y Qiu Y Yin Y l i Y Du Y Liao Y Lira Y Narusaka Y Wang Y Wang Z Li Z Wang Z Xiong Z Zhang Z Brassica rapa Genome Sequencing Project Consortium | 2011 | Nature Genetics2011，43，10： | 1 |
| 8 | The Brassica oleracea genome reveals the asymmetrical evolution of polyploid genomes 显示文摘 | Liu S Liu Y Yang X Tong C Edwards D Parkin I A P Zhao M Ma J Yu J Huang S Wang X Wang J Lu K Fang Z Bancroft I Yang T J Hu Q Wang X Yue Z Li H Yang L Wu J Zhou Q Wang W King G J Chris Pires J Lu C Wu Z Sampath P Wang Z Guo H Pan S Yang L Min J Zhang D Jin D Li W Belcram H Tu J Guan M Qi C Du D Li J Jiang L Batley J Sharpe A G Park B S Ruperao P Cheng F Espinosa Waminal N Huang Y Dong C Wang L Li J Hu Z Zhuang M Huang Y Huang J Shi J Mei D Liu J Lee T Wang J Jin H Li Z Li X Zhang J Xiao L Zhou Y Liu Z Liu X Qin R Tang X Liu W Wang Y Zhang Y Lee J Kim H H Denoeud F Xu X Liang X Hua W Wang X Wang J Chalhoub B Paterson A H | 2014 | Nature Communications2014，5，： | 1 |
| 9 | A test of climate, sun and culture relationships from an 1810-year Chinese cave record 显示文摘 | Zhang P Z Cheng H Edwards R L Chen F H Wang Y J Yang X L Liu J Tan M Wang X F Liu J H An C L Dai Z B Zhou J Zhang D Z Jia J H Jin L Y Johnson K R | 2008 | Science2008，322，： | 1 |
| 10 | Differences in bone microarchitecture between postmenopausal Chinese‐American and white women显示文摘 | Marcella D Walker X Sherry Liu Emily Stein Bin Zhou Ervis Bezati Donald J McMahon Julia Udesky George Liu Elizabeth Shane X Edward Guo John P Bilezikian | 2011 | J Bone Miner Res2011，，7： | 1 |
| 11 | Structures and mechanism for the design of highly potent glucocorticoids显示文摘glucocorticoid 药的进化被降低讨厌的副作用的需求驾驶,当保留有益的反煽动性的效果时。当许多不受欢迎的副作用与高剂量的 glucocorticoids 的使用被联系,力量是这进化的一个重要方面。副作用能被最小化由高度有势力 glucocorticoids 在更低的剂量完成一样的治疗效果。这个要求推进了有增加的力量的合成 glucocorticoids 的连续发展,而是他们的力量的结构的基础糟糕被理解。决定位于力量下面的机制,我们解决了 ligand 有约束力的领域(LBD ) 绑了在它的内长的 ligand 的 glucocorticoid 受体(GR ) 的 X 光检查结构,皮质醇,有相对低的力量,并且一高度有势力合成 glucocorticoid, mometasone furoate (MF ) 。皮质醇界限 GR LBD 表明在类固醇 A 的 C1-C2 单个契约的灵活性响为与 GR 的皮质醇的低亲密关系主要负责。相反,我们证明 MF 的高力量被它的 C-17α 完成;完全充满 ligand 有约束力的衣袋的 furoate 组,因此为高亲密关系的绑定提供另外的锚接触。ligand 有约束力的衣袋里的单个氨基酸, Q642,在在 MF 和皮质醇之间的 ligand 力量起一个区别作用。基于结构的设计与许多改进力量和功效导致了几新奇 glucocorticoids 的合成。一起,这些结果揭示 glucocorticoid 力量的关键结构的机制并且为高度开发小说提供一个合理基础有势力 glucocorticoids。 | Yuanzheng He Wei Yi Kelly Suino-Powell X Edward Zhou W David Tolbert Xiaobo Tang Jing Yang Huaiyu Yang Jingjing Shi Li Hou Hualiang Jiang Karsten Melcher H Eric Xu | 2014 | Cell Research2014，24，6： | 1 |
| 12 | Bone density, microarchitecture and stiffness in Caucasian and Caribbean Hispanic postmenopausal American women显示文摘Hispanic Americans of Caribbean origin are a fast-growing subset of the US population, but there are no studies on bone density, microstructure and biomechanical integrity in this minority group. In this study, we aimed to compare Caucasian and Caribbean Hispanic postmenopausal American women with respect to these characteristics. Thirty-three Caribbean Hispanics were age-matched to thirty-three Caucasian postmenopausal women. At the lumbar spine, the Hispanic women had significantly lower areal bone mineral density(aBMD).At the radius by high-resolution peripheral quantitative computed tomography(HR-pQCT), there were minimal differences between Hispanic and Caucasian women. At the tibia, Hispanic women had lower trabecular volumetric bone density and trabecular number, and higher trabecular separation. Individual trabecula segmentation(ITS) analyses indicated that at the tibia, Hispanic women not only had significantly lower bone volume fraction, but also had significantly lower rod bone volume fraction, plate trabecular number, rod trabecular number and lower plate–plate, plate–rod and rod–rod junction densities compared to Caucasian women. The differences in bone quantity and quality contributed to lower whole bone stiffness at the radius, and both whole bone and trabecular bone stiffness at the tibia in Hispanic women. In conclusion,Hispanic women had poorer bone mechanical and microarchitectural properties than Caucasian women,especially at the load-bearing distal tibia. | Bin Zhou Ji Wang Emily M Stein Zhendong Zhang Kyle K Nishiyama Chiyuan A Zhang Thomas L Nickolas Elizabeth Shane X Edward Guo | 2014 | Bone Research2014，2，3： | 0 |
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