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| 1 | AME证据系列001--转化医学协会:脓毒症诊断和早期识别的临床实践指南显示文摘脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊断需要不断改变来满足临床和研究的要求。然而,尽管有许多新型的生物标记和筛选工具去预测脓毒症发生的风险,但是这些措施的诊断价值和有效性不足以让人满意,并且没有充分的证据去建议临床使用这些新技术。因此,脓毒症的临床诊断标准需要定期更新去适应不断产生的新证据。这篇综述旨在呈现当前脓毒症的诊断和早期识别方面的最新研究证据。临床运用不同的诊断方法的推荐意见依赖于推荐、评价、发展和评估分级体系(Grades of Recommendation Assessment,Development and Evaluation,GRADE),因为大部分的研究是观察性研究,并没有对这些方法进行可靠评估,采用的是两步推理方法。未来需要更多研究来确认或者反驳某一特殊的指标检测,同时应该直接采用相关病人的结果数据。 | Zhongheng Zhang Nathan J.Smischney Haibo Zhang Sven Van Poucke Panagiotis Tsirigotis Jordi Rello Patrick M.Honore Win Sen Kuan Juliet June Ray Jiancang Zhou You Shang Yuetian Yu Christian Jung Chiara Robba Fabio Silvio Taccone Pietro Caironi David Grimaldi Stefan Hofer George Dimopoulos Marc Leone Sang-Bum Hong Mabrouk Bahloul Laurent Argaud Won Young Kim Herbert D.Spapen Jose Rodolfo Rocco 张建成(译) 尚游(译) 钟鸣(校) | 2016 | 临床与病理杂志2016，36，10： | 5 |
| 2 | Slow coherency- based islanding 显示文摘 | You Haibo Vittal V Wang Xiaoming | 2004 | IEEE Transactions on Power Systems2004，19，1： | 1 |
| 3 | Slow coherency-based islanding显示文摘 | You Haibo Vittal V Wang Xiaoming | 2004 | IEEE Transactions on Power Systems2004，19，1： | 1 |
| 4 | Slow coherency based islanding显示文摘 | YOU Haibo VITTAL V WANG Xiaoming | 2004 | IEEE Trans on Power Systems2004，19，1： | 1 |
| 5 | Slow coherency-based islanding显示文摘 | Haibo You Vijay Vittal Xiaoming Wang | 2004 | IEEE Trans on Power System2004，19，1： | 1 |
| 6 | Taurine Attenuates Liver Injury by Downregulating Phosphorylated p38 MAPK of Kupffer Cells in Rats with Severe Acute Pancreatitis显示文摘 | Sidong Wei Qingyong Huang Jinzheng Li Zuojin Liu Haibo You Yong Chen Jianping Gong | 2012 | Inflammation2012，，2： | 1 |
| 7 | Self-healing in power systems:an approach using islanding and rate of frequency decline-based load shedding显示文摘 | YOU Haibo VITYAL V YANG Zhong | 2003 | IEEE Transactions on Power Systems2003，18，1： | 1 |
| 8 | Slow coherency-based islanding显示文摘 | YOU Haibo VITTAL V WANG Xiaoming | 2004 | IEEE Trans on Power Systems2004，19，1： | 1 |
| 9 | Numerical study of underwater fate of oil spilled from deepwater blowout显示文摘 | Haibo Chen Wei An Yunxiang You Fanghui Lei Yupeng Zhao Jianwei Li | 2015 | Ocean Engineering2015，，： | 1 |
| 10 | Slow coherency-based islanding显示文摘 | YOU Haibo VITTAL V WANG Xiaoming | 2004 | IEEE Trans on Power Systems2004，19，1： | 1 |
| 11 | Slow coherency-based islanding 显示文摘 | You Haibo Vijay Vittal Wang Xiaoming | 2004 | IEEE Transactions on Power Systems2004，19，1： | 1 |
| 12 | Elecrochemiluminescence detection with integrated indium tin oxide electrodeon electrophoretic microchip for direct bioanalysis of lincomycin in the urine显示文摘 | Xiaocui Zhao Tianyan You Haibo Qiu | 2004 | Journal of Chromatography B2004，810，： | 1 |
| 13 | Slow coherency-based islanding显示文摘 | YOU Haibo VIJAY V WANG Xiaoming | 2004 | IEEE Trans on Power Systems2004，19，1： | 1 |
| 14 | Slow cohereney-based islanding 显示文摘 | YOU Haibo VIJAY V WANG Xiaoming | 2004 | IEEE Trans on Power System2004，19，1： | 1 |
| 15 | Self-healing in power systems:an approach using islanding and rate of frequency decline-based load shedding 显示文摘 | Haibo You Vijay Vittal Zhong Yang | 2003 | IEEE Transaction on Power System2003，18，1： | 1 |
| 16 | Slow coherency-based islanding显示文摘 | YOU Haibo VITYAL V WANG Xiaoming | 2004 | IEEE Transactions on Power Systems2004，19，1： | 1 |
| 17 | Control of lupus activity during pregnancy via the engagement of IgG sialylation:novel crosstalk between IgG sialylation and pDC functions显示文摘Immunoglobulin(IgG)glycosylation affects the effector functions of IgG in a myriad of biological processes and has been closely associated with numerous autoimmune diseases,including systemic lupus erythematosus(SLE),thus underlining the pathogenic role of glycosylation aberration in autoimmunity.This study aims to explore the relationship between IgG sialylation patterns and lupus pregnancy.Relative to that in serum samples from the control cohort,IgG sialylation level was aberrantly downregulated in serum samples from the SLE cohort at four stages(from preconception to the third trimester of pregnancy)and was significantly associated with lupus activity and fetal loss during lupus pregnancy.The type I interferon signature of pregnant patients with SLE was negatively correlated with the level of IgG sialylation.The lack of sialylation dampened the ability of IgG to suppress the functions of plasmacytoid dendritic cells(pDCs).RNA-seq analysis further revealed that the expression of genes associated with the spleen tyrosine kinase(SYK)signaling pathway significantly differed between IgG-and deSia-IgG-treated pDCs.This finding was confirmed by the attenuation of the ability to phosphorylate SYK and BLNK in deSia-IgG.Finally,the coculture of pDCs isolated from pregnant patients with SLE with IgG/deSia-IgG demonstrated the sialylation-dependent anti-inflammatory function of IgG.Our findings suggested that IgG influences lupus activity through regulating pDCs function via the modulation of the SYK pathway in a sialic acid-dependent manner. | You Wang Sihan Lin Jiayue Wu Meng Jiang Jianhua Lin Yu Zhang Huihua Ding Haibo Zhou Nan Shen Wen Di | 2023 | Frontiers of Medicine2023，17，3： | 0 |
| 18 | An important measure taken for China Organ Transplant Response System显示文摘On September 7,2021,mandated by the Bureau of Medical Administration of the National Health Commission,the China Organ Transplantation Development Foundation(COTDF)established the China Organ Transplant Response System(COTRS)Scientific Committee.The committee is composed of clinical experts in transplantation,health administrative executives,medical ethics experts,and experts from Organ Procurement Organizations(OPO)in China. | Hongtao Zhao Haibo Wang Miao Pu Jie Zhao You Wu Ying Shi Jiefu Huang | 2022 | Hepatobiliary Surgery and Nutrition2022，11，4： | 0 |
| 19 | Preface to the Special Issue on Perovskite Semiconductor Optoelectronic Materials and Devices显示文摘Halide perovskite,a novel semiconductor material,was initially used in solar cells since 2009,and tremendous progresses have been witnessed in the last decade.The power conversion efficiency of the single perovskite solar cells has been incredibly increased up to 25.2%,and close to 30%efficiency was realized in perovskite/silicon tandem solar cells.Recently,the application of perovskite has been extended to the light-emitting diodes and photo-detectors. | Jingbi You Jiang Tang Haibo Zeng Jianpu Wang | 2020 | Journal of Semiconductors2020，41，5： | 0 |
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