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| 1 | A randomized controlled clinical trial on the treatment of Thymosin-a1 versus interferon-α in patients with hepatitis B显示文摘INTRODUCTIONChronic hepatitis B virus (HBV) infection is a serious problem because of its world wide distribution and possible adverse sequelae ,such as cirrhosis and hepatocellular carcinoma .The World Health Organization estimates that HBV has infected mord than 350 million people worldwide ,and up to 20% of them will become chromic carricrs and will be at significant risk for cirrhosis and HCC .The ultimate goal of the therapy for chronic hepatitis B is to prevent progression to cirrhosis and to prevent development of HCC. | Jing You Lin Zhuang Bao Zhang Tang Wei Bo Yang Su Ying Ding Wu Li Rong Xue Wu Hong Li Zhang Yan Mei Zhang Shao Ming Yan Lu Zhang ~1Department of Infectious Diseases,The First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China ~2Departrnent of Hepatology,Kunming Third Municipal People’s Hospital,Kunming 650041,Yunnan Province,China | 2001 | World Journal of Gastroenterology2001，7，3： | 48 |
| 2 | GJB2 mutation spectrum in deaf population in a typical southeastern area of China显示文摘Mutations in GJB2 gene are the most frequently found mutations in patients with nonsyndromic hearing impairment. However, the spectrum and prevalence of mutations in this gene vary among different ethnic groups. In China, 30,000 infants are born with congenital hearing impairment annually. In order to provide appropriate genetic testing and counseling to the families, we investigated the molecular etiology of nonsyndromic deafness in 103 unrelated school children attending Nantong School for the Deaf and Mute in Jiangsu Province, China. The coding exon of the GJB2 gene was PCR amplified and sequenced. Sixty two GJB2 mutant alleles were identified in 35.9% (37/103) of the patients. Twenty five patients carried two pathogenic mutations and 12 patients carried one mutant allele. The 235delC was the most common mutation accounting for 69.4% (43/62) of GJB2 mutant alleles. The GJB2 mutant alleles accounted for 30.1% (62/206) of all chromosomes responsible for nonsyndromic hearing impairment. Testing of the 3 most prevalent deleterious frame shift mutations in this cohort detected 100% of all GJB2 mutant alleles. These results demonstrate that an effective genetic testing of GJB2 gene for patients and families with nonsyndromic hearing impairment is possible. | DAI Pu1*, YOU Yi-wen2*, CUI Jing-hong2*, YU Fei1, HAN Bing 1, KANG Dong-yang1, YUAN Hui-jun1, HAN Dong-yi1, 1. Department of Otolaryngology, PLA General Hospital, Beijing, People’s Republic China, 100853 2. Department of Otolaryngology, Nantong University Affiliated Hospital, Nantong, Jiangsu Province, People’s Republic China, 226001 *Pu Dai, Yiwen You, Jinghong Cui contribute equally to this paper | 2006 | Journal of Otology2006，1，2： | 10 |
| 3 | Current status of intravenous tissue plasminogen activator dosage for acute ischaemic stroke:an updated systematic review显示文摘The optimal dose of recombinant tissue plasminogen activator(rtPA)for acute ischaemic stroke(AIS)remains controversial,especially in Asian countries.We aimed to update the evidence regarding the use of low-dose versus standard-dose rtPA.We performed a systematic literature search across MEDLINE,Embase,Cochrane Central Register of Controlled Trials(CENTRAL),PsycINFO and Cumulative Index to Nursing and Allied Health Literature(CINAHL)from inception to 22 August 2016 to identify all related studies.The outcomes were death or disability(defined by modified Rankin Scale 2-6),death,and symptomatic intracerebral haemorrhage(sICH).Where possible,data were pooled for meta-analysis with ORs and corresponding 95% CIs by means of random-effects or fixed-effects meta-analysis.We included 26 observational studies and 1 randomised controlled trial with a total of 23210 patients.Variable doses of rtPA were used for thrombolysis of AIS in Asia.Meta-analysis shows that low-dose rtPA was not associated with increased risk of death or disability(OR 1.13,95% CI 0.95 to 1.33),or death(OR 0.86,95% CI 0.74 to 1.01),or decreased risk of sICH(OR 1.06,95% CI 0.65 to 1.72).The results remained consistent when sensitivity analyses were performed including only low-dose and standard-dose rtPA or only Asian studies.Our review shows small difference between the outcomes or the risk profile in the studies using low-dose and/or standard-dose rtPA for AIS.Low-dose rtPA was not associated with lower risk of death or disability,death alone,or sICH. | Xia Wang Shoujiang You Shoichiro Sato Jie Yang Cheryl Carcel Danni Zheng Sohei Yoshimura Craig S Anderson Else Charlotte Sandset Thompson Robinson John Chalmers Vijay K Sharma | 2018 | Stroke & Vascular Neurology2018，3，1： | 10 |
| 4 | Monitoring Greenhouses Gases over China Using Space-Based Observations Monitoring Greenhouses Gases over China Using Space-Based Observations显示文摘The atmospheric carbon dioxide(CO 2)concentration has increased to more than 405 parts per million(ppm.1 ppm=10-6 m/s 2)in 2017 due to human activities such as deforestation,land-use change and burning of fossil fuels.Although there is broad scientific consensus on the damaging consequences of the change in climate associated with increasing concentrations of greenhouse gases,fossil CO 2 emissions have continued to increase in recent years mainly from rapidly developing economies and China is now the largest emitter of CO 2 generating about 30%of all emissions globally.To allow more reliable forecast of the future state of the carbon cycle and to support the efforts for mitigation greenhouse gas emissions,a better understanding of the global and regional carbon budget is needed.Space-based measurements of CO 2 can provide the necessary observations with dense coverage and sampling to provide improved constrains on of carbon fluxes and emissions.The Chinese Global Carbon Dioxide Monitoring Scientific Experimental Satellite(TanSat)was established by the National High Technology Research and Development Program of China with the main objective of monitoring atmospheric CO 2 and CO 2 fluxes at the regional and global scale.TanSat has been successfully launched in December 2016 and as part of the Dragon programme of ESA and the Ministry of Science and Technology(MOST),a team of researchers from Europe(UK and Finland)and China has evaluated early TanSat data and contrast it against data from the GOSAT mission and models.In this manuscript,we report on retrieval intercomparisons of TanSat data using two different retrieval algorithms,on validation efforts for the Eastern Asia region using GOSAT CO 2 data and first assessments of TanSat and GOSAT CO 2 data against model calculations using the GEOS-Chem model. | Hartmut BOESCH Yi LIU Paul I PALMER Johanna TAMMINEN Jasdeep S ANAND Zhaonan CAI Ke CHE Huilin CHEN Xi CHEN Liang FENG Janne HAKKARAINEN Pauli HEIKKINEN Nikoleta KALAITZI Rigel KIVI Robert PARKER Peter SOMKUTI Jing WANG Alex WEBB Dongxu YANG Lu YAO You YI | 2020 | Journal of Geodesy and Geoinformation Science2020，3，4： | 2 |
| 5 | 呼出气冷凝液代谢组学对慢加急性肝衰竭预后的预测价值显示文摘[据Hepatology Research 2021年4月报道]题:呼出气冷凝液代谢组学对慢加急性肝衰竭预后的预测价值(作者Jing J等)慢加急性肝衰竭(ACLF)是导致慢性失代偿肝病患者死亡的重要原因之一,也是国内外临床肝病研究领域的热点和难题。部分ACLF患者在治疗“黄金窗”阶段通过积极救治,能够获得可逆性的恢复,因此早期预测ACLF预后对患者及早施救以及重症化防控十分有益。 | 景婧 牛明 王睿林 JING J SANG X YOU S | 2021 | 临床肝胆病杂志2021，37，7： | 2 |
| 6 | Engrafted bone marrow-derived flk-(1+) mesenchymal stem cells regenerate skin tissue显示文摘 | Deng W Han Q Liao L Li C Ge W Zhao Z You S Deng H Murad F Zhao RC | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 7 | Quantitative Histological Study on Changes of the Cortical Bones after Internal Fixation with Plates of Different Rigidity显示文摘In an effect to explore the potemtial role of bone microcirculation causing plate-induced reginal | Wang You et al. Dept Orth, Ninth People’s Hospital, Shanghai Second Med Uni, Shanghai 200011. Chin J Orth | 1995 | Chinese Medical Journal1995，，11： | 2 |
| 8 | Cable-stiffened Pantographic Deployable Structures Part 2: Mesh Reflector显示文摘 | You Z Pellegrino S | 1997 | AIAA Journal1997，35，8： | 1 |
| 9 | An invertible frequency domain transformation for masking-based sub space speech enhancement显示文摘 | YOU C H KOH S N RAHARDJA S | 2005 | IEEE Signal Processing Letters2005，12，1： | 1 |
| 10 | Key role of the GITR/GITR Ligand pathway in the development of murine autoimmune diabetes:A potential therapeutic target显示文摘 | You S Poulton L Cobbold S | 2009 | PLoS One2009，4，11： | 1 |
| 11 | Skin color detection through estimation and conversion of illuminant color under various illuminations 显示文摘 | Do H C You J Y Chien S | 2007 | IEEE Transactions on Consumer Electronics2007，53，3： | 1 |
| 12 | Dynamic modulussimulation of the asphalt concrete using the X-raycomputed tomography images显示文摘 | You Z P Adhikari S Kutay M E | 2009 | Materials andStructures2009，42，5： | 1 |
| 13 | Age-related alterations in the activation of heat shock transcription factor 1in rat hepatocytes显示文摘 | Heydari AR You S Takahashi R | 2000 | Exp Cell Res2000，256，1： | 1 |
| 14 | Order MMSE spectral amplitude estimation for speech enhancement显示文摘 | You C H Koh S N Rahard | 2005 | IEEE Transactions on Speech and Audio2005，13，4： | 1 |
| 15 | Prevalence of sleep disorders breathing in middle-aged Korean men and women显示文摘 | KIM J IN K YOU S | 2004 | J Respir Crit Care Med2004，170，： | 1 |
| 16 | PB/PANI-modified electrode used as a novel oxygen reduction cathode in microbial fuel eell显示文摘 | FU L YOU S J ZHANG GQ | 2011 | Biosens Bioeleetron2011，26，5： | 1 |
| 17 | DynamicModulus Simulation of the Asphalt Concrete Using the X-ray Computed Tomography Images 显示文摘 | YOU Zhanping ADHIKARI S KUTAY M E | 2009 | Materials andStructures2009，42，5： | 1 |
| 18 | Heat Orientation Effects on Pool Boiling of Micro-Porous-Enhanced Surfaces in Saturated FC-72 显示文摘 | Chang J Y You S M | 1996 | ASME Journal of Heat Transfer1996，118，： | 1 |
| 19 | Controllable synthesis of pentagonal silver nanowires via a simple alcoholthermal method显示文摘 | You T Xu S L Sun S X | 2009 | Materials Letters2009，63，： | 1 |
| 20 | Structural stability of Zn3 N2 under highpressure显示文摘 | Zhao J G Yang L X You S J | 2010 | Physica B2010，405，7： | 1 |
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