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| 1 | Fatty liver without a large“belly”:Magnified review of nonalcoholic fatty liver disease in non-obese patients显示文摘Nonalcoholic fatty liver disease(NAFLD) is well described as a common cause of chronic liver disease, mostly in the obese population. It refers to a spectrum of chronic liver disease that starts with simple steatosis than progresses to nonalcoholic steatohepatitis and cirrhosis in patients without significant alcohol consumption. NAFLD in the non-obese population has been increasingly reported and studied recently. The pathogenesis of nonobese NAFLD is poorly understood and is related to genetic predisposition, most notably patatin-like phospholipase domain-containing 33 G allele polymorphism that leads to intrahepatic triglyceride accumulation and insulin resistance. Nonobese NAFLD is associated with components of metabolic syndrome and, especially, visceral obesity which seems to be an important etiological factor in this group. Dietary factors and, specifically, a high fructose diet seem to play a role. Cardiovascular events remain the main cause of mortality and morbidity in NAFLD, including in the nonobese population. There is not enough data regarding treatment in non-obese NAFLD patients, but similar to NAFLD in obese subjects, lifestyle changes that include dietary modification, physical activity, and weight loss remain the mainstay of treatment. | Mohamad H Yousef Alhareth Al Juboori Abdulmajeed A Albarrak Jamal A Ibdah Veysel Tahan | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，3： | 9 |
| 2 | Fulminant hepatic failure caused by Salmonella paratyphi A infection显示文摘我们报导暴发性的肝的失败的一个案例把感染与沙门氏菌 paratyphi 联系了,在进入有二天的发烧的特别护理单位(ICU ) 的一个 29 岁的病人,头疼并且呕吐列在后面由行为变化和丧失方向感。在检查上,病人显得尖锐地病了,鼓动,糊涂,并且深深地 jaundiced。C 的温度 38.5 度,脉搏 92/min,血压 130/89 毫米汞柱。血的两件样品种了 S。paratyphi A,它对 ceftriaxone 和 ciprofloxacin 敏感。Ceftriaxon 与高剂量的地塞米松被管理。有 ceftriaxon 的二星期术后疗法,病人处于令人满意的状况被解除。 | Fahmi Yousef Khan Ahmed A Kamha Ibrahim Y Alomary | 2006 | World Journal of Gastroenterology2006，12，32： | 3 |
| 3 | Sinapic acid ameliorates D-galactosamine/lipopolysaccharideinduced fulminant hepatitis in rats:Role of nuclear factor erythroidrelated factor 2/heme oxygenase-1 pathways显示文摘BACKGROUND Sinapic acid(SA)has been shown to have various pharmacological properties such as antioxidant,antifibrotic,anti-inflammatory,and anticancer activities.Its mechanism of action is dependent upon its ability to curb free radical production and protect against oxidative stress-induced tissue injuries.AIM To study the hepatoprotective effects of SA against lipopolysaccharide(LPS)/Dgalactosamine(D-GalN)-induced acute liver failure(ALF)in rats.METHODS Experimental ALF was induced with an intraperitoneal(i.p.)administration of 8μg LPS and 800 mg/kg D-GalN in normal saline.SA was administered orally once daily starting 7 d before LPS/D-GalN treatment.RESULTS Data showed that SA ameliorates acute liver dysfunction,decreases serum levels of alanine transaminase(ALT),and aspartate aminotransferase(AST),as well as malondialdehyde(MDA)and NO levels in ALF model rats.However,pretreatment with SA(20 mg/kg and 40 mg/kg)reduced nuclear factor kappalight-chain-enhancer of activated B cells(NF-κB)activation and levels of inflammatory cytokines(tumor necrosis factor-αand interleukin 6).Also,SA increased the activity of the nuclear factor erythroid-related factor 2/heme oxygenase-1(Nrf2/HO-1)signaling pathway.CONCLUSION In conclusion,SA offers significant protection against LPS/D-GalN-induced ALF in rats by upregulating Nrf2/HO-1 and downregulating NF-κB. | Mushtaq Ahmad Ansari Mohammad Raish Yousef A Bin Jardan Ajaz Ahmad Mudassar Shahid SheikhFayaz Ahmad Nazrul Haq Mohammad Rashid Khan Saleh A Bakheet | 2021 | World Journal of Gastroenterology2021，27，7： | 2 |
| 4 | Aluminium-induced deterioration in reproductive performance and seminal plasma biochemistry of male rabbits显示文摘 | Yousef M I El-Morsy A M Hassan M S | 2005 | Toxicology2005，215，12： | 1 |
| 5 | , Performance of transcatheter aortic valve implantation in patients with bicuspid aortic valve: systematic review 显示文摘 | Yousef A Simard T Pourdjabbar A | 2014 | Int J Cardiol2014，176，2： | 1 |
| 6 | Influence of Al2O3 nano-dispersionson microstructure features and mechanical properties of cast and T6 heat-treated Al-Si hypoeutectic Alloys显示文摘 | I El-Mahallawi H Abdelkader L Yousef A Amer J Mayer A Schwedt | 2012 | Materials Science&Engineering A2012，556，： | 1 |
| 7 | Zoonotic potential of Chlamydophila显示文摘 | Rodolakis A Yousef M K | 2010 | Vet Microbiol2010，140，34： | 1 |
| 8 | Energy consumption and costs with a multi-stage flashing (MSF)desalting system显示文摘 | M A Darwish Fouad A Yousef N M AI Najem | 1997 | Desalination1997，109，1： | 1 |
| 9 | Effect of ascorbic acid and Vitamin E supplementation on semen quality and biochemical parameters of male rabblts显示文摘 | Yousef M I Abdallah G A Kamel K I | 2003 | Animal Reproduction Science2003，76，2： | 1 |
| 10 | In vitro metabolism of ginsennosides by ginseng root pathogen Pytium irregulae显示文摘 | Lina F Yousef M Bernards A | 2006 | Phytochemistry2006，67，： | 1 |
| 11 | 显示文摘 | AZZEM M A YOUSEF U S PIERRE G | 1998 | Eur Polym J1998，34，： | 1 |
| 12 | Job Satisfaction as a Mediator of the Relationship between Role Stressors and Organizational Commitment: A Study from an Arabic Cultural Perspective 显示文摘 | YOUSEF D A | 2002 | Journal of Managerial Psychology2002，17，4： | 1 |
| 13 | Susceptibility of human rotavirus to ozone, high pressure, and pulsed electric field显示文摘 | KHADRE M A YOUSEF A E | 2002 | J Food Protect2002，65，9： | 1 |
| 14 | Preparation and physic-chemical characterization of naproxen-PLGA nanoparticles 显示文摘 | YOUSEF J FATEMEH A SOODABEH D | 2010 | Colloids Surf B:Biointerf2010，81，2： | 1 |
| 15 | 显示文摘 | AZZEM M A YOUSEF U S LIMOSIN D | 1996 | J Electroanal Chem1996，417，： | 1 |
| 16 | Inactivation kinetics of selected aerobic and anaerobic bacterial spores by pressureassisted thermal processing显示文摘 | AHN J BALASUBRAMANIAM V M YOUSEF A E | 2007 | International Journal of Food Microbiology2007，113，： | 1 |
| 17 | Dietary zinc deficiency induced changes in the activity of en- zymes and the levels of free radicals,lipids and protein elec- trophoretie behaviour in growing rats 显示文摘 | YOUSEF M I EL-HENDY H A EL-DEMERDASH F M | 2002 | Toxicology2002，175，13： | 1 |
| 18 | Spectrofluorimetric assessment of bacterial cell membrane damage by pulsed electric field显示文摘 | Unal R Yousef A E Dunne C P | 2002 | Innovative Food Science & Emerging Technologies2002，3，3： | 1 |
| 19 | herative solutio of linear systems in the 20th century显示文摘 | Yousef Saad Henk A van der Vorst | 2000 | Journal of Compu- tational and Applied Mathematics2000，123，1： | 1 |
| 20 | Infrared spectroscopy of some treated lignins 显示文摘 | NADA A M A YOUSEF M A SHAFFEI K A | 1998 | Polymer Degradation and Stability1998，62，： | 1 |
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