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| 1 | Cryo-EM structure and biochemical analysis reveal the basis of the functional difference between human PI3KC3-C1 and-C2显示文摘Phosphatidylinositol 3 磷酸盐(PI3P ) 在小囊的 trafficking,细胞器生物的续生说和 autophagy 起必要作用。二班 III phosphatidylinositol 3-kinase (PI3KC3 ) 建筑群在哺乳动物, ATG14L 建筑群(PI3KC3-C1 ) 和 UVRAG 建筑群(PI3KC3-C2 ) 被识别了。PI3KC3-C1 为 autophagosome 生物的续生说是关键的,并且 PI3KC3-C2 涉及各种各样的膜 trafficking 事件。这里,我们在亚纳米分辨率报导人的 PI3KC3-C1 和 PI3KC3-C2 的 cryo 他们结构。二结构与不同特征分享普通塑造 L 的全面体系结构。他们检查直接表明 PI3KC3-C1 在类脂化合物单层上站起来,与 ATG14L 蝙蝠领域和 VPS34 C 终端领域(CTD ) 联系膜。生物化学的解剖显示 ATG14L 蝙蝠领域负责膜抛锚,而 VPS34 的 CTD 决定取向。而且, PI3KC3-C2 比 PI3KC3-C1 更微弱地绑在包含 PI liposomes 和净化的 endoplasmic 蜂窝胃(嗯) 泡,被 ATG14L 明确地决定的一个性质打领域。在里面 vivo 嗯本地化分析显示蝙蝠领域被要求为嗯 PI3KC3 的本地化。我们建议不同类脂化合物绑定能力是在 autophagy 区分 PI3KC3-C1 和 PI3KC3-C2 的函数的关键因素。 | Meisheng Ma Jun-Jie Liu Nan Li Yuwei Huang Na Ta Yang Chen Hua Fu Ming-Da Ye Yuehe Ding Weijiao Huang Jia Wang Meng-Qiu Dong Li Yu Hong-Wei Wang | 2017 | Cell Research2017，27，8： | 7 |
| 2 | SciFinder-guided rational design of fluorescent carbon dots for ratiometric monitoring intracellular pH fluctuations under heat shock显示文摘Intracellular pH plays a significant role in various biological processes, including cell proliferation,apoptosis, metabolism, enzyme activity and homeostasis. In this work, a novel design strategy for the preparation of pH responsive carbon dots(CDs-pH) for ratiometric intracellular imaging was reported. By using SciFinder database, fluorescent CDs-pH with the required p Kavalue of 6.84 were rationally designed, which is vital important for precise sensing of intracellular pH. As a result, the synthesized CDspH demonstrated robust ability to test pH fluctuations within the physiological range of 5.4-7.4. The CDspH was further utilized for fluorescent ratiometric imaging of pH in living HeLa cells, effectively avoided the influence of autofluorescence from native cellular species. Moreover, real-time monitoring of intracellular pH fluctuation under heat shock was successfully realized. This SciFinder-guided design strategy is simple and flexible, which has a great potential to be used for the development of other types of CDs for various applications. | Haifang Liu Yuanqiang Sun Zhaohui Li Ran Yang Jie Yang Aaron Albert Aryee Xiaoge Zhang Jia Ge Lingbo Qu Yuehe Lin | 2019 | Chinese Chemical Letters2019，30，9： | 3 |
| 3 | A revisit of three studies related to random testing显示文摘Software testing is an approach that ensures the quality of software through execution, with a goal being to reveal failures and other problems as quickly as possible. Test case selection is a fundamental issue in software testing, and has generated a large body of research, especially with regards to the effectiveness of random testing(RT), where test cases are randomly selected from the software's input domain. In this paper, we revisit three of our previous studies. The first study investigated a sufficient condition for partition testing(PT)to outperform RT, and was motivated by various controversial and conflicting results suggesting that sometimes PT performed better than RT, and sometimes the opposite. The second study aimed at enhancing RT itself, and was motivated by the fact that RT continues to be a fundamental and popular testing technique. This second study enhanced RT fault detection effectiveness by making use of the common observation that failure-causing inputs tend to cluster together, and resulted in a new family of RT techniques: adaptive random testing(ART),which is random testing with an even spread of test cases across the input domain. Following the successful use of failure-causing region contiguity insights to develop ART, we conducted a third study on how to make use of other characteristics of failure-causing inputs to develop more effective test case selection strategies. This third study revealed how best to approach testing strategies when certain characteristics of the failure-causing inputs are known, and produced some interesting and important results. In revisiting these three previous studies, we explore their unexpected commonalities, and identify diversity as a key concept underlying their effectiveness.This observation further prompted us to examine whether or not such a concept plays a role in other areas of software testing, and our conclusion is that, yes, diversity appears to be one of the most important concepts in the field of software testing. | CHEN Tsong Yueh KUO Fei-Ching TOWEY Dave ZHOU Zhi Quan | 2015 | Science China(Information Sciences)2015，58，5： | 3 |
| 4 | Job mobility of residents and migrants in urban China显示文摘 | John Knight Linda Yueh | 2004 | Journal of Comparative Economics2004，，4： | 2 |
| 5 | Multifunctional SnO2/3D graphene hybrid materials for sodium-ion and lithium-ion batteries with excellent rate capability and long cycle life显示文摘 | Jung-ln Lee Junhua Song Younghwan Cha Shaofang Fu Chengzhou Zhu Xiaolin Li Yuehe Lin Min-Kyu Song | 2017 | Nano Research2017，10，12： | 2 |
| 6 | Iron-Imprinted Single-Atomic Site Catalyst-Based Nanoprobe for Detection of Hydrogen Peroxide in Living Cells显示文摘Fe-based single-atomic site catalysts(SASCs),with the natural metalloproteases-like active site structure,have attracted widespread attention in biocatalysis and biosensing.Precisely,controlling the isolated single-atom Fe-N-C active site structure is crucial to improve the SASCs’performance.In this work,we use a facile ion-imprinting method(IIM)to synthesize isolated Fe-N-C single-atomic site catalysts(IIM-Fe-SASC).With this method,the ion-imprinting process can precisely control ion at the atomic level and form numerous well-defined single-atomic Fe-N-C sites.The IIM-Fe-SASC shows better peroxidase-like activities than that of non-imprinted references.Due to its excellent properties,IIM-Fe-SASC is an ideal nanoprobe used in the colorimetric biosensing of hydrogen peroxide(H_(2)O_(2)).Using IIM-Fe-SASC as the nanoprobe,in situ detection of H_(2)O_(2)generated from MDA-MB-231 cells has been successfully demonstrated with satisfactory sensitivity and specificity.This work opens a novel and easy route in designing advanced SASC and provides a sensitive tool for intracellular H_(2)O_(2)detection. | Zhaoyuan Lyu Shichao Ding Maoyu Wang Xiaoqing Pan Zhenxing Feng Hangyu Tian Chengzhou Zhu Dan Du Yuehe Lin | 2021 | Nano-Micro Letters2021，13，9： | 2 |
| 7 | Self-employment in urban China: Networking in a transition economy显示文摘 | Linda YUEH | 2009 | China Economic Review2009，，3： | 2 |
| 8 | A new glycoside, brachynoside, isolated from Clerodendron brachyanthum Schauer 显示文摘 | Yun L L Yueh H | 1992 | Chem Pharm Bull1992，40，7： | 2 |
| 9 | Mesoporous PtPd nanoparticles for ligand-mediated and imaging-guided chemo-photothermal therapy of breast cancer显示文摘The synergistic therapy of chemotherapy and photothermal therapy(PTT)has been reported as a promising antitumor strategy.To achieve effective combination therapy,developing more suitable candidate nanomaterials with optimal photothermal property and high chemical drug loading capacity is very necessary.Herein,a bimetallic PtPd nanoparticle was synthesized with the merits of excellent photothermal effect and mesoporous structure for doxorubicin(DOX)loading.We further designed PtPd-ethylene glycol(PEG)-folic acid(FA)-doxorubicin(DOX)nanoparticle for chemo-photothermal therapy of MCF-7 tumor with folic acid engineering to achieve active targeting.Moreover,excellent photoacoustic(PA)imaging of PtPd-PEG-FA-DOX nanoparticles facilitated the precise in vivo tracking and further evaluation of nanoparticles’targeting effect.The in vitro and in vivo results both demonstrated PtPd-PEG-FA-DOX nanoparticles serve as a safe and promising system for effective treatment of MCF-7 tumor. | Yanpeng Jia Yang Song Ying Qu Jinrong Peng Kun Shi Dan Du He Li Yuehe Lin Zhiyong Qian | 2020 | Nano Research2020，13，6： | 2 |
| 10 | Application of artificial intelligence-driven endoscopic screening and diagnosis of gastric cancer显示文摘The landscape of gastrointestinal endoscopy continues to evolve as new technologies and techniques become available.The advent of image-enhanced and magnifying endoscopies has highlighted the step toward perfecting endoscopic screening and diagnosis of gastric lesions.Simultaneously,with the development of convolutional neural network,artificial intelligence(AI)has made unprecedented breakthroughs in medical imaging,including the ongoing trials of computer-aided detection of colorectal polyps and gastrointestinal bleeding.In the past demi-decade,applications of AI systems in gastric cancer have also emerged.With AI’s efficient computational power and learning capacities,endoscopists can improve their diagnostic accuracies and avoid the missing or mischaracterization of gastric neoplastic changes.So far,several AI systems that incorporated both traditional and novel endoscopy technologies have been developed for various purposes,with most systems achieving an accuracy of more than 80%.However,their feasibility,effectiveness,and safety in clinical practice remain to be seen as there have been no clinical trials yet.Nonetheless,AI-assisted endoscopies shed light on more accurate and sensitive ways for early detection,treatment guidance and prognosis prediction of gastric lesions.This review summarizes the current status of various AI applications in gastric cancer and pinpoints directions for future research and clinical practice implementation from a clinical perspective. | Yu-Jer Hsiao Yuan-Chih Wen Wei-Yi Lai Yi-Ying Lin Yi-Ping Yang Yueh Chien Aliaksandr A Yarmishyn De-Kuang Hwang Tai-Chi Lin Yun-Chia Chang Ting-Yi Lin Kao-Jung Chang Shih-Hwa Chiou Ying-Chun Jheng | 2021 | World Journal of Gastroenterology2021，27，22： | 2 |
| 11 | Incidence of serious complications after uvulopalatopharyngoplasty 显示文摘 | Kezirian E J Weaver EM Yueh B | 2004 | Laryngoscope2004，114，3： | 1 |
| 12 | Differential expression and regulation of gonadotropins and their receptors in the Japanese eel, Anguilla japonica显示文摘 | Jeng S R Yueh W S Chen G R | 2007 | Gen Comp Endocrinol2007，154，13： | 1 |
| 13 | Polarimetric bright- ness temperatures of sea surfaces measured with aircraft K- and Ka-band radiometers显示文摘 | Yueh S H Wilson W J Fuk K Li | 1997 | IEEE Transactions on Geoscience and Remote Sensing1997，35，5： | 1 |
| 14 | Screening and management of adult hearing loss in primary care:scientific review显示文摘 | Yueh B Shapiro N MacLean CH | 2003 | JAMA2003，289，15： | 1 |
| 15 | Optimal controller for homing missiles显示文摘 | C F Lin W R Yueh | 1985 | Journal of Guidance Control and Dynamics1985，8，3： | 1 |
| 16 | Risk factors for serious complication after uvulopalatopharyngoplasty显示文摘 | Kezirian E J Weaver EM Yueh B | 2006 | Arch Otolaryngol Head Neck Surg2006，132，10： | 1 |
| 17 | Incidence of serious complications after uvulopalatopharyngoplasty 显示文摘 | Kezirian EJ Weaver EM Yueh B | 2004 | Laryngoscope2004，114，3： | 1 |
| 18 | Magnesium sulfate effectively reduces blood pressure in an animal model of preeclampsia 显示文摘 | Standley C A Batia L Yueh G | 2006 | J Matern Fetal Neonatal Med2006，19，3： | 1 |
| 19 | Screening and man- agement of adult hearing loss in primary care: Scientific review 显示文摘 | Yueh B Shapiro N MacLean CH | 2003 | Journal of the American Medical Association2003，289，： | 1 |
| 20 | Patient satisfaction in postmastectomy breast reconstruction: a comparative e- valuation of DIEP, TRAM, latissimus flap, and implant techniques显示文摘 | Yueh JH Slavin SA Adesiyun T | 2010 | Plast Reconstr Surg2010，125，6： | 1 |
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