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| 1 | Non-destructive inspection of welding defects in friction stir welds and prediction of their fatigue life显示文摘 | U Yoshihiko S Ichinori Y Yuichiro | 2012 | Quarterly Journal of the Japan Welding Society2012，30，3： | 1 |
| 2 | Circulating desacyl ghrelin improves cardiovascular risk prediction in older hypertensive patients 显示文摘 | Yuichiro Y Masamitsu N Koji T | 2014 | American Journal of Hyperten- sion2014，27，5： | 1 |
| 3 | Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action 显示文摘 | Heying Z Yuichiro Y Katsushi T | 2005 | Biochem Biophys Res Commun2005，335，： | 1 |
| 4 | Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers显示文摘 | Yuichiro M Yukiko Y kiko S | 2010 | J Cancer Res Clin Oncol2010，136，： | 1 |
| 5 | Effect of hygrothermal condition on compression after impact strength of CFRP laminates显示文摘 | Yuichiro A Ken Y Takashi I | | 0，，06： | 1 |
| 6 | Case of skin injuries due to stings by crown-of-thorns starfish显示文摘 | Hironobu S Yuichiro T Yu-Ichi Y | 2008 | Dermatology2008，35，3： | 1 |
| 7 | Inhibition of gastric inhibitory polypeptide signaling prevents obesity显示文摘 | Kazumasa M Yuichiro Y Nobuhiro B | 2002 | Nat Med2002，8，7： | 1 |
| 8 | Basic study of electrochemical treatment of ammonium nitrogen-containing wastewater using Boron-doped diamond anode显示文摘 | Katsuhito Y Shigeru Y Yuichiro S | 2007 | Sei Technical Review2007，，65： | 1 |
| 9 | The commuter's time-of-use decision and optimal pricing and service in urban mass transit 显示文摘 | MARVIN K YUICHIRO Y | 2002 | Journal of Urban Economics2002，5，： | 1 |
| 10 | 100% Fluorescence efficiency of 4,4'-bis]-(N- carbazole)styryl]biphenyl in a solid film and the very low amplified spontaneous emission threshold 显示文摘 | Takanori A Yuichiro K Kenichi G Hidetoshi Y Hiroyuki S Chihaya A | 2005 | Appllied Physics Letters2005，86，07： | 1 |
| 11 | Correlation between tumor blood flow assessed by perfusion CT and effect of neoadjuvant therapy in advanced esophageal cancers 显示文摘 | Yoichi M Takushi Y Yuichiro D | 2007 | J Surg Oncol2007，96，3： | 1 |
| 12 | lntraocular sustained drug delivery using implantable polymeric devices 显示文摘 | Tsutomu Y Yuichiro O Eiji S | 2005 | Adv Drug Deliv Rev2005，57，14： | 1 |
| 13 | Preparation of micro- capsulated enzymes for lowering the allergenic activity of foods 显示文摘 | TETSURO Y KIYOSHI M YUICHIRO K | 1997 | J Agric Food Chem1997，45，10： | 1 |
| 14 | Attenuation of telomerase activity by a hammerhead ribozyme targeting the template region of telomerase RNA in endometrial carcinoma cells 显示文摘 | Yasuhiro Y Yuichiro T Ariyoshi S | 1998 | Cancer Res1998，58，22： | 1 |
| 15 | Preparation and Microcapsulated Enzymes for Lowing the Allergic Activity of Foods显示文摘 | Tetsuro Y Kiyoshi M Yuichiro K | 1997 | J Agric Food Chem1997，45，10： | 1 |
| 16 | TiO2-montmorillonite composites via supercritical intercalation 显示文摘 | Satoshi Y Yuichiro S Akira E | 2002 | Chem Commun2002，14，： | 1 |
| 17 | A case of reversible posterior leukoencephalopathy syndrome caused by transient hypercoagulable state induced by infection 显示文摘 | Yuichiro Y Kazuomi K Takashi F | 2005 | Hypertens Res2005，28，： | 1 |
| 18 | Prospective comparison of real‐time tissue elastography and serum fibrosis markers for the estimation of liver fibrosis in chronic hepatitis C patients显示文摘 | Nobuharu Tamaki Masayuki Kurosaki Shuya Matsuda Toru Nakata Masaru Muraoka Yuichiro Suzuki Yutaka Yasui Shoko Suzuki Takanori Hosokawa Takashi Nishimura Ken Ueda Kaoru Tsuchiya Hiroyuki Nakanishi Jun Itakura Yuka Takahashi Kotaro Matsunaga Kazuhiro Taki Y | 2014 | Hepatol Res2014，，7： | 1 |
| 19 | A case of reversible posterior leukoence-phalopathy syndrome caused by transient hypercoagulable state induced by infection显示文摘 | Yuichiro Y Kazuomi K Takashi F | 2005 | Hypertens Res2005，28，： | 1 |
| 20 | Human IgG1 antibodies suppress angiogenesis in a target-independent manner显示文摘Aberrant angiogenesis is implicated in diseases affecting nearly 10%of the world’s population.The most widely used antiangiogenic drug is bevacizumab,a humanized IgG1 monoclonal antibody that targets human VEGFA.Although bevacizumab does not recognize mouse Vegfa,it inhibits angiogenesis in mice.Here we show bevacizumab suppressed angiogenesis in three mouse models not via Vegfa blockade but rather Fc-mediated signaling through FcγRI(CD64)and c-Cbl,impairing macrophage migration.Other approved humanized or human IgG1 antibodies without mouse targets(adalimumab,alemtuzumab,ofatumumab,omalizumab,palivizumab and tocilizumab),mouse IgG2a,and overexpression of human IgG1-Fc or mouse IgG2a-Fc,also inhibited angiogenesis in wild-type and FcγR humanized mice.This anti-angiogenic effect was abolished by Fcgr1 ablation or knockdown,Fc cleavage,IgG-Fc inhibition,disruption of Fc-FcγR interaction,or elimination of FcRγ-initated signaling.Furthermore,bevacizumab’s Fc region potentiated its anti-angiogenic activity in humanized VEGFA mice.Finally,mice deficient in FcγRI exhibited increased developmental and pathological angiogenesis.These findings reveal an unexpected anti-angiogenic function for FcγRI and a potentially concerning off-target effect of hIgG1 therapies. | Sasha Bogdanovich Younghee Kim Takeshi Mizutani Reo Yasuma Laura Tudisco Valeria Cicatiello Ana Bastos-Carvalho Nagaraj Kerur Yoshio Hirano Judit Z Baffi Valeria Tarallo Shengjian Li Tetsuhiro Yasuma Parthasarathy Arpitha Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Menotti Ruvo Annamaria Sandomenico Miho Nozaki Ryo Ijima Hiroki Kaneko Yuichiro Ogura Hiroko Terasaki Balamurali K Ambati Jeanette HW Leusen Wallace Y Langdon Michael R Clark Kathryn L Armour Pierre Bruhns J Sjef Verbeek Bradley D Gelfand Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 0 |
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