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| 1 | Hydrodynamic Links between Shallow and Deep Mineralization Systems and Implications for Deep Mineral Exploration显示文摘Deep mineral exploration is increasingly important for finding new mineral resources but there are many uncertainties.Understanding the factors controlling the localization of mineralization at depth can reduce the risk in deep mineral exploration.One of the relatively poorly constrained but important factors is the hydrodynamics of mineralization.This paper reviews the principles of hydrodynamics of mineralization,especially the nature of relationships between mineralization and structures,and their applications to various types of mineralization systems in the context of hydrodynamic linkage between shallow and deep parts of the systems.Three categories of mineralization systems were examined,i.e.,magmatic-hydrothermal systems,structurally controlled hydrothermal systems with uncertain fluid sources,and hydrothermal systems associated with sedimentary basins.The implications for deep mineral exploration,including potentials for new mineral resources at depth,favorable locations for mineralization,as well as uncertainties,are discussed. | CHI Guoxiang XU Deru XUE Chunji LI Zenghua Patrick LEDRU DENG Teng WANG Yumeng SONG Hao | 2022 | Acta Geologica Sinica(English Edition)2022，96，1： | 5 |
| 2 | Regulation of innate immune responses by rabies virus显示文摘Rabies virus(RABV)is an infectious and neurotropic pathogen that causes rabies and infects humans and almost all warm-blooded animals,posing a great threat to people and public safety.It is well known that innate immunity is the critical first line of host defense against viral infection.It monitors the invading pathogens by recognizing the pathogen-associated molecular patterns and danger-associated molecular patterns through pattern-recognition receptors,leading to the production of type I interferons(IFNα/β),inflammatory cytokines,and chemokines,or the activation of autophagy or apoptosis to inhibit virus replication.In the case of RABV,the innate immune response is usually triggered when the skin or muscle is bitten or scratched.However,RABV has evolved many ways to escape or even hijack innate immune response to complete its own replication and eventually invades the central nervous system(CNS).Once RABV reaches the CNS,it cannot be wiped out by the immune system or any drugs.Therefore,a better understanding of the interplay between RABV and innate immu-nity is necessary to develop effective strategies to combat its infection.Here,we review the innate immune responses induced by RABV and illustrate the antagonism mechanisms of RABV to provide new insights for the control of rabies. | Haili Zhang Jingbo Huang Yumeng Song Xingqi Liu Meichen Qian Pei Huang Yuanyuan Li Ling Zhao Hualei Wang | 2022 | Animal Models and Experimental Medicine2022，5，5： | 2 |
| 3 | Pulse-width-induced polarization enhancement of optically pumped N-V electron spin in diamond显示文摘The nitrogen-vacancy(N-V)center in diamond is a widely used platform for quantum information processing and sensing.The electron-spin state of the N-V center could be initialized,read out optically,and manipulated by resonate microwave fields.In this work,we analyze the dependence of electron-spin initialization on widths of laser pulses.We build a numerical model to simulate this process and to verify the simulation results in experiments.Both simulations and experiments reveal that shorter laser pulses are helpful to the electron-spin polarization.We therefore propose to use extremely short laser pulses for electron-spin initialization.In this new scheme,the spin-state contrast could be improved about 10%in experiments by using laser pulses as short as 4 ns in width.Furthermore,we provide a mechanism to explain this effect,which is due to the occupation time in the meta-stable spin-singlet states of the N-V center.Our new scheme is applicable in a broad range of N-V-based applications in the future. | YUMENG SONG YU TIAN ZHIYI HU FEIFEI ZHOU TENGTENG XING DAWEI LU BING CHEN YA WANG NANYANG XU JIANGFENG DU | 2020 | Photonics Research2020，8，8： | 1 |
| 4 | Comprehensive characterization of CRC with germline mutations reveals a distinct somatic mutational landscape and elevated cancer risk in the Chinese population显示文摘Objective:Hereditary colorectal cancer(CRC)accounts for approximately 5%–10%of all CRC cases.The full profile of CRC-related germline mutations and the corresponding somatic mutational profile have not been fully determined in the Chinese population.Methods:We performed the first population study investigating the germline mutation status in more than 1,000(n=1,923)Chinese patients with CRC and examined their relationship with the somatic mutational landscape.Germline alterations were examined with a 58-gene next-generation sequencing panel,and somatic alterations were examined with a 605-gene panel.Results:A total of 92 pathogenic(P)mutations were identified in 85 patients,and 81 likely pathogenic(LP)germline mutations were identified in 62 patients,accounting for 7.6%(147/1,923)of all patients.MSH2 and APC was the most mutated gene in the Lynch syndrome and non-Lynch syndrome groups,respectively.Patients with P/LP mutations had a significantly higher ratio of microsatellite instability,highly deficient mismatch repair,family history of CRC,and lower age.The somatic mutational landscape revealed a significantly higher mutational frequency in the P group and a trend toward higher copy number variations in the non-P group.The Lynch syndrome group had a significantly higher mutational frequency and tumor mutational burden than the nonLynch syndrome group.Clustering analysis revealed that the Notch signaling pathway was uniquely clustered in the Lynch syndrome group,and the MAPK and cAMP signaling pathways were uniquely clustered in the non-Lynch syndrome group.Population risk analysis indicated that the overall odds ratio was 11.13(95%CI:8.289–15.44)for the P group and 20.68(95%CI:12.89–33.18)for the LP group.Conclusions:Distinct features were revealed in Chinese patients with CRC with germline mutations.The Notch signaling pathway was uniquely clustered in the Lynch syndrome group,and the MAPK and cAMP signaling pathways were uniquely clustered in the non-Lynch syndrome group.Patients with P/LP germline mutations exhibited higher CRC risk. | Jianfei Yao Yunhuan Zhen Jing Fan Yuan Gong Yumeng Ye Shaohua Guo Hongyi Liu Xiaoyun Li Guosheng Li Pan Yang Xiaohui Wang Danni Liu Tanxiao Huang Huiya Cao Peisu Suo Yuemin Li Jingbo Yu Lele Song | 2022 | Cancer Biology & Medicine2022，19，5： | 1 |
| 5 | An inactivated recombinant rabies virus chimerically expressed RBD induces humoral and cellular immunity against SARS-CoV-2 and RABV显示文摘Many studies suggest that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)can infect various animals and transmit among animals,and even to humans,posing a threat to humans and animals.There is an urgent need to develop inexpensive and efficient animal vaccines to prevent and control coronavirus disease 2019(COVID-19)in animals.Rabies virus(RABV)is another important zoonotic pathogen that infects almost all warmblooded animals and poses a great public health threat.The present study constructed two recombinant chimeric viruses expressing the S1 and RBD proteins of the SARS-CoV-2 Wuhan01 strain based on a reverse genetic system of the RABV SRV9 strain and evaluated their immunogenicity in mice,cats and dogs.The results showed that both inactivated recombinant viruses induced durable neutralizing antibodies against SARS-CoV-2 and RABV and a strong cellular immune response in mice.Notably,inactivated SRV-nCoV-RBD induced earlier antibody production than SRV-nCoV-S1,which was maintained at high levels for longer periods.Inactivated SRV-nCoV-RBD induced neutralizing antibodies against both SARS-CoV-2 and RABV in cats and dogs,with a relatively broadspectrum cross-neutralization capability against the SARS-CoV-2 pseudoviruses including Alpha,Beta,Gamma,Delta,and Omicron,showing potential to be used as a safe bivalent vaccine candidate against COVID-19 and rabies in animals. | Haili Zhang Hongli Jin Feihu Yan Yumeng Song Jiaxin Dai Cuicui Jiao Yujie Bai Jingxuan Sun Di Liu Shen Wang Mengyao Zhang Jilong Lu Jingbo Huang Pei Huang Yuanyuan Li Xianzhu Xia Hualei Wang | 2023 | Virologica Sinica2023，38，2： | 0 |
| 6 | Online optimization for optical readout of a single electron spin in diamond显示文摘The nitrogen-vacancy(NV)center in diamond has been developed as a promising platform for quantum sensing,especially for magnetic field measurements in the nano-tesla range with a nano-meter resolution.Optical spin readout performance has a direct effect on the signal-to-noise ratio(SNR)of experiments.In this work,we introduce an online optimization method to customize the laser waveform for readout.Both simulations and experiments reveal that our new scheme optimizes the optically detected magnetic resonance in NV center.The SNR of optical spin readout has been witnessed a 44.1%increase in experiments.In addition,we applied the scheme to the Rabi oscillation experiment,which shows an improvement of 46.0%in contrast and a reduction of 12.1%in mean deviation compared to traditional constant laser power SNR optimization.This scheme is promising to improve sensitivities for a wide range of NV-based applications in the future. | Xue Lin Jingwei Fan Runchuan Ye Mingti Zhou Yumeng Song Dawei Lu Nanyang Xu | 2023 | Frontiers of physics2023，18，2： | 0 |
| 7 | An ethylene-induced NAC transcription factor acts as a multiple abiotic stress responsor in conifer显示文摘The proper response to various abiotic stresses is essential for plants’survival to overcome their sessile nature,especially for perennial trees with very long-life cycles.However,in conifers,the molecular mechanisms that coordinate multiple abiotic stress responses remain elusive.Here,the transcriptome response to various abiotic stresses like salt,cold,drought,heat shock and osmotic were systematically detected in Pinus tabuliformis(P.tabuliformis)seedlings.We found that four transcription factors were commonly induced by all tested stress treatments,while PtNAC3 and PtZFP30 were highly up-regulated and co-expressed.Unexpectedly,the exogenous hormone treatment assays and the content of the endogenous hormone indicates that the upregulation of PtNAC3 and PtZFP30 are mediated by ethylene.Time-course assay showed that the treatment by ethylene immediate precursor,1-aminocyclopropane-1-carboxylic acid(ACC),activated the expression of PtNAC3 and PtZFP30 within 8 hours.We further confirm that the PtNAC3 can directly bind to the PtZFP30 promoter region and form a cascade.Overexpression of PtNAC3 enhanced unified abiotic stress tolerance without growth penalty in transgenic Arabidopsis and promoted reproductive success under abiotic stress by shortening the lifespan,suggesting it has great potential as a biological tool applied to plant breeding for abiotic stress tolerance.This study provides novel insights into the hub nodes of the abiotic stresses response network as well as the environmental adaptation mechanism in conifers,and provides a potential biofortification tool to enhance plant unified abiotic stress tolerance. | Fangxu Han Peiyi Wang Xi Chen Huanhuan Zhao Qianya Zhu Yitong Song Yumeng Nie Yue Li Meina Guo Shihui Niu | 2023 | Horticulture Research2023，10，8： | 0 |
| 8 | Effects of phosphate on the transport of graphene oxide nanoparticles in saturated clean and iron oxide-coated sand columns显示文摘In this study, transport behaviors of graphene oxide(GO) in saturated uncoated(i.e., clean sand) and goethite-coated sand porous media were examined as a function of the phosphate. We found that phosphate enhanced the transport of GO over a wide range of solution chemistry(i.e., pH 5.0–9.0 and the presence of 10 mmol/L Na^(+) or 0.5 mmol/L Ca^(2+)). The results were mainly ascribed to the increase of electrostatic repulsion between nanoparticles and porous media. Meanwhile, deposition site competition induced by the retained phosphate was another important mechanism leading to promote GO transport. Interestingly, when the phosphate concentration increased from 0.1 to 1.0 mmol/L, the transportenhancement effect of phosphate in goethite-coated sand was to a much larger extent than that in clean sand. The observations were primarily related to the difference in the total mass of retained phosphate between the iron oxide-coated sand and clean sand columns, which resulted in different degrees of the electrostatic repulsion and competitive effect of phosphate. When the background solution contained 0.5 mmol/L Ca^(2+), phosphate could be bind to sand/goethite-coated sand surface by cation bridging;and consequently, promoted competition between phosphate and nanoparticles for deposition sites, which was an important mechanism for the enhanced effect of phosphate. Moreover, the DLVO theory was applicable to describe GO transport behaviors in porous media in the absence or presence of phosphate. Taken together, these findings highlight the important status and role of phosphate on the transport and fate of colloidal graphene oxide in the subsurface environment. | Jiuyan Chen Weifeng Chen Taotao Lu Yumeng Song Haojing Zhang Mengjie Wang Xinhai Wang Zhichong Qi Minghua Lu | 2021 | Journal of Environmental Sciences2021，33，5： | 0 |
| 9 | The long road to bloom in conifers显示文摘More than 600 species of conifers(phylum Pinophyta)serve as the backbone of the Earth’s terrestrial plant community and play key roles in global carbon and water cycles.Although coniferous forests account for a large fraction of global wood production,their productivity relies largely on the use of genetically improved seeds.However,acquisition of such seeds requires recurrent selection and testing of genetically superior parent trees,eventually followed by the establishment of a seed orchard to produce the improved seeds.The breeding cycle for obtaining the next generation of genetically improved seeds can be significantly lengthened when a target species has a long juvenile period.Therefore,development of methods for diminishing the juvenile phase is a cost-effective strategy for shortening breeding cycle in conifers.The molecular regulatory programs associated with the reproductive transition and annual reproductive cycle of conifers are modulated by environmental cues and endogenous developmental signals.Mounting evidence indicates that an increase in global average temperature seriously threatens plant productivity,but how conifers respond to the ever-changing natural environment has yet to be fully characterized.With the breakthrough of assembling and annotating the giant genome of conifers,identification of key components in the regulatory cascades that control the vegetative to reproductive transition is imminent.However,comparison of the signaling pathways that control the reproductive transition in conifers and the floral transition in Arabidopsis has revealed many differences.Therefore,a more complete understanding of the underlying regulatory mechanisms that control the conifer reproductive transition is of paramount importance.Here,we review our current understanding of the molecular basis for reproductive regulation,highlight recent discoveries,and review new approaches for molecular research on conifers. | Jingjing Ma Xi Chen Fangxu Han Yitong Song Biao Zhou Yumeng Nie Yue Li Shihui Niu | 2022 | Forestry Research2022，2，1： | 0 |
| 10 | Advanced Pt hollow nanospheres/rubrene nanoleaves coupled with M-shaped DNA walker for ultrasensitive electrochemiluminescence bioassay显示文摘Herein,an intense electrochemiluminescence(ECL)was achieved based on Pt hollow nanospheres/rubrene nanoleaves(Pt HNSs/Rub NLs)without the addition of any coreactant,which was employed for ultrasensitive detection of carcinoembryonic antigen(CEA)coupled with an M-shaped DNA walker(M-DNA walker)as signal switch.Specifically,in comparison with platinum nanoparticles(Pt NPs),Pt HNSs revealed excellent catalytic performance and pore confinement-enhanced ECL,which could significantly amplify ECL intensity of Rub NLs/dissolved O_(2)(DO)binary system.Then,the tracks and M-DNA walker were confined on the Pt HNSs simultaneously to promote the reaction efficiency,whose M-structure boosted the interaction sites between walking strands and tracks and reduced the rigidity of their recognition.Once the CEA approached the sensing interface,the M-DNA walker was activated based on highly specific aptamer recognition to recover ECL intensity with the assistance of exonucleaseⅢ(ExoⅢ).As proof of concept,the“on-off-on”switch aptasensor was constructed for CEA detection with a low detection limit of 0.20 fg/m L.The principle of the constructed ECL aptasensor also enables a universal platform for sensitive detection of other tumor markers. | Yumeng Song Xiuli Tao Wenbin Liang Xia Zhong Ruo Yuan Ying Zhuo | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
| 11 | Dihydrocelastrol induces antitumor activity and enhances the sensitivity of bortezomib in resistant multiple myeloma by inhibiting STAT3-dependent PSMB5 regulation显示文摘Multiple myeloma(MM)is characterized by excessive aggregation of B-cell-derived malignant plasma cells in the hematopoietic system of bone marrow.Previously,we synthesized an innovative molecule named dihydrocelastrol(DHCE)from celastrol,a triterpene purified from medicinal plant Tripterygium wilfordii.Herein,we explore the therapeutic properties and latent signal transduction mechanism of DHCE action in bortezomib(BTZ)-resistant(BTZ-R)MM cells.In this study,we first report that DHCE shows antitumor activities in vitro and in vivo and exerts stronger inhibitory effects than celastrol on BTZ-R cells.We find that DHCE inhibits BTZ-R cell viability by promoting apoptosis via extrinsic and intrinsic pathways and suppresses BTZ-R MM cell proliferation by inducing G0/G1 phase cell cycle arrest.In addition,inactivation of JAK2/STAT3 and PI3K/Akt pathways are involved in the DHCE-mediated antitumor effect.Simultaneously,DHCE acts synergistically with BTZ on BTZ-R cells.PSMB5,a molecular target of BTZ,is overexpressed in BTZ-R MM cells compared with BTZ-S MM cells and is demonstrated to be a target of STAT3.Moreover,DHCE downregulates PSMB5 overexpression in BTZ-R MM cells,which illustrates that DHCE overcomes BTZ resistance through increasing the sensitivity of BTZ in resistant MM via inhibiting STAT3-dependent PSMB5 regulation.Overall,our findings imply that DHCE may become a potential therapeutic option that warrants clinical evaluation for BTZ-R MM. | Shuhan Jin Bo Li Bibo Zhang Xuejie Gao Xinyan Jia Li Xu Shuaikang Chang Ke Hu Guanli Wang Zhijian Xu Ting Zhang Dongliang Song Guang Yang Xiaosong Wu Huabin Zhu Cheng Huang Yumeng Lu Jumei Shi Weiliang Zhu Gege Chen | 2023 | Acta Biochimica et Biophysica Sinica2023，55，12： | 0 |
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