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| 1 | Mitochondrial dysfunction and mitochondrial DNA mutations in atherosclerotic complications in diabetes显示文摘Mitochondrial DNA(mtDNA) is particularly prone to oxidation due to the lack of histones and a deficient mismatch repair system.This explains an increased mutation rate of mtDNA that results in heteroplasmy,e.g.,the coexistence of the mutant and wild-type mtDNA molecules within the same mitochondrion.In diabetes mellitus,glycotoxicity,advanced oxidative stress,collagen cross-linking,and accumulation of lipid peroxides in foam macrophage cells and arterial wall cells may significantly decrease the mutation threshold required for mitochondrial dysfunction,which in turn further contributes to the oxidative damage of the diabetic vascular wall,endothelial dysfunc-tion,and atherosclerosis. | Dimitry A Chistiakov Igor A Sobenin Yuri V Bobryshev Alexander N Orekhov | 2012 | World Journal of Cardiology2012，4，5： | 17 |
| 2 | Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice显示文摘AIM: To study isolation and chemical characterization of pectin derived from the common cranberry Vaccinium oxycoccos L. (oxycoccusan OP) and the testing of its preventive effect on experimental colitis.METHODS: Mice were administrated orally with OP two days prior to a rectal injection of 5% acetic acid and examined for colonic damage 24 h later. Colonic inflammation was characterized by macroscopical injury and enhanced levels of myeloperoxidase activity measured spectrophotometrically with o-phenylene diamine as the substrate. The mucus contents of the colon were determined by the Alcian blue dye binding method. Vascular permeability was estimated using 4% Evans blue passage after i.p. injection of 0.05 mol/L acetic acid. RESULTS: In the mice treated with OP, colonic macroscopic scores (1.1 ± 0.4 vs 2.7, P < 0.01) and the total square area of damage (10 ± 2 vs 21 ± 7, P < 0.01) were significantly reduced when compared with the vehicle-treated colitis group. OP was shown to decrease the tissue myeloperoxidase activity in colons (42 ± 11 vs 112 ± 40, P < 0.01) and enhance the amount of mucus of colitis mice (0.9 ± 0.1 vs 0.4 ± 0.1, P < 0.01). The level of colonic malondialdehyde was noted to decrease in OP-pretreated mice (3.6 ± 0.7 vs 5.1 ± 0.8, P < 0.01). OP was found to decrease the inflammatory status of mice as was determined by reduction of vascular permeability (161 ± 34 vs 241 ± 21, P < 0.01). Adhesionof peritoneal neutrophils and macrophages was also shown to decrease after administration of OP (141 ± 50 vs 235 ± 37, P < 0.05).CONCLUSION: Thus, a preventive effect of pectin from the common cranberry, namely oxycoccusan OP, on acetic acid-induced colitis in mice was detected. A reduction of neutrophil infiltration and antioxidant action may be implicated in the protective effect of oxycoccusan. | Sergey V Popov Pavel A Markov Ida R Nikitina Sergey Petrishev Vasily Smirnov Yury S Ovodov | 2006 | World Journal of Gastroenterology2006，12，41： | 9 |
| 3 | Bound states in the continuum and Fano resonances in the strong mode coupling regime显示文摘The study of resonant dielectric nanostructures with a high refractive index is a new research direction in the nanoscale optics and metamaterial-inspired nanophotonics.Because of the unique optically induced electric and magnetic Mie resonances,high-index nanoscale structures are expected to complement or even replace different plasmonic components in a range of potential applications.We study a strong coupling between modes of a single subwavelength high-index dielectric resonator and analyze the mode transformation and Fano resonances when the resonator’s aspect ratio varies.We demonstrate that strong mode coupling results in resonances with high-quality factors,which are related to the physics of bound states in the continuum when the radiative losses are almost suppressed due to the Friedrich–Wintgen scenario of destructive interference.We explain the physics of these states in terms of multipole decomposition,and show that their appearance is accompanied by a drastic change in the far-field radiation pattern.We reveal a fundamental link between the formation of the high-quality resonances and peculiarities of the Fano parameter in the scattering cross-section spectra.Our theoretical findings are confirmed by microwave experiments for the scattering of high-index cylindrical resonators with a tunable aspect ratio.The proposed mechanism of the strong mode coupling in single subwavelength high-index resonators accompanied by resonances with high-quality factors helps to extend substantially functionalities of all-dielectric nanophotonics,which opens horizons for active and passive nanoscale metadevices. | Andrey A.Bogdanov Kirill LKoshelev Polina VKapitanova Mikhail VRybin Sergey AGladyshev Zarina FSadrieva Kirill BSamusev Yuri SKivshar a Mikhail FLimonov | 2019 | Advanced Photonics2019，1，1： | 6 |
| 4 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 5 | Neurohumoral,cardiac and inflammatory markers in the evaluation of heart failure severity and progression显示文摘Heart failure is common in adult population,accounting for substantial morbidity and mortality worldwide.The main risk factors for heart failure are coronary artery disease,hypertension,obesity,diabetes mellitus,chronic pulmonary diseases,family history of cardiovascular diseases,cardiotoxic therapy.The main factor associated with poor outcome of these patients is constant progression of heart failure.In the current review we present evidence on the role of established and candidate neurohumoral biomarkers for heart failure progression management and diagnostics.A growing number of biomarkers have been proposed as potentially useful in heart failure patients,but not one of them still resembles the characteristics of the'ideal biomarker.'A single marker will hardly perform well for screening,diagnostic,prognostic,and therapeutic management purposes.Moreover,the pathophysiological and clinical significance of biomarkers may depend on the presentation,stage,and severity of the disease.The authors cover main classification of heart failure phenotypes,based on the measurement of left ventricular ejection fraction,including heart failure with preserved ejection fraction,heart failure with reduced ejection fraction,and the recently proposed category heart failure with mid-range ejection fraction.One could envisage specific sets of biomarker with different performances in heart failure progression with different left ventricular ejection fraction especially as concerns prediction of the future course of the disease and of left ventricular adverse/reverse remodeling.This article is intended to provide an overview of basic and additional mechanisms of heart failure progression will contribute to a more comprehensive knowledge of the disease pathogenesis. | Ekaterina A Polyakova Evgeny N Mikhaylov Dmitry L Sonin Yuri V Cheburkin Mikhail M Galagudza | 2021 | Journal of Geriatric Cardiology2021，18，1： | 4 |
| 6 | Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension显示文摘AIM: To examine whether the heteroplasmy level for 15059G>A mutation in the mitochondrial genome might be associated with essential hypertension. METHODS: This cross-sectional study involved 196 unrelated participants randomly selected from general population (90 males and 106 females) who underwent a regular medical check-up at the Institute for Ath-erosclerosis Research (Moscow, Russia). One hundred and twenty of them (61%) had essential hypertension, and 76 (39%) were apparently healthy normotensive persons. The level of heteroplasmy for 15059G>A mutation occurring in the coding region of cytochrome b gene (MT-CYB) of mtDNA isolated from the blood leukocytes, was quantified using DNA pyrosequencing method. RESULTS: The 15059G>A heteroplasmy level ranged between 4% and 83%, with a median level of 31%. Between the upper and lower quartiles of 15059G>A heteroplasmy distribution, significant differences were observed for patients' age, systolic blood pressure, and triglyceride levels. 15059G>A heteroplasmy correlated both with age (r = 0.331, P < 0.001) and the presence of hypertension (r = 0.228, P = 0.002). Regression analysis revealed that the age explains 12% variability of 15059G>A heteroplasmy, and hypertension independently explains more 5% variability. The 15059G>A heteroplasmy exceeding 31% was found to be significantly associated with a higher risk of essential hypertension (odds ratio 2.76; P (Fisher) 0.019]. The study participants with high 15059G>A heteroplasmy level were found to have significantly higher age (P < 0.001) and the prevalence of essential hypertension (P = 0.033), as compared to those with low 15059G>A heteroplasmy level. These observations suggested a positive correlation between the level of 15059G>A heteroplasmy and essential hypertension. CONCLUSION: This study provides the evidence of association of mtDNA 15059G>A mutation heteroplasmy with essential hypertension. | Igor A Sobenin Dimitry A Chistiakov Margarita A Sazonova Maria M Ivanova Yuri V Bobryshev Alexander N Orekhov Anton Y Postnov | 2013 | World Journal of Cardiology2013，5，5： | 3 |
| 7 | Panax ginseng natural populations: their past, current state and perspectives显示文摘瞄准:人参属人参,遗传和它 Primorye (俄国) 的自然人口的个体发生的结构的交配系统被调查。方法:基因差异用紧密相联的酶和荧光灯地基于的自动化放大碎片长度多型性(AFLP ) 和简单顺序被估计重复(SSR ) 标记。结果:在种类水平的全部的基因差异与紧密相联的酶是低的试金(0.023 ) ,和有 AFLP (0.255 ) 和 SSR (0.259 ) 的高度方法。它根据紧密相联的酶(>99%) 在人口以内被观察, AFLP (>85%) ,和 SSR (>73%) 试金。基因可变性分发的索引指出开拓殖民地在早 Holocene 在温暖的时期期间从南部的避难处由人参的 Sikhote-Alin 种。到异花受粉和自花传粉的人参植物的能力被显示出,人参属人参是容许的单性生殖的植物的假设被证实。人参的繁殖系统拥有授精进程的高粘性和稳定性帮助种类处于压力条件幸存。外部或内部的因素引起的骚乱能由于人参小卵或单性生殖的胚胎开发的形态基因的潜力被减少。因为一些生活阶段是不在的或很少发生,人参人口的生活阶段结构的分析证明所有他们不是完整成分的。结论:在所有 3 张人口,处女和年轻生产个人是占优势的。人口学习了的这个工具是可行的,自然人参人口的再介绍还是可能的。 | Yuri N ZHURAVLEV Olga G KOREN Galina D REUNOVA Tamara I MUZAROK Tatiyana Yu GORPENCHENKO Irina L KATS Yuliya A KHROLENKO | 2008 | Acta Pharmacologica Sinica2008，29，9： | 3 |
| 8 | Molecular pathways of liver regeneration:A comprehensive review显示文摘The liver is a unique parenchymal organ with a regenerative capacity allowing it to restore up to 70%of its volume.Although knowledge of this phenomenon dates back to Greek mythology(the story of Prometheus),many aspects of liver regeneration are still not understood.A variety of different factors,including inflammatory cytokines,growth factors,and bile acids,promote liver regeneration and control the final size of the organ during typical regeneration,which is performed by mature hepatocytes,and during alternative regeneration,which is performed by recently identified resident stem cells called“hepatic progenitor cells”.Hepatic progenitor cells drive liver regeneration when hepatocytes are unable to restore the liver mass,such as in cases of chronic injury or excessive acute injury.In liver maintenance,the body mass ratio is essential for homeostasis because the liver has numerous functions;therefore,a greater understanding of this process will lead to better control of liver injuries,improved transplantation of small grafts and the discovery of new methods for the treatment of liver diseases.The current review sheds light on the key molecular pathways and cells involved in typical and progenitor-dependent liver mass regeneration after various acute or chronic injuries.Subsequent studies and a better understanding of liver regeneration will lead to the development of new therapeutic methods for liver diseases. | Yana V Kiseleva Sevak Z Antonyan Tatyana S Zharikova Kirill A Tupikin Dmitry V Kalinin Yuri O Zharikov | 2021 | World Journal of Hepatology2021，13，3： | 2 |
| 9 | Recent advances and perspectives in next generation sequencing application to the genetic research of type 2 diabetes显示文摘Type 2 diabetes(T2D)mellitus is a common complex disease that currently affects more than 400 million people worldwide and has become a global health problem.High-throughput sequencing technologies such as whole-genome and whole-exome sequencing approaches have provided numerous new insights into the molecular bases of T2D.Recent advances in the application of sequencing technologies to T2D research include,but are not limited to:(1)Fine mapping of causal rare and common genetic variants;(2)Identification of confident genelevel associations;(3)Identification of novel candidate genes by specific scoring approaches;(4)Interrogation of disease-relevant genes and pathways by transcriptional profiling and epigenome mapping techniques;and(5)Investigation of microbial community alterations in patients with T2D.In this work we review these advances in application of next-generation sequencing methods for elucidation of T2D pathogenesis,as well as progress and challenges in implementation of this new knowledge about T2D genetics in diagnosis,prevention,and treatment of the disease. | Yulia A Nasykhova Yury A Barbitoff Elena A Serebryakova Dmitry S Katserov Andrey S Glotov | 2019 | World Journal of Diabetes2019，10，7： | 2 |
| 10 | A sensing mechanism for the detection of carbon nanotubes using selective photoluminescent probes based on ionic complexes with organic dyes显示文摘The multifunctional properties of carbon nanotubes(CNTs)make them a powerful platform for unprecedented innovations in a variety of practical applications.As a result of the surging growth of nanotechnology,nanotubes present a potential problem as an environmental pollutant,and as such,an efficient method for their rapid detection must be established.Here,we propose a novel type of ionic sensor complex for detecting CNTs–an organic dye that responds sensitively and selectively to CNTs with a photoluminescent signal.The complexes are formed through Coulomb attractions between dye molecules with uncompensated charges and CNTs covered with an ionic surfactant in water.We demonstrate that the photoluminescent excitation of the dye can be transferred to the nanotubes,resulting in selective and strong amplification(up to a factor of 6)of the light emission from the excitonic levels of CNTs in the near-infrared spectral range,as experimentally observed via excitation-emission photoluminescence(PL)mapping.The chirality of the nanotubes and the type of ionic surfactant used to disperse the nanotubes both strongly affect the amplification;thus,the complexation provides sensing selectivity towards specific CNTs.Additionally,neither similar uncharged dyes nor CNTs covered with neutral surfactant form such complexes.As model organic molecules,we use a family of polymethine dyes with an easily tailorable molecular structure and,consequently,tunable absorbance and PL characteristics.This provides us with a versatile tool for the controllable photonic and electronic engineering of an efficient probe for CNT detection. | Petro Lutsyk Raz Arif Jan Hruby Anatolii Bukivskyi Olexander Vinijchuk Mykola Shandura Viktor Yakubovskyi Yuri Kovtun Graham A Rance Michael Fay Yuri Piryatinski Oleksiy Kachkovsky Anatoli Verbitsky Aleksey Rozhin | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 11 | Intimal pericytes as the second line of immune defence in atherosclerosis显示文摘Inflammation plays an essential role in the development of atherosclerosis. The initiation and growth of atherosclerotic plaques is accompanied by recruitment of inflammatory and precursor cells from the bloodstream and their differentiation towards pro-inflammatory phenotypes. This process is orchestrated by the production of a number of pro-inflammatory cytokines and chemokines. Human arterial intima consists of structurally distinct leaflets, with a proteoglycan-rich layer lying immediately below the endothelial lining. Recent studies reveal the important role of stellate pericyte-like cells(intimal pericytes) populating the proteoglycan-rich layer in the development of atherosclerosis. During the pathologic process, intimal pericytes may participate in the recruitment of inflammatory cells by producing signalling molecules and play a role in the antigen presentation. Intimal pericytes are also involved in lipid accumulation and the formation of foam cells. This review focuses on the role of pericytelike cells in the development of atherosclerotic lesions. | Ekaterina A Ivanova Yuri V Bobryshev Alexander N Orekhov | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 12 | Caspases: Enemies Within显示文摘 | YURI Lazebnik | 1998 | Science1998，281，5381： | 1 |
| 13 | 显示文摘 | Tatiana S Yury A Vladimir B | 2010 | Journal of Crystal Growth2010，318，： | 1 |
| 14 | 显示文摘 | Tarasov B Yuri A Dobrovolskii | 2009 | Appl Catal A:General2009，12，： | 1 |
| 15 | Phylogenetic analysis of partial S1 and N gene sequences of infectious bronchitis virus isolates from Italy revealed genetic diversity and recombination显示文摘 | YURY A B GIOVANNI T PAOLA M | 2007 | Virus Genes2007，35，： | 1 |
| 16 | Antioxidant and Antimutagenic Activity of N-(2-Carboxyethyl) chitosan显示文摘 | Kogan Grigorij Skorik Yury A Ingrid Zitnanova | 2004 | Toxicol Appl Pharm2004，201，3： | 1 |
| 17 | N- (2-Carboxyethyl) Chitosan: Regioselective Synthesis, Characterization and Protolytic Equilibria显示文摘 | Skorik Yury A Comes Carlos A R Vasconcelos M Teresa S D | 2003 | Carbohydr Res2003，338，3： | 1 |
| 18 | Benefits of the induced polarization geoelectric method to hydrocarbon exploration显示文摘 | Paul C H Veeken Peter J Legeydo Yuri A Davidenko | 2009 | Geophysics2009，74，2： | 1 |
| 19 | The role of microRNA and other non-coding RNA in the pathogenisis of chronic lymphocytic leukemia 显示文摘 | GEORGE A CALIN YURI P | 2007 | Best Practice & Re- search Chn Haema2007，20，3： | 1 |
| 20 | Caspases:enemies within显示文摘 | Nancy A Thornberry Yuri Lazebnik | 1998 | Science1998，281，： | 1 |
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