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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Neurohumoral,cardiac and inflammatory markers in the evaluation of heart failure severity and progression显示文摘Heart failure is common in adult population,accounting for substantial morbidity and mortality worldwide.The main risk factors for heart failure are coronary artery disease,hypertension,obesity,diabetes mellitus,chronic pulmonary diseases,family history of cardiovascular diseases,cardiotoxic therapy.The main factor associated with poor outcome of these patients is constant progression of heart failure.In the current review we present evidence on the role of established and candidate neurohumoral biomarkers for heart failure progression management and diagnostics.A growing number of biomarkers have been proposed as potentially useful in heart failure patients,but not one of them still resembles the characteristics of the'ideal biomarker.'A single marker will hardly perform well for screening,diagnostic,prognostic,and therapeutic management purposes.Moreover,the pathophysiological and clinical significance of biomarkers may depend on the presentation,stage,and severity of the disease.The authors cover main classification of heart failure phenotypes,based on the measurement of left ventricular ejection fraction,including heart failure with preserved ejection fraction,heart failure with reduced ejection fraction,and the recently proposed category heart failure with mid-range ejection fraction.One could envisage specific sets of biomarker with different performances in heart failure progression with different left ventricular ejection fraction especially as concerns prediction of the future course of the disease and of left ventricular adverse/reverse remodeling.This article is intended to provide an overview of basic and additional mechanisms of heart failure progression will contribute to a more comprehensive knowledge of the disease pathogenesis. | Ekaterina A Polyakova Evgeny N Mikhaylov Dmitry L Sonin Yuri V Cheburkin Mikhail M Galagudza | 2021 | Journal of Geriatric Cardiology2021，18，1： | 4 |
| 3 | Mechanisms of autophagy activation in endothelial cell and their targeting during normothermic machine liver perfusion显示文摘Ischaemia-reperfusion injury(IRI) is the leading cause of injury seen in the liver following transplantation. IRI also causes injury following liver surgery and haemodynamic shock. The first cells within the liver to be injured by IRI are the liver sinusoidal endothelial cells(LSEC). Recent evidence suggests that LSEC coordinate and regulates the livers response to a variety of injuries. It is becoming increasingly apparent that the cyto-protective cellular process of autophagy is a key regulator of IRI. In particular LSEC autophagy may be an essential gatekeeper to the development of IRI. The recent availability of liver perfusion devices has allowed for the therapeutic targeting of autophagy to reduce IRI. In particular normothermic machine liver perfusion(NMP-L) allow the delivery of pharmacological agents to donor livers whilst maintaining physiological temperature and hepatic flow rates. In this review we summarise the current understanding of endothelial autophagy and how this may be manipulated during NMP-L to reduce liver IRI. | Yuri L Boteon Richard Laing Hynek Mergental Gary M Reynolds Darius F Mirza Simon C Afford Ricky H Bhogal | 2017 | World Journal of Gastroenterology2017，23，48： | 4 |
| 4 | Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension显示文摘AIM: To examine whether the heteroplasmy level for 15059G>A mutation in the mitochondrial genome might be associated with essential hypertension. METHODS: This cross-sectional study involved 196 unrelated participants randomly selected from general population (90 males and 106 females) who underwent a regular medical check-up at the Institute for Ath-erosclerosis Research (Moscow, Russia). One hundred and twenty of them (61%) had essential hypertension, and 76 (39%) were apparently healthy normotensive persons. The level of heteroplasmy for 15059G>A mutation occurring in the coding region of cytochrome b gene (MT-CYB) of mtDNA isolated from the blood leukocytes, was quantified using DNA pyrosequencing method. RESULTS: The 15059G>A heteroplasmy level ranged between 4% and 83%, with a median level of 31%. Between the upper and lower quartiles of 15059G>A heteroplasmy distribution, significant differences were observed for patients' age, systolic blood pressure, and triglyceride levels. 15059G>A heteroplasmy correlated both with age (r = 0.331, P < 0.001) and the presence of hypertension (r = 0.228, P = 0.002). Regression analysis revealed that the age explains 12% variability of 15059G>A heteroplasmy, and hypertension independently explains more 5% variability. The 15059G>A heteroplasmy exceeding 31% was found to be significantly associated with a higher risk of essential hypertension (odds ratio 2.76; P (Fisher) 0.019]. The study participants with high 15059G>A heteroplasmy level were found to have significantly higher age (P < 0.001) and the prevalence of essential hypertension (P = 0.033), as compared to those with low 15059G>A heteroplasmy level. These observations suggested a positive correlation between the level of 15059G>A heteroplasmy and essential hypertension. CONCLUSION: This study provides the evidence of association of mtDNA 15059G>A mutation heteroplasmy with essential hypertension. | Igor A Sobenin Dimitry A Chistiakov Margarita A Sazonova Maria M Ivanova Yuri V Bobryshev Alexander N Orekhov Anton Y Postnov | 2013 | World Journal of Cardiology2013，5，5： | 3 |
| 5 | Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans显示文摘 | Omenetti Alessia Porrello Alessandro Jung Youngmi Yang Liu Popov Yury Choi Steve S Witek Rafal P Alpini Gianfranco Venter Juliet Vandongen Hendrika M Syn Wing-Kin Baroni Gianluca Svegliati Benedetti Antonio Schuppan Detlef Diehl Anna Mae | 2008 | Journal of Clinical Investigation2008，，10： | 3 |
| 6 | Unique Marine Olenekian-Anisian Boundary Section from South Primorye, Russian Far East显示文摘To show paleontological characteristics of the Olenekian-Anisian boundary beds in the Russian Far East, a review of new data on the Upper Olenekian and Lower Anisian biostratigraphy of South Primorye is given on the basis of five sections: Golyi Cape, Petrovka River, Zhitkov Peninsula, Tchernyschew Bay and Atlasov Cape, using new ammonoid, brachiopod and conodont findings. The most representative ammonoid assemblage at the base of the Anisian was discovered in the Ussuriphyllites amurensis Zone (10.6 m thick) of the Atlasov Cape Section: Parasageceras sp. nov., Prionitidae gen. et sp. nov., Ussuriphyllites amurensis (Kiparisova) (dominant), Megaphyllites atlasoviensis Zakharov, Leiophyllites praematurus Kiparisova, Leiophyllites sp., Ussurites sp., Paradanubites sp. indet., Paracrochordiceras sp. nov., Prohungarites popowi Kiparisova, Arctohungarites primoriensis Zakharov, A. solimani (Toula), Salterites sp. indet. (gigantic shell), and Tropigastrites sublachontanus Zakharov. Conodonts Neospathodus cf. homeri (Bender) were found in the lower part of the Ussuriphyllites amurensis Zone of the Atlasov Cape. The Atlasov Cape seems to be one of the very promising sections of the Russian Far East for detailed investigation of the Olenekian-Anisian boundary. | Yuri D Zakharov Alexander M Popov Galina I Buryi | 2005 | Journal of China University of Geosciences2005，16，3： | 3 |
| 7 | Nitrogen and Carbon Isotope Data of Olenekian to Anisian Deposits from Kamenushka/South Primorye, Far-Eastern Russia and Their Palaeoenvironmental Significance显示文摘The Kamenushka Formation, exposed in the northern part of South Primorye(Kamenushka-1 and Kamenushka-2 sections), is one of the few localities in the world with richly fossiliferous Lower–Upper Olenekian sedimentary successions. Lower to Middle Triassic ammonoid-, brachiopod-and conodont-bearing silty-clayey deposits of the Kamenushka-1 and Kamenushka-2 sections have been isotope-geochemically investigated in detail. As a result, these sections, together with the previously investigated Abrek Section, exposed in the southern part of South Primorye, provide almost complete 15 Norg-and 13 Corg-records for the Lower Triassic of this region. Nine Nisotope intervals and the five negative C-isotope excursions, reflecting, apparently, unstable climatic and hydrological conditions, have been distinguished in the Lower Triassic of South Primorye. On the basis of the new C-isotope data the Mesohedenstroemia bosphorensis Zone(upper part), Shimanskyites shimanskyi and Neocolumbites insignis zones of South Primorye are correlated now with the Lower Smithian part of the Yinkeng Formation, the Upper Smithian part of the Helongshan Formation and the Middle Spathian part of the Nanlinghu Formation in South China, respectively, as has been observed in the Abrek, Kamenushka-2, West Pingdingshan and Majiashan sections. | Yuri D Zakharov Micha Horacek Alexander M Popov Liana G Bondarenko | 2018 | Journal of Earth Science2018，29，4： | 2 |
| 8 | Mollisols Properties and Changes in Ukraine and China显示文摘Soils are the foundation of civilizations and the basis for human food production.Mollisols in Ukraine and Northeast China are two out of the four major Mollisol regions in the world.The natural areas from which Mollisols developed are the prairies and steppes that experience temperate and freezing conditions.This review paper introduces the general climate,vegetation,and topography of Mollisols regions in Ukraine and Northeast China,analyzes their properties,including soil texture,soil organic matter content,soil bulk density,pH,cation exchange capacity and other chemical properties,and compares the property changes and management practices of Mollisols in relation to sustainable grain production. | Yuri S KRAVCHENKO ZHANG Xingyi LIU Xiaobing SONG Chunyu Richard M CRUSE | 2011 | Chinese Geographical Science2011，21，3： | 2 |
| 9 | Normative Design of Organizations-Part Ⅰ: Mission Planning 显示文摘 | Yuri N Levchuk Jie Luo at al | 2002 | IEEE Transactions on Systems Man and Cybernetics-Part A: System and Humans2002，32，3： | 1 |
| 10 | Recent advances of laser-spectroscopy based techniques for applications in breath analysis 显示文摘 | Matthew R M Yury B Gerard W | 2007 | J Breath Res2007，1，1： | 1 |
| 11 | Normative Design of Organizations- Part Ⅱ:Organizational Structure 显示文摘 | Yuri N Levchuk Jie Luo at al | 2002 | IEEE Transactions on Systems Man and Cybernetics-Part A: System and Humans2002，32，3： | 1 |
| 12 | Structural studies on methylated starch granules 显示文摘 | Yuri E M Bergsma J Bleeker I P | 2002 | Starch-Starke2002，52，： | 1 |
| 13 | Expression of genes encoding type Ⅳ collagen-degrading metalloproteinases and tissue inhibitors of metalloproteinases in various human tumor cells显示文摘 | Hiroshi S Yuri K Masayoshi M | 1992 | Oncogene1992，7，： | 1 |
| 14 | Solid-phase extraction fractionation to extend the characterization of naphthenic acids in crude oil by electro spray ionization fourier transform ion cyclotron resonance mass spectrometry显示文摘 | Rowland Steven M Robbins Winston K Corilo Yuri E | 2014 | Energy and Fuels2014，28，8： | 1 |
| 15 | Phylogenetic analysis of partial S1 and N gene sequences of infectious bronchitis virus isolates from Italy revealed genetic diversity and recombination显示文摘 | YURY A B GIOVANNI T PAOLA M | 2007 | Virus Genes2007，35，： | 1 |
| 16 | Are More Resources Always Better for Growth Resource Stickiness in Market and Product Expansion显示文摘 | Yuri M T G Pollock J F Porac | 2004 | Strategic Management Journal2004，25，12： | 1 |
| 17 | 显示文摘 | Sergei I N Yuri K Yitzhak M | 2002 | The European Journal o5 Neuroscience2002，12，： | 1 |
| 18 | N- (2-Carboxyethyl) Chitosan: Regioselective Synthesis, Characterization and Protolytic Equilibria显示文摘 | Skorik Yury A Comes Carlos A R Vasconcelos M Teresa S D | 2003 | Carbohydr Res2003，338，3： | 1 |
| 19 | Effect of welding structure and 8-ferrite on fatigue properties for TIG welded austenitic stainless steels at cryogenic temperatures显示文摘 | YURI T OGATAT SAITO M | 2000 | Cryogenics2000，40，45： | 1 |
| 20 | Prioritizing abandoned coal mine reclamation projects within the contiguous United States using Geographic information system extrapolation显示文摘 | Yuri G~ Andrew V Matthew R and Erica M | 2003 | Environmental Management2003，32，： | 1 |
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