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| 1 | Vitamin K2 suppresses rotenone-induced microglial activation in vitro显示文摘瞄准:增加的证据证明了象毒鱼藤素和 paraquat 那样的环境因素导致 neuroinflammation,它贡献 Parkinsons 疾病(PD ) 的致病。在这研究,我们调查了由 menaquinone-4 (MK-4 ) 位于压抑下面的分子的机制,在 vitro.Methods 的导致毒鱼藤素的 microglial 激活的维生素 K 2, 的一种子类型:一根 microglial 房间线(BV2 ) 暴露于毒鱼藤素(1 μ mol/L ) 与或没有 MK-4 处理。TNF-α 的层次;或 IL-1β在 100 μ BV2 房间的有教养的媒介的 L 用 ELISA 工具包被测量。与毒鱼藤素对待与或没有 MK4 的 BV2 房间受到 mitochondrial 膜潜力, ROS 生产, immunofluorescence 或 immunoblot 试金。neuroblastoma SH-SY5Y 房间与暴露于毒鱼藤素与或没有 MK-4 处理的 BV2 房间的调节媒介(厘米) 被对待,并且房间生存能力用 MTT assay.Results 被估计:在对待毒鱼藤素的 BV2 房间, MK-4 (0.5-20 μ mol/L ) dose-dependently 在 TNF-α 的房间,以及生产在 iNOS 和 COX-2 的表示压制了 upregulation;并且 IL-1β在有教养的媒介。MK-4 (5-20 μ mol/L ) NF-κ 的显著地禁止的导致毒鱼藤素的原子 translocation;在 BV2 房间的 B。MK-4 (5-20 μ mol/L ) 在 BV2 房间的显著地禁止的导致毒鱼藤素的 p38 激活, ROS 生产,和 caspase-1 激活。MK-4 (5-20 μ mol/L ) 也恢复了被毒鱼藤素损坏了的 mitochondrial 膜潜力。到从对待毒鱼藤素的 BV2 房间的厘米的暴露显著地减少了 SH-SY5Y 房间的生存能力。然而,当 BV2 房间与 MK-4 被共同对待时, SH-SY5Y 房间的这激活毒鱼藤素的调停 microglia 的死亡显著地被稀释(5-20 μ mol/L ).Conclusion:维生素 K 2 能直接由镇压在 vitro 压制 microglial BV2 房间的导致毒鱼藤素的激活 ROS 生产和 p38 激活。 | Yan-xia YU Yi-pei LI Feng GAO Qing-song HU Yah ZHANG Dong CHEN Guang-hui WANG | 2016 | Acta Pharmacologica Sinica2016，37，9： | 5 |
| 2 | A New Acylated Iridoid Glucoside from Avicennia marina显示文摘A new acylated iridoid glucoside, namely, 2′-O-(5-phenyl-2E, 4E-pentadienoyl)- mussaenosidic acid, was isolated from the aerial parts of the mangrove plant Avicennia marina. The structure of the new compound was established on the basis of various NMR spectroscopic analyses, including 2D NMR techniques (1H-1H COSY, HMQC, and HMBC) and HR-FAB-MS. This compound displayed moderate antioxidant activity. | Yah FENG Xiao Ming LI Xiao Juan DUAN Bin Gui WANG | 2006 | Chinese Chemical Letters2006，17，9： | 2 |
| 3 | Synthesis, characterization and ring-opening polymerization of a novel six-membered cyclic carbonate bearing pendent allyl ether group显示文摘 | He Feng Wang Yah Ping Zhuo Ren Xi | 2008 | Polymer2008，49，5： | 1 |
| 4 | Influence of psychological,family and contextual factors on residential energy use behaviour:An empirical study of China显示文摘 | Sun Yah Feng Lifang | | 0，，： | 1 |
| 5 | Effects of prenatal alcohol exposure on brain - derived neurotrophic factor and its receptor tyrosine kinase B in offspring 显示文摘 | Mei - Jiang Feng Shu - E Yah and Qing - Shah Yah | 2005 | Brain res2005，1042，2： | 1 |
| 6 | Tea consumption and depressive symp- toms in older people in rural China显示文摘 | Feng L Yah Z Sun B | 2013 | J Am Geriatr Soc2013，61，11： | 1 |
| 7 | A disposable amperometric immunosensor for α-1-fetoprotein based on enzyme-labeled antibody/chitosan-membrane-modified screen-printed carbon electrode显示文摘 | Yah Feng Dai Zong | 2004 | Analytical Biochemistry2004，331，1： | 1 |
| 8 | Effects of prenatal alcohol exposure on brain - derived neurotrophic factor and its receptor tyroxine kinase B in offspring显示文摘 | Feng M J Yah SE Yan Qs | 2005 | Brain Res2005，1042，20： | 1 |
| 9 | A new thinning algorithm for fingerprint image显示文摘 | Feng Xing-kui Li Lin-yan Yah Zu-quan | 1999 | Journal of Image and Graphics1999，4，10： | 1 |
| 10 | The protective effects of a-lipoic acid on kidneys in type 2 diabetic Goto-Kakisaki rats via reducing oxidative stress显示文摘 | Feng B Yah XF Xue JL | 2013 | Int J Mol Sei2013，14，4： | 1 |
| 11 | A selective dopamine biosensor based on AgCl@polyaniline core-shell nanocomposites显示文摘 | Yah Wei Feng Xiaomiao Chen Xiaoj un | 2008 | Bioelectrochemistry2008，72，： | 1 |
| 12 | Treatment of por- tal vein tumor thrombus of hepatocellular carcinoma with percuta- neous laser ablation 显示文摘 | Lu Zheng-Hua Shen Feng Yah Zhen-Lin | 2009 | J Cancer Res Clin Oneol2009，135，： | 1 |
| 13 | Effects of sodium X uoride treatment in vitm on cell proliferation apoptosis and caspase-3 and easpase-9 mRNA expression by neonatal rat osteoblast 显示文摘 | Yah XY Feng CP Chen QL | 2009 | Arch Toxieol2009，83，： | 1 |
| 14 | A simple me~hod for dynami~ cally measuring the diameters of train wheels using a one-dimen- sional laser displacement transducer 显示文摘 | Yah Gao Feng Qibo Cui Jianying | 2014 | Optics and Lasers in Engineering2014，53，： | 1 |
| 15 | Influence of Mg21Ga5Hg3 compound on electrochemical properties of Mg-5%Hg-5%Ga alloy显示文摘 | FENG Yah WANG Ri-chu PENG Chao-qun WANG Nai-guang | 2009 | Transactions of Nonferrous Metals Society of China2009，19，： | 1 |
| 16 | Seroincidence of recent human immunodefi ciencyvirus type 1 infections in China 显示文摘 | Xiao Yao Jiang Yah Feng Jigang | 2007 | Clin Vaccine Immunol2007，14，10： | 1 |
| 17 | Time-reversal wideband communications显示文摘 | CHEN Yah YANG Yuhan HAN Feng | 2013 | IEEE Signal Processing Letters2013，20，12： | 1 |
| 18 | Optical AC voltage sensor based on two Bi4Ge3Ol2 crystals显示文摘 | Feng P Xia X Yah X | 2012 | IEEE Transactions on Instrumentation and Measurement2012，61，4： | 1 |
| 19 | The effect of the microstmcture on the DC-bias superposition characteristic of NiCuZn ferrite 显示文摘 | Yah S Q Dong L Feng Z K | 2014 | J Magn Magn Mater2014，353，： | 1 |
| 20 | A discussion on im- proving hydration activity of steel slag by altering its miner- al compositions显示文摘 | Wang Qiang Yah Peiyu Feng Jianwen | 2011 | Journal of Hazardous Materials2011，186，23： | 1 |
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