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| 1 | 五个月短程化疗及六个月全程间歇方案治疗菌阳肺结核的临床对照研究显示文摘目的考核利福喷丁(L)的疗效;缩短疗程或全程间歇以减少用药次数;观察全程应用吡嗪酰胺(Z)对疗效及毒副反应的影响。方法以利福平(R)为对照,采用5个月疗程方案(Ⅰ组2SHRZ/3R2H2Z2,Ⅱ组2SHRZ/3L1H2Z2)、6个月全间歇方案(Ⅲ组2S3H3R3Z3/4L1H2Z2,Ⅳ组2S3H3R3Z3/4L1H2E2),观察Z的全程应用结果,巩固期以乙胺丁醇(E)为对照。366例初治菌阳肺结核随机分入以上4组。结果(1)339例完成疗程者中329例治疗成功,满疗程时痰菌阴转率Ⅰ~Ⅳ组分别为970%、941%、1000%、972%。X线病灶有效率依序为960%、976%、1000%和944%。5个月组与6个月组空洞关闭率分别为77%及76%。各组相互比较均无显著性差异(P>0.05),未见严重副作用。(2)305例完成3年随访,Ⅰ、Ⅱ、Ⅲ、Ⅳ组细菌学加X线复发分别为2、3、6和3例。结论本研究结果进一步证明L是长效、高效、安全、便于督导的新药;巩固期用Z无必要;现有基本药物合理联用有可能缩短疗程为5个月,值得进一步研究。 | National Cooperative Group On Clinical Study of Pulmonary Tuberculosis (Report prepared by Chu Naihui , Yan Biya, Zhu Lizhen). Beijing Tuberculosis and Thoracic Tumor Institute, Beijing 101149 | 1998 | 中华结核和呼吸杂志1998，21，7： | 26 |
| 2 | Paeoniflorin protects cells from GalN/TNF-α-induced apoptosis via ER stress and mitochondria-dependent pathways in human L02 hepatocytes显示文摘Paeoniflorin (PF ) 是从 Paeonia lactiflora 的根提取的主要有效部件之一,它临床上被使用了在未知的内在的 mechanismremain 的繁体中文药,而是细节对待肝炎。现在的学习被设计在 d-galactosamine (GalN ) 和肿瘤坏死因素上调查 PF 的保护的效果的机制 --(TNF-) 用人的 L02 hepatocytes 导致了房间 apoptosis。我们 PF 能稀释的 resultsconfirmed GalN/TNF -- 以一种剂量依赖者方式的导致的 apoptotic 房间死亡。mitochondrialmembrane 潜力和细胞内部的 Ca 2+ 集中的骚乱的混乱被 PF 也恢复。西方的污点分析表明 GalN/TNF- 导致了一个 numberof 签名 endoplasmic 蜂窝胃的激活(嗯) 压力和 mitochondrial 标记,当 PF 预告的处理在他们上有显著 dose-dependentsuppression 时。另外, PF 的 anti-apoptotic 效果被 caspase-3/9activities 的抑制进一步在 L02 房间证实。这些调查结果建议那 PF 能有效地禁止与调整调停人有关的 hepatocyte apoptosis 和内在的 mechanismis 在嗯压力和线粒体依赖者小径。 | Zequn Jiang Funding This work was supported by grants from the National Natural Science Foundation of China (81072777 and 81273638) and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).Weiping Chen Xiaojing Yan Lei Bi Sheng Guo Zhen Zhan | 2014 | Acta Biochimica et Biophysica Sinica2014，46，5： | 5 |
| 3 | A Wavelet-Based Fuzzy Neural Network for Interpolation of Fuzzy If-Then Rules显示文摘In this paper, a wavelet-based fuzzy neural network with its structure and a learningalgorithm is proposed and the simulation results are given to prove its feasibility. | Jiao Licheng Liu Fang Wang Ling & Zhang Yanning(State Key Lab. of RSP and Center for Neural Networks, Xidian University, Xi’an 710071, P. R. China) (This project was partly supported by the National Thud of Intercent. Expert and partly supported bythe | 1998 | Journal of Systems Engineering and Electronics1998，9，4： | 3 |
| 4 | Cytoplasmic expression of P33^(ING1b) is correlated withtumorigenesis anti progression of human esophageal squamous cell arcinoma 显示文摘 | ZHU ZL YAN BY ZHANG Y | 2013 | Ontology Lefts2013，5，1： | 1 |
| 5 | PINCH expression and its clinicopathological significancein gastric adenocarcinoma 显示文摘 | ZHU ZL YAN BY ZHANG Y | 2012 | Dis Markers2012，33，4： | 1 |
| 6 | Overexpression of FXYD-3 is involved in the tumorigenesis and development of esophageal squamous cell carcinoma 显示文摘 | ZHU ZL YAN BY ZHANG Y | 2013 | Dis Markers2013，35，3： | 1 |
| 7 | Blockade of p38 mitogen-activated protein kinase pathway ameliorates delayed gastric emptying in streptozotocin-induced diabetic rats显示文摘 | YangK Qiu BY Yan J | 2014 | Int Immunopharmaool2014，23，2： | 1 |
| 8 | Cytoplasmic expression of P33^ING1b is correlated with tumori- genesis and progression of human esophageal squamous cell arcinoma 显示文摘 | Zhu ZL Yan BY Zhang Y | 2013 | Oncology Letts2013，5，1： | 1 |
| 9 | Polynomial analysis of canopy spectra and biochemical component content inversion显示文摘A polynomial expression model was developed in this paper to describe directional canopy spectra, and the decomposition of the polynomial expression was used as a tool for re-trieving biochemical component content from canopy multi-angle spectra. First, the basic formula of the polynomial expression was introduced and the physical meaning of its terms and coeffi-cients was discussed. Based on this analysis, a complete polynomial expression model and its decomposition method were given. By decomposing the canopy spectra simulated with SAILH model, it shows that the polynomial expression can not only fit well the canopy spectra, but also show the contribution of every order scattering to the whole reflectance. Taking the first scattering coefficients a10 and a01 for example, the test results show that the polynomial coefficients reflect very well the hot spot phenomenon and the effects of viewing angles, LAI and leaf inclination angle on canopy spectra. By coupling the polynomial expression with leaf model PROSPECT, a canopy biochemical component content inversion model was given. In the simulated test, the canopy multi-angle spectra were simulated by two different models, SAILH and 4-SCALE re-spectively, then the biochemical component content was retrieved by inverting the coupled polynomial expression + PROSPECT model. Results of the simulated test are promising, and when applying the algorithm to measured corn canopy multi-angle spectra, we also get relatively accurate chlorophyll content. It shows that the polynomial analysis provides a new method to get biochemical component content independent of any specific canopy model. | YAN Chunyan1, LIU Qiang1, NIU Zheng1, WANG Jihua2, HUANG Wenjiang2 & LIU Liangyun 2 1. State Key Laboratory of Remote Sensing Science, Jointly Sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101, China 2. National Engineering Research Center for Information Technology in Agriculture, Beijing 100089, China | 2005 | Science China Earth Sciences2005，48，10： | 1 |
| 10 | MicroRNA -29a Promotes Pan- creatic Cancer Growth by Inhibiting Tristetraprolin 显示文摘 | Sun XJ Liu BY Yan S | 2015 | Cell Physi- ol Biochem2015，37，2： | 1 |
| 11 | Overexpression of MAC30 in the Cytoplasm of Oral Squamous Cell Car- cinoma Predicts Nodal Metastasis and poor Differen- tiation显示文摘 | Yan BY Wang DW Zhu ZL | 2010 | Chemotherapy2010，56，： | 1 |
| 12 | Effects of argon plasma treating on surface morphology and gas ionization property of carbon nanotubes显示文摘 | Yan BY Qian K Y Zhang Y F | 2005 | Physica E2005，28，1： | 1 |
| 13 | Relationship between plasma lipid concentrations and HDL subclasses 显示文摘 | ] Yang YY Yan BY Fu MD | 2005 | Clin Chim Acta2005，354，12： | 1 |
| 14 | Selective hepatic blood flow occlusion technique in the application of laparoscopic liver re- section显示文摘 | YAN YH LU BY CAI XY | 2010 | Chin J Surg2010，48，15： | 1 |
| 15 | PINCH expression and its clinicopathological significance in gastric adenocarcinoma显示文摘 | Zhu ZL Yan BY Zhang Y | 2012 | Dis Markers2012，33，4： | 1 |
| 16 | Adsorption of atrizine by natural organic matter and surfactant dispersed carbon nanotubes显示文摘 | Shi BY Zhang XY Yan XM | 2011 | Journal of Environmental Science2011，22，8： | 1 |
| 17 | Cancer-associated fibroblasts attenuate Cisplatin-inducedapoptosis in ovarian cancer cells by promoting STAT3 signaling显示文摘 | Yan H Guo BY Zhang S | 2016 | Biochem BiophysRes Commun2016，470，4： | 1 |
| 18 | In Vitro Antioxidant and Antimicrobial Activities of the Extract of Pericarpium Citri Reticulatae of a new Citrus Cultivar and Its Main Flavonoids显示文摘 | Yan Y Yi ZL | 2007 | LWT-Food Science and Technology2007，25，： | 1 |
| 19 | The Manufacturing Art, Development Trendand Market Anticipation of Technological Equipmentfor Auto Assembly in China | By BIAN Yan and LI Honggang (CATARC) | 2002 | 中国汽车(英文版)2002，，12： | 0 |
| 20 | HARMONY IN DIVERSITY显示文摘The combination of pluralism and unity may go a long way toward bringing about harmony in the international community In the face of grave challenges confronting humanity, which range from regional conflicts and terrorism to environmental pollution and severe epidemics, China has pledged to channel its efforts into bringing harmony to the international community. The promise was reinforced | By YAN WEI | 2006 | Beijing Review2006，49，2： | 0 |
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