4篇
您的检索式：作者名="Yan Chengda"
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| 1 | Numerical simulation of reservoir sediment and effects on hydrodynamic response of arch dams 显示文摘 | ZHANG Chuhan YAN Chengda WANG Guanglun | 2001 | Earthquake Engineering and Structure Dynamics2001，30，： | 1 |
| 2 | Nu- merical Simulation of Reservoir Sediment and Effects on Hydro-dynamic Response of Arch Dams 显示文摘 | Zhang Chuhan Yan Chengda Wang Guanglun | 2001 | Earthquake Engineering and Structure Dynam- ics2001，30，： | 1 |
| 3 | Numerical simulation of reservoir sediment and effects on hydrodynamic response of arch dams显示文摘 | Zhang Chuhan Yan Chengda Wang Guanglun | 2001 | Earthquake Engineering and Structure Dynamics2001，30，： | 1 |
| 4 | A boronic acid conjugation integrates antitumor drugs into albumin-binding prodrugs-based nanoparticles with robust efficiency for cancer therapy显示文摘Despite great therapeutic effect of Abraxane®,complex preparation technology and unfavorable pharmacokinetics still restricted the clinical application of albumin-based paclitaxel(PTX)nanoparticles(NPs).Herein,we reported that an albumin-binding prodrug,phenylboronic acid-conjugated PTX(P-PTX),can form the uniform NPs with the diameters around 100 nm with the help of albumin via simple one-step nano-precipitation method.The albumin-based nanomedicines were stabilized by the integration of a single boronic acid with PTX due to the increased affinity based on multiple intermolecular interactions.We found that albumin-based P-PTX NPs exhibited superior colloidal stability over albumin-based PTX NPs through one-step nanoprecipitation approach,achieving longer in vivo circulation time and higher concentration in tumor than those of the marketed Abraxane®.Furthermore,the albumin-based P-PTX NPs with great stability and enhanced intratumoral enrichment,increased the maximum tolerated dose of PTX,remarkably suppressed the growth of breast tumor and lung metastasis,prolonged survival of melanoma tumors-bearing mice.Such a convenient and effective system gains an insight into the impact of phenylboronic acid group on the albumin-based PTX NPs,provides potent strategy for the rational design of albumin-based antitumor nanomedicines. | Weiyue Ban Qiuhua Luo Chengda Yan Xiaoying Fan Guorui Zhu Maosheng Cheng Zhonggui He Mengchi Sun Jin Sun | 2023 | Nano Research2023，16，5： | 0 |
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