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| 1 | Population Genomic Analysis and De Novo Assembly Reveal the Origin of Weedy Rice as an Evolutionary Game显示文摘Crop weediness,especially that of weedy rice(Oryza sativa f.spontanea),remains mysterious.Weedy rice possesses robust ecological adaptability;however,how this strain originated and gradually formed proprietary genetic features remains unclear?Here,we demonstrate that weedy rice at Asian high latitudes(WRAH)is phylogenetically well defined and possesses unselected genomic characteristics in many divergence regions between weedy and cultivated rice.We also identified novel quantitative trait loci underlying weedy-specific traits,and revealed that a genome block on the end of chromosome 1 is associated with rice weediness.To identify the genomic modifications underlying weedy rice evolution,we generated the first de novo assembly of a high-quality weedy rice genome(WR04-6),and conducted a comparative genomics study between WR04-6 with other rice reference genomes.Multiple lines of evidence,including the results of demographic scenario comparisons,suggest that differentiation between weedy rice and cultivated rice was initiated by genetic improvement of cultivated rice and that the essence of weediness arose through semi-domestication.A plant height model further implied that the origin of WRAH can be modeled as an evolutionary game and indicated that strategy-based selection driven by fitness shaped its genomic diversity. | Jian Sun Dianrong Ma Liang Tang Minghui Zhao Guangchen Zhangh Wenjia Wang Jiayu Song Xiang Li Zimeng Liu Wenxing Zhang Quan Xu Yuncheng Zhou Jianzhong Wu Toshio Yamamoto Fei Dai Yan Lei Song Li Gang Zhou Hongkun Zheng Zhengjin Xu Wenfu Chen | 2019 | Molecular Plant2019，12，5： | 9 |
| 2 | Preliminary Results of Acoustic Radiation Force Impulse (ARFI) Ultrasound Imaging of Breast Lesions显示文摘 | Wei Meng Guangchen Zhang Changjun Wu Guozhu Wu Yan Song Zhaoling Lu | 2011 | Ultrasound in Medicine & Biology2011，，9： | 2 |
| 3 | Preliminary Results of Acoustic Radiation Force Impulse (ARFI) Ultrasound Imaging of Breast Lesions显示文摘 | Wei Meng Guangchen Zhang Changjun Wu Guozhu Wu Yan Song Zhaoling Lu | 2011 | Ultrasound in Medicine & Biology2011，，9： | 2 |
| 4 | Multi-fractal measures of city-size distributions based on the three-parameter Zipfmodel显示文摘 | YAN Guangchen YI Xing zhou | 2004 | Chaos Solitons & Fractals2004，22，3： | 1 |
| 5 | MicroRNA-708 inhibits the proliferation and chemoresistance of pancreatic cancer cells显示文摘Pancreatic cancer is one of the most aggressive malignancies with poor prognosis and high mortality.Recent studies showed that microRNAs are dysregulated and involved in the initiation and progression of pancreatic cancer.In this study,we found that miR-708 was significantly downregulated in pancreatic cancer tissues and cell lines.Lentivirus-mediated overexpression of miR-708 could significantly inhibit the proliferation and invasion,while enhanced chemosensitivity to gemcitabine in both Panc-1 and SW1990 cells.Luciferase reporter assay showed that miR-708 bound the 3’-untranslated region of survivin and suppressed the expression of survivin in pancreatic cancer cells.In pancreatic cancer tissues,survivin protein was highly expressed and negatively correlated with miR-708 expression.Furthermore,the restoration of survivin expression could partially antagonize proliferation inhibition and apoptosis induction by miR-708 in pancreatic cancer cells.The Panc-1 cells with overexpression of miR-708 also showed decreased proliferation capability in nude mouse model compared with parental cells.In conclusion,our results suggest that miR-708 inhibits pancreatic cancer and could be a novel potential candidate to treat pancreatic cancer. | Wensong LIU Yunjie LU Dong ZHANG Longqing SHI Guangchen ZU Haijiao YAN Donglin SUN | 2020 | BIOCELL2020，44，1： | 1 |
| 6 | Multi -fractal measures of city -size distributions based on the three- parameter zipfmodel 显示文摘 | Yan Guangchen Yi Xingzhou | 2004 | Chaos Soliton&Fractal2004，22，3： | 1 |
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