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| 1 | Genetic associations with adverse events from anti-tumor necrosis factor therapy in inflammatory bowel disease patients显示文摘AIM To study the type and frequency of adverse events associated with anti-tumor necrosis factor(TNF)therapy and evaluate for any serologic and genetic associations.METHODS This study was a retrospective review of patients attending the inflammatory bowel disease(IBD) centers at Cedars-Sinai IBD Center from 2005-2016. Adverse events were identified via chart review. IBD serologies were measured by ELISA. DNA samples were genotyped at Cedars-Sinai using Illumina Infinium Immunochipv1 array per manufacturer's protocol. SNPs underwent methodological review and were evaluated using several SNP statistic parameters to ensure optimal allele-calling. Standard and rigorous QC criteria were applied to the genetic data, which was generated using immunochip. Genetic association was assessed by logistic regression after correcting for population structure.RESULTS Altogether we identified 1258 IBD subjects exposed to anti-TNF agents in whom Immunochip data were available. 269/1258 patients(21%) were found to have adverse events to an anti-TNF-α agent that required the therapy to be discontinued. 25% of women compared to 17% of men experienced an adverse event. All adverse events resolved after discontinuing the antiTNF agent. In total: n = 66(5%) infusion reactions; n = 49(4%) allergic/serum sickness reactions; n = 19(1.5%) lupus-like reactions, n = 52(4%) rash, n = 18(1.4%) infections. In Crohn's disease, Ig A ASCA(P = 0.04) and Ig G-ASCA(P = 0.02) levels were also lower in patients with any adverse events, and anti-I2 level in ulcerative colitis was significantly associated with infusion reactions(P = 0.008). The logistic regression/human annotation and network analyses performed on the Immunochip data implicated the following five signaling pathways: JAK-STAT(Janus Kinase-signal transducer and activator of transcription), measles, IBD, cytokine-cytokine receptor interaction, and toxoplasmosis for any adverse event. CONCLUSION Our study shows 1 in 5 IBD patients experience an adverse event to anti-TNF therapy with novel serologic, genetic, and pathways associations. | Daniel Lew Soon Man Yoon Xiaofei Yan Lori Robbins Talin Haritunians Zhenqiu Liu Dalin Li Dermot PB McGovern | 2017 | World Journal of Gastroenterology2017，23，40： | 4 |
| 2 | Absence of TLR4 Asp299Gly and Thr399Ile polymorphisms in Chinese Han population with type 2 diabetes 显示文摘 | Lai PB Zhang L Yan JJ | 2010 | Lab Med2010，41，9： | 1 |
| 3 | Tribological properties of bismaleimide composites with surface-modified SiO2 nanopartieles显示文摘 | Yan HX Li PB Ning RC Ma X Y Zhang Z P | 2008 | Journal of Applied Polymer Science2008，110，3： | 1 |
| 4 | A metabonomic approach to early prognostic evaluation of experimental sepsis by (1) H NMR and pattern recognition显示文摘 | Lin ZY Xu PB Yan SK | 2009 | NMR Biomed2009，22，6： | 1 |
| 5 | Absence of TLR4 asp299Gly and Thr399Ile polymorphisms in Chinese Han population with type 2 diabetes显示文摘 | Lai PB Zhang L Yan SJ | 2010 | Lab Med2010，41，9： | 1 |
| 6 | Metallo-beta-lactamases in clinical Pseudomonas isolates in Taiwan and identification of VIM-3, a novel variant of the VIM-2 enzyme 显示文摘 | Yan JJ Hsueh PB Ko WC | 2001 | Antimicrob Agents Chemother2001，45，8： | 1 |
| 7 | A metabonomic approach to early prognostic evaluation of experimental sepsis by (1)H NMR and pat- tern recognition 显示文摘 | Lin ZY Xu PB Yan SK | 2009 | NMR Biomed2009，22，6： | 1 |
| 8 | Estimation of nitrogen dioxide concentrations in homes equipped with unvented gas space heaters显示文摘 | Yan PB Hemphill CP Billick IH | 1989 | Environment International1989，15，1： | 1 |
| 9 | Clinical management of organo- phosphate poisoning in pregnancy显示文摘 | Sun L Li GQ Yan PB | 2015 | Am J Emerg Med2015，33，30： | 1 |
| 10 | Prediction of outcome following paraquat poisoning by arterial lactate concentration-time data 显示文摘 | Sun L Li GQ Yan PB | 2014 | Exp Ther Med2014，8，2： | 1 |
| 11 | A metabonomic approach to early prognostic evaluation of experimental sepsis by (1)H NMR and pat- tern recognition显示文摘 | Lin ZY Xu PB Yan SK | 2009 | NMR Biomed2009，22，6： | 1 |
| 12 | Size-controllable glynitratelow temperature combustion synthesis (LCS) of nanocrystalline LaxSr1-xMnO3显示文摘 | XIE PB ZHANG WP YAN K | 2000 | J Alloys and Compounds2000，311，1： | 1 |
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