|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 不同能量和营养浓度饲粮添加益生素对生长肥育猪生长性能、养分消化率、肉品质和血液指标的影响显示文摘本研究旨在测定添加益生素(枯草芽孢杆菌孢子和丁酸梭菌孢子混合物)以及不同能量和营养浓度对生长肥育猪生长性能、养分消化率和肉品质的影响。选择96头初始体重为(47.50±1.14)kg的生猪,试验期10周。 | Meng Q W Yan L Ao X(等) 闫轶洁(译) 无 | 2010 | 养猪2010，，6： | 65 |
| 2 | Malignant peritoneal mesothelioma显示文摘Malignant mesothelioma is a highly aggressive neoplasm.The incidence of malignant mesothelioma is increasing worldwide.Diffuse malignant peritoneal mesothelioma(DMPM) represents one-fourth of all mesotheliomas.Association of asbestos exposure with DMPM has been observed,especially in males.The great majority of patients present with abdominal pain and distension,caused by accumulation of tumors and ascitic ? uid.In the past,DMPM was considered a pre-terminal condition;therefore attracted little attention.Patients invariably died from their disease within a year.Recently,several prospective trials have demonstrated a median survival of 40 to 90 mo and 5-year survival of 30% to 60% after combined treatment using cytoreductive surgery and perioperative intraperitoneal chemotherapy.This remarkable improvement in survival has prompted new search into the medical science related to DMPM,a disease previously ignored as uninteresting.This review article focuses on the key advances in the epidemiology,diagnosis,staging,treatments and prognosis of DMPM that have occurred in the past decade. | Stine Munkholm-Larsen Christopher Q Cao Tristan D Yan | 2009 | World Journal of Gastrointestinal Surgery2009，1，1： | 19 |
| 3 | DEC1 nuclear expression:A marker of differentiation grade in hepatocellular carcinoma显示文摘AIM: To investigate the expression patterns of human differentiated embryo chondrocyte 1 (DEC1) in hepatocellular carcinoma (HCC) and corresponding adjacent non-tumor and the normal liver tissues, the association between DEC1 expression and histopathological variables and the role of DEC1 in hepatocarcinogenesis. METHODS: The expression of DEC1 was detected immunohistochemically in 176 paraffin-embedded sections from 63 patients with HCC and 50 subjects with normal liver tissues. RESULTS: DEC1 protein was persistently expressed in the cytoplasm of hepatocytes in normal liver and HCC tissues. Compared with adjacent non-tumor liver tissues, HCC tissues showed high nuclear expression of DEC1 protein. However, high DEC1 nuclear expression was more frequently detected in well-differentiated (83.3%) than in moderately (27.3%) and poorly differentiated HCC (16.7%). Low DEC1 expression was associated with poor histological differentiation and malignancy progression. A correlation was found between the nuclear expression of DEC1 protein and histological differentiation (r = 0.376, P = 0.024). CONCLUSION: DEC1 is expressed in the cytoplasm of hepatocytes and because nuclear DEC1 expression is decreased with decreasing differentiation status of HCC, nuclear DEC1 might be a marker of HCC differentiation. | Xiao-Hong Shi Yan Zheng Qing Sun Jing Cui Qing-Hua Liu Fei Qü Yun-Shan Wang | 2011 | World Journal of Gastroenterology2011，17，15： | 15 |
| 4 | Novel functional proteins interact with midkine in hepatic cancer cells显示文摘BACKGROUND: Midkine is a heparin-binding growth factor that promotes the proliferation, survival, migration and differentiation of various target cells. Midkine plays an important role in tumorigenesis and tumor progression, and is overexpressed in many human malignant tumors. Patients with high tumor midkine expression frequently have a worse prognosis than those with low expression. The present study was designed to investigate the interaction network of midkine in hepatic cancer cells, and to elucidate its role in hepatocellular carcinoma. METHODS: DNA encoding full-length midkine was cloned into pDBLeu vector to serve as bait in yeast two-hybrid screening to identify interacting proteins. Candidate proteins were examined on SC-Leu-Trp-His+3-AT (20 mmol/L) plates and assayed for X-gal activity, then sequenced and classified according to the GenBank. Finally, identified proteins were expressed by the in vitro expression system pCMVTnT, and protein interactions were confirmed by co-immunoprecipitation. RESULTS: Using the yeast two-hybrid system, we found 6 proteins that interacted with midkine: NK-kappa-B inhibitor alpha (I-κ-B-α), Dvl-binding protein naked cuticle 2, granulin, latent active TGF-β binding protein 3, latent active TGF-β binding protein 4, and phospholipid scramblase 1. In vitro co-immunoprecipitation demonstrated that all identified proteins directly interacted with midkine.CONCLUSION: The identification of midkine-interacting proteins in hepatic cancer cells indicates that midkine is a multifunctional factor that may participate in cell migration, differentiation, and proliferation, and is also associated with the multicellular response feedback during the development of hepatocellular carcinoma. | Qiang Yan, Hui-Lian Huang, Xing Yao, Jing Li, Li-Qin Li, Jing Zhong, Li-Shan Min, Li-Cheng Dai and Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery, Huzhou Central Hospital (Yan Q and Yao X) Huzhou Key Laboratory of Molecular Medicine, Affiliated Central Hospital of Huzhou Teachers College (Huang HL, Li J, Li LQ, Zhong J, Min LS and Dai LC), Huzhou 313000, China Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Yan Q and Zheng SS) | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 7 |
| 5 | Expression analysis of a-smooth muscle actin and tenascin-C in the periodontal ligament under orthodontic loading or in vitro culture显示文摘α-smooth muscle actin(α-SMA) and tenascin-C are stress-induced phenotypic features of myofibroblasts. The expression levels of these two proteins closely correlate with the extracellular mechanical microenvironment. We investigated how the expression of α-SMA and tenascin-C was altered in the periodontal ligament(PDL) under orthodontic loading to indirectly reveal the intrinsic mechanical microenvironment in the PDL. In this study, we demonstrated the synergistic effects of transforming growth factor-β1(TGF-β1) and mechanical tensile or compressive stress on myofibroblast differentiation from human periodontal ligament cells(h PDLCs). The h PDLCs under higher tensile or compressive stress significantly increased their levels of α-SMA and tenascin-C compared with those under lower tensile or compressive stress. A similar trend was observed in the tension and compression areas of the PDL under continuous light or heavy orthodontic load in rats. During the time-course analysis of expression, we observed that an increase in α-SMA levels was matched by an increase in tenascin-C levels in the PDL under orthodontic load in vivo. The time-dependent variation of α-SMA and tenascin-C expression in the PDL may indicate the time-dependent variation of intrinsic stress under constant extrinsic loading. | Hui Xu Ding Bai L-Bruno Ruest Jian Q Feng Yong-Wen Guo Ye Tian Yan Jing Yao He Xiang-Long Han | 2015 | International Journal of Oral Science2015，7，4： | 5 |
| 6 | FAILURE ANALYSIS OF PEELING PROCESS FOR TITANIUM ANODES COATINGS显示文摘FAILUREANALYSISOFPEELINGPROCESSFORTITANIUMANODESCOATINGSTangDian;ChenShiren(InstituteforMaterialsResearch,FuzhouUniversity,Fu... | Tang, DA Chen, SR Lin, XA Cui, X Yan, Q | 1995 | 中国有色金属学会会刊:英文版1995，5，4： | 3 |
| 7 | First-Principles Study of Phase Stability and Mechanical Property of Co_3(Al,W) Precipitates with Different Ratio of Al to W in Co Base Alloys显示文摘The energetics, electronic structure and mechanical property of Co3(Al,W) precipitates with different ratio of Al to W in Co base alloys were investigated by the method of supercell and augmented plane waves plus local orbitals within generalized gradient approximation. The calculated results show that the L12 Co3(Al,W) precipitate is the most stable when the ratio of Al to W is equal to 1. When the content of W is higher than 18.5 at%, the L12 and hexagonal structures co-exist in Co3(Al,W) precipitates at 1173 K. It is also shown that the L12 ordered Co3(Al,W) precipitates have an obvious strengthening effect in the disordered fcc cobalt matrix. | Yao Q Su X M Yan Y Zhao L W Sun J | 2009 | 稀有金属材料与工程2009，38，A03： | 3 |
| 8 | Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages显示文摘 | Liu,YJ Lu,SH Xu,B Yang,RC Ren,Q Liu,B Lu,M Yan,FY Han,ZB Han,ZC | 2005 | 中国生物学文摘2005，19，3： | 2 |
| 9 | Application of metamaterials to ultra-thin radar-absorbing material design显示文摘 | Gao Q Yin Y Yan D B | | 0，，17： | 2 |
| 10 | 卫星专用传感器微波成像仪/探测仪(SSMIS)观测资料在天气和气候研究中的应用(英文)显示文摘2003年10月18日,美国国防气象卫星计划成功发射搭载了专用传感器微波成像仪/探测仪的F-16卫星。然而由于天线自身热辐射和校准暖黑体的不稳定,第一个专用传感器微波成像仪/探测仪出现了一些重要的异常观测。美国海军实验室与美国国家海洋和大气管理局(NOAA)分别开发了两种算法来订正这些异常值。剔除了定标异常值后,专用传感器微波成像仪/探测仪资料目前在探空数据产品反演和资料同化中发挥了更加显著的作用。NOAA利用专用传感器微波成像仪已有算法生成了专用传感器微波成像仪/探测仪成像仪产品。此外,一些新开发的算法可以从专用传感器微波成像仪/探测仪资料中提取出云和降水的信息。在云冰云水的反演算法中,亮温是与云冰云水路径和粒子的平均直径相关的。利用一维变分反演系统,同时反演出了多数大气和地表条件下的大气温度、湿度以及水凝物的垂直廓线。在各种天气形势下,由专用传感器微波成像仪/探测仪资料反演得到的温度和湿度廓线的均方根误差通常分别小于2K和15%。为了同化专用传感器微波成像仪/探测仪资料,还发展了新的质量控制和偏差订正方法。在NOAA的全球预报系统中同化了专用传感器微波成像仪/探测仪资料后,对提高全球中期数值预报水平产生了中性和较小的正效果。 | Weng F Zou X Yan B Han Y Liu Q | 2011 | 气象科技进展2011，1，1： | 2 |
| 11 | The biological responses of axotomized adult motoneurons to brain-derived neurotrophic factor显示文摘 | Yan Q Matheson C Lopez OT | 1994 | J Neurosci1994，14，9： | 2 |
| 12 | Aurora C is directly associated with Survivin and required for cytokinesis 显示文摘 | Yan X Cao L Li Q | 2005 | Genes Cells2005，10，6： | 1 |
| 13 | Recent progress in studies on pharmacological activity of Perilla frutescens oil显示文摘 | Yan X Y Wang Y Q | 2000 | Shi-zhen Chin Med Drug2000，11，3： | 1 |
| 14 | Effects of static magnetic field on bone formation of rat femurs 显示文摘 | Yan Q C Tomita N Ikada Y | 1998 | Medical Engineering and Physics1998，20，： | 1 |
| 15 | Apoptosis in the ocular lens: role in development and pathogenesis 显示文摘 | Yan Q Liu JP Li DW | 2006 | Differentiation2006，74，5： | 1 |
| 16 | Integrated magnetic full wave converter with flexible output inductor显示文摘 | Liang Yan Dayu Q Lehman B | 2003 | IEEE Transactions on Power Electronics2003，18，2： | 1 |
| 17 | Genetic polymorphism of Malus sieversii populations in Xinjiang, China 显示文摘 | Yan G R Long H Song W Q | 2008 | Genet Resour Crop Evol2008，，55： | 1 |
| 18 | Early inhibition of HIF-1alpha with small interfering RNA reduces ischemic-reperfused brain injury in rats显示文摘 | Chen C Hu Q Yan J | 2009 | Neurobiol Dis2009，33，3： | 1 |
| 19 | Construction and co-expression of a polycistronic plasmid encoding carbonyl reductase and glucose dehydrogenase for production of ethyl (S)-4-chloro- 3-hydroxybutanoate显示文摘 | Ye Q Cao H Yan M | 2010 | Bioresour Technol2010，101，17： | 1 |
| 20 | Elevated levels of serum soluble E - selectin in patients with chronic hepatitis B : Correlation with T lymphocyte subsets, NK cells and liver inflammation显示文摘 | Yan MX Mao HT Liu Q | 2006 | Hepatol Res2006，35，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员