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| 1 | Mechanistic links between gut microbial community dynamics, microbial functions and metabolic health显示文摘Gut microbes comprise a high density, biologically active community that lies at the interface of an animal with its nutritional environment. Consequently their activity profoundly influences many aspects of the physiology and metabolism of the host animal. A range of microbial structural components and metabolites directly interact with host intestinal cells and tissues to influence nutrient uptake and epithelial health. Endocrine, neuronal and lymphoid cells in the gut also integrate signals from these microbial factors to influence systemic responses. Dysregulation of these host-microbe interactions is now recognised as a major risk factor in the development of metabolic dysfunction. This is a two-way process and understanding the factors that tip host-microbiome homeostasis over to dysbiosis requires greater appreciation of the host feedbacks that contribute to regulation of microbial community composition. To date, numerous studies have employed taxonomic profiling approaches to explore the links between microbial composition and host outcomes(especially obesity and its comorbidities), but inconsistent host-microbe associations have been reported. Available data indicates multiple factors have contributed to discrepancies between studies. These include the high level of functional redundancy in host-microbiome interactions combined with individual variation in microbiome composition; differences in study design, diet composition and host system between studies; and inherent limitations to the resolution of r RNA-based community profiling. Accounting for these factors allows for recognition of the common microbial and host factors driving community composition and development of dysbiosis on high fat diets. New therapeutic intervention options are now emerging. | Connie WY Ha Yan Y Lam Andrew J Holmes | 2014 | World Journal of Gastroenterology2014，20，44： | 4 |
| 2 | Can the rat donor liver tolerate prolonged warm ischemia?显示文摘INTRODUCTIONThe last two decades of the twentieth century havewitnessed increasingly successful rates of livertransplantation.The number of liver transplantations hasincreased steadily while the number of organ donors | Yan JQ Li HW Cai WY Zhang MJ Yang WP | 2000 | World Journal of Gastroenterology2000，6，4： | 3 |
| 3 | Overexpression of CDX2in gastric cancer cells promotes the development of multidrug resistance显示文摘 | Yan LH Wei WY Cao WL | 2015 | Am J Cancer Res2015，5，1： | 1 |
| 4 | Prevalence of diabetes among men and women in China显示文摘 | Yan WY Lu JM Weng JP | | 0，，12： | 1 |
| 5 | Chemical constituents of plants from the genus Paris显示文摘 | Wei JC Gao WY Yan XD | 2014 | Chemistry&Biodiversity2014，11，9： | 1 |
| 6 | Standardized ultrasound hepatic/renal ratio and hepatic attenuation rate to quantify liver fat content: animprovement method 显示文摘 | Xia MF Yan HM He WY | 2012 | Obesity2012，20，2： | 1 |
| 7 | Functional electrical stimulation improves motor recovery of the lower extremity and walking ability of subjects with first acute stroke:a randomized placebo-controlled trial显示文摘 | Teibin Yan Christina WY HUI-Chan | | 0，，01： | 1 |
| 8 | Standardized ultrasound hepatic/re- nal ratio and hepatic attenuation rate to quantify liver fat content: an improvement method显示文摘 | Xia MF Yan HM He WY | 2012 | Obosity (Silver Spring)2012，20，2： | 1 |
| 9 | Facile Synthesis of trans-3,4-Diol Derivatives of Substituted Chromans via Catalytic Epoxidation显示文摘A praedcal opthesis of trans-3,4-aiol derivatives of subnituted chromans via epoxidation with combined use of mangenese (III) salen complex 3 and hydrgen perokide has been developed. These diol derivatives are key intermediates for the syntheis of a series of biologicallimportant chroman compounds. | Sun, HB Yan, Z Hua, WY Huang, WL Peng, SX | 1997 | Chinese Chemical Letters1997，8，1： | 1 |
| 10 | Standardized ultrasound hepatic/renal ratio and hepatic attenuation rate to quantify liver fat content:an improvement method显示文摘 | Xia MF Yan HM He WY | 2012 | Obesity2012，20，2： | 1 |
| 11 | Suppression of liver regener- ation affects hepatic graft survival in small-for-size liver transplan- tation in rats显示文摘 | Fu WY Yan JQ Shi MM | 2013 | Hepatol Res2013，43，3： | 1 |
| 12 | Experience of endoscopic thyroidectomy显示文摘 | BAO YY YAN B ZHU WY | 2004 | Journal of Tongji University Medical Science2004，25，4： | 1 |
| 13 | Standardized ultrasound he- patic/renal ratio and hepatic attenuation rate to quantify liver fat content: all improvement method显示文摘 | Xia MF Yan HM He WY | 2012 | Obesity ( Silver Spring)2012，20，2： | 1 |
| 14 | Estimating parameters of synchronous generators using square-root unscented kalman filter显示文摘 | Huang M Li WY Yan W | | 0，，09： | 1 |
| 15 | Standardized ultrasound hepat- ic/renal ratio and hepatic attenuation rate to quantify liver fat content:an improvement method 显示文摘 | Xia MF Yan HM He WY | 2012 | Obesity2012，20，2： | 1 |
| 16 | Functional electrical stimulation improves motor recovery of the lower extremity and walking ability of subjects with first acute stroke显示文摘 | Tiebin Yan Christina WY Leonard SW | 2005 | Stroke2005，36，： | 1 |
| 17 | Cardiac oxidative stress and re- modeling following infarction:Role of NADPH Oxidase显示文摘 | Zhao WY Zhao D Yan R | 2009 | Cardio- vasc Pathol2009，18，3： | 1 |
| 18 | RNA interference targeting VP1 inhibits foot-and-mouth disease virus replication in BHK-21 cells and suckling mice显示文摘 | Chen WZ Yan WY Du QY | 2004 | J Virol2004，78，13： | 1 |
| 19 | Standardized ultrasound hepatic/renal ratio and hepatic attenuation rate to quantify liver fat content: an improvement method 显示文摘 | Xia MF Yan HM He WY | 2012 | Obesity2012，20，： | 1 |
| 20 | Prevalence of diabetes a- mong men and women in China显示文摘 | Yan WY Lu JM Weng JP | 2010 | N Engl J Med2010，362，11： | 1 |
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