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| 1 | Efficacies of β-L-D4A against Hepatitis B virus in 2.2.15 cells显示文摘AIM:To investigate the antiviral effect of beta-L-enantiomer of 2',3'-didehydro-2',3'-dideoxyadenosine (β-L-D4A) on 2.2.15 cells transfected with the hepatitis B virus (HBV) genome. METHODS:Lamivudine (3TC) as a positive control. Then, HBV DNA in treated 2.2.15 cells and the Hepatitis B surface antigen (HBsAg) in the culture supernatants were detected to determine the inhibitory effect of β-L-D4A. At the same time, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) was used to detect the survival ratio of 2.2.15 cells. RESULTS:β-L-D4A has a dose-dependent inhibitory effect on HBV DNA replication;this effect was apparent when the concentration was above 1 mol/L. When β-L-D4A was at the highest concentration, 100 mol/L, the HBsAg inhibition ratio was above 50%. The Therapeutic index (TI) of β-L-D4A was above 2.1. CONCLUSION:β-L-D4A has a dose-dependent inhibitory effect on the replication of HBV DNA and the secretion of HBsAg at low toxicity. | Lin-Lin Gao, Xiao-Yan Wang, Ju-Sheng Lin, Ying-Hui Zhang, Yan Li, Institute of Liver Diseases, Tongji Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China Author contributions:Gao LL and Wang XY contributed equally to this work Gao LL, Wang XY, Lin JS, Zhang YH, Li Y designed the research Gao LL and Wang XY performed the research Gao LL wrote the paper | 2008 | World Journal of Gastroenterology2008，14，8： | 7 |
| 2 | Giant magneto-impedance effects in nanocrystalline soft magnetic alloy ribbons显示文摘SINCE the discovery of the giant magneto-impedance (GMI) effects in amorphous wire (or rib-bon) of CoFeSiB and nanocrystalline wire (or film) of FeCuNbSiB, it has attracted greatattention due to its promising potential applications in industry. Amorphous (and nanocrys-talline) soft magnetic alloys have very large magnetic permeability, when an ac driving currentand an external magnetic field (EMF) are applied, the EMF will damp the magnetic fluxchange caused by the ac driving current, thus the magnetic permeability will decrease; as a re- | Ku, WJ Ge, FD Yan, G Wang, XY Zhu, J | 1997 | Chinese Science Bulletin1997，42，12： | 5 |
| 3 | BML - 111, a lipoxin receptor agonist, protected carbon tetrachloride - induced hepatic fibrosis in rats显示文摘 | Zhou XY Yu ZJ Yan D | 2013 | Inflammation2013，36，5： | 1 |
| 4 | Activation of NMDA receptors and L-type voltage-gated calcium channels mediates enhanced formation of fyn-PSD95-NR2A complex after transient brain ischemia显示文摘 | Hou XY Zhang GY Yan JZ | 2002 | Brain Res2002，955，： | 1 |
| 5 | Overexpression of ZNF217 in glioblastoma contributes to the maintenance of glioma stein cells regulated by hypoxia-inducible factors显示文摘 | Mao XG Yan M Xue XY | 2011 | Lab Invest2011，91，7： | 1 |
| 6 | Activation of NMDA receptors and L- type voltage - gated calcium channels mediates enhanced formation of Fyn - PSD95 - NR2A complex after transient brain ischemia显示文摘 | Hou XY Zhang GY Yan JZ | 2002 | Brain Res2002，955，12： | 1 |
| 7 | Spatial and temporal variation of inorganic nitrogen wet deposition to the Yangtze River Delta Region,China显示文摘 | Zhao X Yan XY Xiong ZQ | | 0，，： | 1 |
| 8 | Identification and characterization of two novel variants of the DUF1208 protein FAM92A1 显示文摘 | Ruan XZ Yan F Zhao XY | 2007 | Mol Ceils2007，23，3： | 1 |
| 9 | Study of the correlation of imipenem resistance with efflux pumps AdeABC,AdeIJK,AdeDE and AbeM in clinical isolates of Acinetobacter baumannii显示文摘 | Hou PF Chen XY Yan GF | 2012 | Chemotherapy2012，58，2： | 1 |
| 10 | Overexpression of ZNF217 inglioblastoma contributes to the maintenance of glioma stem cellsregulated by hypoxia-inducible factors显示文摘 | Mao XG Yan M Xue XY | 2011 | Lab Invest2011，91，7： | 1 |
| 11 | Long-term manure and fertilizer effects on soil organic matter fractions and microbes under a wheat-maize cropping system in northern China显示文摘 | Gong W Yan XY Wang JY | 2009 | Geoderma2009，149，： | 1 |
| 12 | Expression of Toll-like receptor (TLR) 2 and TLR4 in the livers of miceinfected by Clonorchis sinensis显示文摘 | Yan C Li XY Li B | 2015 | J InfectDevCtries2015，299，10： | 1 |
| 13 | A novel anti-CD146 monoclonal antibody,AA98,inhibits angiogenesis and tumor growth显示文摘 | Yan XY Lin Y Yang DL | 2003 | Blood2003，102，： | 1 |
| 14 | Horizontal transmission of rhesus monkey rotavirus-based quadrivalent vaccine during a phase 3 clinical trial in Caracas, Venezuela 显示文摘 | Hoshino Y Wagner M Yan XY | 2003 | J Infect Dis2003，187，5： | 1 |
| 15 | Cavitation erosion and corrosion behavior of copper-manganese-aluminum alloy weldment 显示文摘 | Li XY Yan YG Ma L | 2004 | Materials Science and Engineering A2004，382，： | 1 |
| 16 | Identification of synthetic peptides that inhibitlipopolysaccharide (LPS) binding to myeloid differentiationProtein-2 (MD-2)显示文摘 | Yan H Gu CG Xu FL Wu XH Yin HH Hu CX ZhuXD Liu F Ge HJ Chen LY Zhang XY Wang ZG XingZ Li L | 2013 | J Immunotherapy2013，36，3： | 1 |
| 17 | Overexpression of ZNF217 in glioblastoma contributes to the maintenance of glioma stem ceils regulated by hypoxia-inducible factors 显示文摘 | Mao XG Yan M Xue XY | 2011 | Lab Invest2011，91，7： | 1 |
| 18 | A combinatorial approach to detecting gene gene and gene-environment interactions in family studies显示文摘 | Lou XY ('hen GB Yan L | 2008 | The American Journal of Human Genet ics2008，83，4： | 1 |
| 19 | Epidemiology of community pre - hypertensive patients and related risk factors in Chengdu city 显示文摘 | Chen XY Yan YF Qin F | 2014 | Fam Med Community Health2014，1，3： | 1 |
| 20 | MicroRNA regulation associated chondrogenesis of mouse MSCs grown on polyhydroxyalkanoates显示文摘 | Yan C Wang Y Shen XY | 2011 | Biomaterials2011，32，27： | 1 |
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