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| 1 | An essential role for TAK1 in the contact hypersensitivity response显示文摘Contact hypersensitivity(CHS)is a delayed-type hypersensitivity that can be induced by haptens,such as 2,4-dinitrofluorobenzene(DNFB).Innate and adaptive immunities are both important for the development of CHS.To treat CHS-related diseases,such as allergic contact dermatitis,a disease prevalent in industrialized countries,ways of interfering with improper immune function during CHS responses need to be identified.Transforming growth factor-b-activated kinase-1(TAK1),a member of mitogen-activated protein kinase kinase kinase family,is important for both innate and adaptive immunities.We thus hypothesized that the CHS response could be inhibited by interfering with TAK1 activity.Using a mouse model in which TAK1 deletion can be locally induced,we observed that TAK deficiency led to an impaired CHS response and was associated with defective T-cell expansion,activation and interferon(IFN)-c production.In addition,we investigated the effect of deleting TAK1 specifically in dendritic cells(DC)on the CHS response.We found that when TAK1 is deficient in DC,the CHS response was abolished and hapten-elicited T-cell responses were defective.Collectively,this study demonstrates an essential role of TAK1 in the induction of CHS and suggests that targeting TAK1 could be a viable approach to treat CHS. | Yan G Zhao Yunqi Wang Weidong Hao Yisong Y Wan | 2011 | Cellular & Molecular Immunology2011，8，4： | 4 |
| 2 | Methane and nitrous oxide emissions from rice paddy fields as affected by nitrogen fertilisers and water management显示文摘 | Cai Z C Xing G X Yan X Y | 1997 | Plant Soil1997，196，： | 1 |
| 3 | Comparison of efficacy of selamectin, ivermectin and mebendazole for the control of gastrointestinal nematodes in rhesus macaques, China显示文摘 | WANG T YANG G Y YAN H J | 2008 | Vet Parasitol2008，153，12： | 1 |
| 4 | Joule heating and its effects on electrokinetic transport of solutes in rectangular microchannels显示文摘 | TANG G Y YAN D G | 2007 | Sensors and Actuators A:Physical2007，139，： | 1 |
| 5 | Digital nuclear magnetic resonance spectrometer显示文摘 | Li Y G Jiang Y Yan X L | 2001 | Rev Sci Instrum2001，72，： | 1 |
| 6 | Determination of near coincident site lattice orientation in MgO/Cu composite显示文摘 | Wang Y G Zhang Z Yan G H | 2002 | Journal of Materials Science2002，37，： | 1 |
| 7 | Methane and nitrous oxide emissions from rice paddy fields as affected by nitrogen fertilizers and water management显示文摘 | Cai Z C Xing G X Yan X Y | 1997 | Plant and Soil1997，196，1： | 1 |
| 8 | Thermodynamics of interaction between cationic gemini surfactants and hydrophobically modified polymers in aqueous solutions 显示文摘 | Bai G Wang Y Yan H | 2002 | JPhys Chem B2002，106，9： | 1 |
| 9 | The effect of electric field, annealing temperature and filler loading on the percolation threshold of polystyrene containing carbon nanotubes and graphene nanosheets 显示文摘 | Pang H Chen C Zhang Y C Ren P G Yan D X Li Z M | 2011 | Carbon2011，49，6： | 1 |
| 10 | Comparison of the effects of nitrigen on removal,growth and some physiological characteristics of immobilizedand freeChlorells Vulgaris:I Growth and nutrient removal显示文摘 | YAN G A YU J Y | 1997 | Toxicological andEnvironmental Chemistry1997，58，： | 1 |
| 11 | Sesquiterpenoids fromIncarvillea arguta: absolute configuration and biologicalevaluation 显示文摘 | Yan Y M Wu G S Dong X P | 2012 | J Nat Prod2012，75，6： | 1 |
| 12 | Chemical analysis of Astragalus mongholicus polysaccharides and antiox- idant activity of the polysaccharides 显示文摘 | YAN H XIE Y P SUN S G | 2010 | Carbohydrate Polymers2010，82，3： | 1 |
| 13 | High Critical Current Density in Ti-Doped MgB2/Ta/Cu Tape by Powder-in-Tube Process显示文摘 | Fu B Q Feng Y Yan G | | 0，，12： | 1 |
| 14 | Enhancement of the light output power of InGaN/GaN lightemitting diodes grown on pyramidal patterned sapphire substrates in the micro-and nanoscale显示文摘 | Gao H Y Yan F W Zhang Y Li J M Zeng Y P Wang G H | | 0，，01： | 1 |
| 15 | Effects of Yb3+on the corrosion resistance and deposition rate of electroless Ni-P deposits显示文摘 | Yan M Ying H G Ma T Y | 2008 | Applied Surface Science2008，255，5： | 1 |
| 16 | The performances of BMI nanocomposites filled with nanometer SIC显示文摘 | Yan H X Ning R C Liang G Z Ma X Y | 2005 | Journal of Applied Polymer Science2005，95，5： | 1 |
| 17 | iang H, et al, 显示文摘 | Yan Y G Chen Y G I | | J Alloys Compd0，，： | 1 |
| 18 | 显示文摘 | YAN Z Y XING G M LI Z X | 2004 | Microchim Acta2004，144，： | 1 |
| 19 | High-resolution thermogravimetric analysis of poly( trimethylene terephthalate) with different molecular weights显示文摘 | Wang X S Li X G Yan D Y | 2001 | Polym Test2001，20，5： | 1 |
| 20 | Applying improved fast marching method to endocardial boundary detection in echocardiographic images显示文摘 | YAN J Y ZHUANG T G | 2003 | Pattern Recognition Letters2003，24，15： | 1 |
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