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| 1 | Inhibitory effects of RRR-α-tocopheryl succinate on benzo (a) pyrene (B (a) P)-induced forestomach carcinogenesis in female mice显示文摘AIM To study the inhibitory effects of VES( RRR-α-tocopheryl Succinate, VES ), aderivative of natural Vitamin E, on benzo (a)pyrene (B (a) P)-induced forestomach tumor infemale mice.METHODS The model of B (a)P-inducedforestomach tumor was established according tothe methods of Wattenberg with slightmodifications. One hundred and eighty femalemice (6 weeks old) were divided into six groupsequally; negative control (Succinic acid),vehicle control ( Succinate + B (a) P), positivecontrol(B(a) P), high VES(2.5g/kg. b. w + B(a)P), Iow VES(1 .25 g/kg. b. w + B(a) P) ig as wellas VES by ip (20 mg/kg, b. w + B(a) P). Exceptthe negative control group, the mice wereadministrated with B(a)P ig. and correspondingtreatments for 4 weeks to study the anti-carcinogenetic effect of VES during the initiationperiod. The experiment lasted 29 weeks, inwhich the inhibitory effects of VES both ontumor incidence and tumor size were tested.RESULTS The models of B (a)P-inducedforestomach tumor in female mice wereestablished successfully. Some werecauliflower-like, others looked like papilla, evena few were formed into the ulcer cavities. VES at1.25 g/kg. b. w, 2.5 g/kg. b.w. by ig and 20 mg/kg. b. w. via ip could decrease the number oftumors per mouse (1.7 ± 0. 41, 1.6 ± 0.34 and 1.1±0.43), being lower than that of B(a)P group(5.4 ± 0.32, P<0.05). The tumor incidence wasinhibited by 18.2%, 23.1% and 50.0%. VES at1.25g/kg.b.w., 2.5 g/ kg.b.w. by ig and20 mg/kg. b.w. via ip reduced the total volumeof tumors per mouse (54.8 ± 8.84, 28.4 ± 8.32and 23.9± 16.05), being significantly lower thanthat of B(a)P group (150.2±20.93, P<0.01).The inhibitory rates were 63.5%, 81.1% and84.1%, respectively.CONCLUSION VES has inhibitory effects on B(a) P-induced forestomach carcinogenesis infemale mice, especially by ip and it may be apotential anti-cancer agent in vivo. | Kun Wu1 Yu Juan Shan1 Yan Zhao1 Jian Wu Yu2 Bai He Liu1 1Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150001, Heilongjiang Province, China2The Second Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang Province, China | 2001 | World Journal of Gastroenterology2001，7，1： | 24 |
| 2 | Synthesis and Biological Activities of N-Phosphoryl Branched Peptides显示文摘A series of N-phosphoryl branched peptides were synthesized by coupling of various N-phosphoryl amino acids to L-Lysine methyl ester, and their structures were confirmed by 31P NMR, 1H NMR, MS and elemental analysis. The results of cell biological tests indicated that compound 1d and 1e obviously inhibited the growth of both K562 and A2780 cells. | Sheng Li CAO1,2, Yu Yang JIANG1, Yu Ping FENG1, Yan Ling NIU1, Yu Fen ZHAO1* 1Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education Department of Chemistry, Tsinghua University, Beijing 100084 2Department of Chemistry, Capital Normal University, Beijing 100037 | 2003 | Chinese Chemical Letters2003，14，4： | 1 |
| 3 | Saikosaponin v-2 from Bupleurum chinense显示文摘Saikosaponin v-2(1), was isolated from the roots of the title plant and the structure was identified on the basis of spectral analysis. Saikosaponin v-2 is a new compound, which was identified as 3(,16(,23,28-tetrahydroxy-olean-11,13(18)-dien-30-oic acid-3-O-(-D-glucopyrano- syl-(1?2)glucopyranosyl-(1?3)-(-D-fucopyranosyl-30-O-xylitol ester. | Hong LIANG1, Yan Jun CUI1, Yu Ying ZHAO1*, Bin WANG1, Wen Xiu YANG2, Yi YU2 1Department of Natural Medicines, Peking University, Beijing 100083 2Department of Biophysical Science and Technology, Tianjin university, Tianjin 300071 | 2001 | Chinese Chemical Letters2001，12，4： | 0 |
| 4 | Hydrolysis of Dipeptide Heptyl Esters with Newlase F显示文摘Newlase F is a rude enzyme which contains triacylglycerol lipase and acid protease. Hydrolysis of dipeptide heptyl esters with Newlase F was studied in phosphate buffer-organic solvent by HPLC. When the Newlase F’s level reached 5 mg/mL under mild condition (pH 7.0, 30(C), the lipase had the highest activity. The reaction was also affected greatly by organic solvents and their concentrations. It is found that protease in Newlase F does not hydrolyze amide bond under this condition (pH 7.0, r.t.). | Zhong Zhou CHEN1, Yan Mei LI1*, Xiu Fen KOU2, Xue LI1, Fu Rong HUANG1, Hai Yan WANG1, Ming Ming MA1, Yu Fen ZHAO1 1Key Laboratory for Bioorganic Phosphorus Chemistry of Education Ministry, Department of Chemistry, School of Life Science and Engineering, | 2001 | Chinese Chemical Letters2001，12，8： | 0 |
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