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| 1 | Contrasting trends of PM2.5 and surface-ozone concentrations in China from 2013 to 2017显示文摘Although much attention has been paid to investigating and controlling air pollution in China,the trends of air-pollutant concentrations on a national scale have remained unclear.Here,we quantitatively investigated the variation of air pollutants in China using long-term comprehensive data sets from 2013 to 2017,during which Chinese government made major efforts to reduce anthropogenic emission in polluted regions.Our results show a significant decreasing trend in the PM2.5 concentration in heavily polluted regions of eastern China,with an annual decrease of〜7%compared with measurements in 2013.The measured decreased concentrations of SO2>NO2 and CO(a proxy for anthropogenic volatile organic compounds)could explain a large fraction of the decreased PM2.5 concentrations in different regions.As a consequence;the heavily polluted days decreased significantly in corresponding regions.Concentrations of organic aerosol;nitrate;sulfate,ammonium and chloride measured in urban Beijing revealed a remarkable reduction from 2013 to 2017;connecting the decreases in aerosol precursors with corresponding chemical components closely.However;surface-ozone concentrations showed increasing trends in most urban stations from 2013 to 2017;which indicates stronger photochemical pollution.The boundary-layer height in capital c让ies of eastern China showed no significant trends over the Beijing-Tianjin-Hebei,Yangtze River Delta and Pearl River Delta regions from 2013 to 2017;which confirmed the reduction in anthropogenic emissions.Our results demonstrated that the Chinese government was successful in the reduction of particulate matter in urban areas from 2013 to 2017,although the ozone concentration has increased significantly;suggesting a more complex mechanism of improving Chinese air quality in the future. | Yonghong Wang Wenkang Gao Shuai Wang Tao Song Zhengyu Gong Dongsheng Ji Lili Wang Zirui Liu Guiqian Tang Yanfeng Huo Shili Tian Jiayun Li Mingge Li Yuan Yang Biwu Chu Tuukka Petaja Veli-Matti Kerminen Hong He Jiming Hao Markku Kulmala Yuesi Wang Yuanhang Zhang | 2020 | National Science Review2020，7，8： | 51 |
| 2 | Property theory of Chinese materia medica: Clinical pharmacodynamics of traditional Chinese medicine显示文摘The property theory of Chinese materia medica is one of the foundations of traditional Chinese medicine.The property of Chinese materia medica(PCMM)is a multi-dimensional expression of the effect of Chinese materia medica(CMM),and it is related to the clinical prescription that fully reflects the clinical effect evaluation of CMM in a holistic,systematic,and scientific way.This paper discusses the source,development,and application of the PCMM by considering not only the five dimensions that constitute the PCMM but also the recognition of the human body and disease as given in traditional Chinese medicine.This paper aims to provide theoretical guidance for the rational use and development of CMM. | Yanjiang Qiao Yanling Zhang Sha Peng Mengqi Huo Jing Li Yanfeng Cao Zhao Chen | 2022 | Journal of Traditional Chinese Medical Sciences2022，9，1： | 2 |
| 3 | Influence of shear on polypropylene crystallization kinetics显示文摘 | Huo Hong Meng Yanfeng Li Hongfei | 2004 | Eur Phys J E2004，15，2： | 1 |
| 4 | Association study of SNPs related sex steroid hormone of genes and digit ratio显示文摘Using bioinformatics methods,44 functional SNPs of 21 steroid sex hormone genes potentially related to the formation of digit ratio were selected.In our study,the relationship between 2D:4D and the above SNPs genotyped by using multiple PCR method was evaluated in a Ningxia population(400 men and 408 women). | Dang Jie Zhang Jing Lu Hong Yang Menyi Luan Pengfei Ma Zhanbin Ma Qian Wang Yanfeng Huo Zhenghao | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 5 | Association study of SNPs related finger bone development and digit ratio显示文摘Using bioinformatics methods,79 functional SNPs of 44 finger bone development genes potentially related to the formation of digit ratio were selected.In our study,the relationship between 2D:4D and the above SNPs genotyped by using multiple PCR method was evaluated in a Ningxia population(400 men and 408 women).L2D:4D was statistically different among different genotypes of rs3809346(COL4A2)in whole population and female;R2D:4D was different among genotypes in the female and the genotype carrying minor allele A had increased R2D:4D in the additive genetic model.L2D:4D was statistically different among rs3825490(COL4A2)in the whole population and male,and L2D:4D of T/T genotype under recessive model was higher than the C/C-T/C genotype.A statistical difference was found in different genotypes of rs7984100(COL4A2)in the whole population.L2D:4D differed among different genotypes for rs1042917(COL6A2).L2D:4D in women was significantly different among rs2839110(COL6A2).L2D:4D in females was different between genotypes of rs755793(FGFR2)gene.R2D:4D was statistically different in genotypes of rs17576(MMP9). | Dang Jie Zhang Jing Lu Hong Yang Menyi Luan Pengfei Ma Zhanbin Ma Qian Wang Yanfeng Huo Zhenghao | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 6 | Validation of the association between 2D:4D and SNPs of genes identified in GWAS显示文摘At present,11 loci have been identified in 2D:4D related GWAS,including rs4927012(GLIS1),rs11581730(EFNA1),rs340600(LDAH),rs12474669(OLA1),rs10790969(FLII),rs847158(HOXD11/12),rs77640775(GLI3),rs2332175(SMOC1),rs6499762(SALL1),rs1080014(TOX3)and rs4799176(SALL3).In our study,the relationship between 2D:4D and the above SNPs genotyped by using multiple PCR method was evaluated in a Ningxia population(400 men and 408 women).L2D:4D of rs340600(LDAH)was significantly different among genotypes in whole population and female;rs10790969(FLI1)was statistically different among genotypes for L2D:4D in the male. | Ma Zhanbin Zhang Jing Dang Jie Lu Hong Yang Menyi Luan Pengfei Ma Qian Wang Yanfeng Huo Zhenghao | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 7 | Sexual difference analysis of finger bone development related SNPs of genes显示文摘DAVID,METASCAPE,STRING and other gene databases was used to screen the finger bone development genes that may be related to the digit ratio;the online genomic SNP database SNPinfo Web Server was applied to select functional SNPs;79 SNPs of 43 steroid sex hormone genes were genotyped by using multiple PCR method in a healthy Ningxia population(400 men and 408 women). | Zhang Jing Yang Menyi Luan Pengfei Ma Qian Wang Yanfeng Ma Zhanbin Dang Jie Lu Hong Huo Zhenghao | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 8 | Sexual difference analysis of steroid sex hormone related SNPs of genes显示文摘Using bioinformatics methods,44 functional SNPs of 21 steroid sex hormone genes potentially related to the formation of digit ratio were selected.The genes were genotyped by using multiple PCR method in a healthy Ningxia population(400 men and 408 women).The recessive model of CYP17A1(rs1004467)gene showed sexual differences.AKR1C3(rs12529)gene showed a significantly lower proportion of C/G genotypes in males than in females under the co-dominant model.GPER1(rs12702047)gene,the recessive model was the genetic model with significant sexual differences. | Zhang Jing Lu Hong Yang Menyi Luan Pengfei Ma Zhanbin Dang Jie Ma Qian Wang Yanfeng Huo Zhenghao | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 9 | Fat distribution characteristics among Hui and Han ethnic of students in Ningxia显示文摘To analyze the body fat distribution characteristics of Hui and Han college students in Ningxia.Using a bioelectrical impedance analyzer connected with computer to determine the body fat distribution of 808 college students(Hui:417,including 197 males and 220 females;Han:391,including 203 males and 188 females)in Ningxia. | Yang Menyi Zhang Jing Ma Zhanbin Dang Jie Lu Hong Luan Pengfei Ma Qian Wang Yanfeng Huo Zhenghao | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 10 | Association between the digit ratio(2D:4D)and body fat distribution in Ningxia population显示文摘Using a bioelectrical impedance method,the body fat distribution characteristics of 808 people(400 males and 408 females)were measured,such as height,weight,body mass index,body fat mass,fat free mass,visceral fat area,soft lean mass,skeletal muscle mass,waist and hip circumference,waist-hip ratio and waist-height ratio. | Yang Menyi Zhang Jing Ma Zhanbin Dang Jie Lu Hong Luan Pengfei Ma Qian Wang Yanfeng Huo Zhenghao | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 11 | Identification of the material basis of the medicinal properties in Curcuma Longa L. to enhance targeted clinical application显示文摘Objective:To identify the relationship between the active compounds in turmeric(Curcuma Longa L.,C.Longa)and their medicinal properties,and clarify the chemical material basis of the medicinal properties in C.Longa.Methods:High throughput screening models of the thermo-transient receptor potentials(thermo-TRPs)and human taste type 2 receptors(hTAS2Rs)were established to evaluate the activity of the active compounds in C.Longa.The biological processes and distributions of the related targets of the active compounds were acquired by data mining.The above results were then used as basic data to comprehensively analyze the material basis of the medicinal properties of turmeric.Results:Curcumin inhibited TRPV1,TRPV2,TRPV3,and TRPA1,while demethoxycurcumin(DMC)inhibited TRPV3,TRPA1,and TRPM8.In terms of the 21 hTAS2Rs,the response values of hTAS2R38,hTAS2R16,and hTAS2R44 intervened by curcumin were ranked top three;the response values of hTAS2R3,hTAS2R1,and hTAS2R9 by DMC were in top three;the response values of hTAS2R47,hTAS2R39,and hTAS2R43 by bisdemethoxycurcumin(BDMC)were in top three.The biological processes related to active compounds primarily involved blood circulation,ossification,and regulation of the inflammatory response.Conclusion:Curcumin,DMC,and BDMC were identified as the material basis of the property of Chinese materia medica of C.Longa.Among these,curcumin and DMC may contribute to its warming effect in the four qi.Curcumin,DMC,and BDMC may lead to its bitter flavor,and the three active compounds were consistent with the meridian entry of C.Longa.Although different compounds play diverse roles in the four qi,five flavors,and meridian entry,they all were relevant to the efficacy of C.Longa.It is helpful to further understand the important role of the property of Chinese materia medica for the clinical application of traditional Chinese medicine. | Sha Peng Jing Li Mengqi Huo Yanfeng Cao Zhao Chen Yanling Zhang Yanjiang Qiao | 2022 | Journal of Traditional Chinese Medical Sciences2022，9，4： | 0 |
| 12 | A Differential Optical Absorption Spectroscopy Method for X_(CO_2) Retrieval from Ground-Based Fourier Transform Spectrometers Measurements of the Direct Solar Beam显示文摘A differential optical absorption spectroscopy(DOAS)-like algorithm is developed to retrieve the column-averaged dryair mole fraction of carbon dioxide from ground-based hyper-spectral measurements of the direct solar beam. Different to the spectral fitting method, which minimizes the difference between the observed and simulated spectra, the ratios of multiple channel-pairs—one weak and one strong absorption channel—are used to retrieve XCO2 from measurements of the shortwave infrared(SWIR) band. Based on sensitivity tests, a super channel-pair is carefully selected to reduce the effects of solar lines, water vapor, air temperature, pressure, instrument noise, and frequency shift on retrieval errors. The new algorithm reduces computational cost and the retrievals are less sensitive to temperature and H2 O uncertainty than the spectral fitting method. Multi-day Total Carbon Column Observing Network(TCCON) measurements under clear-sky conditions at two sites(Tsukuba and Bremen) are used to derive XCO2 for the algorithm evaluation and validation. The DOAS-like results agree very well with those of the TCCON algorithm after correction of an airmass-dependent bias. | HUO Yanfeng DUAN Minzheng TIAN Wenshou MIN Qilong | 2015 | Advances in Atmospheric Sciences2015，32，8： | 0 |
| 13 | Discovery of the relationship between bitter taste and bitter flavor (efficacy) based on hTAS2Rs显示文摘Objective:To explore the relationship between bitter taste and bitter flavor(efficacy),their character-istics were analyzed at the target and pharmacodynamic points.Methods:Compounds with bitter receptor activity were obtained by high-throughput screening models of the human bitter taste receptors(hTAS2Rs),which were used to analyze bitter taste.The efficacy of anti-asthma medications was used as an example to research bitter flavor(efficacy).The pharmacological effects of bitter taste and bitter flavor(efficacy)were classified according to the functional modules.The coverage for the same targets or pharmacological effects in the overall protein interaction network(PIN)of bitter taste and bitter flavor(efficacy)was analyzed to reveal their relationship.The effect of the compound polydatin with anti-asthma activation on hTAS2R14 was studied to verify the reliability of the aforementioned idea.Results:A total of 121 Chinese materia medica(CMM)compounds that activate hTAS2R10,hTAS2R14,and hTAS2R49 were obtained.The analysis results indicated that 108 same targets for bitter taste and bitter flavor(efficacy)were obtained,accounting for 13.9%in the PIN of bitter taste and 72.5%in the PIN of bitter flavor(efficacy).The pharmacological effects shared by bitter taste and bitter flavor(efficacy)accounted for 79%of the PIN of bitter taste and 81%of the PIN of bitter flavor(efficacy).The activating effect of the anti-asthma compound polydatin on hTAS2R14 was dose-dependent with EC 50 of 4.3 m M.Conclusion:In this study,the relationship between bitter taste and bitter flavor(efficacy)has been demonstrated from the target and pharmacodynamic points,which are based on hTAS2Rs and anti-asthma effect.Bitter taste and bitter flavor(efficacy)exhibited a high correlation.This study provides a theoretical and scientific basis for the hypothesis that“the property theory of CMM is the clinical pharmacodynamics of CMM.” | Jing Li Sha Peng Mengqi Huo Yanfeng Cao Zhao Chen Yanling Zhang Yanjiang Qiao | 2023 | Journal of Traditional Chinese Medical Sciences2023，10，2： | 0 |
| 14 | Comparison of the clinical effect features of Han-Ku-Gan and Wen-Xin-Gan based on the efficacy of promoting blood circulation and removing blood stasis显示文摘Objective:The application of Chinese materia medica(CMM)in clinical diseases is the embodiment and continuation of the property theory of CMM(PTCMM).However,due to a lack of precise quantitative description methods,it is difficult to systematically analyze the property of CMM(PCMM)and clinical effect features at the micro molecular level.Methods:The therapeutic drugs and targets were obtained from the Drugbank database.The molecular descriptors of these drugs were calculated based on Dragon software.Drug-effect relationships that integrated the molecular descriptors and effect descriptors were plotted as grayscale images.These images were used to train the Le Net-5 model and the Alex Net model.The best-performing model was used to predict the effect features of the CMM compounds.Finally,the effect features of the PCMM combinations were calculated based on the support vector machine recursive feature elimination algorithm.Results:The Alex Net model showed a superior prediction performance.The results showed that its accuracy,precision,sensitivity,F-measure,and Matthews correlation coefficient on the training set were 0.940,0.936,0.945,0.940,and 0.880,respectively,and those of the test set were 0.909,0.901,0.920,0.910,and 0.819,respectively.A total of 399 compounds in the 42 CMMs for promoting blood circulation and removing blood stasis were predicted by this model.The key effect features of the Han-Ku-Gan combination were anti-inflammatory,anti-tumor,anti-atherosclerosis,anti-Parkinson,hypoglycemic,and anti-coagulant properties,as well as excitation of uterine smooth muscle.The key effect features of the Wen-Xin-Gan combination were anti-inflammatory,anti-atherosclerosis,anti-hypertensive,anticoagulant,anti-tumor,and anti-cardiac insufficiency effects,as well as enhanced immunity,sedation and hypnosis,and analgesia.Conclusion:This study provides a new method for the further exploration of the relationship between the PCMM and clinical effect features. | Mengqi Huo Sha Peng Jing Li Yanfeng Cao Zhao Chen Yanling Zhang Yanjiang Qiao | 2022 | Journal of Traditional Chinese Medical Sciences2022，9，3： | 0 |
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