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3篇 您的检索式：作者名="Yang Fangshe"

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		题名	作者	年代	出处	被引量
	1	Simu- lation of sediment retention effects of the single seabuck- thorn flexible dam in Pisha sandstone area 显示文摘	Yang Fangshe Cao Mingming Li Huai'en	2013	Ecological Engineering2013，52，：	1
	2	Simulation of Sediment Retention Effects of the Single Seabuckthorn Flexible Dam in the Pisha Sandstone Area显示文摘	YANG Fangshe CAO Mingming LI Huaien	2013	Ecological Engineering2013，52，：	1
	3	Metabolomic profiles in a green alga (Raphidocelis subcapitata) following erythromycin treatment: ABC transporters and energy metabolism显示文摘A recent study showed that erythromycin(ERY)exposure caused hormesis in a model alga(Raphidocelis subcapitata)where the growth was promoted at an environmentally realistic concentration(4μg/L)but inhibited at two higher concentrations(80 and 120μg/L),associated with opposite actions of certain signaling pathways(e.g.,xenobiotic metabolism,DNA replication).However,these transcriptional alterations remain to be investigated and verified at the metabolomic level.This study uncovered metabolomic profiles and detailed toxic mechanisms of ERY in R.subcapitata using untargetedmetabolomics.Themetabolomic analysis showed that metabolomic pathways including ABC transporters,fatty acid biosynthesis and purine metabolism were associated with growth promotion in algae treated with 4μg/L ERY.An overcompensation was possibly activated by the low level of ERY in algae where more resources were reallocated to efficiently restore the temporary impairments,ultimately leading to the outperformance of growth.By contrast,algal growth inhibition in the 80 and 120μg/L ERY treatments was likely attributed to the dysfunction of metabolomic pathways related to ABC transporters,energy metabolism and metabolism of nucleosides.Apart from binding of ERY to the 50S subunit of ribosomes to inhibit protein translation as in bacteria,the data presented here indicate that inhibition of protein translation and growth performance of algae by ERY may also result from the suppression of amino acid biosynthesis and aminoacyl-tRNA biosynthesis.This study provides novel insights into the dose-dependent toxicity of ERY on R.subcapitata.	Jiezhang Mo Zhihua Ma Shiwei Yan Napo KM Cheung Fangshe Yang Xiunan Yao Jiahua Guo	2023	Journal of Environmental Sciences2023，，2：	0

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