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| 1 | Response of PM_(2.5)-bound elemental species to emission variations and associated health risk assessment during the COVID-19 pandemic in a coastal megacity显示文摘The coronavirus(COVID-19)pandemic is disrupting the world from many aspects.In this study,the impact of emission variations on PM_(2.5)-bound elemental species and health risks associated to inhalation exposure has been analyzed based on real-time measurements at a remote coastal site in Shanghai during the pandemic.Most trace elemental species decreased significantly and displayed almost no diel peaks during the lockdown.After the lockdown,they rebounded rapidly,of which V and Ni even exceeded the levels before the lockdown,suggesting the recovery of both inland and shipping activities.Five sources were identified based on receptor modeling.Coal combustion accounted for more than 70%of the measured elemental concentrations before and during the lockdown.Shipping emissions,fugitive/mineral dust,and waste incineration all showed elevated contributions after the lockdown.The total non-carcinogenic risk(HQ)for the target elements exceeded the risk threshold for both children and adults with chloride as the predominant species contributing to HQ.Whereas,the total carcinogenic risk(TR)for adults was above the acceptable level and much higher than that for children.Waste incineration was the largest contributor to HQ,while manufacture processing and coal combustion were the main sources of TR.Lockdown control measures were beneficial for lowering the carcinogenic risk while unexpectedly increased the non-carcinogenic risk.From the perspective of health effects,priorities of control measures should be given to waste incineration,manufacture processing,and coal combustion.A balanced way should be reached between both lowering the levels of air pollutants and their health risks. | Guochen Wang Kan Huang Qingyan Fu Jia Chen Juntao Huo Qianbiao Zhao Yusen Duan Yanfen Lin Fan Yang Wenjie Zhang Hao Li Jian Xu Xiaofei Qin Na Zhao Congrui Deng | 2022 | Journal of Environmental Sciences2022，34，12： | 2 |
| 2 | Mantle contributions to crustal thickening during continental collision: Evidence from Cenozoic igneous rocks in southern Tibet显示文摘 | Xuanxue Mo Zengqian Hou Yaoling Niu Guochen Dong Xiaoming Qu Zhidan Zhao Zhiming Yang | 2006 | LITHOS2006，，1： | 2 |
| 3 | Test on evaluation method for biodegradability of lubricants显示文摘 | Yang Lihe Zhu Yong Fan Guochen | 2008 | Transactions of Tianjin University2008，14，： | 1 |
| 4 | Comparison between INT and TTC assay to determine the dehydrogenase activity of flocs 显示文摘 | ZHENG Guochen ZHAO Feng YANG Hang | 2011 | Water Resour Environ Prot ( ISWREP)2011，，5： | 1 |
| 5 | Salicylic acid analogues with biological activity may induce chilling toler- ance of maize (Zea mays) seeds 显示文摘 | WANG Yang HU Jin QIN Guochen | 2012 | Botany2012，90，9： | 1 |
| 6 | The first order Freedericksz transition at saturation point for weak anchoring NLC cells 显示文摘 | Yang Guochen Zhang Suhua | 2002 | Liquid Crystals2002，29，： | 1 |
| 7 | SWO1 modulates cell wall integrity under salt stress by interacting with importinɑin Arabidopsis显示文摘Maintenance of cell wall integrity is of great importance not only for plant growth and development,but also for the adaptation of plants to adverse environments.However,how the cell wall integrity is modulated under salt stress is still poorly understood.Here,we report that a nuclear-localized Agenet domain-containing protein SWO1(SWOLLEN 1)is required for the maintenance of cell wall integrity in Arabidopsis under salt stress.Mutation in SWO1 gene results in swollen root tips,disordered root cell morphology,and root elongation inhibition under salt stress.The swo1 mutant accumulates less cellulose and pectin but more lignin under high salinity.RNA-seq and ChIP-seq assays reveal that SWO1 binds to the promoter of several cell wall-related genes and regulates their expression under saline conditions.Further study indicates that SWO1 interacts with importinɑIMPA1 and IMPA2,which are required for the import of nuclear-localized proteins.The impa1 impa2 double mutant also exhibits root growth inhibition under salt stress and mutations of these two genes aggravate the salt-hypersensitive phenotype of the swo1 mutant.Taken together,our data suggest that SWO1 functions together with importinɑto regulate the expression of cell wall-related genes,which enables plants to maintain cell wall integrity under high salinity. | Zhidan Wang Mugui Wang Changhong Yang Lun Zhao Guochen Qin Li Peng Qijie Zheng Wenfeng Nie Chun-Peng Song Huazhong Shi Jian-Kang Zhu Chunzhao Zhao | 2021 | Stress Biology2021，1，1： | 0 |
| 8 | Characteristics of TP53 germline variants and their correlations with Li-Fraumeni syndrome or Li-Fraumeni-like syndrome in Chinese tumor patients显示文摘Li-Fraumeni syndrome(LFS),a rare autosomal-dominant inheritance condition,is associated with a family cancer history as well as pathogenic/likely-pathogenic TP53 germline variants(P/LP TP53 GV).The current clinical methods for detecting LFS are limited.Here,we retrospectively investigate P/LP TP53 GV among Chinese cancer patients by next-generation sequencing and evaluate its relationship with a family cancer history.A total of 270 out of 19,226 cancer patients have TP53 GV,including 53 patients with P/LP TP53 GV.Patients with P/LP TP53 GV are mainly found in male with glioma,lung cancer or sarcoma.The median age of diagnosis for P/LP TP53 GV patients is significantly lower than that of non-P/LP TP53 GV patients(31-years vs.53-years;P<0.01).One LFS patient and 3 Li-Fraumeni-like syndrome(LFL)patients are among the 26 followed-up P/LP TP53 GV patients.Among 25 types of P/LP TP53 GV,the highest variant frequencies occurred at codon 175 and 248.p.M237 I,p.R158 H,p.C238 Y and p.C275 R,are firstly identified among the Chinese LFS/LFL patients.This study reports the(P/LP)TP53 GV characteristics of Chinese pan-cancer patients.These findings suggest analyzing the P/LP TP53 GV in cancer patients is an effective strategy for identifying cancer predisposition syndrome. | Panwen Tian Xiaoyan Zhang Sheng Yang Yu Fang Hongling Yuan Wei Li Honglin Zhu Fangping Zhao Jinlei Ding Yunshu Zhu Sizhen Wang Guochen Sun Hongbin Ni Tonghui Ma Ting Lei | 2022 | Journal of Genetics and Genomics2022，49，7： | 0 |
| 9 | Smartphone-based rapid and visual pathological diagnosis of glioma using perovskite probes显示文摘Histopathology plays a great role in diagnosing various diseases,which is considered as a golden standard for tumor identification.The tissue constituents must be stained by visible labels for microscopic analysis by medical experts.However,this process is time-consuming,labor-intensive,and expensive,which requires rapid pathological approaches for diagnosis in the operating room.Here,we present an easy-to-process and high-performance perovskite biological probes for rapid and visual pathological diagnosis of glioma.Perovskite quantum dots can be encapsulated by the copolymer into nanocrystals(PNCs)with a diameter of 100 nm,which is modified with chlorotoxin to achieve the specific recognition of glioma.Benefiting from the super photoluminescence quantum yield(above 93%)of EVA@PNCs aqueous solution,the glioma can be clearly imaged and captured via a smartphone under the excitation of a handheld UV lamp.To demonstrate the visualization and efficiency of PNC probes,different malignant grades of brain tumor sections can be distinguished in no more than 5 min.This strategy provides a general auxiliary diagnosis platform for achieving the histopathology analysis near the operating bed,which is currently not feasible with standard histochemical staining methods. | Dongdong Wu Jimei Chi Junzhen Fan Lijun Cheng Xuning Wang Xu Yang Meng Zhang Zewei Lian Zengqi Huang Huadong Wang Hongfei Xie Sisi Chen Qi Pan Zeying Zhang Bingda Chen Guochen Sun Bainan Xu Meng Su Yanlin Song | 2023 | InfoMat2023，5，11： | 0 |
| 10 | Multi-stage metallogeny in the southwestern part of South China,and paleotectonic and climatic implications:A high precision geochronologic study显示文摘The South China Block(SCB)is among the large-scale W-Sn mineralized regions of the globe.The Laojunshan W-Sn-dominant ore area(LOA)in the western part of the SCB preserves the records of the tectonic history of the Tethys realm extending through North Vietnam,and Yangtze to Cathaysia blocks,with coeval formation of giant metallic deposits.The prolonged tectonic activities and their control on the genesis and spatio-temporal distribution of giant metallic deposits in the LOA provide a window for a holistic understanding of the tectono-metallogenesis of the SCB.In this study,we present results from a multi-chronologic study to determine the timing of formation of the cassiterite-wolframite-schee lite mineralization.The results suggest three distinct tectono-metallogenic periods in the LOA during the geodynamic evolution of the surrounding tectonic units.The opening of the Proto-Tethys Ocean between the Yangtze-Indochina blocks and the westward Paleo-Pacific subduction beneath the Cathaysia block(420–380 Ma)jointly contributed to the Silurian to early Devonian intracontinental orogeny in the middle of the SCB that involved top-to-the-north thrusting along NE-striking shear zones.This event generated the Dulong-Song Chay granitoids,together with the formation of Xinzhai Sn deposit related to sheared mylonitic granites(ca.419 Ma)and pegmatites(ca.389 Ma),which include the early-stage Sn-sulfide skarn(ca.418 Ma)and the late-stage Sn-bearing schist(ca.389 Ma).During the Late Permian to Late Triassic(260–220 Ma),with the closure of the Proto-Tethys oceans in the west and ongoing Paleo-Pacific westward subduction in the east,the SCB and Indochina Block(IB)were amalgamated which also marks the time of formation of the Nanwenhe scheelite skarn deposit.The subducted PaleoTethys oceanic crust was likely entrained by the nearby rising Emeishan mantle plume(270–259 Ma),which formed the Maguan diabase(ca.260 Ma)that shows significantly older Re-Os model age of ca.268 Ma,suggesting that the Nanwenhe mineralization is potentially derived from ca.260 Ma source.Furthermore,the intraplate shortening induced thin skinned crustal deformation and low grade metamorphism(ca.230 Ma),with the main stage of scheelite-Sn-Mo mineralization(229.9,229.8 and 219 Ma)and contemporary formation of the pegmatite(230.7 Ma).The Late Cretaceous involved two episodes of alternate extension and shortening,driven by the subduction polarity change from northwestward subduction of the Okhotomorsk block to northward subduction of the NeoTethys seafloor.The evolution of the LOA consists of the NW–SE transpression ending ca.100 Ma,the WNW–ESE extension in the earlier episode lasting from 100 Ma to 86 Ma,the WNW–ESE transpression beginning at ca.85 Ma and the NAS extension in the later episode during the latest Cretaceous,which produced the extension-related three periods of Laojunshan granitic magmatism and coeval Sn-W mineralization,with ages in the range of 90–89 Ma,87–85 Ma and 83–79 Ma.We also evaluate the implications of magmaticmetamorphic-metallogenic degassing on the regional paleoclimatic history. | Yanbin Liu Lifei Zhang MSantosh Guochen Dong Hongying Zhou Chaoyang Que Cheng-Xue Yang | 2023 | Geoscience Frontiers2023，14，3： | 0 |
| 11 | Molecular Short Range Correlations in Nematic Liquid Crystal Films显示文摘A generalized functional variation theory of nematics is presented to take account of the local short range correlations between molecules.This theory is used to study nematics liquid crystal films.The nematics-isotropic transition temperature is determined.The orientational order parameter in each molecular layer and the internal energy per molecule associated with each layer are calculated.The numerical results are compared with those of the Monte Carlo simulation and of the mean field theory. | ZHANG Zhidong YANG Guochen | 1995 | Chinese Physics Letters1995，12，3： | 0 |
| 12 | Functional β-Cyclodextrin Coating by Electrodeposition on Stainless Steel for Drug Loading and Release显示文摘 | CHEN Bin CHEN Jie YANG Liming ZHAO Guochen DING Guowei | 2016 | Chemical Research in Chinese Universities2016，32，2： | 0 |
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