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| 1 | Sensitivity analysis of fatigue life prediction for deepwater steel lazy wave catenary risers显示文摘Steel lazy wave catenary riser (SLWR) has been an attractive choice for deepwater oil field developments. However, fatigue is a critical issue in assessing the feasibility of applying SLWR to large motion vessels such as floating production storage and offloading (FPSO) or semi-submersibles. In this work, the time-domain fatigue analysis of SLWR was adopted for better representing the structural nonlinearity, fluid load nonlinearity and riser-soil nonlinear interaction. The Palmgren-Miner rule was employed for the fatigue life prediction along the riser length. The main purpose of this analysis is to present sensitivity analyses of SLWR fatigue life under various input parameters, which include the structural damping, the hydrodynamic coefficients along the riser, the seabed stiffness, the vessel motions, etc. The analyses indicated the strong dependence of the riser fatigue life on these parameters. The results can help designers to understand the dynamic behavior of the SLWR and provide guidance for selection of some critical parameters that are used in the fatigue design. | YANG HeZhen LI HuaJun | 2011 | Science China(Technological Sciences)2011，54，7： | 19 |
| 2 | Multi-objective optimization for deepwater dynamic umbilical installation analysis显示文摘We suggest a method of multi-objective optimization based on approximation model for dynamic umbilical installation. The optimization aims to find out the most cost effective size, quantity and location of buoyancy modules for umbilical installation while maintaining structural safety. The approximation model is constructed by the design of experiment (DOE) sampling and is utilized to solve the problem of time-consuming analyses. The non-linear dynamic analyses considering environmental loadings are executed on these sample points from DOE. Non-dominated Sorting Genetic Algorithm (NSGA-II) is employed to obtain the Pareto solution set through an evolutionary optimization process. Intuitionist fuzzy set theory is applied for selecting the best compromise solution from Pareto set. The optimization results indicate this optimization strategy with approximation model and multiple attribute decision-making method is valid, and provide the optimal deployment method for deepwater dynamic umbilical buoyancy modules. | YANG HeZhen WANG AiJun LI HuaJun | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，8： | 5 |
| 3 | Compound Gaoziban tablet(复方高滋斑片) alleviates depression via toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-kappa B pathway显示文摘OBJECTIVE: To evaluate the effect of compound Gaoziban tablet(复方高滋斑片, CGZBT) on depression, and to investigate the underlying mechanism. METHODS: The components of CGZBT were analysed by high-performance liquid chromatography. Then, we assessed the effects of varying doses of CGZBT on an established chronic unpredictable mild stress(CUMS) model in rats. Whether animals were depressed was evaluated by sucrose preference test, open field test and forced swimming test. Neurotransmitters of hippocampus were detected by liquid chromatography-mass spectrometry. Serum levels of tumor necrosis factor-alpha(TNF-α), interleukin(IL)-1β, IL-6, IL-4, and IL-10 were measured by enzyme-linked immunosorbent assay. Expressions of toll-like receptor 4(TLR4), myeloid differentiation factor 88(My D88), phospho-nuclear factorkappa B(p-NF-κB), cyclooxygenase-2(COX-2), ionized calcium binding adapter molecule-1(IBA-1) were assessed by immunohistochemical staining and western blotting. RESULTS: Eight compounds were identified from CGZBT, moreover, our results showed that CGZBT effectively reversed the CUMS-induced decrease in sucrose preference, shortened the movement distance and prolonged immobility time. CGZBT significantly increased levels of 5-hydroxytryptamine, dopamine, norepinephrine, 5-hydroxyindoleacetic acid levels, and reduced the expression of TNF-α, IL-1β, IL-6, yet increased IL-4 and IL-10. Furthermore, the expressions of TLR4, My D88, COX-2, p-NF-κB and IBA-1 in hippocampus were effectively reversed after treatment with CGZBT. CONCLUSIONS: These results indicated that CGZBT could, at least in part, alleviate depression induced by CUMS via the TLR4/My D88/NF-κB pathway, suggesting its potential as an antidepressant drug. | ZOU Xinshuang SHI Lei YIN Hailong LI Haiping WANG Mengheng SONG Wanci LUO Laichun WU Hezhen YANG Yanfang ZAN Junfeng LIU Yanwen DAN Hanxiong YIN Qiang YOU Pengtao | 2022 | Journal of Traditional Chinese Medicine2022，42，6： | 2 |
| 4 | Characterization of neuroprotective effects of Biphalin, an opioid receptor ago nist, in a model of focal brain显示文摘 | Li Yang Kaushik Shah Hezhen Wang | 2011 | Pharmacol Exp Ther2011，339，： | 1 |
| 5 | Damage localization of offshore platform under ambient excitation显示文摘 | YANG Hezhen LI Huajun | 2003 | China Ocean Engineering2003，17，3： | 1 |
| 6 | Multiaxial fatigue analysis on reeled steel tube umbilical显示文摘 | Yang Hezhen Li Qingquan Li Huajun | 2013 | Journal of Offshore Mechanics and Arctic Engineering-Transactions of the ASME2013，135，1： | 1 |
| 7 | Damage Localization of Marine Risers Using Time Series of Vibration Signals显示文摘Based on dynamic response signals a damage detection algorithm is developed for marine risers. Damage detection methods based on numerous modal properties have encountered issues in the researches in offshore oil community. For example, significant increase in structure mass due to marine plant/animal growth and changes in modal properties by equipment noise are not the result of damage for riser structures. In an attempt to eliminate the need to determine modal parameters, a data-based method is developed. The implementation of the method requires that vibration data are first standardized to remove the influence of different loading conditions and the autoregressive moving average(ARMA) model is used to fit vibration response signals. In addition, a damage feature factor is introduced based on the autoregressive(AR) parameters. After that, the Euclidean distance between ARMA models is subtracted as a damage indicator for damage detection and localization and a top tensioned riser simulation model with different damage scenarios is analyzed using the proposed method with dynamic acceleration responses of a marine riser as sensor data. Finally, the influence of measured noise is analyzed. According to the damage localization results, the proposed method provides accurate damage locations of risers and is robust to overcome noise effect. | LIU Hao YANG Hezhen LIU Fushun | 2014 | Journal of Ocean University of China2014，13，5： | 1 |
| 8 | The Impact of Urban Expansion on Plant Diversity Change in Karst Regions of Southwest China显示文摘Biodiversity is vital for the integrity and stability of ecosystems and sustainable development.Karst regions of Southwest China is featured for undulating and broken karst terrain as well as high plant diversity.Land use changes induced by the growing population and expanding human settlement have threatened biodiversity preservation in this region.However,the impact of urban expansion on plant diversity remains unclear here.This study focuses on how expanding countryside landscapes affect the recovery rate of plant diversity and demonstrate how urban expansion affects plant diversity conservation in karst regions of Southwest China.In situ biodiversity investigations and multisource remote sensing images were combined to analyze the role of human settlement evolution in the conservation of plant diversity using descriptive statistics and regression analysis.Unmanned vehicle images,historical aerial photographs,and long-term remote sensing images were used to observe the human settlement pattern changes over 40 yr and found that plant diversity is restored faster in countryside ecosystems than in island ecosystems restricted by water.Forests,however,contribute the most to plant diversity conservation in both ecosystems.While the forest area is stable during urban expansion,massive forest patches play an essential role in plant diversity conservation.Arable lands and grasslands shrank but with a fragmenting trend,which was conducive to preserving plant diversity,whereas increased and regularized large patches of built-up areas were not beneficial to plant diversity.Accordingly,forest protection should be prioritized to coordinate future socioeconomic development and plant diversity conservation in karst and broader regions.Furthermore,large built-up patches should be limited,and the irregularity should be improved during urban expansion.Irregular shaped cultivated land and grassland were suggested to promote biological information exchanges as landscape corridors. | YANG Shengtian LI Chaojun LOU Hezhen LUO Ya WANG Pengfei ZHANG Jun LI Xi WU Xijin | 2022 | Chinese Geographical Science2022，32，3： | 0 |
| 9 | Effect of compound Sophorae decoction in the treatment of ulcerative colitis by tissue extract metabolomics approach显示文摘OBJECTIVE: To investigate how compound Sophorae decoction(CSD) works on rats' models of ulcerative colitis(UC) induced by 2,4,6-trinitrobenzenesulfonic acid solution(TNBS) by metabolomics studies of colon, liver, and kidney tissue extracts.METHODS: Rats with UC induced by TNBS enema were used as models in this study. Metabolic profiles of the three tissues were analyzed and pathway analysis of biomarkers was performed after CSD administration and further integration of metabolic networks.RESULTS: Thirteen biomarkers were screened from colon, liver, and kidney tissue extracts, and the levels of these substances were up-or down-regulated in the model group, but their levels were reversed after CSD administration. These biomarkers were mainly related to Phenylalanine, tyrosine and tryptophan biosynthesis, Phenylalanine metabolism, Glutathione metabolism, Arachidonic acid metabolism, Nicotinate and nicotinamide metabolism,Alanine, aspartate and glutamate metabolism.CONCLUSION: CSD could significantly ameliorate the symptoms of UC by regulating multiple metabolic pathways. | HONG Zongchao CAI Quan DUAN Xueyun YANG Yanfang WU Hezhen JIANG Nan FAN Heng | 2021 | Journal of Traditional Chinese Medicine2021，41，3： | 0 |
| 10 | Reduction Process of Blue Tungsten Oxide and its Microcomputer Process Control显示文摘The grain size control of the tungsten powder is essential for high quality tungsten products making. Based on the studies onthe hydrogen reduction process of tungsten oxide, a microcomputer system is introduced to the reduction process parameters con-trol. The microcomputer process control system, which is now running in Zhuzhou Tungsten and Molybdenum Materials Plant,controls the process parameters including the temperature of the reduction furnace and the pressure of hydrogen. It also controlsa mechanical pusher which pushs the boats charged with blue tungsten oxide into the furnace tubes. Some of the technique prob-lems appeared in the reduction process and the process control are analysed in this paper. The result of the experiment is alsogiven. | Yang, Zhangyuan Shu, Daixuan Zhang, Hezhen Zhang, Wanwu | 1990 | Rare Metals1990，10，2： | 0 |
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