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| 1 | PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix显示文摘Biofilms 是在细胞外的矩阵嵌入的微生物的联系表面的社区。Exopolysaccharide 是在维持 biofilm 建筑学并且保护居民 biofilm 细菌免受抗菌剂和主人免疫者攻击的伤害的细胞外的矩阵的一个批评部件。然而,指向矩阵 exopolysaccharides 的自我生产的因素,仍然糟糕被理解。这里,我们显示出那 PslG,在 Pseudomonas aeruginosa 涉及关键 biofilm 矩阵 exopolysaccharide Psl 的合成的蛋白质,阻止 biofilm 形成并且拆卸存在在外长地供应的在 nanomolar 集中的分钟以内的 biofilms。PslG 的水晶结构显示 endoglycosidase 的典型特征。PslG 主要破坏 Psl 矩阵从 biofilms 驱散细菌。PslG 处理显著地提高 biofilm 敏感到抗菌素和巨噬细胞房间,导致在一只老鼠的改进 biofilm 清理植入感染模型。而且, PslG 对大量 Pseudomonas 种类显示出 biofilm 抑制和拆卸活动,显示它在与 biofilm 相关的复杂并发症作斗争的大潜力。 | Shan Yu Tiantian Su Huijun Wu Shiheng Liu Di Wang Tianhu Zhao Zengjun Jin Wenbin Du Mei-Jun Zhu Song Lin Chua Liang Yang Deyu Zhu Lichuan Gu Luyan Z Ma | 2015 | Cell Research2015，25，12： | 13 |
| 2 | Value of diffusion-weighted imaging in distinguishing pancreatic carcinoma from mass-forming chronic pancreatitis: a meta-analysis显示文摘 | Niu Xiangke Sushant Kumar Das Anup Bhetuwal Xiao Yingquan Sun Feng Zeng Lichuan Wang Wenxuan Yang Hanfeng Yang Hanyu | 2014 | Chinese Medical Journal2014，，19： | 11 |
| 3 | Feed-Forward Active Noise Control System Using Microphone Array显示文摘Feedforward active noise control(ANC) system are widely used to reduce the wide-band noise in different application. In feedforward ANC systems, when the noise source is unknown, the misplacement of the reference microphone may violate the causality constraint. We present a performance analysis of the feedforward ANC system under a noncausal condition. The ANC system performance degrades when the degree of noncausality increases. This research applies the microphone array technique to feedforward ANC systems to solve the unknown noise source problem. The generalized cross-correlation(GCC) and steering response power(SRP) methods based on microphone array are used to estimate the noise source location.Then, the ANC system selects the proper reference microphone for a noise control algorithm. The simulation and experiment results show that the SRP method can estimate the noise source direction with 84% accuracy. The proposed microphone array integrated ANC system can dramatically improve the system performance. | Yang Li Lichuan Liu Sen M. Kuo | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，5： | 3 |
| 4 | Expression of P-gp, MRP, LRP, GST-π and TopoIIα and intrinsic resistancein human lung cancer cell lines显示文摘 | Jiarui Wang Jinhui Zhang Lichuan Zhang Long Zhao Sufang Fan Zhonghai Yang Fei Gao Ying Kong Gary Xiao Qi Wang | 2011 | Oncology Reports2011，，5： | 1 |
| 5 | Therapeutic effects of coenzyme Q10 and reduced CoQ10 in the MPTP model of Parkinsonism显示文摘 | Cleren Carine Yang Lichuan Lorenzo Beverly | 2008 | Journal of Neurochemistry2008，104，6： | 1 |
| 6 | Prefrontal attention and multiple reference frames during working memory in primates显示文摘The prefrontal cortex (PFC) is responsible for executive functions, including planning, goal setting, problem solving, inhibitory control, monitoring, and action adjusting. Executive functions also include selective attention and the flexibility or switching of attention; therefore, attention is an executive function in which the PFC participates. Working memory (WM), which is the temporary maintenance and processing of particular information, is usually considered to be a basic neural mechanism underlying the executive functions. This review systematically discusses the relationship between the prefrontal WM and attention and empha- sizes two forms of prefrontal attention. The first form occurs in the dlPFC, which encodes the location of objects with respect to the position of the head, thereby providing a frame of reference from which the focus of attention can be centered. The second occurs in the inferior convexity of the prefrontal cortex (IFC), which encodes the different attributes (shape, texture, color) of objects to enable the ability to focus on one or to switch attention between sensory attributes of objects. | YANG LiChuan LI MingHong WILSON Fraser A HU XinTian MA YuanYe | 2013 | Chinese Science Bulletin2013，58，4： | 1 |
| 7 | A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivo显示文摘 | Lichuan Yang Shuei Sugama Ronald P. Mischak Mahmoud Kiaei Nicolas Bizat Emmanuel Brouillet Tong H. Joh M. Flint Beal | 2004 | Neurobiology of Disease2004，，2： | 1 |
| 8 | Synthesis of yttrium iron garnet/bismuth quantum dot heterostructures with localized plasmon enhanced magneto-optical performance显示文摘Interactions between light and magnetic matter attracted great attention lately due to their potential applications in nanophotonics,spintronics,and high-accuracy sensing.Here,we grew bismuth quantum dots(Bi–QDs)with strong spin–orbit coupling on a magnetic insulator yttrium iron garnet(YIG)via molecular beam epitaxy.The YIG/Bi–QDs material shows an enhanced magneto-optical Kerr rotation up to 130%compared with that of a bare YIG film.The Bi–QDs were also introduced onto a lutetium–bismuth co-doped YIG film to form a hybrid system with remarkably enhanced Kerr rotation(from 1626 to 2341 mdeg).Ferromagnetic resonance measurements showed an increased effective magnetization as well as interfacial spin–orbit field in the YIG/Bi–QD heterostructures.Localized plasmons were mapped using electron energy loss spectroscopy with high spatial resolution,revealing enhanced plasmon intensity at both the Bi–QD surface and YIG/Bi–QD interface.Introducing Bi-QDs onto the YIG film enhanced Kerr rotation owing to the attenuated optical reflection and increased effective magnetization.The Bi–QDenhanced magneto-optical effect enables development of efficient nanoscale light switching,spintronics,and even plasmonic nano-antennas. | Lichuan Jin Caiyun Hong Dainan Zhang Peng Gao Yiheng Rao Gang Wang Qinghui Yang Zhiyong Zhong Huaiwu Zhang | 2020 | Journal of Materials Science & Technology2020，47，16： | 0 |
| 9 | Electric field-driven folding of single molecules显示文摘Folding of molecules is an essential process in nature,and various molecular machines achieve their chemical and mechanical function via controlled folding of molecular conformations.The electric field offers a unique strategy to drive the folding of molecular conformation and to control charge transport through single molecules but remains unexplored.The single-molecule break junction technique provides access to detect the conformational changes via the monitoring of single-molecule conductance,and the electric field between two metal electrodes with nanoscale spacing can provide an extremely strong to achieve in-situ control and detection of molecular folding at the single-molecule level.Here,we use the electric field to control the single-molecule folding using the scanning tunneling microscope break junction(STM-BJ)technique.The electric fields induced folding could lead to a∼1400%conductance change of the single-molecule junctions,and the folding/unfolding process can be in-situ switched at the scale of milliseconds.DFT calculations suggest the conformational control originates from the electric fieldinduced charge injection,and the formation of homoconjugated conformation with the overlapped orbitals.This work provides the first demonstration of electric field-driven molecular folding,which is essential for the understanding of molecular machines in nature and for the design of artificial molecular machines. | Saisai Yuan Yu Zhou Tengyang Gao Lichuan Chen Wei Xu Ping Duan Juejun Wang Zhichao Pan Chun Tang Yang Yang Ruiyun Huang Zongyuan Xiao Wenjing Hong | 2024 | Chinese Chemical Letters2024，35，1： | 0 |
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