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| 1 | Effects of tachyplesin on the morphology and ultrastructure of human gastric carcinoma cell line BGC-823显示文摘AIM To investigate the morphological andultrastructural changes in the human gastriccarcinoma cell line BGC-823 after being treatedwith tachyplesin.METHODS Tachyplesin was isolated from acidextracts of Chinese horseshoe crab(Tachypleustridentatus)hemocytes.BGC-823 cells and thecells treated with 2.0mg/L tachyplesin wereexamined respectively under light microscope,scanning and transmission electron microscope.RESULTS BGC-823 cells had undergone therestorational alteration in morphology andultrastructure after tachyplesin treatment.Thechanges were as follows:the shape of cells wasunanimous,the volume enlarged and cellsturned to be flat and spread,the nucleo-cytoplasmic ratio lessened and nuclear shapebecame rather regular,the number of nucleolusreduced and its volume lessened,heter-chromatin decreased while euchromatinincreased in nucleus.In the cytoplasm,mitochondria grew in number with consistentstructure relatively,Golgi complex turned to betypical and well-developed,rough endoplasmicreticulum increased and polyribosomedecreased.The microvilli at cellular surfacewere rare and the filopodia reduced whilelamellipodia increased at the cell edge.CONCLUSION Tachyplesin could alter themalignant morphological and ultrastructuralcharacteristics of human gastric carcinoma cellseffectively and have a certain inducing differen-tiation effect on human gastric carcinoma cells. | Li QF Ou Yang GL Li CY Hong SG | 2000 | World Journal of Gastroenterology2000，6，5： | 19 |
| 2 | Expression of perforin and granzyme B mRNA in judgement of immunosuppressive effect in rat liver transplantation显示文摘AIM To explore the expression of perform andgranzyme B genes mRNA to judge the effect ofimmunosuppression in acute rejection of livertransplantation.METHODS The expression of perform andgranzyme B genes mRNA was examined byreverse transcriptase-polymerase chain reaction(RT--PCR) in hamster to rat liver grafts under theimmunosuppression of cyclosporine or/andsplenectomy. Histological findings were studiedcomparatively.RESULTS Cyclosporine could obviouslydecrease the cellular infiltration, and completelyrepress the expression of mRNA for perform andgranzyme B, but could not change severehepatocyte necrosis and hemorrhage.SPlenectomy could significantly lightenhepatocyte necrosis, and completely eliminatehemorrhage, but not atfect the cellularinfiltration and the expression of perform andgranzyme B genes mRNA. Cyclosporine orsplenectomy alone could not prolong theSurvival time, however, their combination couldcompletely repress the rejection of liver grafts.The survival time of animals were significantlyprolonged (37.1 days ). The architecture ofhepatic lobules was preserved. There was slightcellular infiltration in the portal tracts and noexpression of perform and granzyme B genesmRNA could be seen in three weeks aftertransplantation.CONCLUSION Perform and granzyme B genesare valuable in judging the effect ofimmunosuppression in liver transplantation. | Zhang SG Wu MC Tan JW Chen H Yang JM Qian QJ | 1999 | World Journal of Gastroenterology1999，5，3： | 15 |
| 3 | Systemic infusion of FLKI(+) mesenchymal stem cells ameliorate carbon tetrachloride-induced liver fibrosis in mice显示文摘 | Fang,BJ Shi,MX Liao,LM Yang,SG Liu,YH Zhao,RC | 2005 | 中国生物学文摘2005，19，3： | 2 |
| 4 | Calculation of Hydro-Dynamic Stability of the Soil Inside Bucket in the Process of Bucket Foundation Penetration显示文摘—The offshore platform with bucket foundations is a new type of offshore platform that distin-guishes from traditional template platforms by replacing driven piles with bucket foundations.The suctionpenentration of bucket foundation is a complicated hydro-dynamic process.The key of this process is theseepage field caused by the difference of pressure applied on purpose inside and outside the bucket.The ap-pearance and developement of seepage field has a decisive influence on the suction penetration process.Inthis study,the finite element analysis method is applied to the dynamic simulation of the seepage field ofsuction penetration of bucket foundation.A criterion is suggested to distinguish the hydro-dynamic stabili-ty of the soil inside the bucket according to the critical hydraulic gradient method.The reliability of themodel and its applicability to engineering practice have been proved through comparison between the re-sults of model test and finite element calculation. | Yang, SG Xu, T Meng, ZY Ren, GY | 1998 | China Ocean Engineering1998，13，4： | 2 |
| 5 | Biocompatibility and antibacterial activity of chitosan and collagen immobilized poly(3-hydroxybutyric acid-co-3- hydroxyvaleric acid) 显示文摘 | Hu SG Jou CH Yang MC | 2004 | Carthohydrate Polymer2004，58，2： | 1 |
| 6 | Protein adsorption,fibroblast activity and antibacterial properties of poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) grafted with chitosan and chitooligosaccharide after immobilized with hyaluronic acid显示文摘 | Hu SG Jou CH Yang MC | 2003 | Biomaterials2003，24，16： | 1 |
| 7 | Multi-Walled Carbon Nanotube-Based Gas Sensors for NH3 Detection显示文摘 | Wang SG Qing Zhang Yang D J Sellin P J Zhong G F | 2004 | Diamond and Related Materials2004，13，： | 1 |
| 8 | The usefulness of oncoplas-tic volume displacement techniques in the superiorly located breastcancers for Korean patients with small to moderate-sized breasts显示文摘 | Yang JD Bae SG Chung HY | 2011 | Ann Plast Surg2011，679，47： | 1 |
| 9 | Activation of P2X receptors induces apoptosis in human retinal pigment epithelium 显示文摘 | Yang D Elner SG Clark A J | 2011 | Invest Ophthalmol Vis Sci2011，52，： | 1 |
| 10 | Peroxisome proliferator-activated receptor-gamma and retinoic acid X receptor alpha represses the TGFbetal gene via PTEN-mediated p70 ribosomal S6 kinase-1 inhibition: role for Zf9 dephosphorylation显示文摘 | Lee SJ Yang EK Kim SG | 2006 | Mol Pharmacol2006，70，1： | 1 |
| 11 | Abuse of antibiotics in China and its potential interference in determining the etiology of pediatric bacterial diseases 显示文摘 | Yang YH Fu SG Peng H | 1993 | Pediatr Infect Dis J1993，12，12： | 1 |
| 12 | Evaluation of ventricular septal defect repair using intraoperative transesophageal echocardiography: frequency and significance of residual defects in infants and children 显示文摘 | Yang SG Novello R Nicolson S | 2000 | Echocardiography2000，17，7： | 1 |
| 13 | Regulation of the class II and class I MHC pathways in human THP-1 monocytic cells by interleukin-27显示文摘 | Feng XM Liu N Yang SG | 2008 | Biochem Biophys Res Commun2008，367，3： | 1 |
| 14 | Changes in H202 content and antioxidant enzyme gene expression during the somatic embryogenesis of Lar/x/epto/ep/s显示文摘 | Zhang SG Han SY Yang WH | 2010 | PCTOC2010，100，1： | 1 |
| 15 | Effect of combined cataract surgery and ranibizumab injection in postoperative macular edema in nonproliferative diabetic retinopathy 显示文摘 | Chae JB Joe SG Yang SJ | 2014 | Retina2014，34，1： | 1 |
| 16 | Antiviral therapy and outcomes of patients with pneumonia caused by influenza A pandemic (H1N1) virus显示文摘 | Yang SG Cao B Liang LR | 2012 | PLoS One2012，7，29： | 1 |
| 17 | Isolation and characteri- zation of human umbilical cord mesenchymal stem ceils with hematopoiesis-supportive function and other po- tentials显示文摘 | Lu LL Liu YJ Yang SG | 2006 | Haematologica2006，91，8： | 1 |
| 18 | Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials显示文摘 | Lu LL Liu YJ Yang SG | 2006 | Haematologica2006，91，： | 1 |
| 19 | Good response to pemetrexed in patients of lung adenocarcinoma with epidermal growth factor receptor(EGFR) mutations 显示文摘 | Wu SG Yang CH Yu C J | 2011 | Lung Cancer2011，72，3： | 1 |
| 20 | Report and analysis of a scarlet fever outbreak among adults through food_borne transmission in China显示文摘 | Yang SG Dong HJ Li FR | 2007 | J Infect2007，55，5： | 1 |
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